Loss of AMPK activation promotes the invasion and metastasis of pancreatic cancer through an HSF1-dependent pathway

The role of stromal cancer-associated fibroblasts in pancreatic cancer

(2017) Dagny von Ahrens et al.   Journal of Hematology & Oncology

Pharmacological macrophage inhibition decreases metastasis formation in a genetic model of pancreatic cancer

(2016) Heidi Griesmann et al.   GUT

Neutrophil-Derived Proteases in the Microenvironment of Pancreatic Cancer -Active Players in Tumor Progression

(2016) Klaus Felix et al.   International Journal of Biological Sciences

Pancreatic cancer

(2016) Terumi Kamisawa et al.   LANCET

Targeting Epithelial–Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer

(2016) Bowen Du et al.   MOLECULES

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

(2016) Cristovão M. Sousa et al.   NATURE

Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis

(2016) Sebastian R. Nielsen et al.   NATURE CELL BIOLOGY

HGF/Met and FOXM1 form a positive feedback loop and render pancreatic cancer cells resistance to Met inhibition and aggressive phenotypes

(2016) J Cui et al.   ONCOGENE

KRAS-related proteins in pancreatic cancer

(2016) Karen M. Mann et al.   PHARMACOLOGY & THERAPEUTICS

Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer

(2016) Biplab Dasgupta et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

YAP Inhibition by Resveratrol via Activation of AMPK Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine

(2016) Zhengdong Jiang et al.   Nutrients

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

(2016) Hongyun Zhao et al.   eLife

CXCR2-Dependent Accumulation of Tumor-Associated Neutrophils Regulates T-cell Immunity in Pancreatic Ductal Adenocarcinoma

(2016) T. Chao et al.   Cancer Immunology Research

Heat shock factor 1 induces cancer stem cell phenotype in breast cancer cell lines

(2015) Bin Wang et al.   BREAST CANCER RESEARCH AND TREATMENT

Hypoxic Microenvironment Induces EMT and Upgrades Stem-Like Properties of Gastric Cancer Cells

(2015) Jinbao Guo et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

Prognostic role of the neutrophil-to-lymphocyte ratio in pancreatic cancer: a meta-analysis

(2015) Hao Cheng et al.   Scientific Reports

AMPK Reverses the Mesenchymal Phenotype of Cancer Cells by Targeting the Akt–MDM2–Foxo3a Signaling Axis

(2014) Chih-Chien Chou et al.   CANCER RESEARCH

Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling

(2014) Susann Weissmueller et al.   CELL

Sonic Hedgehog Paracrine Signaling Activates Stromal Cells to Promote Perineural Invasion in Pancreatic Cancer

(2014) X. Li et al.   CLINICAL CANCER RESEARCH

A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis

(2014) G. Zadra et al.   EMBO Molecular Medicine

Myeloid-derived suppressor cells in pancreatic cancer: more than a hidden barrier for antitumour immunity?

(2014) Tim F Greten   GUT

HSF1 at a glance

(2014) A. Vihervaara et al.   JOURNAL OF CELL SCIENCE

Microenvironment-dependent cues trigger miRNA-regulated feedback loop to facilitate the EMT/MET switch

(2014) Julienne L. Carstens et al.   JOURNAL OF CLINICAL INVESTIGATION

Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage–stellate cell interaction

(2014) Chanjuan Shi et al.   LABORATORY INVESTIGATION

Upregulation of heat shock factor 1 transcription activity is associated with hepatocellular carcinoma progression

(2014) SHULIAN LI et al.   Molecular Medicine Reports

A gain-of-function mutant p53–HSF1 feed forward circuit governs adaptation of cancer cells to proteotoxic stress

(2014) D Li et al.   Cell Death & Disease

Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer

(2013) Y Ino et al.   BRITISH JOURNAL OF CANCER

Role of the immune system in pancreatic cancer progression and immune modulating treatment strategies

(2013) K. Sideras et al.   CANCER TREATMENT REVIEWS

Heat shock factor 1 accelerates hepatocellular carcinoma development by activating nuclear factor-κB/mitogen-activated protein kinase

(2013) Makoto Chuma et al.   CARCINOGENESIS

A Starring Role for Stellate Cells in the Pancreatic Cancer Microenvironment

(2013) Minoti V. Apte et al.   GASTROENTEROLOGY

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

(2013) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

SDF-1/CXCR4 signaling induces pancreatic cancer cell invasion and epithelial–mesenchymal transition in vitro through non-canonical activation of Hedgehog pathway

(2012) Xuqi Li et al.   CANCER LETTERS

HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers

(2012) Marc L. Mendillo et al.   CELL

Persistent activation of pancreatic stellate cells creates a microenvironment favorable for the malignant behavior of pancreatic ductal adenocarcinoma

(2012) Dong Tang et al.   INTERNATIONAL JOURNAL OF CANCER

Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis

(2012) Chengkai Dai et al.   JOURNAL OF CLINICAL INVESTIGATION

Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B

(2012) Hyun-Soo Cho et al.   Nature Communications

Neutrophil granulocyte derived MMP-9 is a VEGF independent functional component of the angiogenic switch in pancreatic ductal adenocarcinoma

(2011) Dirk Bausch et al.   ANGIOGENESIS

Heat Shock Transcription Factor 1 Is a Key Determinant of HCC Development by Regulating Hepatic Steatosis and Metabolic Syndrome

(2011) Xiongjie Jin et al.   Cell Metabolism

AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

Functional Inactivation of Endogenous MDM2 and CHIP by HSP90 Causes Aberrant Stabilization of Mutant p53 in Human Cancer Cells

(2011) D. Li et al.   MOLECULAR CANCER RESEARCH

FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

(2011) Thierry Conroy et al.   NEW ENGLAND JOURNAL OF MEDICINE

High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer

(2011) S. Santagata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

KRIBB11 Inhibits HSP70 Synthesis through Inhibition of Heat Shock Factor 1 Function by Impairing the Recruitment of Positive Transcription Elongation Factor b to thehsp70Promoter

(2010) Young Ju Yoon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

(2009) F. Colotta et al.   CARCINOGENESIS

HSF1-mediated BAG3 Expression Attenuates Apoptosis in 4-Hydroxynonenal-treated Colon Cancer Cells via Stabilization of Anti-apoptotic Bcl-2 Proteins

(2009) Aaron T. Jacobs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY