UBXN2A enhances CHIP-mediated proteasomal degradation of oncoprotein mortalin-2 in cancer cells

Covalent ISG15 conjugation to CHIP promotes its ubiquitin E3 ligase activity and inhibits lung cancer cell growth in response to type I interferon

(2018) Lang Yoo et al.   Cell Death & Disease

Identifying the substrate proteins of U-box E3s E4B and CHIP by orthogonal ubiquitin transfer

(2018) Karan Bhuripanyo et al.   Science Advances

Mortalin expression in pancreatic cancer and its clinical and prognostic significance

(2017) Xuelian Cui et al.   HUMAN PATHOLOGY

Identifying the ubiquitination targets of E6AP by orthogonal ubiquitin transfer

(2017) Yiyang Wang et al.   Nature Communications

Orthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes

(2017) Xianpeng Liu et al.   Nature Communications

Prognostic significance of mortalin expresion in gastric adenocarcinoma with wild-type p53.

(2017) E. Oki et al.   JOURNAL OF CLINICAL ONCOLOGY

Stress Chaperone Mortalin Contributes to Epithelial-to-Mesenchymal Transition and Cancer Metastasis

(2016) Y. Na et al.   CANCER RESEARCH

Heat Shock Protein 70s as Potential Molecular Targets for Colon Cancer Therapeutics

(2016) Jennifer D. Black et al.   CURRENT MEDICINAL CHEMISTRY

The clinicopathological significance of Mortalin overexpression in invasive ductal carcinoma of breast

(2016) Haidan Jin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cell Cycle Phase-Specific Drug Resistance as an Escape Mechanism of Melanoma Cells

(2016) Kimberley A. Beaumont et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The opposite role of two UBA–UBX containing proteins, p47 and SAKS1 in the degradation of a single ERAD substrate, α-TCR

(2016) Eun Sil Park et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

EZH2 mediates lidamycin-induced cellular senescence through regulating p21 expression in human colon cancer cells

(2016) Ming-Quan Sha et al.   Cell Death & Disease

Dexamethasone Inhibits TGF-β1–Induced Cell Migration by Regulating the ERK and AKT Pathways in Human Colon Cancer Cells Via CYR61

(2016) Sanghoon Han et al.   Cancer Research and Treatment

Optimising methods for the preservation, capture and identification of ubiquitin chains and ubiquitylated proteins by immunoblotting

(2015) Christoph H. Emmerich et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

UBXN2A regulates nicotinic receptor degradation by modulating the E3 ligase activity of CHIP

(2015) Yanfen Teng et al.   BIOCHEMICAL PHARMACOLOGY

Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy

(2015) Sanam Sane et al.   CELL STRESS & CHAPERONES

The ubiquitin ligase CHIP inactivates NF-κB signaling and impairs the ability of migration and invasion in gastric cancer cells

(2015) FEI LIU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Biochemical and Proteomic Analysis of Ubiquitination of Hsc70 and Hsp70 by the E3 Ligase CHIP

(2015) Sarah E. Soss et al.   PLoS One

Human Mitochondrial Hsp70 (Mortalin): Shedding Light on ATPase Activity, Interaction with Adenosine Nucleotides, Solution Structure and Domain Organization

(2015) Paulo R. Dores-Silva et al.   PLoS One

A Bipartite Interaction between Hsp70 and CHIP Regulates Ubiquitination of Chaperoned Client Proteins

(2015) Huaqun Zhang et al.   STRUCTURE

Targeting the ROR1 and ROR2 receptors in epithelial ovarian cancer inhibits cell migration and invasion

(2015) Claire Henry et al.   Oncotarget

Nucleocytoplasmic Translocation of UBXN2A Is Required for Apoptosis during DNA Damage Stresses in Colon Cancer Cells

(2015) Ammara Abdullah et al.   Journal of Cancer

Cell-cycle fate-monitoring distinguishes individual chemosensitive and chemoresistant cancer cells in drug-treated heterogeneous populations demonstrated by real-time FUCCI imaging

(2015) Shinji Miwa et al.   CELL CYCLE

CHIP is a novel tumor suppressor in pancreatic cancer and inhibits tumor growth through targeting EGFR

(2015) Tianxiao Wang et al.   Oncotarget

Induction of p21-Dependent Senescence by an NAE Inhibitor, MLN4924, as a Mechanism of Growth Suppression

(2015) Lijun Jia et al.   NEOPLASIA

Enteral glutamine infusion modulates ubiquitination of heat shock proteins, Grp-75 and Apg-2, in the human duodenal mucosa

(2014) Julien Bertrand et al.   AMINO ACIDS

Ubiquitin ligase CHIP suppresses cancer stem cell properties in a population of breast cancer cells

(2014) Mai Tsuchiya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification and Functional Characterization of Nuclear Mortalin in Human Carcinogenesis

(2014) Jihoon Ryu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p16 Protein and Gigaxonin Are Associated with the Ubiquitination of NFκB in Cisplatin-induced Senescence of Cancer Cells

(2014) Mysore S. Veena et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The E3 Ligase CHIP Mediates Ubiquitination and Degradation of Mixed-Lineage Kinase 3

(2014) Natalya A. Blessing et al.   MOLECULAR AND CELLULAR BIOLOGY

Mortalin (GRP75/HSPA9) upregulation promotes survival and proliferation of medullary thyroid carcinoma cells

(2014) D Starenki et al.   ONCOGENE

Proteasome Inhibitors Alter Levels of Intracellular Peptides in HEK293T and SH-SY5Y Cells

(2014) Sayani Dasgupta et al.   PLoS One

Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells

(2014) S Sane et al.   Cell Death & Disease

Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1

(2014) L F Burbulla et al.   Cell Death & Disease

CHIP/Stub1 functions as a tumor suppressor and represses NF- B-mediated signaling in colorectal cancer

(2013) Y. Wang et al.   CARCINOGENESIS

Mortalin is a prognostic factor of gastric cancer with normal p53 function

(2013) Koji Ando et al.   Gastric Cancer

Elevated levels of mitochondrial mortalin and cytosolic HSP70 in blood as risk factors in patients with colorectal cancer

(2013) Perri Rozenberg et al.   INTERNATIONAL JOURNAL OF CANCER

Overexpression of Mortalin in hepatocellular carcinoma and its relationship with angiogenesis and epithelial to mesenchymal transition

(2013) JING CHEN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Complex of Fas-associated Factor 1 (FAF1) with Valosin-containing Protein (VCP)-Npl4-Ufd1 and Polyubiquitinated Proteins Promotes Endoplasmic Reticulum-associated Degradation (ERAD)

(2013) Jae-Jin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Mortalin/HSPA9-Mediated Switch in Tumor-Suppressive Signaling of Raf/MEK/Extracellular Signal-Regulated Kinase

(2013) P.-K. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

Cytoplasmic sequestration of the tumor suppressor p53 by a heat shock protein 70 family member, mortalin, in human colorectal adenocarcinoma cell lines

(2012) Erin E. Gestl et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Orthogonal Ubiquitin Transfer through Engineered E1-E2 Cascades for Protein Ubiquitination

(2012) Bo Zhao et al.   CHEMISTRY & BIOLOGY

CHIP functions as a novel suppressor of tumour angiogenesis with prognostic significance in human gastric cancer

(2012) Shouyu Wang et al.   GUT

Androgen receptor degradation by the E3 ligase CHIP modulates mitotic arrest in prostate cancer cells

(2012) S Sarkar et al.   ONCOGENE

Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor

(2012) L M Lindqvist et al.   Cell Death & Disease

Carboxyl terminus of Hsp70-interacting protein (CHIP) contributes to human glioma oncogenesis

(2011) Tao Xu et al.   CANCER SCIENCE

Mortalin–p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy

(2011) W-J Lu et al.   CELL DEATH AND DIFFERENTIATION

Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1

(2011) Xiao-Xin Sun et al.   EMBO JOURNAL

Withanone binds to mortalin and abrogates mortalin–p53 complex: Computational and experimental evidence

(2011) Abhinav Grover et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

STK35L1 Associates with Nuclear Actin and Regulates Cell Cycle and Migration of Endothelial Cells

(2011) Pankaj Goyal et al.   PLoS One

The signal pathways in azoxymethane-induced colon cancer and preventive implications

(2010) Jiezhong Chen et al.   CANCER BIOLOGY & THERAPY

Induction of mutant p53-dependent apoptosis in human hepatocellular carcinoma by targeting stress protein mortalin

(2010) Wen-Jing Lu et al.   INTERNATIONAL JOURNAL OF CANCER

Tumor suppression by apoptotic and anti-angiogenic effects of mortalin-targeting adeno-oncolytic virus

(2010) Ji Young Yoo et al.   JOURNAL OF GENE MEDICINE

Efficient protection and isolation of ubiquitylated proteins using tandem ubiquitin-binding entities

(2009) Roland Hjerpe et al.   EMBO REPORTS

Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α

(2009) Weibo Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Residues on Hsp70 and Hsp90 Ubiquitinated by the Cochaperone CHIP

(2009) Lenka Kundrat et al.   JOURNAL OF MOLECULAR BIOLOGY

UBXD4, a UBX-Containing Protein, Regulates the Cell Surface Number and Stability of  3-Containing Nicotinic Acetylcholine Receptors

(2009) K. Rezvani et al.   JOURNAL OF NEUROSCIENCE

From proliferative to neurological role of an hsp70 stress chaperone, mortalin

(2008) Custer C. Deocaris et al.   BIOGERONTOLOGY

UBXD7 Binds Multiple Ubiquitin Ligases and Implicates p97 in HIF1α Turnover

(2008) Gabriela Alexandru et al.   CELL

CHIP Deficiency Decreases Longevity, with Accelerated Aging Phenotypes Accompanied by Altered Protein Quality Control

(2008) J.-N. Min et al.   MOLECULAR AND CELLULAR BIOLOGY