New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival

Mammalian Heat Shock Response and Mechanisms Underlying Its Genome-wide Transcriptional Regulation

(2016) Dig B. Mahat et al.   MOLECULAR CELL

Structure of human heat-shock transcription factor 1 in complex with DNA

(2016) Tobias Neudegger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structures of HSF2 reveal mechanisms for differential regulation of human heat-shock factors

(2016) Alex M Jaeger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of human heat-shock transcription factor 1 in complex with DNA

(2016) Tobias Neudegger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structures of HSF2 reveal mechanisms for differential regulation of human heat-shock factors

(2016) Alex M Jaeger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Interplay of Acetyltransferase EP300 and the Proteasome System in Regulating Heat Shock Transcription Factor 1

(2014) Swasti Raychaudhuri et al.   CELL

Synthesis of Rigidified eIF4E/eIF4G Inhibitor-1 (4EGI-1) Mimetic and Their in Vitro Characterization as Inhibitors of Protein–Protein Interaction

(2014) Poornachandran Mahalingam et al.   JOURNAL OF MEDICINAL CHEMISTRY

ATF1 Modulates the Heat Shock Response by Regulating the Stress-Inducible Heat Shock Factor 1 Transcription Complex

(2014) Ryosuke Takii et al.   MOLECULAR AND CELLULAR BIOLOGY

HDAC6–ubiquitin interaction controls the duration of HSF1 activation after heat shock

(2014) Lydia Pernet et al.   MOLECULAR BIOLOGY OF THE CELL

Inhibiting Heat Shock Factor 1 in Human Cancer Cells with a Potent RNA Aptamer

(2014) H. Hans Salamanca et al.   PLoS One

Transcriptional response to stress in the dynamic chromatin environment of cycling and mitotic cells

(2013) Anniina Vihervaara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update

(2012) Daniel R. Ciocca et al.   ARCHIVES OF TOXICOLOGY

HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers

(2012) Marc L. Mendillo et al.   CELL

Heat Shock Transcription Factor Hsf1 Is Involved in Tumor Progression via Regulation of Hypoxia-Inducible Factor 1 and RNA-Binding Protein HuR

(2012) V. L. Gabai et al.   MOLECULAR AND CELLULAR BIOLOGY

RPA Assists HSF1 Access to Nucleosomal DNA by Recruiting Histone Chaperone FACT

(2012) Mitsuaki Fujimoto et al.   MOLECULAR CELL

mTOR Is Essential for the Proteotoxic Stress Response, HSF1 Activation and Heat Shock Protein Synthesis

(2012) Shiuh-Dih Chou et al.   PLoS One

Promotion of Heat Shock Factor Hsf1 Degradation via Adaptor Protein Filamin A-interacting Protein 1-Like (FILIP-1L)

(2011) Yanzhong Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer

(2011) S. Santagata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

KRIBB11 Inhibits HSP70 Synthesis through Inhibition of Heat Shock Factor 1 Function by Impairing the Recruitment of Positive Transcription Elongation Factor b to thehsp70Promoter

(2010) Young Ju Yoon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Silencing HSF1 by short hairpin RNA decreases cell proliferation and enhances sensitivity to hyperthermia in human melanoma cell lines

(2010) Yoshitaka Nakamura et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

The Heat Shock Response: Life on the Verge of Death

(2010) Klaus Richter et al.   MOLECULAR CELL

Heat shock factors: integrators of cell stress, development and lifespan

(2010) Malin Åkerfelt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis

(2010) L Meng et al.   ONCOGENE

Chromatin Landscape Dictates HSF Binding to Target DNA Elements

(2010) Michael J. Guertin et al.   PLoS Genetics

Heterotrimerization of Heat-Shock Factors 1 and 2 Provides a Transcriptional Switch in Response to Distinct Stimuli

(2009) Anton Sandqvist et al.   MOLECULAR BIOLOGY OF THE CELL

Heat shock factor-1 modulates p53 activity in the transcriptional response to DNA damage

(2009) Ian R. Logan et al.   NUCLEIC ACIDS RESEARCH

Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth

(2009) Y H Zhao et al.   ONCOGENE

Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1

(2009) S. D. Westerheide et al.   SCIENCE

The genetics of the p53 pathway, apoptosis and cancer therapy

(2008) Alexei Vazquez et al.   NATURE REVIEWS DRUG DISCOVERY