Hsp70 in cancer: back to the future

Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades

(2015) James Andrew McCubrey et al.   Oncotarget

Hsp70–Bag3 Interactions Regulate Cancer-Related Signaling Networks

(2014) Teresa A. Colvin et al.   CANCER RESEARCH

Proteotoxicity is not the reason for the dependence of cancer cells on the major chaperone Hsp70

(2014) Teresa A Colvin et al.   CELL CYCLE

The HSP70 Modulator MAL3-101 Inhibits Merkel Cell Carcinoma

(2014) Christian Adam et al.   PLoS One

A gain-of-function mutant p53–HSF1 feed forward circuit governs adaptation of cancer cells to proteotoxic stress

(2014) D Li et al.   Cell Death & Disease

BAG3 protein expression in melanoma metastatic lymph nodes correlates with patients’ survival

(2014) L Guerriero et al.   Cell Death & Disease

Synthesis and Initial Evaluation of YM-08, a Blood-Brain Barrier Permeable Derivative of the Heat Shock Protein 70 (Hsp70) Inhibitor MKT-077, Which Reduces Tau Levels

(2013) Yoshinari Miyata et al.   ACS Chemical Neuroscience

BAG3 Is a Novel Serum Biomarker for Pancreatic Adenocarcinomas

(2013) Antonia Falco et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Heat shock factor 1 accelerates hepatocellular carcinoma development by activating nuclear factor-κB/mitogen-activated protein kinase

(2013) Makoto Chuma et al.   CARCINOGENESIS

The HSP70 family and cancer

(2013) M. E. Murphy   CARCINOGENESIS

Identification of an Allosteric Pocket on Human Hsp70 Reveals a Mode of Inhibition of This Therapeutically Important Protein

(2013) Anna Rodina et al.   CHEMISTRY & BIOLOGY

Cellular Mechanotransduction Relies on Tension-Induced and Chaperone-Assisted Autophagy

(2013) Anna Ulbricht et al.   CURRENT BIOLOGY

A Modified HSP70 Inhibitor Shows Broad Activity as an Anticancer Agent

(2013) Gregor M. Balaburski et al.   MOLECULAR CANCER RESEARCH

The Association of BAG6 with SGTA and Tail-Anchored Proteins

(2013) Pawel Leznicki et al.   PLoS One

Heat shock protein 70 (HSP70) expression is associated with poor prognosis in intestinal type gastric cancer

(2013) Hyoun Wook Lee et al.   VIRCHOWS ARCHIV

Expression of the Antiapoptotic Protein BAG3 Is a Feature of Pancreatic Adenocarcinoma and Its Overexpression Is Associated With Poorer Survival

(2012) Alessandra Rosati et al.   AMERICAN JOURNAL OF PATHOLOGY

Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update

(2012) Daniel R. Ciocca et al.   ARCHIVES OF TOXICOLOGY

Tumor Cell Expression of Heat Shock Protein (HSP) 72 is Influenced by HSP72 [HSPA1B A(1267)G] Polymorphism and Predicts Survival in Small Cell Lung Cancer (SCLC) Patients

(2012) Klara Szondy et al.   CANCER INVESTIGATION

Cysteine Reactivity Distinguishes Redox Sensing by the Heat-Inducible and Constitutive Forms of Heat Shock Protein 70

(2012) Yoshinari Miyata et al.   CHEMISTRY & BIOLOGY

Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?

(2012) L. Neckers et al.   CLINICAL CANCER RESEARCH

Hsp70 Protein Complexes as Drug Targets

(2012) Victoria A. Assimon et al.   CURRENT PHARMACEUTICAL DESIGN

Imbalance of Hsp70 family variants fosters tau accumulation

(2012) Umesh K. Jinwal et al.   FASEB JOURNAL

Prognostic significance of heat shock proteins in urothelial carcinoma of the urinary bladder

(2012) Hui-Jung Yu et al.   HISTOPATHOLOGY

Expression of heat shock protein 70 in nasopharyngeal carcinomas: different expression patterns correlate with distinct clinical prognosis

(2012) Man-Bo Cai et al.   Journal of Translational Medicine

Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation

(2012) Adrienne M Wang et al.   Nature Chemical Biology

mTOR Is Essential for the Proteotoxic Stress Response, HSF1 Activation and Heat Shock Protein Synthesis

(2012) Shiuh-Dih Chou et al.   PLoS One

Rhodacyanine Derivative Selectively Targets Cancer Cells and Overcomes Tamoxifen Resistance

(2012) John Koren et al.   PLoS One

Molecular Mechanism of Mutant p53 Stabilization: The Role of HSP70 and MDM2

(2012) Milena Wiech et al.   PLoS One

High HSP27 and HSP70 expression levels are independent adverse prognostic factors in primary resected colon cancer

(2012) Karina Bauer et al.   CELLULAR ONCOLOGY

BAG3 Protein Is Overexpressed in Human Glioblastoma and Is a Potential Target for Therapy

(2011) Michelina Festa et al.   AMERICAN JOURNAL OF PATHOLOGY

Myricetin induces pancreatic cancer cell death via the induction of apoptosis and inhibition of the phosphatidylinositol 3-kinase (PI3K) signaling pathway

(2011) P.A. Phillips et al.   CANCER LETTERS

Peptides and Aptamers Targeting HSP70: A Novel Approach for Anticancer Chemotherapy

(2011) Anne-Laure Rérole et al.   CANCER RESEARCH

Identification of Aneuploidy-Selective Antiproliferation Compounds

(2011) Yun-Chi Tang et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Targeting HSP70: The second potentially druggable heat shock protein and molecular chaperone?

(2011) Marissa V. Powers et al.   CELL CYCLE

Chemical Screens against a Reconstituted Multiprotein Complex: Myricetin Blocks DnaJ Regulation of DnaK through an Allosteric Mechanism

(2011) Lyra Chang et al.   CHEMISTRY & BIOLOGY

BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins

(2011) Martin Gamerdinger et al.   EMBO REPORTS

The clinicopathological significance of heat shock protein 70 and glutamine synthetase expression in hepatocellular carcinoma

(2011) Eun Shin et al.   Journal of Hepato-Biliary-Pancreatic Sciences

Expression of the Anti-Apoptotic Protein BAG3 in Human Melanomas

(2011) Renato Franco et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Allosteric Drugs: The Interaction of Antitumor Compound MKT-077 with Human Hsp70 Chaperones

(2011) Aikaterini Rousaki et al.   JOURNAL OF MOLECULAR BIOLOGY

Emerging roles of molecular chaperones and co-chaperones in selective autophagy: focus on BAG proteins

(2011) Martin Gamerdinger et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesis

(2011) L Meng et al.   ONCOGENE

Down-Regulated Expression of HSP70 in Correlation with Clinicopathology of Cholangiocarcinoma

(2011) Sirintip Boonjaraspinyo et al.   PATHOLOGY & ONCOLOGY RESEARCH

Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators

(2011) D. M. Huryn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prognostic significance of heat shock protein 70 (HSP70) in patients with oral cancer

(2011) Frank Tavassol et al.   Head and Neck Optical Diagnostics Society

Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101

(2011) Marc J. Braunstein et al.   Journal of Oncology

Bag1 directly routes immature BCR-ABL for proteasomal degradation

(2010) F. Tsukahara et al.   BLOOD

Protein Quality Control in the Cytosol and the Endoplasmic Reticulum: Brothers in Arms

(2010) Alexander Buchberger et al.   MOLECULAR CELL

Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast

(2010) Norman Pavelka et al.   NATURE

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells

(2009) Andrew J. Massey et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

Pharmacological Targeting of the Hsp70 Chaperone

(2009) Srikanth Patury et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Facilitating Akt Clearance via Manipulation of Hsp70 Activity and Levels

(2009) John Koren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Small Molecule Inhibitor of Inducible Heat Shock Protein 70

(2009) J. I-Ju Leu et al.   MOLECULAR CELL

YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway

(2009) Jianmin Zhang et al.   NATURE CELL BIOLOGY

Hsp70 molecular chaperones are required to support p53 tumor suppressor activity under stress conditions

(2009) D Walerych et al.   ONCOGENE

Structural and Functional Diversities between Members of the Human HSPB, HSPH, HSPA, and DNAJ Chaperone Families†

(2008) Michel J. Vos et al.   BIOCHEMISTRY

Dual Targeting of HSC70 and HSP72 Inhibits HSP90 Function and Induces Tumor-Specific Apoptosis

(2008) Marissa V. Powers et al.   CANCER CELL

Inducible heat shock protein 70 prevents multifocal flat dysplastic lesions and invasive tumors in an inflammatory model of colon cancer

(2008) Yun Tao et al.   CARCINOGENESIS

Heat-shock proteins as powerful weapons in vaccine development

(2008) Azam Bolhassani et al.   Expert Review of Vaccines

Heat shock proteins: Stress proteins with Janus-like properties in cancer

(2008) Stuart K. Calderwood et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

The Hsp90 Chaperone Machinery

(2008) Sebastian Karl Wandinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

bag3 gene expression is regulated by heat shock factor 1

(2008) Silvia Franceschelli et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Heat Shock Protein Hsp72 Controls Oncogene-Induced Senescence Pathways in Cancer Cells

(2008) V. L. Gabai et al.   MOLECULAR AND CELLULAR BIOLOGY

Chaperone-dependent stabilization and degradation of p53 mutants

(2008) P Muller et al.   ONCOGENE

HSP72 protects against obesity-induced insulin resistance

(2008) J. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY