Crosstalk between ER stress, NLRP3 inflammasome, and inflammation

Mitochondrial DNA Promotes NLRP3 Inflammasome Activation and Contributes to Endothelial Dysfunction and Inflammation in Type 1 Diabetes

(2020) Camila A. Pereira et al.   Frontiers in Physiology

Viroporins and inflammasomes: A key to understand virus-induced inflammation

(2020) N.S. Farag et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Endoplasmic Reticulum Stress Impaired Uncoupling Protein 1 Expression via the Suppression of Peroxisome Proliferator-Activated Receptor γ Binding Activity in Mice Beige Adipocytes

(2019) Ana Yuliana et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Modulation of the sigma-1 receptor–IRE1 pathway is beneficial in preclinical models of inflammation and sepsis

(2019) Dorian A. Rosen et al.   Science Translational Medicine

Oligodendrocyte-specific ATF4 inactivation does not influence the development of EAE

(2019) Yuan Yue et al.   Journal of Neuroinflammation

Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR

(2019) Denis A. Mogilenko et al.   CELL

Activation of the endoplasmic reticulum stress response impacts the NOD1 signaling pathway

(2019) Jonathan M. Mendez et al.   INFECTION AND IMMUNITY

The role of autophagy in the pathogenesis of exposure keratitis

(2019) Guoliang Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Regulation of oxidized LDL-induced inflammatory process through NLRP3 inflammasome activation by the deubiquitinating enzyme BRCC36

(2019) Mohit Singh et al.   INFLAMMATION RESEARCH

Protein quality control in the secretory pathway

(2019) Zhihao Sun et al.   JOURNAL OF CELL BIOLOGY

The unfolded protein response and hepatic lipid metabolism in non alcoholic fatty liver disease

(2019) Myeong Jun Song et al.   PHARMACOLOGY & THERAPEUTICS

Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β

(2019) Aaron Talty et al.   Cell Death & Disease

Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes

(2019) Rajarshi Ghosh et al.   Molecular Metabolism

Relationship Between Oxidative Stress, ER Stress, and Inflammation in Type 2 Diabetes: The Battle Continues

(2019) Burgos-Morón et al.   Journal of Clinical Medicine

ER-Mitochondria Communication in Cells of the Innate Immune System

(2019) Dmitry Namgaladze et al.   Cells

EPHB4 inhibition activates ER stress to promote immunogenic cell death of prostate cancer cells

(2019) Vinay Sagar et al.   Cell Death & Disease

The Role of Inflammasome-Dependent and Inflammasome-Independent NLRP3 in the Kidney

(2019) Yang Gyun Kim et al.   Cells

AβPP-induced UPR Transcriptomic Signature of Glial Cells to Oxidative Stress as an Adaptive Mechanism to Preserve Cell Function and Survival

(2018) Naima Chalour et al.   Current Alzheimer Research

IRE1α inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic–ischemic brain injury in rats

(2018) Di Chen et al.   Journal of Neuroinflammation

Paradoxical roles of ATF6α and ATF6β in modulating disease severity caused by mutations in collagen X

(2018) M. Forouhan et al.   MATRIX BIOLOGY

ROS signaling and ER stress in cardiovascular disease

(2018) Cristhiaan D. Ochoa et al.   MOLECULAR ASPECTS OF MEDICINE

Dynamic changes in complexes of IRE1α, PERK, and ATF6α during endoplasmic reticulum stress

(2018) Arunkumar Sundaram et al.   MOLECULAR BIOLOGY OF THE CELL

Interleukin 17A exacerbates ER-stress-mediated inflammation of macrophages following ICH

(2018) Zhao Yang et al.   MOLECULAR IMMUNOLOGY

Orchestration of NLRP3 Inflammasome Activation by Ion Fluxes

(2018) Tao Gong et al.   TRENDS IN IMMUNOLOGY

ER–mitochondria signaling in Parkinson’s disease

(2018) Patricia Gómez-Suaga et al.   Cell Death & Disease

Zika virus infection induces host inflammatory responses by facilitating NLRP3 inflammasome assembly and interleukin-1β secretion

(2018) Wenbiao Wang et al.   Nature Communications

Paeoniflorin prevents endoplasmic reticulum stress-associated inflammation in lipopolysaccharide-stimulated human umbilical vein endothelial cells via the IRE1α/NF-κB signaling pathway

(2018) Juan Chen et al.   Food & Function

IRE1α Implications in Endoplasmic Reticulum Stress-Mediated Development and Pathogenesis of Autoimmune Diseases

(2018) Raghu Patil Junjappa et al.   Frontiers in Immunology

Melatonin inhibits endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in lipopolysaccharide-induced endometritis in mice

(2018) Xiaoyu Hu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The role of mitochondria in NLRP3 inflammasome activation

(2018) Qiuyun Liu et al.   MOLECULAR IMMUNOLOGY

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

FXR Inhibits Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome in Hepatocytes and Ameliorates Liver Injury

(2018) Chang Yeob Han et al.   Cell Reports

ATF3 Stimulates IL-17A by Regulating Intracellular Ca2+/ROS-Dependent IL-1β Activation During Streptococcus pneumoniae Infection

(2018) Seungyeop Lee et al.   Frontiers in Immunology

Alterations of EDEM1 functions enhance ATF6 pro-survival signaling

(2018) Alexandra Papaioannou et al.   FEBS Journal

Unfolded Protein Response-Dependent Communication and Contact among Endoplasmic Reticulum, Mitochondria, and Plasma Membrane

(2018) Atsushi Saito et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MiR-24 inhibits inflammatory responses in LPS-induced acute lung injury of neonatal rats through targeting NLRP3

(2018) Yanfeng Lin et al.   PATHOLOGY RESEARCH AND PRACTICE

Berberine ameliorates lipopolysaccharide-induced acute lung injury via the PERK-mediated Nrf2/HO-1 signaling axis

(2018) Yuan Liang et al.   PHYTOTHERAPY RESEARCH

NLRP3 inflammasome mediates interleukin-1βproduction in immune cells in response toAcinetobacter baumanniiand contributes to pulmonary inflammation in mice

(2017) Min-Jung Kang et al.   IMMUNOLOGY

HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing the NF-κB pathway and ROS production

(2017) Xin Yu et al.   JOURNAL OF HEPATOLOGY

The UPR ER : Sensor and Coordinator of Organismal Homeostasis

(2017) Ashley E. Frakes et al.   MOLECULAR CELL

Targeting IRE1 with small molecules counteracts progression of atherosclerosis

(2017) Ozlem Tufanli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intestinal Epithelial Cell Endoplasmic Reticulum Stress and Inflammatory Bowel Disease Pathogenesis: An Update Review

(2017) Xiaoshi Ma et al.   Frontiers in Immunology

Actin polymerization plays a significant role in asbestos-induced inflammasome activation in mesothelial cells in vitro

(2016) Maximilian MacPherson et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Amyloid β induces NLRP3 inflammasome activation in retinal pigment epithelial cells via NADPH oxidase- and mitochondria-dependent ROS production

(2016) Ke Wang et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Nuclear Matrix Protein 4 Is a Novel Regulator of Ribosome Biogenesis and Controls the Unfolded Protein Response via Repression ofGadd34Expression

(2016) Sara K. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological Responses

(2016) Lauren N. Guthrie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A small molecule inhibitor of NFκB blocks ER stress and the NLRP3 inflammasome and prevents progression of pancreatitis

(2016) Mazhar A. Kanak et al.   JOURNAL OF GASTROENTEROLOGY

Endoplasmic Reticulum Stress Is a Danger Signal Promoting Innate Inflammatory Responses in Bronchial Epithelial Cells

(2016) Vedrana Mijošek et al.   Journal of Innate Immunity

Role of Mitochondria-Associated Endoplasmic Reticulum Membrane in Inflammation-Mediated Metabolic Diseases

(2016) Themis Thoudam et al.   MEDIATORS OF INFLAMMATION

NOD1 and NOD2 signalling links ER stress with inflammation

(2016) A. Marijke Keestra-Gounder et al.   NATURE

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis

(2016) Rossana G. Iannitti et al.   Nature Communications

Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells

(2016) Megan M. Robblee et al.   Cell Reports

Alum: an old dog with new tricks

(2016) Yumei Wen et al.   Emerging Microbes & Infections

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

(2015) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage

(2015) Denise N. Bronner et al.   IMMUNITY

Endoplasmic Reticulum Stress–Induced IRE1α Activation Mediates Cross-Talk of GSK-3β and XBP-1 To Regulate Inflammatory Cytokine Production

(2015) Sena Kim et al.   JOURNAL OF IMMUNOLOGY

Anti-dsDNA antibodies induce inflammation via endoplasmic reticulum stress in human mesangial cells

(2015) Hui Zhang et al.   Journal of Translational Medicine

Innate immunity at mucosal surfaces: the IRE1-RIDD-RIG-I pathway

(2015) Wayne I. Lencer et al.   TRENDS IN IMMUNOLOGY

ER stress induces NLRP3 inflammasome activation and hepatocyte death

(2015) C Lebeaupin et al.   Cell Death & Disease

Crosstalk between the Unfolded Protein Response and NF-κB-Mediated Inflammation in the Progression of Chronic Kidney Disease

(2015) Zahraa Mohammed-Ali et al.   Journal of Immunology Research

ATF6 Mediates a Pro-Inflammatory Synergy Between ER Stress and TLR Activation in the Pathogenesis of Liver Ischemia-Reperfusion Injury

(2014) J. Rao et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease

(2014) Stewart Siyan Cao et al.   ANTIOXIDANTS & REDOX SIGNALING

Lysosomes Integrate Metabolic-Inflammatory Cross-talk in Primary Macrophage Inflammasome Activation

(2014) Kassandra Weber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol Crystals Induce Complement-Dependent Inflammasome Activation and Cytokine Release

(2014) E. O. Samstad et al.   JOURNAL OF IMMUNOLOGY

PERK-Dependent Activation of JAK1 and STAT3 Contributes to Endoplasmic Reticulum Stress-Induced Inflammation

(2014) G. P. Meares et al.   MOLECULAR AND CELLULAR BIOLOGY

Stress, Inflammation, and Defense of Homeostasis

(2014) Raj Chovatiya et al.   MOLECULAR CELL

A Novel ER Stress-Independent Function of the UPR in Angiogenesis

(2014) Hery Urra et al.   MOLECULAR CELL

Proteostasis in endoplasmic reticulum—new mechanisms in kidney disease

(2014) Reiko Inagi et al.   Nature Reviews Nephrology

A Molecular Web: Endoplasmic Reticulum Stress, Inflammation, and Oxidative Stress

(2014) Namrata Chaudhari et al.   Frontiers in Cellular Neuroscience

Ire1 Has Distinct Catalytic Mechanisms for XBP1/HAC1 Splicing and RIDD

(2014) Arvin B. Tam et al.   Cell Reports

ATF6 upregulates XBP1S and inhibits ER stress-mediated apoptosis in osteoarthritis cartilage

(2013) Feng-Jin Guo et al.   CELLULAR SIGNALLING

Endoplasmic reticulum stress is sufficient for the induction of IL-1β production via activation of the NF-κB and inflammasome pathways

(2013) Sena Kim et al.   Innate Immunity

Kir6.2 knockout aggravates lipopolysaccharide-induced mouse liver injury via enhancing NLRP3 inflammasome activation

(2013) Ren-Hong Du et al.   JOURNAL OF GASTROENTEROLOGY

IL-1β Drives Inflammatory Responses to Propionibacterium acnes In Vitro and In Vivo

(2013) Magdalena Kistowska et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Glial Uptake of Amyloid Beta Induces NLRP3 Inflammasome Formation via Cathepsin-Dependent Degradation of NLRP10

(2013) Niamh Murphy et al.   NEUROMOLECULAR MEDICINE

Oxidized low-density lipoprotein induces secretion of interleukin-1β by macrophages via reactive oxygen species-dependent NLRP3 inflammasome activation

(2012) Yugang Jiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome

(2012) Christine M. Oslowski et al.   Cell Metabolism

Protein disulfide isomerase-associated 6 is an ATF6-inducible ER stress response protein that protects cardiac myocytes from ischemia/reperfusion-mediated cell death

(2012) John A. Vekich et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

NLRP3 Inflammasome: Key Mediator of Neuroinflammation in Murine Japanese Encephalitis

(2012) Deepak Kumar Kaushik et al.   PLoS One

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

(2012) T. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER stress-induced inflammation: does it aid or impede disease progression?

(2012) Abhishek D. Garg et al.   TRENDS IN MOLECULAR MEDICINE

Inflammation and Fibrosis during Chlamydia pneumoniae Infection Is Regulated by IL-1 and the NLRP3/ASC Inflammasome

(2010) X. He et al.   JOURNAL OF IMMUNOLOGY

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

(2010) Fabio Martinon et al.   NATURE IMMUNOLOGY

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

(2010) Kristiina Rajamäki et al.   PLoS One

Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression

(2010) Jane C. Goodall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans

(2009) Amy G. Hise et al.   Cell Host & Microbe

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE