A small molecule inhibitor of NFκB blocks ER stress and the NLRP3 inflammasome and prevents progression of pancreatitis

Total Pancreatectomy With Islet Autotransplantation

(2015) Melena D. Bellin et al.   ANNALS OF SURGERY

Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKKβ

(2014) Karen Heyninck et al.   BIOCHEMICAL PHARMACOLOGY

Chronic pancreatitis, a comprehensive review and update. Part I: Epidemiology, etiology, risk factors, genetics, pathophysiology, and clinical features

(2014) Thiruvengadam Muniraj et al.   DM DISEASE-A-MONTH

Endoplasmic Reticulum Stress Is Chronically Activated in Chronic Pancreatitis

(2014) Raghuwansh P. Sah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New insights into the pathogenesis of pancreatitis

(2013) Raghuwansh P. Sah et al.   CURRENT OPINION IN GASTROENTEROLOGY

Withaferin A inhibits pro-inflammatory cytokine-induced damage to islets in culture and following transplantation

(2013) J. A. SoRelle et al.   DIABETOLOGIA

Cerulein-Induced Chronic Pancreatitis Does Not Require Intra-Acinar Activation of Trypsinogen in Mice

(2013) Raghuwansh P. Sah et al.   GASTROENTEROLOGY

Genetic Risk Factors for Pancreatic Disorders

(2013) David C. Whitcomb   GASTROENTEROLOGY

Models of Acute and Chronic Pancreatitis

(2013) Markus M. Lerch et al.   GASTROENTEROLOGY

The complexity of NF-κB signaling in inflammation and cancer

(2013) Bastian Hoesel et al.   Molecular Cancer

Molecular insight in the multifunctional activities of Withaferin A

(2012) Wim Vanden Berghe et al.   BIOCHEMICAL PHARMACOLOGY

Deletion of IκBα Activates RelA to Reduce Acute Pancreatitis in Mice Through Up-regulation of Spi2A

(2012) Patrick Neuhöfer et al.   GASTROENTEROLOGY

Nuclear Factor-κB in Pancreatitis: Jack-of-All-Trades, But Which One Is More Important?

(2012) Ilya Gukovsky et al.   GASTROENTEROLOGY

Activation of Nuclear Factor-κB in Acinar Cells Increases the Severity of Pancreatitis in Mice

(2012) Haojie Huang et al.   GASTROENTEROLOGY

Involvement of Nuclear Factor Kappa B in High-Fat Diet-Related Pancreatic Fibrosis in Rats

(2012) Ming-Xian Yan et al.   Gut and Liver

Total Pancreatectomy and Islet Autotransplantation for Chronic Pancreatitis

(2012) David E.R. Sutherland et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

TLR9 and the NLRP3 Inflammasome Link Acinar Cell Death With Inflammation in Acute Pancreatitis

(2011) Rafaz Hoque et al.   GASTROENTEROLOGY

Reactive Oxygen Species Induced by Bile Acid Induce Apoptosis and Protect Against Necrosis in Pancreatic Acinar Cells

(2011) David M. Booth et al.   GASTROENTEROLOGY

Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation

(2011) Jose T. Thaiparambil et al.   INTERNATIONAL JOURNAL OF CANCER

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Type of pain, pain-associated complications, quality of life, disability and resource utilisation in chronic pancreatitis: a prospective cohort study

(2010) D. K. Mullady et al.   GUT

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY