The Role of Inflammasome-Dependent and Inflammasome-Independent NLRP3 in the Kidney

DAMPening sterile inflammation of the kidney

(2019) Mirjam Meissner et al.   KIDNEY INTERNATIONAL

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

(2019) Rebecca C. Coll et al.   Nature Chemical Biology

A small molecule inhibitor MCC950 ameliorates kidney injury in diabetic nephropathy by inhibiting NLRP3 inflammasome activation

(2019) CongXiao Zhang et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Artesunate ameliorates high glucose-induced rat glomerular mesangial cell injury by suppressing the TLR4/NF-κB/NLRP3 inflammasome pathway

(2018) Zhiqiang Sun et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Tranilast directly targets NLRP3 to treat inflammasome‐driven diseases

(2018) Yi Huang et al.   EMBO Molecular Medicine

Renal immune surveillance and dipeptidase-1 contribute to contrast-induced acute kidney injury

(2018) Arthur Lau et al.   JOURNAL OF CLINICAL INVESTIGATION

The macrophage phenotype and inflammasome component NLRP3 contributes to nephrocalcinosis-related chronic kidney disease independent from IL-1–mediated tissue injury

(2018) Hans-Joachim Anders et al.   KIDNEY INTERNATIONAL

Tranilast prevents renal interstitial fibrosis by blocking mast cell infiltration in a rat model of diabetic kidney disease

(2018) Dan‑Dan Yin et al.   Molecular Medicine Reports

NLRP3 deficiency ameliorates renal inflammation and fibrosis in diabetic mice

(2018) Ming Wu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Caspase-11-mediated tubular epithelial pyroptosis underlies contrast-induced acute kidney injury

(2018) Zhen Zhang et al.   Cell Death & Disease

Development of covalent NLRP3 inflammasome inhibitors: Chemistry and biological activity

(2018) Massimo Bertinaria et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension

(2018) Shalini M Krishnan et al.   CARDIOVASCULAR RESEARCH

Inflammasome-Independent Role of NLRP3 Mediates Mitochondrial Regulation in Renal Injury

(2018) Su-Mi Kim et al.   Frontiers in Immunology

NLRP3 Deficiency Attenuates Renal Fibrosis and Ameliorates Mitochondrial Dysfunction in a Mouse Unilateral Ureteral Obstruction Model of Chronic Kidney Disease

(2017) Honglei Guo et al.   MEDIATORS OF INFLAMMATION

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anakinra reduces blood pressure and renal fibrosis in one kidney/DOCA/salt-induced hypertension

(2017) Yeong Hann Ling et al.   PHARMACOLOGICAL RESEARCH

Interleukin-22 ameliorated renal injury and fibrosis in diabetic nephropathy through inhibition of NLRP3 inflammasome activation

(2017) Shaofei Wang et al.   Cell Death & Disease

NLRP3 inflammasome: Pathogenic role and potential therapeutic target for IgA nephropathy

(2017) Yu-Ling Tsai et al.   Scientific Reports

Metabolic injury-induced NLRP3 inflammasome activation dampens phospholipid degradation

(2017) Elena Rampanelli et al.   Scientific Reports

The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity

(2017) Katharina S. Schneider et al.   Cell Reports

β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares

(2017) Emily L. Goldberg et al.   Cell Reports

Podocyte Activation of NLRP3 Inflammasomes Contributes to the Development of Proteinuria in Lupus Nephritis

(2017) Rong Fu et al.   Arthritis & Rheumatology

Contrast-Induced Nephropathy: From Pathophysiology to Preventive Strategies

(2016) Lorenzo Azzalini et al.   CANADIAN JOURNAL OF CARDIOLOGY

NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis

(2016) H Chung et al.   CELL DEATH AND DIFFERENTIATION

Role of Inflammation and Immunity in Hypertension: Recent Epidemiological, Laboratory, and Clinical Evidence

(2016) Antoine Caillon et al.   CURRENT HYPERTENSION REPORTS

Hyperactivation of the NLRP3 Inflammasome in Myeloid Cells Leads to Severe Organ Damage in Experimental Lupus

(2016) Ailing Lu et al.   JOURNAL OF IMMUNOLOGY

High-Fat Diet–Induced Lysosomal Dysfunction and Impaired Autophagic Flux Contribute to Lipotoxicity in the Kidney

(2016) Takeshi Yamamoto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice

(2016) Isis Ludwig-Portugall et al.   KIDNEY INTERNATIONAL

Thioredoxin-Interacting Protein Mediates NLRP3 Inflammasome Activation Involved in the Susceptibility to Ischemic Acute Kidney Injury in Diabetes

(2016) Ye Da Xiao et al.   Oxidative Medicine and Cellular Longevity

Predominant Tubular Interleukin-18 Expression in Polyomavirus-Associated Nephropathy

(2016) Geurt Stokman et al.   TRANSPLANTATION

NLRP3 Localizes to the Tubular Epithelium in Human Kidney and Correlates With Outcome in IgA Nephropathy

(2016) Justin Chun et al.   Scientific Reports

NLRP3 inflammasome mediates contrast media-induced acute kidney injury by regulating cell apoptosis

(2016) Jianxiao Shen et al.   Scientific Reports

Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induced hypertension in mice

(2015) S M Krishnan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

NLRP3 Deficiency Improves Angiotensin II-Induced Hypertension But Not Fetal Growth Restriction During Pregnancy

(2015) Koumei Shirasuna et al.   ENDOCRINOLOGY

BAY 11-7082 ameliorates diabetic nephropathy by attenuating hyperglycemia-mediated oxidative stress and renal inflammation via NF-κB pathway

(2015) Sambasiva Rao Kolati et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells

(2015) Jonathan L. Schmid-Burgk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Excess aldosterone is a critical danger signal for inflammasome activation in the development of renal fibrosis in mice

(2015) Hiroyuki Kadoya et al.   FASEB JOURNAL

Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy

(2015) Khurrum Shahzad et al.   KIDNEY INTERNATIONAL

Targeting the NLRP3 Inflammasome to Reduce Diet-Induced Metabolic Abnormalities in Mice

(2015) Fausto Chiazza et al.   MOLECULAR MEDICINE

The receptor NLRP3 is a transcriptional regulator of TH2 differentiation

(2015) Mélanie Bruchard et al.   NATURE IMMUNOLOGY

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

(2015) Yun-Hee Youm et al.   NATURE MEDICINE

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Mast cell involvement in the progression of peritoneal fibrosis in rats with chronic renal failure

(2015) Itsuro Kazama et al.   NEPHROLOGY

Tranilast: A review of its therapeutic applications

(2015) Sara Darakhshan et al.   PHARMACOLOGICAL RESEARCH

Mechanisms of inflammasome activation: recent advances and novel insights

(2015) Sivapriya K. Vanaja et al.   TRENDS IN CELL BIOLOGY

Role of NLRP3 Inflammasomes for Rhabdomyolysis-induced Acute Kidney Injury

(2015) Takanori Komada et al.   Scientific Reports

NADPH Oxidase-Induced NALP3 Inflammasome Activation Is Driven by Thioredoxin-Interacting Protein Which Contributes to Podocyte Injury in Hyperglycemia

(2015) Pan Gao et al.   Journal of Diabetes Research

A Tissue-Specific Role for Nlrp3 in Tubular Epithelial Repair after Renal Ischemia/Reperfusion

(2014) Pieter J. Bakker et al.   AMERICAN JOURNAL OF PATHOLOGY

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Innate Immunity in Hypertension

(2014) Muhammad Oneeb Rehman Mian et al.   CURRENT HYPERTENSION REPORTS

NLRP3 Inflammasome Mediates Albumin-induced Renal Tubular Injury through Impaired Mitochondrial Function

(2014) Yibo Zhuang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial NLRP3 Protein Induces Reactive Oxygen Species to Promote Smad Protein Signaling and Fibrosis Independent from the Inflammasome

(2014) Nathan A. Bracey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Mitochondrial MAVS/Caspase-8 Platform Links RNA Virus-Induced Innate Antiviral Signaling to Bax/Bak-Independent Apoptosis

(2014) S. El Maadidi et al.   JOURNAL OF IMMUNOLOGY

P2X7Blockade Attenuates Murine Lupus Nephritis by Inhibiting Activation of the NLRP3/ASC/Caspase 1 Pathway

(2013) Jijun Zhao et al.   ARTHRITIS AND RHEUMATISM

The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

(2013) Naeha Subramanian et al.   CELL

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

(2013) V Sagulenko et al.   CELL DEATH AND DIFFERENTIATION

OxLDL-induced IL-1beta secretion promoting foam cells formation was mainly via CD36 mediated ROS production leading to NLRP3 inflammasome activation

(2013) Weiwei Liu et al.   INFLAMMATION RESEARCH

Bay11-7082 attenuates murine lupus nephritis via inhibiting NLRP3 inflammasome and NF-κB activation

(2013) Jijun Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Self Double-Stranded (ds)DNA Induces IL-1  Production from Human Monocytes by Activating NLRP3 Inflammasome in the Presence of Anti-dsDNA Antibodies

(2013) M. S. Shin et al.   JOURNAL OF IMMUNOLOGY

The purinergic 2X7receptor participates in renal inflammation and injury induced by high-fat diet: possible role of NLRP3 inflammasome activation

(2013) Anna Solini et al.   JOURNAL OF PATHOLOGY

NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy

(2013) Felix Knauf et al.   KIDNEY INTERNATIONAL

Regulation of lipid accumulation by AMK-activated kinase in high fat diet–induced kidney injury

(2013) Anne-Emilie Declèves et al.   KIDNEY INTERNATIONAL

Nlrp3 is a key modulator of diet-induced nephropathy and renal cholesterol accumulation

(2013) Pieter J. Bakker et al.   KIDNEY INTERNATIONAL

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

(2013) Takuma Misawa et al.   NATURE IMMUNOLOGY

Ketone bodies as signaling metabolites

(2013) John C. Newman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Inflammasome activation in bovine monocytes by extracellular ATP does not require the purinergic receptor P2X7

(2012) Jamal Hussen et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

(2012) Hye-Mi Lee et al.   DIABETES

Activation of Nod-Like Receptor Protein 3 Inflammasomes Turns on Podocyte Injury and Glomerular Sclerosis in Hyperhomocysteinemia

(2012) Chun Zhang et al.   HYPERTENSION

Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation

(2012) James E. Vince et al.   IMMUNITY

Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1β secretion

(2012) Shrikant R. Mulay et al.   JOURNAL OF CLINICAL INVESTIGATION

U1-Small Nuclear Ribonucleoprotein Activates the NLRP3 Inflammasome in Human Monocytes

(2012) M. S. Shin et al.   JOURNAL OF IMMUNOLOGY

Inflammasome-Independent NLRP3 Augments TGF-  Signaling in Kidney Epithelium

(2012) W. Wang et al.   JOURNAL OF IMMUNOLOGY

Regulation of inflammasome signaling

(2012) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Pathogenesis of IgA nephropathy

(2012) Kar Neng Lai   Nature Reviews Nephrology

Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation

(2011) Pei-Yi Tsai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Anti-GBM Glomerulonephritis Involves IL-1 but Is Independent of NLRP3/ASC Inflammasome-Mediated Activation of Caspase-1

(2011) Julia Lichtnekert et al.   PLoS One

Pivotal Role of Toll-Like Receptors 2 and 4, Its Adaptor Molecule MyD88, and Inflammasome Complex in Experimental Tubule-Interstitial Nephritis

(2011) Matheus Correa-Costa et al.   PLoS One

Inflammasome is a central player in the induction of obesity and insulin resistance

(2011) R. Stienstra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Sterile Inflammatory Response

(2010) Kenneth L. Rock et al.   Annual Review of Immunology

Human NLRP3 inflammasome activation is Nox1-4 independent

(2010) R. van Bruggen et al.   BLOOD

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

(2010) Rinke Stienstra et al.   Cell Metabolism

Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome

(2010) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Inflammasome-Independent Role for Epithelial-Expressed Nlrp3 in Renal Ischemia-Reperfusion Injury

(2010) A. A. Shigeoka et al.   JOURNAL OF IMMUNOLOGY

The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD

(2010) A. Vilaysane et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Tranilast modulates fibrosis, epithelial-mesenchymal transition and peritubular capillary injury in unilateral ureteral obstruction rats

(2010) Tomoki Kaneyama et al.   PATHOLOGY

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

(2010) B. McDonald et al.   SCIENCE

Toll-like receptors: linking inflammation to metabolism

(2010) A. Christine Könner et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Sensing pathogens and danger signals by the inflammasome

(2009) Joao HF Pedra et al.   CURRENT OPINION IN IMMUNOLOGY

Intracellular Shuttling and Mitochondrial Function of Thioredoxin-interacting Protein

(2009) Geetu Saxena et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

(2009) S. S. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation and Cardiovascular Disease

(2008) William F. Fearon et al.   CIRCULATION

Cardiolipin provides an essential activating platform for caspase-8 on mitochondria

(2008) Francois Gonzalvez et al.   JOURNAL OF CELL BIOLOGY

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY