Silencing Heat Shock Protein 27 Inhibits the Progression and Metastasis of Colorectal Cancer (CRC) by Maintaining the Stability of Stromal Interaction Molecule 1 (STIM1) Proteins

Enhanced Stim1 expression is associated with acquired chemo-resistance of cisplatin in osteosarcoma cells

(2017) Xilong Sun et al.   Human Cell

IGFBP2 plays an important role in heat shock protein 27-mediated cancer progression and metastasis

(2017) Chin-Sheng Hung et al.   Oncotarget

A phase I dose-escalation study of apatorsen (OGX-427), an antisense inhibitor targeting heat shock protein 27 (Hsp27), in patients with castration-resistant prostate cancer and other advanced cancers

(2016) K. N. Chi et al.   ANNALS OF ONCOLOGY

STIM and calcium channel complexes in cancer

(2016) Isaac Jardin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Sigma1 receptors inhibit store-operated Ca 2+ entry by attenuating coupling of STIM1 to Orai1

(2016) Shyam Srivats et al.   JOURNAL OF CELL BIOLOGY

Inhibition of Orai1-mediated Ca2+entry enhances chemosensitivity of HepG2 hepatocarcinoma cells to 5-fluorouracil

(2016) Bao-Dong Tang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

New HSP27 inhibitors efficiently suppress drug resistance development in cancer cells

(2016) Jörg C. Heinrich et al.   Oncotarget

A Targetable Molecular Chaperone Hsp27 Confers Aggressiveness in Hepatocellular Carcinoma

(2016) Yurong Zhang et al.   Theranostics

Thrombomodulin Influences the Survival of Patients with Non-Metastatic Colorectal Cancer through Epithelial-To-Mesenchymal Transition (EMT)

(2016) Yu-Jia Chang et al.   PLoS One

STIM and Orai proteins as novel targets for cancer therapy. A Review in the Theme: Cell and Molecular Processes in Cancer Metastasis

(2015) Ayushi Vashisht et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Small heat shock proteins: Role in cellular functions and pathology

(2015) Raman Bakthisaran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Hsp27 Acts as a Master Molecular Chaperone and Plays an Essential Role in Hepatocellular Carcinoma Progression

(2015) Jun Cheng et al.   DIGESTION

Heat shock proteins in hepatocellular carcinoma: Molecular mechanism and therapeutic potential

(2015) Cun Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Proteomic Characterization of Annexin l (ANX1) and Heat Shock Protein 27 (HSP27) as Biomarkers for Invasive Hepatocellular Carcinoma Cells

(2015) Ruo-Chiau Wang et al.   PLoS One

Glucose-regulated protein 94 mediates metastasis by CCT8 and the JNK pathway in hepatocellular carcinoma

(2015) Po-Li Wei et al.   TUMOR BIOLOGY

Glucose-regulated protein 94 mediates cancer progression via AKT and eNOS in hepatocellular carcinoma

(2015) Chien-Yu Huang et al.   TUMOR BIOLOGY

Correlation of clinical features and genetic profiles of stromal interaction molecule 1 (STIM1) in colorectal cancers

(2015) Henry Sung-Ching Wong et al.   Oncotarget

Stromal Expression of Heat-Shock Protein 27 Is Associated with Worse Clinical Outcome in Patients with Colorectal Cancer Lung Metastases

(2015) Thomas Schweiger et al.   PLoS One

Proteins of the VEGFR and EGFR pathway as predictive markers for adjuvant treatment in patients with stage II/III colorectal cancer: results of the FOGT-4 trial

(2014) Thomas Thomaidis et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

STIM1, a direct target of microRNA-185, promotes tumor metastasis and is associated with poor prognosis in colorectal cancer

(2014) Z Zhang et al.   ONCOGENE

Immediate and transient phosphorylation of the heat shock protein 27 initiates chemoresistance in prostate cancer cells

(2014) MATTHIAS B. STOPE et al.   ONCOLOGY REPORTS

Store-Operated Ca2+ Entry (SOCE) Regulates Melanoma Proliferation and Cell Migration

(2014) Masanari Umemura et al.   PLoS One

Silencing survivin activates autophagy as an alternative survival pathway in HCC cells

(2014) Yu-Jia Chang et al.   TUMOR BIOLOGY

The apoptosis of non-small cell lung cancer induced by cisplatin through modulation of STIM1

(2013) Wenjun Li et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Glucose-regulated protein 78 silencing down-regulates vascular endothelial growth factor/vascular endothelial growth factor receptor 2 pathway to suppress human colon cancer tumor growth

(2013) Li-Jen Kuo et al.   JOURNAL OF SURGICAL RESEARCH

Blockade of store-operated Ca2+ entry inhibits hepatocarcinoma cell migration and invasion by regulating focal adhesion turnover

(2012) Ning Yang et al.   CANCER LETTERS

Small heat shock proteins in cancer therapy and prognosis

(2012) Amina Zoubeidi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

High HSP27 and HSP70 expression levels are independent adverse prognostic factors in primary resected colon cancer

(2012) Karina Bauer et al.   CELLULAR ONCOLOGY

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis

(2011) Y.-F. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Colorectal cancer

(2010) David Cunningham et al.   LANCET

Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E

(2010) C Andrieu et al.   ONCOGENE

Ion channels and the hallmarks of cancer

(2010) Natalia Prevarskaya et al.   TRENDS IN MOLECULAR MEDICINE

Orai1 and STIM1 Are Critical for Breast Tumor Cell Migration and Metastasis

(2009) Shengyu Yang et al.   CANCER CELL

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

(2009) Chan Young Park et al.   CELL

The role of Hsp27 and actin in the regulation of movement in human cancer cells responding to heat shock

(2009) Bindi M. Doshi et al.   CELL STRESS & CHAPERONES

Heat shock protein 27 is over-expressed in tumor tissues and increased in sera of patients with gastric adenocarcinoma

(2009) Qiaojia Huang et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

STIM1 gates the store-operated calcium channel ORAI1 in vitro

(2009) Yubin Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Synchronous Hepatic Metastases from Colon Cancer: Changing Treatment Strategies and Results of Surgical Intervention

(2008) Bridget N. Fahy et al.   ANNALS OF SURGICAL ONCOLOGY

Guidelines for the nomenclature of the human heat shock proteins

(2008) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES