Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis

The critical molecular interconnections in regulating apoptosis and autophagy

(2015) Gao-Xiang Zhao et al.   ANNALS OF MEDICINE

A close connection between the PERK and IRE arms of the UPR and the transcriptional regulation of autophagy

(2015) Shane Deegan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Melatonin ameliorates ER stress-mediated hepatic steatosis through miR-23a in the liver

(2015) Seung-Jae Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Biochemical and Molecular Alterations Following Arsenic-Induced Oxidative Stress and Mitochondrial Dysfunction in Rat Brain

(2015) Chandra Prakash et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells

(2015) P. Plaimee et al.   CELL PROLIFERATION

The switch from ER stress-induced apoptosis to autophagy via ROS-mediated JNK/p62 signals: A survival mechanism in methotrexate-resistant choriocarcinoma cells

(2015) Yun Shen et al.   EXPERIMENTAL CELL RESEARCH

Basic mechanisms in endoplasmic reticulum stress and relation to cardiovascular diseases

(2015) Erdi Sozen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Taxol-induced unfolded protein response activation in breast cancer cells exposed to hypoxia: ATF4 activation regulates autophagy and inhibits apoptosis

(2015) Annick Notte et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Melatonin inhibits autophagy and endoplasmic reticulum stress in mice with carbon tetrachloride-induced fibrosis

(2015) Beatriz San-Miguel et al.   JOURNAL OF PINEAL RESEARCH

Autophagy and protein kinase RNA-like endoplasmic reticulum kinase (PERK)/eukaryotic initiation factor 2 alpha kinase (eIF2α) pathway protect ovarian cancer cells from metformin-induced apoptosis

(2015) Hee-sun Moon et al.   MOLECULAR CARCINOGENESIS

N-linked sugar-regulated protein folding and quality control in the ER

(2015) Abla Tannous et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Functional Roles of Calreticulin in Cancer Biology

(2015) Yi-Chien Lu et al.   Biomed Research International

Stress Responses from the Endoplasmic Reticulum in Cancer

(2015) Hironori Kato et al.   Frontiers in Oncology

Circadian and Melatonin Disruption by Exposure to Light at Night Drives Intrinsic Resistance to Tamoxifen Therapy in Breast Cancer

(2014) R. T. Dauchy et al.   CANCER RESEARCH

Melatonin and ubiquitin: what’s the connection?

(2014) Jerry Vriend et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cyclic-3-hydroxymelatonin (C3HOM), A Potent Antioxidant, Scavenges Free Radicals and Suppresses Oxidative Reactions

(2014) Dun-Xian Tan et al.   CURRENT MEDICINAL CHEMISTRY

Melatonin potentiates the anti-tumour effect of pravastatin in rat mammary gland carcinoma model

(2014) Peter Orendáš et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Lipase Maturation Factor 1 (Lmf1) Is Induced by Endoplasmic Reticulum Stress Through Activating Transcription Factor 6α (Atf6α) Signaling

(2014) Hui Z. Mao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER-associated degradation: Protein quality control and beyond

(2014) Annamaria Ruggiano et al.   JOURNAL OF CELL BIOLOGY

Melatonin modulates the autophagic response in acute liver failure induced by the rabbit hemorrhagic disease virus

(2014) Beatriz San-Miguel et al.   JOURNAL OF PINEAL RESEARCH

Melatonin and its metabolites as copper chelating agents and their role in inhibiting oxidative stress: a physicochemical analysis

(2014) Annia Galano et al.   JOURNAL OF PINEAL RESEARCH

Melatonin reduces endoplasmic reticulum stress and preserves sirtuin 1 expression in neuronal cells of newborn rats after hypoxia-ischemia

(2014) Silvia Carloni et al.   JOURNAL OF PINEAL RESEARCH

Melatonin: a well-documented antioxidant with conditional pro-oxidant actions

(2014) Hong-Mei Zhang et al.   JOURNAL OF PINEAL RESEARCH

Melatonin as a proteasome inhibitor. Is there any clinical evidence?

(2014) Jerry Vriend et al.   LIFE SCIENCES

Endoplasmic Reticulum Stress Plays a Key Role in Rotenone-Induced Apoptotic Death of Neurons

(2014) Poonam Goswami et al.   MOLECULAR NEUROBIOLOGY

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hydrogen Sulfide Inhibits Formaldehyde-Induced Endoplasmic Reticulum Stress in PC12 Cells by Upregulation of SIRT-1

(2014) Xiang Li et al.   PLoS One

Melatonin Combined with Endoplasmic Reticulum Stress Induces Cell Death via the PI3K/Akt/mTOR Pathway in B16F10 Melanoma Cells

(2014) Han Sung Kim et al.   PLoS One

Melatonin Inhibits Endoplasmic Reticulum Stress and Epithelial-Mesenchymal Transition during Bleomycin-Induced Pulmonary Fibrosis in Mice

(2014) Hui Zhao et al.   PLoS One

Melatonin Reverses Fas, E2F-1 and Endoplasmic Reticulum Stress Mediated Apoptosis and Dysregulation of Autophagy Induced by the Herbicide Atrazine in Murine Splenocytes

(2014) Shweta Sharma et al.   PLoS One

Heat Stress Induces Apoptosis through a Ca2+-Mediated Mitochondrial Apoptotic Pathway in Human Umbilical Vein Endothelial Cells

(2014) Li Li et al.   PLoS One

ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload

(2014) Robert A. Egnatchik et al.   Molecular Metabolism

Endoplasmic reticulum stress signaling: the microRNA connection

(2013) Marion Maurel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The DAPK family: a structure–function analysis

(2013) Ruth Shiloh et al.   APOPTOSIS

The endoplasmic reticulum–mitochondria connection: One touch, multiple functions

(2013) Saverio Marchi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Bax Inhibitor-1-mediated Ca2+ leak is decreased by cytosolic acidosis

(2013) Santeri Kiviluoto et al.   CELL CALCIUM

ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis

(2013) J J Sandow et al.   CELL DEATH AND DIFFERENTIATION

Regulatory crosstalk within the mammalian unfolded protein response

(2013) Joseph W. Brewer   CELLULAR AND MOLECULAR LIFE SCIENCES

Nrf2 and Nrf1 signaling and ER stress crosstalk: implication for proteasomal degradation and autophagy

(2013) Hadi Digaleh et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review

(2013) Mariano Bizzarri et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Intracellular signaling in ER stress-induced autophagy in skeletal muscle cells

(2013) Luca Madaro et al.   FASEB JOURNAL

Membrane lipid saturation activates IRE1α without inducing clustering

(2013) Yuto Kitai et al.   GENES TO CELLS

Enhanced Phosphatidylinositol 3-kinase (PI3K)/Akt Signaling Has Pleiotropic Targets in Hippocampal Neurons Exposed to Iron-induced Oxidative Stress

(2013) Romina María Uranga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading

(2013) Anna Fernandez et al.   JOURNAL OF HEPATOLOGY

Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy

(2013) Virginia Hernández-Gea et al.   JOURNAL OF HEPATOLOGY

Melatonin prevents pancreaticβ-cell loss due to glucotoxicity: the relationship between oxidative stress and endoplasmic reticulum stress

(2013) Jae-Hyung Park et al.   JOURNAL OF PINEAL RESEARCH

Melatonin-mediated insulin synthesis during endoplasmic reticulum stress involves HuD expression in rat insulinoma INS-1E cells

(2013) Yeong-Min Yoo   JOURNAL OF PINEAL RESEARCH

Melatonin treatment reduces endoplasmic reticulum stress and modulates the unfolded protein response in rabbits with lethal fulminant hepatitis of viral origin

(2013) María J. Tuñón et al.   JOURNAL OF PINEAL RESEARCH

AMPK involvement in endoplasmic reticulum stress and autophagy modulation after fatty liver graft preservation: a role for melatonin and trimetazidine cocktail

(2013) Mohamed Amine Zaouali et al.   JOURNAL OF PINEAL RESEARCH

Melatonin reverses tunicamycin-induced endoplasmic reticulum stress in human hepatocellular carcinoma cells and improves cytotoxic response to doxorubicin by increasing CHOP and decreasing Survivin

(2013) Lulu Fan et al.   JOURNAL OF PINEAL RESEARCH

Targeting the unfolded protein response in disease

(2013) Claudio Hetz et al.   NATURE REVIEWS DRUG DISCOVERY

Identification and Rescue of  -Synuclein Toxicity in Parkinson Patient-Derived Neurons

(2013) C. Y. Chung et al.   SCIENCE

Potential for therapeutic manipulation of the UPR in disease

(2013) Sang Won Park et al.   Seminars in Immunopathology

The Molecular Chaperone GRP78/BiP in the Development of Chemoresistance: Mechanism and Possible Treatment

(2013) Corinna Roller et al.   Frontiers in Pharmacology

Unfolded protein response to autophagy as a promising druggable target for anticancer therapy

(2012) Dong Hoon Suh et al.   Annals of the New York Academy of Sciences

Utilidad clínica e impacto económico de la punción transbronquial convencional de adenopatías mediastínicas en el carcinoma broncogénico

(2012) Jorge Castelao Naval et al.   ARCHIVOS DE BRONCONEUMOLOGIA

Recent developments in acute liver failure

(2012) William M. Lee   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

A Thrombospondin-Dependent Pathway for a Protective ER Stress Response

(2012) Jeffrey M. Lynch et al.   CELL

Role of the inositol 1,4,5-trisphosphate receptor/Ca2+-release channel in autophagy

(2012) Jan B Parys et al.   Cell Communication and Signaling

Redox signaling loops in the unfolded protein response

(2012) Arisa Higa et al.   CELLULAR SIGNALLING

IRE1, a Double-Edged Sword in Pre-miRNA Slicing and Cell Death

(2012) Justin Hassler et al.   DEVELOPMENTAL CELL

Endoplasmic Reticulum Stress Is Important for the Manifestations of  -Synucleinopathy In Vivo

(2012) E. Colla et al.   JOURNAL OF NEUROSCIENCE

Melatonin attenuates inflammation and promotes regeneration in rabbits with fulminant hepatitis of viral origin

(2012) Almudena Laliena et al.   JOURNAL OF PINEAL RESEARCH

A review of the molecular aspects of melatonin’s anti-inflammatory actions: recent insights and new perspectives

(2012) José L. Mauriz et al.   JOURNAL OF PINEAL RESEARCH

On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK

(2012) Annia Galano et al.   JOURNAL OF PINEAL RESEARCH

Endoplasmic reticulum–mitochondria contacts: function of the junction

(2012) Ashley A. Rowland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stress management at the ER: Regulators of ER stress-induced apoptosis

(2012) Adrienne M. Gorman et al.   PHARMACOLOGY & THERAPEUTICS

Fasudil Protects the Heart against Ischemia-Reperfusion Injury by Attenuating Endoplasmic Reticulum Stress and Modulating SERCA Activity: The Differential Role for PI3K/Akt and JAK2/STAT3 Signaling Pathways

(2012) Yapeng Li et al.   PLoS One

IRE1  Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2

(2012) J.-P. Upton et al.   SCIENCE

Induction of ER stress protects gastric cancer cells against apoptosis induced by cisplatin and doxorubicin through activation of p38 MAPK

(2011) Ruo Feng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting

(2011) Min Ni et al.   BIOCHEMICAL JOURNAL

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

A review of the mammalian unfolded protein response

(2011) Anirikh Chakrabarti et al.   BIOTECHNOLOGY AND BIOENGINEERING

Dual inhibition of V600EBRAF and the PI3K/AKT/mTOR pathway cooperates to induce apoptosis in melanoma cells through a MEK-independent mechanism

(2011) Irene Sánchez-Hernández et al.   CANCER LETTERS

Modulation of STIM1 and capacitative Ca2+ entry by the endoplasmic reticulum luminal oxidoreductase ERp57

(2011) Daniel Prins et al.   EMBO REPORTS

Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver

(2011) Yu Li et al.   FASEB JOURNAL

The Cell Biology of the Unfolded Protein Response

(2011) J. Alan Diehl et al.   GASTROENTEROLOGY

The contribution of endoplasmic reticulum stress to liver diseases

(2011) Lily Dara et al.   HEPATOLOGY

Physiological unfolded protein response regulated by OASIS family members, transmembrane bZIP transcription factors

(2011) Shinichi Kondo et al.   IUBMB LIFE

Melatonin alleviates lipopolysaccharide-induced placental cellular stress response in mice

(2011) Hua Wang et al.   JOURNAL OF PINEAL RESEARCH

Melatonin alleviates cadmium-induced cellular stress and germ cell apoptosis in testes

(2011) Yan-Li Ji et al.   JOURNAL OF PINEAL RESEARCH

Reaction mechanism of melatonin oxidation by reactive oxygen species in vitro

(2011) Dominique Bonnefont-Rousselot et al.   JOURNAL OF PINEAL RESEARCH

Melatonin as a natural ally against oxidative stress: a physicochemical examination

(2011) Annia Galano et al.   JOURNAL OF PINEAL RESEARCH

Melatonin sensitizes human hepatoma cells to endoplasmic reticulum stress-induced apoptosis

(2011) Lixia Zha et al.   JOURNAL OF PINEAL RESEARCH

Human Adenovirus Type 5 Induces Cell Lysis through Autophagy and Autophagy-Triggered Caspase Activity

(2011) H. Jiang et al.   JOURNAL OF VIROLOGY

The Role of Autophagy in Cancer: Therapeutic Implications

(2011) Z. J. Yang et al.   MOLECULAR CANCER THERAPEUTICS

Gene expression profiling indicate role of ER stress in miR-23a~27a~24-2 cluster induced apoptosis in HEK293T cells

(2011) Ravindresh Chhabra et al.   RNA Biology

InterfERing with endoplasmic reticulum stress

(2011) Honorata Kraskiewicz et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Molecular Mechanisms Regulating Oxidative Activity of the Ero1 Family in the Endoplasmic Reticulum

(2010) Timothy J. Tavender et al.   ANTIOXIDANTS & REDOX SIGNALING

Unfolded Protein Response (UPR) is activated during normal lens development

(2010) Zeynep Firtina et al.   GENE EXPRESSION PATTERNS

Decrease in Membrane Phospholipid Unsaturation Induces Unfolded Protein Response

(2010) Hiroyuki Ariyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles of GRP78 in physiology and cancer

(2010) Lu-Hua Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Melatonin attenuates apoptotic liver damage in fulminant hepatic failure induced by the rabbit hemorrhagic disease virus

(2010) María J. Tuñón et al.   JOURNAL OF PINEAL RESEARCH

Protective effect of melatonin on oxaliplatin-induced apoptosis through sustained Mcl-1 expression and anti-oxidant action in renal carcinoma Caki cells

(2010) Hee Jung Um et al.   JOURNAL OF PINEAL RESEARCH

Melatonin suppresses cyclosporine A-induced autophagy in rat pituitary GH3 cells

(2010) Yeong-Min Yoo et al.   JOURNAL OF PINEAL RESEARCH

Endoplasmic reticulum stress is a mediator of posttransplant injury in severely steatotic liver allografts

(2010) Christopher D. Anderson et al.   LIVER TRANSPLANTATION

The UPR and the Anti-oxidant Response: Relevance to Sleep and Sleep Loss

(2010) Marishka K. Brown et al.   MOLECULAR NEUROBIOLOGY

Transcriptional Regulation of VEGF-A by the Unfolded Protein Response Pathway

(2010) Rajarshi Ghosh et al.   PLoS One

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

(2010) E Wirawan et al.   Cell Death & Disease

Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL

(2009) Einat Zalckvar et al.   Autophagy

Endoplasmic reticulum Ca2+ release through ryanodine and IP3 receptors contributes to neuronal excitotoxicity

(2009) Asier Ruiz et al.   CELL CALCIUM

Inhibiting PI3K as a therapeutic strategy against cancer

(2009) Luis Paz-Ares et al.   Clinical & Translational Oncology

Melatonin protects against alcoholic liver injury by attenuating oxidative stress, inflammatory response, and apoptosis

(2009) Shilian Hu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis

(2009) Gang Li et al.   JOURNAL OF CELL BIOLOGY

GRP78 expression inhibits insulin and ER stress–induced SREBP-1c activation and reduces hepatic steatosis in mice

(2009) Hélène L. Kammoun et al.   JOURNAL OF CLINICAL INVESTIGATION

Cisternal Organization of the Endoplasmic Reticulum during Mitosis

(2009) Lei Lu et al.   MOLECULAR BIOLOGY OF THE CELL

ATF6 Is a Transcription Factor Specializing in the Regulation of Quality Control Proteins in the Endoplasmic Reticulum

(2008) Yusuke Adachi et al.   CELL STRUCTURE AND FUNCTION

Role of JNK1-dependent Bcl-2 Phosphorylation in Ceramide-induced Macroautophagy

(2008) Sophie Pattingre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of PI3K-AKT-mTOR Signaling Sensitizes Melanoma Cells to Cisplatin and Temozolomide

(2008) Tobias Sinnberg et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Melatonin induces cell cycle arrest and apoptosis in hepatocarcinoma HepG2 cell line

(2008) Javier Martín-Renedo et al.   JOURNAL OF PINEAL RESEARCH

Melatonin inhibits arsenite-induced peripheral neurotoxicity

(2008) Anya M. Y. Lin et al.   JOURNAL OF PINEAL RESEARCH

Melatonin and Bright-Light Treatment for Rest–Activity Disruption in Institutionalized Patients with Alzheimer's Disease

(2008) Glenna A. Dowling et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL

Targeting phosphoinositide 3-kinase—Moving towards therapy

(2007) Romina Marone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Cytoprotective effects of melatonin against necrosis and apoptosis induced by ischemia/reperfusion injury in rat liver

(2007) Sung-Hwa Kim et al.   JOURNAL OF PINEAL RESEARCH