Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling

Thermoneutral Housing Accelerates Metabolic Inflammation to Potentiate Atherosclerosis but Not Insulin Resistance

(2016) Xiao Yu Tian et al.   Cell Metabolism

Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol

(2016) Khalidur Rahman et al.   GASTROENTEROLOGY

Comparison of Gene Expression Patterns Between Mouse Models of Nonalcoholic Fatty Liver Disease and Liver Tissues From Patients

(2016) Andreas Teufel et al.   GASTROENTEROLOGY

NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis

(2016) Chi Ma et al.   NATURE

Modulation of ambient temperature promotes inflammation and initiates atherosclerosis in wild type C57BL/6 mice

(2016) Daniel A. Giles et al.   Molecular Metabolism

Regulation of Inflammation by IL-17A and IL-17F Modulates Non-Alcoholic Fatty Liver Disease Pathogenesis

(2016) Daniel A. Giles et al.   PLoS One

An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses

(2015) Teruyuki Sano et al.   CELL

IL-17 Axis Driven Inflammation in Non-Alcoholic Fatty Liver Disease Progression

(2015) Daniel Giles et al.   CURRENT DRUG TARGETS

Progression from Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis Is Marked by a Higher Frequency of Th17 Cells in the Liver and an Increased Th17/Resting Regulatory T Cell Ratio in Peripheral Blood and in the Liver

(2015) Monika Rau et al.   JOURNAL OF IMMUNOLOGY

A perisinusoidal niche for extramedullary haematopoiesis in the spleen

(2015) Christopher N. Inra et al.   NATURE

Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

(2015) Mark J W Hanssen et al.   NATURE MEDICINE

Temperature-dependent innate defense against the common cold virus limits viral replication at warm temperature in mouse airway cells

(2015) Ellen F. Foxman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Housing temperature-induced stress drives therapeutic resistance in murine tumour models through β2-adrenergic receptor activation

(2015) Jason W.-L. Eng et al.   Nature Communications

Plasma high mobility group box 1 protein reflects fibrosis in pediatric nonalcoholic fatty liver disease

(2014) Anna Alisi et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Thermoneutral housing is a critical factor for immune function and diet-induced obesity in C57BL/6 nude mice

(2014) K Stemmer et al.   INTERNATIONAL JOURNAL OF OBESITY

Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids

(2014) Radha Ramesh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hepatic toll-like receptor 4 expression is associated with portal inflammation and fibrosis in patients with NAFLD

(2014) Umberto Vespasiani-Gentilucci et al.   LIVER INTERNATIONAL

TLR4 Gene Polymorphism in Patients with Nonalcoholic Fatty Liver Disease in Comparison to Healthy Controls

(2014) Safak Kiziltas et al.   Metabolic Syndrome and Related Disorders

Distinct Tlr4-expressing cell compartments control neutrophilic and eosinophilic airway inflammation

(2014) J W McAlees et al.   Mucosal Immunology

Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans

(2014) M. Kox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MRI-diagnosed Nonalcoholic Fatty Liver Disease Is Correlated to Insulin Resistance in Adolescents

(2013) José Hermes Ribas do Nascimento et al.   ACADEMIC RADIOLOGY

Propranolol, a β-adrenoceptor antagonist, worsens liver injury in a model of non-alcoholic steatohepatitis

(2013) Chad McKee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice

(2013) Isaac T.W. Harley et al.   HEPATOLOGY

In Vitro and in Vivo Models of Non-Alcoholic Fatty Liver Disease (NAFLD)

(2013) Giridhar Kanuri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Gordian Knot of dysbiosis, obesity and NAFLD

(2013) Wajahat Z. Mehal   Nature Reviews Gastroenterology & Hepatology

IL-17 cytokines in immunity and inflammation

(2013) Wei Jin et al.   Emerging Microbes & Infections

Interleukin-17 Signaling in Inflammatory, Kupffer Cells, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice

(2012) Fanli Meng et al.   GASTROENTEROLOGY

Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH

(2012) Lixin Zhu et al.   HEPATOLOGY

Unstressing intemperate models: how cold stress undermines mouse modeling

(2012) Christopher L. Karp   JOURNAL OF EXPERIMENTAL MEDICINE

Metabolic Control by S6 Kinases Depends on Dietary Lipids

(2012) Tamara R. Castañeda et al.   PLoS One

Will the increased prevalence of nonalcoholic steatohepatitis (NASH) in the age of better hepatitis C virus therapy make NASH the deadlier disease?

(2011) Mary E. Rinella   HEPATOLOGY

Interleukin-13 (IL-13)/IL-13 Receptor α1 (IL-13Rα1) Signaling Regulates Intestinal Epithelial Cystic Fibrosis Transmembrane Conductance Regulator Channel-dependent Cl−Secretion

(2011) David Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Therapeutic Enhancement of Protective Immunity during Experimental Leishmaniasis

(2011) Senad Divanovic et al.   PLoS Neglected Tropical Diseases

Metagenomic biomarker discovery and explanation

(2011) Nicola Segata et al.   GENOME BIOLOGY

Nonalcoholic Fatty Liver Disease: Pathology and Pathogenesis

(2010) Dina G. Tiniakos et al.   Annual Review of Pathology-Mechanisms of Disease

Uncoupling protein UCP2: When mitochondrial activity meets immunity

(2010) Yalin Emre et al.   FEBS LETTERS

Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings

(2010) Elizabeth M. Brunt et al.   HEPATOLOGY

Phenotyping small animals as models for the human metabolic syndrome: thermoneutrality matters

(2010) J M Overton   INTERNATIONAL JOURNAL OF OBESITY

Down-regulation of SREBP-1c is associated with the development of burned-out NASH

(2010) Tadanobu Nagaya et al.   JOURNAL OF HEPATOLOGY

QIIME allows analysis of high-throughput community sequencing data

(2010) J Gregory Caporaso et al.   NATURE METHODS

Animal models of nonalcoholic fatty liver disease

(2010) Lionel Hebbard et al.   Nature Reviews Gastroenterology & Hepatology

Predicting Fibrosis Worsening in Obese Patients With NASH Through Parenchymal Fibronectin, HOMA-IR and Hypertension

(2009) Paolo Sorrentino et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Introducing mothur: Open-Source, Platform-Independent, Community-Supported Software for Describing and Comparing Microbial Communities

(2009) P. D. Schloss et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease

(2009) Luca Miele et al.   HEPATOLOGY

ToppGene Suite for gene list enrichment analysis and candidate gene prioritization

(2009) J. Chen et al.   NUCLEIC ACIDS RESEARCH

Increased Hepatic and Circulating Interleukin-6 Levels in Human Nonalcoholic Steatohepatitis

(2008) Anna Wieckowska et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Vagal tone dominates autonomic control of mouse heart rate at thermoneutrality

(2008) S. J. Swoap et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Stressor-specific alterations in corticosterone and immune responses in mice

(2007) Stephanie L. Bowers et al.   BRAIN BEHAVIOR AND IMMUNITY