Iron alters macrophage polarization status and leads to steatohepatitis and fibrogenesis

CC chemokine receptor 2 promotes recruitment of myeloid cells associated with insulin resistance in nonalcoholic fatty liver disease

(2018) Richard Parker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Pathophysiology of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis

(2018) Vignan Manne et al.   Clinics in Liver Disease

Cenicriviroc for the treatment of non-alcoholic steatohepatitis and liver fibrosis

(2018) Frank Tacke   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Hepatic peroxisome proliferator-activated receptor γ coactivator 1β drives mitochondrial and anabolic signatures that contribute to hepatocellular carcinoma progression in mice

(2018) Elena Piccinin et al.   HEPATOLOGY

Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis

(2018) Oliver Krenkel et al.   HEPATOLOGY

Targeting hepatic macrophages to treat liver diseases

(2017) Frank Tacke   JOURNAL OF HEPATOLOGY

The Role of Tissue Macrophage-Mediated Inflammation on NAFLD Pathogenesis and Its Clinical Implications

(2017) Anna Alisi et al.   MEDIATORS OF INFLAMMATION

Effect of modulation of PPAR-γ activity on Kupffer cells M1/M2 polarization in the development of non-alcoholic fatty liver disease

(2017) Wenjing Luo et al.   Scientific Reports

RORα Induces KLF4-Mediated M2 Polarization in the Liver Macrophages that Protect against Nonalcoholic Steatohepatitis

(2017) Yong-Hyun Han et al.   Cell Reports

Iron overload results in hepatic oxidative stress, immune cell activation, and hepatocellular ballooning injury, leading to nonalcoholic steatohepatitis in genetically obese mice

(2016) Priya Handa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies

(2016) Cynthia Ju et al.   Cellular & Molecular Immunology

Efficacy and safety study of cenicriviroc for the treatment of non-alcoholic steatohepatitis in adult subjects with liver fibrosis: CENTAUR Phase 2b study design

(2016) Scott Friedman et al.   Contemporary Clinical Trials

Innate Immunity and Inflammation in NAFLD/NASH

(2016) Marco Arrese et al.   DIGESTIVE DISEASES AND SCIENCES

Activation of the NLRP3 inflammasome by cellular labile iron

(2016) Kyohei Nakamura et al.   EXPERIMENTAL HEMATOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Hepatocellular carcinoma is accelerated by NASH involving M2 macrophage polarization mediated by hif-1αinduced IL-10

(2016) Aditya Ambade et al.   OncoImmunology

The impact of phlebotomy in nonalcoholic fatty liver disease: A prospective, randomized, controlled trial

(2015) Leon A. Adams et al.   HEPATOLOGY

Transcription Factors STAT6 and KLF4 Implement Macrophage Polarization via the Dual Catalytic Powers of MCPIP

(2015) Nidhi Kapoor et al.   JOURNAL OF IMMUNOLOGY

Adenosine 5′-Monophosphate–Activated Protein Kinase Regulates IL-10–Mediated Anti-Inflammatory Signaling Pathways in Macrophages

(2014) Yanfang Peipei Zhu et al.   JOURNAL OF IMMUNOLOGY

Iron Chelation by Deferoxamine Prevents Renal Interstitial Fibrosis in Mice with Unilateral Ureteral Obstruction

(2014) Yasumasa Ikeda et al.   PLoS One

A randomized trial of iron depletion in patients with nonalcoholic fatty liver disease and hyperferritinemia

(2014) Luca Valenti   WORLD JOURNAL OF GASTROENTEROLOGY

Dietary Iron Overload Induces Visceral Adipose Tissue Insulin Resistance

(2013) Paola Dongiovanni et al.   AMERICAN JOURNAL OF PATHOLOGY

AMPKα1 Regulates Macrophage Skewing at the Time of Resolution of Inflammation during Skeletal Muscle Regeneration

(2013) Rémi Mounier et al.   Cell Metabolism

Hepatic-specific activation of peroxisome proliferator-activated receptor γ coactivator-1β protects against steatohepatitis

(2013) Elena Bellafante et al.   HEPATOLOGY

Reduced adiponectin signaling due to weight gain results in nonalcoholic steatohepatitis through impaired mitochondrial biogenesis

(2013) Priya Handa et al.   HEPATOLOGY

Macrophage plasticity and polarization in liver homeostasis and pathology

(2013) Antonio Sica et al.   HEPATOLOGY

Effects of excess dietary iron and fat on glucose and lipid metabolism

(2013) Joo Sun Choi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2

(2012) Kouichi Miura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Kuppfer Cells Trigger Nonalcoholic Steatohepatitis Development in Diet-induced Mouse Model through Tumor Necrosis Factor-α Production

(2012) Annie-Carole Tosello-Trampont et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron reduction by deferoxamine leads to amelioration of adiposity via the regulation of oxidative stress and inflammation in obese and type 2 diabetes KKAy mice

(2011) Soichiro Tajima et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Krüppel-like factor 4 regulates macrophage polarization

(2011) Xudong Liao et al.   JOURNAL OF CLINICAL INVESTIGATION

Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease

(2010) James E. Nelson et al.   HEPATOLOGY