Article
Biochemistry & Molecular Biology
Jing Yang, Jian Li, Haoqi Guo, Yuwei Zhang, Ziwei Guo, Yu Liu, Taoguang Huo
Summary: This study investigates the role of autophagy in realgar-induced liver injury. The results demonstrate that autophagy alleviates liver injury caused by realgar by inhibiting ROS-mediated NLRP3 inflammasome activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Xiujing Dou, Di Yan, Siqi Liu, Lujia Gao, Anshan Shan
Summary: Thymol has been shown to protect the liver from LPS-induced injury by inhibiting the activation of NLRP3 inflammasome. It alleviates inflammatory cell infiltration and structural damage in the liver, and reduces the levels of liver damage indicators. Additionally, thymol regulates the activity of lactate dehydrogenase and the expression of inflammatory cytokines and apoptosis-related genes, thereby exerting a protective effect on the liver.
Article
Pharmacology & Pharmacy
Wenmin Dong, Chenglin Jia, Ji Li, Yi Zhou, Yun Luo, Jibo Liu, Zhiguo Zhao, Jiaqi Zhang, Shan Lin, Ying Chen
Summary: This study finds that fisetin can alleviate high glucose-induced podocyte injury and STZ-induced DN by restoring autophagy-mediated CDKN1B/P70S6K pathway and inhibiting NLRP3 inflammasome.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Ruowei Zhao, Qing Zhang, Wenjing Liu, Yifan Lin, Yuhui He, Dennis Chang, Shaohua Li, Wen Xu, Yanxiang Lin, Yanfang Zheng, Xian Zhou, Mingqing Huang
Summary: The study found that Pien Tze Huang has anti-inflammatory properties and can protect the liver against APAP-induced liver injury. This protective effect may be related to the inhibition of NLRP3 inflammasome by Pien Tze Huang through promoting autophagy activity. These findings support the traditional use of Pien Tze Huang in treating liver diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Xiaona Gao, Shuhui Liu, Lei Tan, Chenchen Ding, Wentao Fan, Zhangshan Gao, Mengcong Li, Zhihui Tang, Yuting Wu, Lei Xu, Liping Yan, Yan Luo, Suquan Song
Summary: This study demonstrated that estrogen receptor alpha plays a role in negatively controlling hepatocyte pyroptosis by inhibiting NLRP3 inflammasome activation. Inhibiting pyroptosis was found to alleviate metabolic dysfunction, insulin resistance, and liver injury caused by ER alpha deletion. Additionally, treatment with a phytoestrogen could attenuate high-fat diet-induced liver lipid steatosis and inhibit NLRP3-GSDMD-mediated pyroptosis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Cell Biology
Qianqian Di, Xibao Zhao, Haimei Tang, Xunwei Li, Yue Xiao, Han Wu, Zherui Wu, Jiazheng Quan, Weilin Chen
Summary: The research shows that USP22 inhibits the activation of NLRP3 inflammasome by promoting autophagy, and has the potential to be a therapeutic target for NLRP3 inflammasome-related diseases.
Article
Biochemistry & Molecular Biology
Ting Xiao, Yulong Cui, Heyu Ji, Lulu Yan, Dongjie Pei, Shuangquan Qu
Summary: The study found that baicalein alleviates infection and/or drug-induced acute liver injury by inhibiting NLRP3 inflammasome, suggesting its potential therapeutic value.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Neurosciences
Jia-quan Lin, He Tian, Xiao-guang Zhao, Sen Lin, Dao-yong Li, Yuan-ye Liu, Chang Xu, Xi-fan Mei
Summary: The study demonstrates that zinc provides neuroprotection after SCI by regulating the NLRP3 inflammasome through autophagy and ubiquitination.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Cell Biology
Baoshan Cai, Jian Zhao, Yuling Zhang, Yaxing Liu, Chunhong Ma, Fan Yi, Yi Zheng, Lei Zhang, Tian Chen, Huiqing Liu, Bingyu Liu, Chengjiang Gao
Summary: USP5 acts as a key scaffold protein in recruiting the E3 ligase MARCHF7 for autophagic degradation of NLRP3 independently of its deubiquitinating enzyme activity. Knockdown of USP5 promotes inflammatory signaling release, while overexpression has inhibitory effects.
Review
Biochemistry & Molecular Biology
Shuangyu Lv, Huiyang Liu, Honggang Wang
Summary: Ischemia/reperfusion (I/R) injury is characterized by limited blood supply to organs followed by restoration of blood flow and reoxygenation. The interaction between autophagy and the NLRP3 inflammasome plays a crucial role in I/R injury, but the specific mechanisms are not fully understood and require further research for clarification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Critical Care Medicine
Pan Pan, Jie Chen, Xudong Liu, Junping Fan, Dong Zhang, Weiguo Zhao, Lixin Xie, Longxiang Su
Summary: In this study, FUNDC1 knockout mice model was used to investigate the role of FUNDC1-mediated autophagy in lung injury induced by lipopolysaccharide, finding that loss of FUNDC1 leads to decreased autophagy, increased ROS and inflammation, aggravating lung injury. Compared to wild-type mice, FUNDC1 knockout mice showed inhibited autophagy and enhanced inflammasome activation after LPS intervention.
Review
Biochemistry & Molecular Biology
Fernando Lucas-Ruiz, Alejandro Penin-Franch, Jose Antonio Pons, Pablo Ramirez, Pablo Pelegrin, Santiago Cuevas, Alberto Baroja-Mazo
Summary: The NLRP3 inflammasome and pyroptosis play important roles in liver transplantation, affecting the progression of liver disease and treatment outcomes. Studying this pathway may lead to new strategies for the future treatment of LT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Xuelian Li, Xianjie Zhu, Yumiao Wei
Summary: Atherosclerosis is a lipid-driven disease characterized by the imbalance between inflammatory and regressive processes. Recent studies have suggested a link between autophagy and vascular inflammation. This review summarizes the underlying mechanisms associated with different autophagic pathways and NLRP3 inflammasomes in vascular inflammation, aiming to provide additional evidence for atherosclerosis research.
Article
Biochemistry & Molecular Biology
Yuanyuan Liu, Nianyu Xue, Boxi Zhang, Hongming Lv, Shize Li
Summary: This study investigates the effects of chronic cold exposure on liver function, apoptosis, oxidative stress, and inflammation in mice. The results suggest that cold stress can lead to liver injury and activate apoptosis, oxidative stress, and pyroptosis. The findings provide new insights into the underlying mechanisms of the cold stress response.
Article
Pharmacology & Pharmacy
Hui Fan, Jiajia Cui, Feixue Liu, Wei Zhang, Haitao Yang, Nana He, Zibo Dong, Jingquan Dong
Summary: The study suggests that malvidin is a potential protective agent against LPS-induced acute liver injury (ALI) by up-regulating the Nrf2 signaling pathway, suppressing NLRP3 inflammasome, and inhibiting apoptosis and autophagy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Oncology
Jun Yu, Binghai Chen, Bo Zheng, Chen Qiao, Xia Chen, Yidan Yan, Xiaojin Luan, Bing Xie, Jiajia Liu, Cong Shen, Zeyu He, Xing Hu, Mingxi Liu, Hong Li, Qixiang Shao, Jie Fang
MOLECULAR MEDICINE REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Jun Yu, Xiaojin Luan, Yidan Yan, Chen Qiao, Yuanyuan Liu, Dan Zhao, Bing Xie, Qianwen Zheng, Min Wang, Wanyin Chen, Cong Shen, Zeyu He, Xing Hu, Xiaoyan Huang, Hong Li, Binghai Chen, Bo Zheng, Xia Chen, Jie Fang
Article
Cell Biology
Jun Yu, Yidan Yan, Xiaojin Luan, Chen Qiao, Yuanyuan Liu, Dan Zhao, Bing Xie, Qianwen Zheng, Min Wang, Wanyin Chen, Cong Shen, Zeyu He, Xing Hu, Xiaoyan Huang, Hong Li, Qixiang Shao, Xia Chen, Bo Zheng, Jie Fang
CELL DEATH & DISEASE
(2019)
Article
Multidisciplinary Sciences
Juan Song, Qifei Xie, Lin Wang, Yi Lu, Peijing Liu, Ping Yang, Rui Chen, Chen Shao, Chen Qiao, Zhongqun Wang, Jinchuan Yan
SCIENTIFIC REPORTS
(2019)
Article
Oncology
Jun Yu, Qianwen Zheng, Xiaoxing Ding, Bo Zheng, Xia Chen, Binghai Chen, Cong Shen, Yu Zhang, Xiaojin Luan, Yidan Yan, Wanyin Chen, Bing Xie, Min Wang, Jiajia Liu, Jie Fang, Xing Hu, Hong Li, Chen Qiao, Peifang Yang
Article
Multidisciplinary Sciences
Xia Chen, Xiaojin Luan, Qianwen Zheng, Chen Qiao, Wanyin Chen, Min Wang, Yidan Yan, Bing Xie, Cong Shen, Zeyu He, Jun Zhang, Mingxi Liu, Xing Hu, Hong Li, Bo Zheng, Jie Fang, Jun Yu
SCIENTIFIC REPORTS
(2019)
Article
Medicine, Research & Experimental
Jialei Hu, Hanyou Mu, Linshan Gao, Ying Pan, Chuanfei Wu, Dong Zhang, Qiaojun Chen, Honghui Ding
Summary: This study confirmed the expression levels and diagnostic value of two candidate ncRNAs in patients with GDM, suggesting that Pax8-AS1 and miR-4646 may serve as promising diagnostic biomarkers for GDM.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Cell Biology
Qianwen Zheng, Xia Chen, Chen Qiao, Min Wang, Wanyin Chen, Xiaojin Luan, Yidan Yan, Cong Shen, Jie Fang, Xing Hu, Bo Zheng, Yibo Wu, Jun Yu
Summary: The study revealed that somatic CG6015 regulates the maintenance of CySC and differentiation of GSC in the Drosophila testis through EGFR signaling pathway. CG6015, along with Dsor1 and rl, are crucial for the survival of Drosophila cell line Schneider 2 (S2) cells.
CELL DEATH DISCOVERY
(2021)
Article
Medicine, Research & Experimental
Shi-Yu Zhao, Zhi Wang, Xiang-Bai Wu, Shuai Zhang, Qiao Chen, Dong-Dong Wang, Qiong-Feng Tan
Summary: This study reveals that CERS6-AS1 facilitates malignant phenotypes of colorectal cancer cells by targeting miR-15b-5p to upregulate SPTBN2, including the inhibition of cell viability, proliferation, migration, and invasion.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kai Wang, Cai Lu, Tong Wang, Chen Qiao, Linyu Lu, Die Wu, Ming Lu, Ruini Chen, Lu Fan, Juanjuan Tang
Summary: This study found that Hyperoside can inhibit the activation of the NLRP3 inflammasome by reducing the secretion of inflammatory factors, protecting dopaminergic neurons, and reversing motor dysfunction caused by MPTP. Hyperoside achieves this by upregulating PACAP levels.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Review
Biotechnology & Applied Microbiology
Qiao Chen, Xiaoning Wang, Meifang He
Summary: Cell-in-cell structures are commonly found in biological systems and may play important roles in disease development. Recent research on CICs has focused on their potential clinical implications in diagnosis and treatment, aiming to bridge the gap in our understanding of these structures.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Behavioral Sciences
Chen Qiao, Tao Dang, Yan Zhou, Yuan-Zhang Zhou, Rong Zhao, Min Wang
Summary: This study highlights the detrimental role of microglial NLRP3 in the survival of DA neurons in the SNc region, providing a potential strategy for rescuing DA neurons in PD progression. Knockdown of microglial NLRP3 shows promise in attenuating PD pathologies, suggesting a new avenue for disease-modifying therapy targeting NLRP3.
BRAIN AND BEHAVIOR
(2022)
Review
Medicine, Research & Experimental
Tao Dang, Wen-Jing Cao, Rong Zhao, Ming Lu, Gang Hu, Chen Qiao
Summary: ATP13A2, as a late endosomal/lysosomal transport protein, plays a crucial role in maintaining the homeostasis of metal ions and polyamines in the central nervous system. It regulates the normal function of various organelles and protects dopaminergic neurons against Parkinson's disease. Understanding the pathological mechanisms of ATP13A2 mutations in PD can provide insight into the essential regulatory role of ATP13A2 in the disease.
JOURNAL OF BIOMEDICAL RESEARCH
(2022)
Article
Cell Biology
Min Wang, Juan-Juan Tang, Lin-Xiao Wang, Jun Yu, Li Zhang, Chen Qiao
Summary: Hydrogen sulfide (H2S) can reduce neuronal loss and protect dopaminergic neurons in Parkinson's disease (PD), as well as increase the proliferation of neural stem cells in the subventricular zone.
NEURAL REGENERATION RESEARCH
(2021)
Article
Oncology
Jun Yu, Xueke Guo, Xia Chen, Chen Qiao, Binghai Chen, Bing Xie, Xiaojin Luan, Cong Shen, Jiawei Zhu, Jiajia Liu, Yidan Yan, Zeyu He, Bo Zheng, Hong Li, Jie Fang
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
(2018)