Heat Shock Proteins: Agents of Cancer Development and Therapeutic Targets in Anti-Cancer Therapy

Increased Expression of DNAJC12 is Associated with Aggressive Phenotype of Gastric Cancer

(2019) Yasuo Uno et al.   ANNALS OF SURGICAL ONCOLOGY

Induction of HSP27 and HSP70 by constitutive overexpression of Redd1 confers resistance of lung cancer cells to ionizing radiation

(2019) Hyeon‑Ok Jin et al.   ONCOLOGY REPORTS

Overexpression of Hsc70 promotes proliferation, migration, and invasion of human glioma cells

(2019) Guan Sun et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

FAM3C‐YY1 axis is essential for TGFβ‐promoted proliferation and migration of human breast cancer MDA‐MB‐231 cells via the activation of HSF1

(2019) Weili Yang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Inhibition of HSP90 overcomes resistance to chemotherapy and radiotherapy in pancreatic cancer

(2019) Ganji Purnachandra Nagaraju et al.   INTERNATIONAL JOURNAL OF CANCER

Overcoming acquired resistance to HSP90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancer

(2019) Nuramalina H. Mumin et al.   BMC CANCER

Ganetespib in Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor-resistant Non-small Cell Lung Cancer

(2019) EISUKE KURIHARA et al.   ANTICANCER RESEARCH

C-terminal HSP90 inhibitor L80 elicits anti-metastatic effects in triple-negative breast cancer via STAT3 inhibition

(2019) Tae-Min Cho et al.   CANCER LETTERS

Mortalin is a distinct bio-marker and prognostic factor in serous ovarian carcinoma

(2019) Ming Xu et al.   GENE

Keys to unlock androgen receptor translocation

(2019) Amy H. Tien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pifithrin-μ induces necroptosis through oxidative mitochondrial damage but accompanies epithelial–mesenchymal transition-like phenomenon in malignant mesothelioma cells under lactic acidosis

(2019) Yoon-Jin Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

Phosphorylation of HSF1 by PIM2 induces PD-L1 expression and promotes tumor growth in breast cancer

(2019) Tingting Yang et al.   CANCER RESEARCH

KNK437 restricts the growth and metastasis of colorectal cancer via targeting DNAJA1/CDC45 axis

(2019) Shaoshan Yang et al.   ONCOGENE

Targeting Heat Shock Protein 27 in Cancer: A Druggable Target for Cancer Treatment?

(2019) Choi et al.   Cancers

Part I of GANNET53: A European Multicenter Phase I/II Trial of the Hsp90 Inhibitor Ganetespib Combined With Weekly Paclitaxel in Women With High-Grade, Platinum-Resistant Epithelial Ovarian Cancer—A Study of the GANNET53 Consortium

(2019) Isabelle Ray-Coquard et al.   Frontiers in Oncology

HSP60-regulated Mitochondrial Proteostasis and Protein Translation Promote Tumor Growth of Ovarian Cancer

(2019) Jianying Guo et al.   Scientific Reports

miR-223/Hsp70/JNK/JUN/miR-223 feedback loop modulates the chemoresistance of osteosarcoma to cisplatin

(2018) Qi Tang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cellular Prion Protein Enhances Drug Resistance of Colorectal Cancer Cells via Regulation of a Survival Signal Pathway

(2018) Jun Hee Lee et al.   Biomolecules & Therapeutics

EGFR-TKI-induced HSP70 degradation and BER suppression facilitate the occurrence of the EGFR T790 M resistant mutation in lung cancer cells

(2018) Xiang Cao et al.   CANCER LETTERS

Panaxynol, a natural Hsp90 inhibitor, effectively targets both lung cancer stem and non-stem cells

(2018) Huong Thuy Le et al.   CANCER LETTERS

Cantharidin-encapsulated thermal-sensitive liposomes coated with gold nanoparticles for enhanced photothermal therapy on A431 cells

(2018) Sijia Wang et al.   International Journal of Nanomedicine

The HSP90 inhibitor NVP-AUY922 inhibits growth of HER2 positive and trastuzumab-resistant breast cancer cells

(2018) Alexandra Canonici et al.   INVESTIGATIONAL NEW DRUGS

Fucoidan Rescues p-Cresol-Induced Cellular Senescence in Mesenchymal Stem Cells via FAK-Akt-TWIST Axis

(2018) Jun Lee et al.   Marine Drugs

Heat Shock Factor 1 Epigenetically Stimulates Glutaminase-1-Dependent mTOR Activation to Promote Colorectal Carcinogenesis

(2018) Jiaqiu Li et al.   MOLECULAR THERAPY

Sensitization of prostate cancer to radiation therapy: Molecules and pathways to target

(2018) Mu Yao et al.   RADIOTHERAPY AND ONCOLOGY

A study on the biological function of heat shock factor 1 proteins in breast cancer

(2018) Xiaolan Wang et al.   Oncology Letters

Glucose-Related Protein 78 Expression and Its Effects on Cisplatin-Resistance in Cervical Cancer

(2018) Chengyan Luo et al.   MEDICAL SCIENCE MONITOR

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma

(2018) Xin Xiao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

UBXN2A enhances CHIP-mediated proteasomal degradation of oncoprotein mortalin-2 in cancer cells

(2018) Sanam Sane et al.   Molecular Oncology

High serum Hsp70 level predicts poor survival in colorectal cancer: Results obtained in an independent validation cohort

(2018) László Gráf et al.   Cancer Biomarkers

HSF1 as a Cancer Biomarker and Therapeutic Target

(2018) Richard L. Carpenter et al.   CURRENT CANCER DRUG TARGETS

Increased expression of heat shock factor 1 (HSF1) is associated with poor survival in gastric cancer patients

(2018) Weigang Dai et al.   Diagnostic Pathology

Melatonin protects chronic kidney disease mesenchymal stem cells against senescence via PrPC -dependent enhancement of the mitochondrial function

(2018) Yong-Seok Han et al.   JOURNAL OF PINEAL RESEARCH

HSP90 interacts with HMGCR and promotes the progression of hepatocellular carcinoma

(2018) Li Dong et al.   Molecular Medicine Reports

Heat Shock Proteins as Immunomodulants

(2018) Tawanda Zininga et al.   MOLECULES

Silencing Heat Shock Protein 27 Inhibits the Progression and Metastasis of Colorectal Cancer (CRC) by Maintaining the Stability of Stromal Interaction Molecule 1 (STIM1) Proteins

(2018) Chien-Yu Huang et al.   Cells

Mortalin expression in pancreatic cancer and its clinical and prognostic significance

(2017) Xuelian Cui et al.   HUMAN PATHOLOGY

Targeting Heat Shock Proteins in Cancer: A Promising Therapeutic Approach

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ganetespib induces G2/M cell cycle arrest and apoptosis in gastric cancer cells through targeting of receptor tyrosine kinase signaling

(2017) Harry Lee et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Heat shock proteins and cancer: How can nanomedicine be harnessed?

(2017) Félix Sauvage et al.   JOURNAL OF CONTROLLED RELEASE

DNAJB1/HSP40 Suppresses Melanoma Differentiation-Associated Gene 5-Mitochondrial Antiviral Signaling Protein Function in Conjunction with HSP70

(2017) Ken Takashima et al.   Journal of Innate Immunity

Hsp90β promoted endothelial cell-dependent tumor angiogenesis in hepatocellular carcinoma

(2017) Jing Meng et al.   Molecular Cancer

Inhibition of Hsp90 Suppresses PI3K/AKT/mTOR Signaling and Has Antitumor Activity in Burkitt Lymphoma

(2017) Lisa Giulino-Roth et al.   MOLECULAR CANCER THERAPEUTICS

Loss of AMPK activation promotes the invasion and metastasis of pancreatic cancer through an HSF1-dependent pathway

(2017) Ke Chen et al.   Molecular Oncology

The HSP90 chaperone machinery

(2017) Florian H. Schopf et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival

(2017) Nuria Vilaboa et al.   NUCLEIC ACIDS RESEARCH

Role of HSPA1L as a cellular prion protein stabilizer in tumor progression via HIF-1α/GP78 axis

(2017) J H Lee et al.   ONCOGENE

HSP90 stabilizes B-cell receptor kinases in a multi-client interactome: PU-H71 induces CLL apoptosis in a cytoprotective microenvironment

(2017) A Guo et al.   ONCOGENE

Low co-expression of epidermal growth factor receptor and its chaperone heat shock protein 90 is associated with worse prognosis in primary glioblastoma, IDH-wild-type

(2017) Elsa Sartori et al.   ONCOLOGY REPORTS

Heat Shock Protein 27, a Novel Regulator of Transforming Growth Factor β Induced Resistance to Cisplatin in A549 Cell

(2017) Zhicheng Huang et al.   PHARMACOLOGY

The Hsp40 J-domain modulates Hsp70 conformation and ATPase activity with a semi-elliptical spring

(2017) Neil Andrew D. Bascos et al.   PROTEIN SCIENCE

Rethinking HSF1 in Stress, Development, and Organismal Health

(2017) Jian Li et al.   TRENDS IN CELL BIOLOGY

Heat Shock Proteins and Cancer

(2017) Jianming Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mortalin overexpression predicts poor prognosis in early stage of non–small cell lung cancer

(2017) Jie Sun et al.   TUMOR BIOLOGY

HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes

(2017) Rina M. Mbofung et al.   Nature Communications

Efficacy of an HSP90 inhibitor, ganetespib, in preclinical thyroid cancer models

(2017) Shu-Fu Lin et al.   Oncotarget

Targeting oral cancer stemness and chemoresistance by isoliquiritigenin-mediated GRP78 regulation

(2017) Fang-Wei Hu et al.   Oncotarget

Pre-incubation with hucMSC-exosomes prevents cisplatin-induced nephrotoxicity by activating autophagy

(2017) Bingying Wang et al.   Stem Cell Research & Therapy

Safety and tolerability of autologous bone marrow mesenchymal stromal cells in ADPKD patients

(2017) Atieh Makhlough et al.   Stem Cell Research & Therapy

Clinical, Prognostic and Therapeutic Significance of Heat Shock Proteins in Cancer

(2017) Jasleen Saini et al.   CURRENT DRUG TARGETS

Relevance of mortalin to cancer cell stemness and cancer therapy

(2017) Chae-Ok Yun et al.   Scientific Reports

Identification of protein biomarkers and signaling pathways associated with prostate cancer radioresistance using label-free LC-MS/MS proteomic approach

(2017) Lei Chang et al.   Scientific Reports

HSP90 is a promising target in gemcitabine and 5-fluorouracil resistant pancreatic cancer

(2016) Tarik Ghadban et al.   APOPTOSIS

Selective killing of cancer cells by small molecules targeting heat shock stress response

(2016) Daniel Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protection of stromal cell-derived factor 2 by heat shock protein 72 prevents oxaliplatin-induced cell death in oxaliplatin-resistant human gastric cancer cells

(2016) Katsuyuki Takahashi et al.   CANCER LETTERS

Stress Chaperone Mortalin Contributes to Epithelial-to-Mesenchymal Transition and Cancer Metastasis

(2016) Y. Na et al.   CANCER RESEARCH

Mitochondria and Cancer

(2016) Sejal Vyas et al.   CELL

Hsp90 Inhibitor Ganetespib Sensitizes Non-Small Cell Lung Cancer to Radiation but Has Variable Effects with Chemoradiation

(2016) Y. Wang et al.   CLINICAL CANCER RESEARCH

Global patterns and trends in colorectal cancer incidence and mortality

(2016) Melina Arnold et al.   GUT

Oncogenic role of mortalin contributes to ovarian tumorigenesis by activating the MAPK-ERK pathway

(2016) Yingying Hu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Heat shock protein 70-2 (HSP70-2) overexpression in breast cancer

(2016) Nirmala Jagadish et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Quercetin sensitizes glioblastoma to t-AUCB by dual inhibition of Hsp27 and COX-2 in vitro and in vivo

(2016) Junyang Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Quercetin blocks t-AUCB-induced autophagy by Hsp27 and Atg7 inhibition in glioblastoma cells in vitro

(2016) Junyang Li et al.   JOURNAL OF NEURO-ONCOLOGY

Melatonin as an antioxidant: under promises but over delivers

(2016) Russel J. Reiter et al.   JOURNAL OF PINEAL RESEARCH

PU-H71, a novel Hsp90 inhibitor, as a potential cancer-specific sensitizer to carbon-ion beam therapy

(2016) Huizi Keiko Li et al.   JOURNAL OF RADIATION RESEARCH

IGF-1 C Domain-Modified Hydrogel Enhances Cell Therapy for AKI

(2016) G. Feng et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TAS-116, a Novel Hsp90 Inhibitor, Selectively Enhances Radiosensitivity of Human Cancer Cells to X-rays and Carbon Ion Radiation

(2016) Younghyun Lee et al.   MOLECULAR CANCER THERAPEUTICS

Pifithrin-μ is efficacious against non-small cell lung cancer via inhibition of heat shock protein 70

(2016) Yang Zhou et al.   ONCOLOGY REPORTS

HSP27 Knockdown Increases Cytoplasmic p21 and Cisplatin Sensitivity in Ovarian Carcinoma Cells

(2016) Hao Lu et al.   ONCOLOGY RESEARCH

Dnajb8, a Member of the Heat Shock Protein 40 Family Has a Role in the Tumor Initiation and Resistance to Docetaxel but Is Dispensable for Stress Response

(2016) Masamichi Yamashita et al.   PLoS One

Heat Shock Proteins Promote Cancer: It's a Protection Racket

(2016) Stuart K. Calderwood et al.   TRENDS IN BIOCHEMICAL SCIENCES

Geldanamycin, an inhibitor of Hsp90, increases paclitaxel-mediated toxicity in ovarian cancer cells through sustained activation of the p38/H2AX axis

(2016) Qingqing Mo et al.   TUMOR BIOLOGY

Downregulation of HSP60 disrupts mitochondrial proteostasis to promote tumorigenesis and progression in clear cell renal cell carcinoma

(2016) Haiping Tang et al.   Oncotarget

Hsp60 exerts a tumor suppressor function by inducing cell differentiation and inhibiting invasion in hepatocellular carcinoma

(2016) Jing Zhang et al.   Oncotarget

A novel HSP90 inhibitor with reduced hepatotoxicity synergizes with radiotherapy to induce apoptosis, abrogate clonogenic survival, and improve tumor control in models of colorectal cancer

(2016) Linda Kinzel et al.   Oncotarget

Molecular chaperone Hsp27 regulates the Hippo tumor suppressor pathway in cancer

(2016) Sepideh Vahid et al.   Scientific Reports

Identification and validation of multiple cell surface markers of clinical-grade adipose-derived mesenchymal stromal cells as novel release criteria for good manufacturing practice-compliant production

(2016) Emily T. Camilleri et al.   Stem Cell Research & Therapy

Down-regulation of HSP60 Suppresses the Proliferation of Glioblastoma Cells via the ROS/AMPK/mTOR Pathway

(2016) Haiping Tang et al.   Scientific Reports

DNAJB1 negatively regulates MIG6 to promote epidermal growth factor receptor signaling

(2015) Soo-Yeon Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Sensitizing tumor cells to radiation by targeting the heat shock response

(2015) Daniela Schilling et al.   CANCER LETTERS

The role of heat shock protein 70 (Hsp70) in radiation-induced immunomodulation

(2015) Gabriele Multhoff et al.   CANCER LETTERS

Tyrosine phosphorylation of HSC70 and its interaction with RFC mediates methotrexate resistance in murine L1210 leukemia cells

(2015) Tuoen Liu et al.   CANCER LETTERS

Fisetin, a dietary flavonoid, induces apoptosis of cancer cells by inhibiting HSF1 activity through blocking its binding to the hsp70 promoter

(2015) J. A. Kim et al.   CARCINOGENESIS

Overexpression of DNAJC12 predicts poor response to neoadjuvant concurrent chemoradiotherapy in patients with rectal cancer

(2015) Hong-Lin He et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis

(2015) Anna Fernández et al.   JOURNAL OF PINEAL RESEARCH

AKI Recovery Induced by Mesenchymal Stromal Cell-Derived Extracellular Vesicles Carrying MicroRNAs

(2015) F. Collino et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Heat Shock Protein 90 Is a Potential Therapeutic Target in Cholangiocarcinoma

(2015) T. Shirota et al.   MOLECULAR CANCER THERAPEUTICS

Suppression of HSP27 increases the anti-tumor effects of quercetin in human leukemia U937 cells

(2015) XI CHEN et al.   Molecular Medicine Reports

Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells

(2015) Devon A. Lawson et al.   NATURE

Risks for mortality and renal replacement therapy in atherosclerotic renovascular disease compared with other causes of chronic kidney disease

(2015) James Ritchie et al.   NEPHROLOGY

The Effects of HSP27 on Gemcitabine-Resistant Pancreatic Cancer Cell Line Through Snail

(2015) Song Zhang et al.   PANCREAS

Dendritic-Tumor Fusion Cells Derived Heat Shock Protein70-Peptide Complex Has Enhanced Immunogenicity

(2015) Yunfei Zhang et al.   PLoS One

Role of membrane Hsp70 in radiation sensitivity of tumor cells

(2015) Naoya Murakami et al.   Radiation Oncology

Multifaceted roles of HSF1 in cancer

(2015) Sufang Jiang et al.   TUMOR BIOLOGY

GRP78 confers the resistance to 5-FU by activating the c-Src/LSF/TS Axis in hepatocellular carcinoma

(2015) Yan-jiao Gu et al.   Oncotarget

Acquired resistance to 5-fluorouracil via HSP90/Src-mediated increase in thymidylate synthase expression in colon cancer

(2015) Ji-Young Ahn et al.   Oncotarget

Pharmacologic resistance in colorectal cancer: a review

(2015) William A. Hammond et al.   Therapeutic Advances in Medical Oncology

Heat Shock Protein 70 (Hsp70) Peptide Activated Natural Killer (NK) Cells for the Treatment of Patients with Non-Small Cell Lung Cancer (NSCLC) after Radiochemotherapy (RCTx) – From Preclinical Studies to a Clinical Phase II Trial

(2015) Hanno M. Specht et al.   Frontiers in Immunology

Colorectal cancer

(2015) Ernst J. Kuipers et al.   Nature Reviews Disease Primers

Stromal Expression of Heat-Shock Protein 27 Is Associated with Worse Clinical Outcome in Patients with Colorectal Cancer Lung Metastases

(2015) Thomas Schweiger et al.   PLoS One

Targeting Mortalin by Embelin Causes Activation of Tumor Suppressor p53 and Deactivation of Metastatic Signaling in Human Breast Cancer Cells

(2015) Nupur Nigam et al.   PLoS One

Mitochondrial dysfunction in cancer chemoresistance

(2014) Nicoletta Guaragnella et al.   BIOCHEMICAL PHARMACOLOGY

Human heat shock protein-specific cytotoxic T lymphocytes display potent antitumour immunity in multiple myeloma

(2014) Rong Li et al.   BRITISH JOURNAL OF HAEMATOLOGY

Heat shock protein 90 (HSP90) is overexpressed in p16-negative oropharyngeal squamous cell carcinoma, and its inhibition in vitro potentiates the effects of chemoradiation

(2014) Kirtesh Patel et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Heat shock protein DNAJB8 is a novel target for immunotherapy of colon cancer-initiating cells

(2014) Rena Morita et al.   CANCER SCIENCE

Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via β-catenin/ABCG2 signaling

(2014) Neng Wang et al.   CARCINOGENESIS

Identification of an Allosteric Small-Molecule Inhibitor Selective for the Inducible Form of Heat Shock Protein 70

(2014) Matthew K. Howe et al.   CHEMISTRY & BIOLOGY

Cantharidin induces DNA damage and inhibits DNA repair-associated protein levels in NCI-H460 human lung cancer cells

(2014) Te-Chun Hsia et al.   ENVIRONMENTAL TOXICOLOGY

Effective immunotherapy of rat glioblastoma with prolonged intratumoral delivery of exogenous heat shock protein Hsp70

(2014) Maxim A. Shevtsov et al.   INTERNATIONAL JOURNAL OF CANCER

Hsp27 regulates EGF/β-catenin mediated epithelial to mesenchymal transition in prostate cancer

(2014) Thomas Cordonnier et al.   INTERNATIONAL JOURNAL OF CANCER

2,4-Bis(4-hydroxybenzyl)phenol Inhibits Heat Shock Transcription Factor 1 and Sensitizes Lung Cancer Cells to Conventional Anticancer Modalities

(2014) Taesook Yoon et al.   JOURNAL OF NATURAL PRODUCTS

Heat shock protein 70 is involved in malignant behaviors and chemosensitivities to cisplatin in cervical squamous cell carcinoma cells

(2014) Keiko Yoshidomi et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

Overexpression of DNAJB6 promotes colorectal cancer cell invasion through an IQGAP1/ERK-dependent signaling pathway

(2014) Tong-Tong Zhang et al.   MOLECULAR CARCINOGENESIS

Heat shock protein 90 promotes epithelial to mesenchymal transition, invasion, and migration in colorectal cancer

(2014) Ganji Purnachandra Nagaraju et al.   MOLECULAR CARCINOGENESIS

Hsp70 in cancer: back to the future

(2014) M Y Sherman et al.   ONCOGENE

Identification of 5-fluorouracil response proteins in colorectal carcinoma cell line SW480 by two-dimensional electrophoresis and MALDI-TOF mass spectrometry

(2014) Cesar Wong et al.   ONCOLOGY REPORTS

Immediate and transient phosphorylation of the heat shock protein 27 initiates chemoresistance in prostate cancer cells

(2014) MATTHIAS B. STOPE et al.   ONCOLOGY REPORTS

Mesenchymal Stem Cells Modulate Albumin-Induced Renal Tubular Inflammation and Fibrosis

(2014) Hao Jia Wu et al.   PLoS One

Heat Shock Protein-90 Inhibitors Enhance Antigen Expression on Melanomas and Increase T Cell Recognition of Tumor Cells

(2014) Timothy J. Haggerty et al.   PLoS One

Ibuprofen enhances the anticancer activity of cisplatin in lung cancer cells by inhibiting the heat shock protein 70

(2014) H Endo et al.   Cell Death & Disease

Microvesicles derived from human Wharton’s Jelly mesenchymal stromal cells ameliorate renal ischemia-reperfusion injury in rats by suppressing CX3CL1

(2014) Xiangyu Zou et al.   Stem Cell Research & Therapy

Inhibition of mortalin expression reverses cisplatin resistance and attenuates growth of ovarian cancer cells

(2013) Ling Yang et al.   CANCER LETTERS

Hsp27 Regulates Epithelial Mesenchymal Transition, Metastasis, and Circulating Tumor Cells in Prostate Cancer

(2013) M. Shiota et al.   CANCER RESEARCH

The HSP70 family and cancer

(2013) M. E. Murphy   CARCINOGENESIS

1,3,5-Trihydroxy-13,13-dimethyl-2H-pyran [7,6-b] xanthone directly targets heat shock protein 27 in hepatocellular carcinoma

(2013) Wei-ming Fu et al.   CELL BIOLOGY INTERNATIONAL

Heat Shock Factor 1 (HSF1) Controls Chemoresistance and Autophagy through Transcriptional Regulation of Autophagy-related Protein 7 (ATG7)

(2013) Shruti Desai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp27: A novel therapeutic target for pediatric M4/M5 acute myeloid leukemia

(2013) LIANGCHUN YANG et al.   ONCOLOGY REPORTS

Peptide aptamers: tools to negatively or positively modulate HSPB1(27) function

(2013) B. Gibert et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Geldanamycin-Induced Osteosarcoma Cell Death Is Associated with Hyperacetylation and Loss of Mitochondrial Pool of Heat Shock Protein 60 (Hsp60)

(2013) Magdalena Gorska et al.   PLoS One

Inhibition of Inducible Heat Shock Protein-70 (Hsp72) Enhances Bortezomib-Induced Cell Death in Human Bladder Cancer Cells

(2013) Wei Qi et al.   PLoS One

Current concepts in clinical radiation oncology

(2013) Michael Orth et al.   RADIATION AND ENVIRONMENTAL BIOPHYSICS

Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro

(2013) Ying Zhou et al.   Stem Cell Research & Therapy

Use of Mesenchymal Stem Cells and Darbepoetin Improve Ischemia-Induced Acute Kidney Injury Outcomes

(2012) Bulent Altun et al.   AMERICAN JOURNAL OF NEPHROLOGY

Novel inhibitors of heat shock protein Hsp70-mediated luciferase refolding that bind to DnaJ

(2012) Joel A. Cassel et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hsp70 promotes chemoresistance by blocking Bax mitochondrial translocation in ovarian cancer cells

(2012) Xiaokui Yang et al.   CANCER LETTERS

Combination Therapy with HSP90 Inhibitor 17-DMAG Reconditions the Tumor Microenvironment to Improve Recruitment of Therapeutic T cells

(2012) A. Rao et al.   CANCER RESEARCH

Molecular cloning and characterization of Hsp27.6: the first reported small heat shock protein from Apis cerana cerana

(2012) Zhaohua Liu et al.   CELL STRESS & CHAPERONES

Proteomic investigation of anti-tumor activities exerted by sinularin against A2058 melanoma cells

(2012) Tzu-Rong Su et al.   ELECTROPHORESIS

Immune Mechanism of the Antitumor Effects Generated by Bortezomib

(2012) C.-L. Chang et al.   JOURNAL OF IMMUNOLOGY

A review of the molecular aspects of melatonin’s anti-inflammatory actions: recent insights and new perspectives

(2012) José L. Mauriz et al.   JOURNAL OF PINEAL RESEARCH

Heat shock protein 27 mediates the effect of 1,3,5-trihydroxy-13,13-dimethyl-2H-pyran [7,6-b] xanthone on mitochondrial apoptosis in hepatocellular carcinoma

(2012) Wei-ming Fu et al.   Journal of Proteomics

Pre-conditioned mesenchymal stem cells ameliorate renal ischemic injury in rats by augmented survival and engraftment

(2012) Muhammad Masoud et al.   Journal of Translational Medicine

Molecular Mechanism of Mutant p53 Stabilization: The Role of HSP70 and MDM2

(2012) Milena Wiech et al.   PLoS One

Quercetin Suppresses Drug-Resistant Spheres via the p38 MAPK–Hsp27 Apoptotic Pathway in Oral Cancer Cells

(2012) Su-Feng Chen et al.   PLoS One

Antitumor activity of NVP-AUY922, a novel heat shock protein 90 inhibitor, in human gastric cancer cells is mediated through proteasomal degradation of client proteins

(2011) Kyung-Hun Lee et al.   CANCER SCIENCE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment

(2011) Hardik J Patel et al.   Expert Opinion on Drug Discovery

RP101 (brivudine) binds to heat shock protein HSP27 (HSPB1) and enhances survival in animals and pancreatic cancer patients

(2011) Jörg-Christian Heinrich et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Cancer theory faces doubts

(2011) Heidi Ledford   NATURE

Inhibition of heat shock protein 27 (HspB1) tumorigenic functions by peptide aptamers

(2011) B Gibert et al.   ONCOGENE

14S,21R-dihydroxy-docosahexaenoic Acid Treatment Enhances Mesenchymal Stem Cell Amelioration of Renal Ischemia/Reperfusion Injury

(2011) Haibin Tian et al.   STEM CELLS AND DEVELOPMENT

Major heat shock protein Hsp72 controls oncogene-induced senescence

(2010) Michael Sherman   Annals of the New York Academy of Sciences

Chemoresistance of lung cancer stemlike cells depends on activation of Hsp27

(2010) Han-Shui Hsu et al.   CANCER

Targeting heat shock proteins in cancer

(2010) Gaëtan Jego et al.   CANCER LETTERS

Heat shock protein 70 is acute phase reactant: response elicited by tumor treatment with photodynamic therapy

(2010) Soroush Merchant et al.   CELL STRESS & CHAPERONES

Dual Role of Heat Shock Proteins as Regulators of Apoptosis and Innate Immunity

(2010) Anne-Laure Joly et al.   Journal of Innate Immunity

Silencing Heat Shock Protein 27 Decreases Metastatic Behavior of Human Head and Neck Squamous Cell Cancer Cells in Vitro

(2010) Zhenkun Zhu et al.   MOLECULAR PHARMACEUTICS

The protective effect of royal jelly against cisplatin-induced renal oxidative stress in rats

(2010) Sibel Silici et al.   WORLD JOURNAL OF UROLOGY

Mechanisms of Cisplatin Nephrotoxicity

(2010) Ronald P. Miller et al.   Toxins

Silencing of Heat Shock Protein 70 Expression Enhances Radiotherapy Efficacy and Inhibits Cell Invasion in Endometrial Cancer Cell Line

(2009) Xue-lian Du et al.   CROATIAN MEDICAL JOURNAL

Heat shock proteins, cell survival and drug resistance: The mitochondrial chaperone TRAP1, a potential novel target for ovarian cancer therapy

(2009) Matteo Landriscina et al.   GYNECOLOGIC ONCOLOGY

Association of hsp90 to the hTERT promoter is necessary for hTERT expression in human oral cancer cells

(2008) R. H. Kim et al.   CARCINOGENESIS

Guidelines for the nomenclature of the human heat shock proteins

(2008) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

Ex Vivo Pretreatment with Melatonin Improves Survival, Proangiogenic/Mitogenic Activity, and Efficiency of Mesenchymal Stem Cells Injected into Ischemic Kidney

(2008) Céline Mias et al.   STEM CELLS