Targeting Heat Shock Protein 27 in Cancer: A Druggable Target for Cancer Treatment?

How a fortuitous collaboration helped catalyze new insights into helper proteins

(2019) Catherine M. Goodman   JOURNAL OF BIOLOGICAL CHEMISTRY

Dependence of HSP27 cellular level on protein kinase CK2 discloses novel therapeutic strategies

(2018) Christian Borgo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau

(2018) Rebecca Freilich et al.   Nature Communications

High expression of heat shock proteins and heat shock factor-1 distinguishes an aggressive subset of clear cell renal cell carcinoma

(2017) Pao-Shu Wu et al.   HISTOPATHOLOGY

Targeting Heat Shock Proteins in Cancer: A Promising Therapeutic Approach

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Randomized, Double‐Blinded, Phase II Trial of Gemcitabine and Nab‐Paclitaxel Plus Apatorsen or Placebo in Patients with Metastatic Pancreatic Cancer: The RAINIER Trial

(2017) Andrew H. Ko et al.   ONCOLOGIST

Clinicopathological significance of HSP27 in gastric cancer: a meta-analysis

(2017) Hua Ge et al.   OncoTargets and Therapy

Sensitization of lung cancer cells by altered dimerization of HSP27

(2017) Byeol Choi et al.   Oncotarget

CK2 and PI3K are direct molecular targets of quercetin in chronic lymphocytic leukaemia

(2017) Maria Russo et al.   Oncotarget

A phase I trial of intravesical antisense oligonucleotide targeting heat shock protein 27 (OGX-427) for the treatment of non-muscle-invasive bladder cancer.

(2017) Alan I. So et al.   JOURNAL OF CLINICAL ONCOLOGY

Increased HSP27 correlates with malignant biological behavior of non-small cell lung cancer and predicts patient’s survival

(2017) Baowei Sheng et al.   Scientific Reports

Heat shock protein 27 downstream of P38-PI3K/Akt signaling antagonizes melatonin-induced apoptosis of SGC-7901 gastric cancer cells

(2016) Wenjie Deng et al.   Cancer Cell International

Overcoming HSP27-mediated resistance by altered dimerization of HSP27 using small molecules

(2016) Jee Hye Kim et al.   Oncotarget

New HSP27 inhibitors efficiently suppress drug resistance development in cancer cells

(2016) Jörg C. Heinrich et al.   Oncotarget

Long noncoding RNA BX357664 regulates cell proliferation and epithelial-to-mesenchymal transition via inhibition of TGF-β1/p38/HSP27 signaling in renal cell carcinoma

(2016) Yiyang Liu et al.   Oncotarget

HSPB1 Enhances SIRT2-Mediated G6PD Activation and Promotes Glioma Cell Proliferation

(2016) Hongxing Ye et al.   PLoS One

Quantitative proteomic analysis shows differentially expressed HSPB1 in glioblastoma as a discriminating short from long survival factor and NOVA1 as a differentiation factor between low-grade astrocytoma and oligodendroglioma

(2015) Marcela Gimenez et al.   BMC CANCER

Relationship between the expression of phosphorylated heat shock protein beta-1 with lymph node metastases of breast cancer

(2015) Evgeniya V. Kaigorodova et al.   Cancer Biomarkers

Phosphomimics Destabilize Hsp27 Oligomeric Assemblies and Enhance Chaperone Activity

(2015) Blagojce Jovcevski et al.   CHEMISTRY & BIOLOGY

Hsp27 Inhibition with OGX-427 Sensitizes Non-Small Cell Lung Cancer Cells to Erlotinib and Chemotherapy

(2015) B. Lelj-Garolla et al.   MOLECULAR CANCER THERAPEUTICS

The Effects of HSP27 on Gemcitabine-Resistant Pancreatic Cancer Cell Line Through Snail

(2015) Song Zhang et al.   PANCREAS

Targeting cancer with peptide aptamers

(2015) Renaud Seigneuric et al.   Oncotarget

Heat shock protein 27 regulates human prostate cancer cell motility and metastatic progression

(2015) Eric A. Voll et al.   Oncotarget

Quantitative proteomic analysis reveals potential diagnostic markers and pathways involved in pathogenesis of renal cell carcinoma

(2015) Nicole M.A. White et al.   Oncotarget

HSP27, 70 and 90, anti-apoptotic proteins, in clinical cancer therapy

(2014) XIAOXIA WANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The Functional Landscape of Hsp27 Reveals New Cellular Processes such as DNA Repair and Alternative Splicing and Proposes Novel Anticancer Targets

(2014) Maria Katsogiannou et al.   MOLECULAR & CELLULAR PROTEOMICS

Immediate and transient phosphorylation of the heat shock protein 27 initiates chemoresistance in prostate cancer cells

(2014) MATTHIAS B. STOPE et al.   ONCOLOGY REPORTS

Heat shock protein 27 phosphorylation state is associated with cancer progression

(2014) Maria Katsogiannou et al.   Frontiers in Genetics

Heat shock proteins 27, 40, and 70 as combinational and dual therapeutic cancer targets

(2013) Jeanette R. McConnell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hsp27 Regulates Epithelial Mesenchymal Transition, Metastasis, and Circulating Tumor Cells in Prostate Cancer

(2013) M. Shiota et al.   CANCER RESEARCH

One size does not fit all: The oligomeric states of αB crystallin

(2013) Scott P. Delbecq et al.   FEBS LETTERS

Protein interactomes of three stress inducible small heat shock proteins: HspB1, HspB5 and HspB8

(2013) André-Patrick Arrigo et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Online Survival Analysis Software to Assess the Prognostic Value of Biomarkers Using Transcriptomic Data in Non-Small-Cell Lung Cancer

(2013) Balázs Győrffy et al.   PLoS One

Downregulation of Hsp27 (HSPB1) in MCF-7 human breast cancer cells induces upregulation of PTEN

(2012) Niubys Cayado-Gutiérrez et al.   CELL STRESS & CHAPERONES

Molecular cloning and characterization of Hsp27.6: the first reported small heat shock protein from Apis cerana cerana

(2012) Zhaohua Liu et al.   CELL STRESS & CHAPERONES

The Role of Intrinsically Disordered Regions in the Structure and Functioning of Small Heat Shock Proteins

(2012) Maria V. Sudnitsyna et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Small heat shock proteins in cancer therapy and prognosis

(2012) Amina Zoubeidi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cotargeting Stress-Activated Hsp27 and Autophagy as a Combinatorial Strategy to Amplify Endoplasmic Reticular Stress in Prostate Cancer

(2012) M. Kumano et al.   MOLECULAR CANCER THERAPEUTICS

Suppression of heat shock protein 27 expression promotes 5-fluorouracil sensitivity in colon cancer cells in a xenograft model

(2012) RYOHEI HAYASHI et al.   ONCOLOGY REPORTS

Suppression of heat shock protein 27 induces long-term dormancy in human breast cancer

(2012) O. Straume et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association between DNA methylation of HSPB1 and death in low Gleason score prostate cancer

(2012) N Vasiljević et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Quercetin-mediated Mcl-1 and survivin downregulation restores TRAIL-induced apoptosis in non-Hodgkin's lymphoma B cells

(2011) G. Jacquemin et al.   HAEMATOLOGICA

Altered Cross-Linking of HSP27 by Zerumbone as a Novel Strategy for Overcoming HSP27-Mediated Radioresistance

(2011) Seo-Hyun Choi et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

RP101 (brivudine) binds to heat shock protein HSP27 (HSPB1) and enhances survival in animals and pancreatic cancer patients

(2011) Jörg-Christian Heinrich et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Three-Dimensional Structure of α-Crystallin Domain Dimers of Human Small Heat Shock Proteins HSPB1 and HSPB6

(2011) E.V. Baranova et al.   JOURNAL OF MOLECULAR BIOLOGY

Quaternary Dynamics of αB-Crystallin as a Direct Consequence of Localised Tertiary Fluctuations in the C-Terminus

(2011) Andrew J. Baldwin et al.   JOURNAL OF MOLECULAR BIOLOGY

Identification of phosphorylated serine-15 and -82 residues of HSPB1 in 5-fluorouracil-resistant colorectal cancer cells by proteomics

(2011) Akiko Sakai et al.   Journal of Proteomics

Heat Shock Proteins as Danger Signals for Cancer Detection

(2011) Renaud Seigneuric et al.   Frontiers in Oncology

Chemoresistance of lung cancer stemlike cells depends on activation of Hsp27

(2010) Han-Shui Hsu et al.   CANCER

Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer

(2010) E. M. Tweedle et al.   GUT

Clinical significance of HSP27 expression in colorectal cancer

(2010) Xu   Molecular Medicine Reports

The pivotal role of the β7 strand in the intersubunit contacts of different human small heat shock proteins

(2009) Evgeny V. Mymrikov et al.   CELL STRESS & CHAPERONES

Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology

(2009) Sergiy Kostenko et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hsp27 inhibits IKKβ-induced NF-κB activity and skeletal muscle atrophy

(2009) Stephen L. Dodd et al.   FASEB JOURNAL

Heat Shock Protein 27 as a New Therapeutic Target for Radiation Sensitization of Head and Neck Squamous Cell Carcinoma

(2009) Elie Hadchity et al.   MOLECULAR THERAPY

Upregulated HSP27 in human breast cancer cells reduces Herceptin susceptibility by increasing Her2 protein stability

(2008) Se Hun Kang et al.   BMC CANCER

Multitargeted cancer prevention by quercetin

(2008) Akira Murakami et al.   CANCER LETTERS

Thehsp27gene of the Mediterranean fruit fly,Ceratitis capitata: structural characterization, regulation and developmental expression

(2008) G. Kokolakis et al.   INSECT MOLECULAR BIOLOGY

αB-Crystallin: A Hybrid Solid-State/Solution-State NMR Investigation Reveals Structural Aspects of the Heterogeneous Oligomer

(2008) Stefan Jehle et al.   JOURNAL OF MOLECULAR BIOLOGY

Small heat shock proteins in smooth muscle

(2008) Sonemany Salinthone et al.   PHARMACOLOGY & THERAPEUTICS