EPHB4 inhibition activates ER stress to promote immunogenic cell death of prostate cancer cells

Cancer statistics, 2019

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eIF2α phosphorylation is pathognomonic for immunogenic cell death

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Anaplastic Lymphoma Kinase Mutation (ALKF1174C) in Small Cell Carcinoma of the Prostate and Molecular Response to Alectinib

(2018) Benedito A. Carneiro et al.   CLINICAL CANCER RESEARCH

PARP inhibitors for homologous recombination-deficient prostate cancer

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Multi-faceted immunomodulatory and tissue-tropic clinical bacterial isolate potentiates prostate cancer immunotherapy

(2018) Jonathan F. Anker et al.   Nature Communications

eIF2α phosphorylation: A hallmark of immunogenic cell death

(2018) Lucillia Bezu et al.   OncoImmunology

Genetics and biology of prostate cancer

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Targeting receptor tyrosine kinase EphB4 in cancer therapy

(2017) Yinnan Chen et al.   SEMINARS IN CANCER BIOLOGY

Modeling African American prostate adenocarcinoma by inducing defined genetic alterations in organoids

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Organoids model distinct Vitamin E effects at different stages of prostate cancer evolution

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Myc-Driven Glycolysis Is a Therapeutic Target in Glioblastoma

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KSR1 and EPHB4 Regulate Myc and PGC1β To Promote Survival of Human Colon Tumors

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Characterizing the molecular features of ERG-positive tumors in primary and castration resistant prostate cancer

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PIM1 destabilization activates a p53-dependent response to ribosomal stress in cancer cells

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The tumour-promoting receptor tyrosine kinase, EphB4, regulates expression of Integrin-β8 in prostate cancer cells

(2015) Inga Mertens-Walker et al.   BMC CANCER

Erythropoietin Stimulates Tumor Growth via EphB4

(2015) Sunila Pradeep et al.   CANCER CELL

Src Inhibition Blocks c-Myc Translation and Glucose Metabolism to Prevent the Development of Breast Cancer

(2015) S. Jain et al.   CANCER RESEARCH

The third line of treatment for metastatic prostate cancer patients: Option or strategy?

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Src Tyrosine Kinase Activation by 4-Hydroxynonenal Upregulates p38, ERK/AP-1 Signaling and COX-2 Expression in YPEN-1 Cells

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eIF2α phosphorylation as a biomarker of immunogenic cell death

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The tyrosine kinase inhibitor nilotinib has antineoplastic activity in prostate cancer cells but up-regulates the ERK survival signal—Implications for targeted therapies1Equal contributions.

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Integration of copy number and transcriptomics provides risk stratification in prostate cancer: A discovery and validation cohort study

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Targeting RTK Signaling Pathways in Cancer

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Prognostic Significance of Time to Prostate-Specific Antigen (PSA) Nadir and Its Relationship to Survival Beyond Time to PSA Nadir for Prostate Cancer Patients With Bone Metastases After Primary Androgen Deprivation Therapy

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Tyrosine kinase inhibitors in the treatment of prostate cancer: taking the next step in clinical development

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MYC and Mitochondrial Biogenesis

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Consensus guidelines for the detection of immunogenic cell death

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Crosstalk between ER stress and immunogenic cell death

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Chemotherapy-induced immunogenic modulation of tumor cells enhances killing by cytotoxic T lymphocytes and is distinct from immunogenic cell death

(2013) James W. Hodge et al.   INTERNATIONAL JOURNAL OF CANCER

ATP increases within the lumen of the endoplasmic reticulum upon intracellular Ca2+ release

(2013) Neelanjan Vishnu et al.   MOLECULAR BIOLOGY OF THE CELL

The EphB4 Receptor Tyrosine Kinase Promotes Lung Cancer Growth: A Potential Novel Therapeutic Target

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MYC, Metabolism, Cell Growth, and Tumorigenesis

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Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

Kinase Inhibitors in Prostate Cancer

(2012) Suwicha Limvorasak et al.   Anti-Cancer Agents in Medicinal Chemistry

N-glycans in cell survival and death: Cross-talk between glycosyltransferases

(2012) Dipak K. Banerjee   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

EphB4 promotes or suppresses Ras/MEK/ERK pathway in a context-dependent manner

(2012) Zhan Xiao et al.   CANCER BIOLOGY & THERAPY

Activation of Ras/PI3K/ERK Pathway Induces c-Myc Stabilization to Upregulate Argininosuccinate Synthetase, Leading to Arginine Deiminase Resistance in Melanoma Cells

(2012) W.-B. Tsai et al.   CANCER RESEARCH

The mutational landscape of lethal castration-resistant prostate cancer

(2012) Catherine S. Grasso et al.   NATURE

Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12

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ER and aging—Protein folding and the ER stress response

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The Significance of EphB4 and EphrinB2 Expression and Survival in Head and Neck Squamous Cell Carcinoma

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Tumor Immunobiological Differences in Prostate Cancer between African-American and European-American Men

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Eph-Ephrin Bidirectional Signaling in Physiology and Disease

(2008) Elena B. Pasquale   CELL

Src family kinase oncogenic potential and pathways in prostate cancer as revealed by AZD0530

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Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1

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