Mechanisms of lung fibrosis induced by carbon nanotubes: towards an Adverse Outcome Pathway (AOP)

Use of a Pro-Fibrogenic Mechanism-Based Predictive Toxicological Approach for Tiered Testing and Decision Analysis of Carbonaceous Nanomaterials

(2015) Xiang Wang et al.   ACS Nano

Mechanisms of Multi-walled Carbon Nanotubes–Induced Oxidative Stress and Genotoxicity in Mouse Fibroblast Cells

(2015) Saud Alarifi et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

mRNAs and miRNAs in whole blood associated with lung hyperplasia, fibrosis, and bronchiolo-alveolar adenoma and adenocarcinoma after multi-walled carbon nanotube inhalation exposure in mice

(2015) Brandi N. Snyder-Talkington et al.   JOURNAL OF APPLIED TOXICOLOGY

Towards predicting the lung fibrogenic activity of MWCNT: Key role of endocytosis, kinase receptors and ERK 1/2 signaling

(2015) Giulia Vietti et al.   Nanotoxicology

NADPH Oxidase-Dependent NLRP3 Inflammasome Activation and its Important Role in Lung Fibrosis by Multiwalled Carbon Nanotubes

(2015) Bingbing Sun et al.   Small

Multi-walled carbon nanotube-induced gene expression in vitro : Concordance with in vivo studies

(2015) Brandi N. Snyder-Talkington et al.   TOXICOLOGY

Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos

(2015) Matthew S.P. Boyles et al.   TOXICOLOGY IN VITRO

Toxicological assessment of multi-walled carbon nanotubes on A549 human lung epithelial cells

(2015) Giuseppa Visalli et al.   TOXICOLOGY IN VITRO

Endocytosis of Multiwalled Carbon Nanotubes in Bronchial Epithelial and Mesothelial Cells

(2015) Kayo Maruyama et al.   Biomed Research International

Pathologic and molecular profiling of rapid-onset fibrosis and inflammation induced by multi-walled carbon nanotubes

(2014) Jie Dong et al.   ARCHIVES OF TOXICOLOGY

The role of Rho-kinases in IL-1β release through phagocytosis of fibrous particles in human monocytes

(2014) Sanae Kanno et al.   ARCHIVES OF TOXICOLOGY

Apoptotic, inflammatory, and fibrogenic effects of two different types of multi-walled carbon nanotubes in mouse lung

(2014) D. van Berlo et al.   ARCHIVES OF TOXICOLOGY

Multi-walled carbon nanotube length as a critical determinant of bioreactivity with primary human pulmonary alveolar cells

(2014) Sinbad Sweeney et al.   CARBON

ESR evidence for in vivo formation of free radicals in tissue of mice exposed to single-walled carbon nanotubes

(2014) A.A. Shvedova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effect of Fiber Length on Carbon Nanotube-Induced Fibrogenesis

(2014) Amruta Manke et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Multiwalled carbon nanotubes induce altered morphology and loss of barrier function in human bronchial epithelium at noncytotoxic doses

(2014) Ryan J Snyder et al.   International Journal of Nanomedicine

MWCNT causes extensive damage to the ciliated epithelium of the trachea of rodents

(2014) Teruya Ohba et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Thirteen-week study of toxicity of fiber-like multi-walled carbon nanotubes with whole-body inhalation exposure in rats

(2014) Tatsuya Kasai et al.   Nanotoxicology

Inflammasome activation in airway epithelial cells after multi-walled carbon nanotube exposure mediates a profibrotic response in lung fibroblasts

(2014) Salik Hussain et al.   Particle and Fibre Toxicology

The carcinogenic effect of various multi-walled carbon nanotubes (MWCNTs) after intraperitoneal injection in rats

(2014) Susanne Rittinghausen et al.   Particle and Fibre Toxicology

Promotion of lung adenocarcinoma following inhalation exposure to multi-walled carbon nanotubes

(2014) Linda M Sargent et al.   Particle and Fibre Toxicology

Free radical scavenging and formation by multi-walled carbon nanotubes in cell free conditions and in human bronchial epithelial cells

(2014) Penny Nymark et al.   Particle and Fibre Toxicology

Atomic Layer Deposition Coating of Carbon Nanotubes with Aluminum Oxide Alters Pro-Fibrogenic Cytokine Expression by Human Mononuclear Phagocytes In Vitro and Reduces Lung Fibrosis in Mice In Vivo

(2014) Alexia J. Taylor et al.   PLoS One

Multiwall Carbon Nanotubes Directly Promote Fibroblast-Myofibroblast and Epithelial-Mesenchymal Transitions through the Activation of the TGF-β/Smad Signaling Pathway

(2014) Peng Wang et al.   Small

Epithelial–mesenchymal transition involved in pulmonary fibrosis induced by multi-walled carbon nanotubes via TGF-beta/Smad signaling pathway

(2014) Tian Chen et al.   TOXICOLOGY LETTERS

Surface Charge and Cellular Processing of Covalently Functionalized Multiwall Carbon Nanotubes Determine Pulmonary Toxicity

(2013) Ruibin Li et al.   ACS Nano

Pulmonary toxicity of carbon nanotubes and asbestos — Similarities and differences

(2013) Ken Donaldson et al.   ADVANCED DRUG DELIVERY REVIEWS

Long-term effects of carbon containing engineered nanomaterials and asbestos in the lung: one year postexposure comparisons

(2013) Anna A. Shvedova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Purification and sidewall functionalization of multiwalled carbon nanotubes and resulting bioactivity in two macrophage models

(2013) Raymond F. Hamilton et al.   INHALATION TOXICOLOGY

The Role of Iron Impurities in the Toxic Effects Exerted by Short Multiwalled Carbon Nanotubes (MWCNT) in Murine Alveolar Macrophages

(2013) E. Aldieri et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Repetitive Dissociation from Crocidolite Asbestos Acts as Persistent Signal for Epidermal Growth Factor Receptor

(2013) Eric S. Taylor et al.   LANGMUIR

Distribution and fibrotic response following inhalation exposure to multi-walled carbon nanotubes

(2013) Robert R Mercer et al.   Particle and Fibre Toxicology

Towards predicting the lung fibrogenic activity of nanomaterials: experimental validation of an in vitro fibroblast proliferation assay

(2013) Giulia Vietti et al.   Particle and Fibre Toxicology

Additional Histopathologic Examination of the Lungs from a 3-Month Inhalation Toxicity Study with Multiwall Carbon Nanotubes in Rats

(2013) Silke Treumann et al.   TOXICOLOGICAL SCIENCES

Systematic Analysis of Multiwalled Carbon Nanotube-Induced Cellular Signaling and Gene Expression in Human Small Airway Epithelial Cells

(2013) Brandi N. Snyder-Talkington et al.   TOXICOLOGICAL SCIENCES

Multi-walled carbon nanotubes translocate into the pleural cavity and induce visceral mesothelial proliferation in rats

(2012) Jiegou Xu et al.   CANCER SCIENCE

Asbestos exposure induces alveolar epithelial cell plasticity through MAPK/Erk signaling

(2012) Jenni A. Tamminen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Length-dependent effect of single-walled carbon nanotube exposure in a dynamic cell growth environment of human alveolar epithelial cells

(2012) Hemang J Patel et al.   Journal of Exposure Science and Environmental Epidemiology

Functionalized single-walled carbon nanotubes cause reversible acute lung injury and induce fibrosis in mice

(2012) Yanli Zhang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Pluronic F108 Coating Decreases the Lung Fibrosis Potential of Multiwall Carbon Nanotubes by Reducing Lysosomal Injury

(2012) Xiang Wang et al.   NANO LETTERS

Reactive oxygen species-mediated p38 MAPK regulates carbon nanotube-induced fibrogenic and angiogenic responses

(2012) Neelam Azad et al.   Nanotoxicology

Acute pulmonary dose–responses to inhaled multi-walled carbon nanotubes

(2012) Dale W. Porter et al.   Nanotoxicology

Factoring-in agglomeration of carbon nanotubes and nanofibers for better prediction of their toxicity versus asbestos

(2012) Ashley R Murray et al.   Particle and Fibre Toxicology

Impaired Clearance and Enhanced Pulmonary Inflammatory/Fibrotic Response to Carbon Nanotubes in Myeloperoxidase-Deficient Mice

(2012) Anna A. Shvedova et al.   PLoS One

A Carbon Nanotube Toxicity Paradigm Driven by Mast Cells and the IL-33/ST2 Axis

(2012) Pranita Katwa et al.   Small

Pulmonary toxicity and fibrogenic response of carbon nanotubes

(2012) Amruta Manke et al.   TOXICOLOGY MECHANISMS AND METHODS

Long, Needle-like Carbon Nanotubes and Asbestos Activate the NLRP3 Inflammasome through a Similar Mechanism

(2011) Jaana Palomäki et al.   ACS Nano

Dispersal State of Multiwalled Carbon Nanotubes Elicits Profibrogenic Cellular Responses That Correlate with Fibrogenesis Biomarkers and Fibrosis in the Murine Lung

(2011) Xiang Wang et al.   ACS Nano

A single intratracheal instillation of single-walled carbon nanotubes induced early lung fibrosis and subchronic tissue damage in mice

(2011) Eun-Jung Park et al.   ARCHIVES OF TOXICOLOGY

Thickness of Multiwalled Carbon Nanotubes Affects Their Lung Toxicity

(2011) Ivana Fenoglio et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Multiwalled Carbon Nanotubes Induce a Fibrogenic Response by Stimulating Reactive Oxygen Species Production, Activating NF-κB Signaling, and Promoting Fibroblast-to-Myofibroblast Transformation

(2011) Xiaoqing He et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Integrating mechanisms of pulmonary fibrosis

(2011) Thomas A. Wynn   JOURNAL OF EXPERIMENTAL MEDICINE

Effects of single and multi walled carbon nanotubes on macrophages: Cyto and genotoxicity and electron microscopy

(2011) Maria Laura Di Giorgio et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Double-walled carbon nanotubes trigger IL-1β release in human monocytes through Nlrp3 inflammasome activation

(2011) Etienne Meunier et al.   Nanomedicine-Nanotechnology Biology and Medicine

Epithelial-mesenchymal transition contributes to SWCNT-induced pulmonary fibrosis

(2011) Chih-Ching Chang et al.   Nanotoxicology

Pulmonary fibrotic response to aspiration of multi-walled carbon nanotubes

(2011) Robert R Mercer et al.   Particle and Fibre Toxicology

Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis

(2011) H. Nagai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative Techniques for Assessing and Controlling the Dispersion and Biological Effects of Multiwalled Carbon Nanotubes in Mammalian Tissue Culture Cells

(2010) Xiang Wang et al.   ACS Nano

In Vivo Behavior of Large Doses of Ultrashort and Full-Length Single-Walled Carbon Nanotubes after Oral and Intraperitoneal Administration to Swiss Mice

(2010) Jelena Kolosnjaj-Tabi et al.   ACS Nano

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Pulmonary Toxicity of Intratracheally Instilled Multiwall Carbon Nanotubes in Male Fischer 344 Rats

(2010) Shigetoshi AISO et al.   INDUSTRIAL HEALTH

Direct Fibrogenic Effects of Dispersed Single-Walled Carbon Nanotubes on Human Lung Fibroblasts

(2010) Liying Wang et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Relating the physicochemical characteristics and dispersion of multiwalled carbon nanotubes in different suspension media to their oxidative reactivityin vitroand inflammationin vivo

(2010) Barbara Rothen-Rutishauser et al.   Nanotoxicology

Asbestos, carbon nanotubes and the pleural mesothelium: a review and the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma

(2010) Ken Donaldson et al.   Particle and Fibre Toxicology

Distribution and persistence of pleural penetrations by multi-walled carbon nanotubes

(2010) Robert R Mercer et al.   Particle and Fibre Toxicology

Dispersion of single-walled carbon nanotubes by a natural lung surfactant for pulmonary in vitro and in vivo toxicity studies

(2010) Liying Wang et al.   Particle and Fibre Toxicology

Comparative Proteomics and Pulmonary Toxicity of Instilled Single-Walled Carbon Nanotubes, Crocidolite Asbestos, and Ultrafine Carbon Black in Mice

(2010) Justin G. Teeguarden et al.   TOXICOLOGICAL SCIENCES

Biological response and morphological assessment of individually dispersed multi-wall carbon nanotubes in the lung after intratracheal instillation in rats

(2010) Norihiro Kobayashi et al.   TOXICOLOGY

Uptake and cytotoxic effects of multi-walled carbon nanotubes in human bronchial epithelial cells

(2010) Seishiro Hirano et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Uptake of Noncytotoxic Acid-Treated Single-Walled Carbon Nanotubes into the Cytoplasm of Human Macrophage Cells

(2009) Alexandra E. Porter et al.   ACS Nano

Bacterial Lipopolysaccharide Enhances PDGF Signaling and Pulmonary Fibrosis in Rats Exposed to Carbon Nanotubes

(2009) Mark F. Cesta et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Airway barrier dysfunction induced by exposure to carbon nanotubes in vitro: which role for fiber length?

(2009) BM Rotoli et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Induction of apoptosis in rat lung epithelial cells by multiwalled carbon nanotubes

(2009) Prabakaran Ravichandran et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhaled carbon nanotubes reach the subpleural tissue in mice

(2009) Jessica P. Ryman-Rasmussen et al.   Nature Nanotechnology

Inhalation Toxicity of Multiwall Carbon Nanotubes in Rats Exposed for 3 Months

(2009) Lan Ma-Hock et al.   TOXICOLOGICAL SCIENCES

Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes

(2009) Dale W. Porter et al.   TOXICOLOGY

Biopersistence and potential adverse health impacts of fibrous nanomaterials: what have we learned from asbestos?

(2009) Vanesa C. Sanchez et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis

(2008) A. A. Shvedova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Structural Defects Play a Major Role in the Acute Lung Toxicity of Multiwall Carbon Nanotubes: Toxicological Aspects

(2008) Julie Muller et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Genotoxicity, cytotoxicity, and reactive oxygen species induced by single‐walled carbon nanotubes and C60fullerenes in the FE1‐Muta™Mouse lung epithelial cells

(2008) Nicklas Raun Jacobsen et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: the role of particle size, shape and composition

(2008) Hui Yang et al.   JOURNAL OF APPLIED TOXICOLOGY

Single-Walled Carbon Nanotubes Can Induce Pulmonary Injury in Mouse Model

(2008) Cheng-Chung Chou et al.   NANO LETTERS

Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study

(2008) Craig A. Poland et al.   Nature Nanotechnology

Induction of apoptosis and absence of inflammation in rat lung after intratracheal instillation of multiwalled carbon nanotubes

(2008) D. Elgrabli et al.   TOXICOLOGY

Increased accumulation of neutrophils and decreased fibrosis in the lung of NADPH oxidase-deficient C57BL/6 mice exposed to carbon nanotubes

(2008) A.A. Shvedova et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Alteration of deposition pattern and pulmonary response as a result of improved dispersion of aspirated single-walled carbon nanotubes in a mouse model

(2007) R. R. Mercer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY