Molecular Mechanism of Mutant p53 Stabilization: The Role of HSP70 and MDM2
Published 2012 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Molecular Mechanism of Mutant p53 Stabilization: The Role of HSP70 and MDM2
Authors
Keywords
-
Journal
PLoS One
Volume 7, Issue 12, Pages e51426
Publisher
Public Library of Science (PLoS)
Online
2012-12-13
DOI
10.1371/journal.pone.0051426
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome
- (2015) Paul M. Neilsen et al. Oncotarget
- The p53 mRNA-Mdm2 Interaction Controls Mdm2 Nuclear Trafficking and Is Required for p53 Activation following DNA Damage
- (2012) Madhavsai Gajjar et al. CANCER CELL
- High frequency of complex TP53 mutations in CNS metastases from breast cancer
- (2011) C Lo Nigro et al. BRITISH JOURNAL OF CANCER
- Multiple Stress Signals Activate Mutant p53 In Vivo
- (2011) Y.-A. Suh et al. CANCER RESEARCH
- Molecular chaperones in targeting misfolded proteins for ubiquitin-dependent degradation
- (2011) Franziska Kriegenburg et al. FEBS Journal
- p53 and its mutants in tumor cell migration and invasion
- (2011) Patricia A. J. Muller et al. JOURNAL OF CELL BIOLOGY
- Missense Mutations Located in Structural p53 DNA-Binding Motifs Are Associated With Extremely Poor Survival in Chronic Lymphocytic Leukemia
- (2011) Martin Trbusek et al. JOURNAL OF CLINICAL ONCOLOGY
- Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras
- (2011) Sergio Acin et al. JOURNAL OF PATHOLOGY
- Functional Inactivation of Endogenous MDM2 and CHIP by HSP90 Causes Aberrant Stabilization of Mutant p53 in Human Cancer Cells
- (2011) D. Li et al. MOLECULAR CANCER RESEARCH
- Molecular chaperones in protein folding and proteostasis
- (2011) F. Ulrich Hartl et al. NATURE
- Gain of function of mutant p53 by coaggregation with multiple tumor suppressors
- (2011) Jie Xu et al. Nature Chemical Biology
- Co-localization of mutant p53 and amyloid-like protein aggregates in breast tumors
- (2010) Claudia B. Levy et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- ATP Binding to Hsp90 Is Sufficient for Effective Chaperoning of p53 Protein
- (2010) Dawid Walerych et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The kinetic parameters and energy cost of the Hsp70 chaperone as a polypeptide unfoldase
- (2010) Sandeep K Sharma et al. Nature Chemical Biology
- Drug discovery and mutant p53
- (2010) Magda M. Maslon et al. TRENDS IN CELL BIOLOGY
- Ligand Binding and Hydration in Protein Misfolding: Insights from Studies of Prion and p53 Tumor Suppressor Proteins†
- (2009) Jerson L. Silva et al. ACCOUNTS OF CHEMICAL RESEARCH
- Mutant p53 Drives Invasion by Promoting Integrin Recycling
- (2009) Patricia A.J. Muller et al. CELL
- Impact of heat-shock protein 90 on cancer metastasis
- (2009) Shinji Tsutsumi et al. Future Oncology
- The p53 Core Domain Is a Molten Globule at Low pH
- (2009) Ana Paula D. Ano Bom et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Function for the RING Finger Domain in the Allosteric Control of MDM2 Conformation and Activity
- (2009) Bartosz Wawrzynow et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hsp70 molecular chaperones are required to support p53 tumor suppressor activity under stress conditions
- (2009) D Walerych et al. ONCOGENE
- The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss
- (2008) T. Terzian et al. GENES & DEVELOPMENT
- Chaperone-dependent stabilization and degradation of p53 mutants
- (2008) P Muller et al. ONCOGENE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now