Pentose Phosphate Shunt Modulates Reactive Oxygen Species and Nitric Oxide Production Controlling Trypanosoma cruzi in Macrophages

Loss of Nardilysin, a Mitochondrial Co-chaperone for α-Ketoglutarate Dehydrogenase, Promotes mTORC1 Activation and Neurodegeneration

(2017) Wan Hee Yoon et al.   NEURON

Participation of TLR2 and TLR4 in Cytokines Production by Patients with Symptomatic and Asymptomatic Chronic Chagas Disease

(2017) L. D. Mendes da Silva et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis

(2016) Nicole M. Kettner et al.   CANCER CELL

Innate immunomodulation to trypanosomatid parasite infections

(2016) A.L.A. Dos-Santos et al.   EXPERIMENTAL PARASITOLOGY

Glycolytic pathway affects differentiation of human monocytes to regulatory macrophages

(2016) Hiroaki Suzuki et al.   IMMUNOLOGY LETTERS

TcI Isolates of Trypanosoma cruzi Exploit the Antioxidant Network for Enhanced Intracellular Survival in Macrophages and Virulence in Mice

(2016) María Paola Zago et al.   INFECTION AND IMMUNITY

Macrophages Promote Oxidative Metabolism To Drive Nitric Oxide Generation in Response to Trypanosoma cruzi

(2016) Sue-jie Koo et al.   INFECTION AND IMMUNITY

GM-CSF Induces Inflammatory Macrophages by Regulating Glycolysis and Lipid Metabolism

(2016) Yi Rang Na et al.   JOURNAL OF IMMUNOLOGY

Proinflammatory signal suppresses proliferation and shifts macrophage metabolism from Myc-dependent to HIF1α-dependent

(2016) Lingling Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trypanosoma cruzi Needs a Signal Provided by Reactive Oxygen Species to Infect Macrophages

(2016) Grazielle R. Goes et al.   PLoS Neglected Tropical Diseases

SIRT1-PGC1α-NFκB Pathway of Oxidative and Inflammatory Stress during Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving Heart Function in Chagas Disease

(2016) Xianxiu Wan et al.   PLoS Pathogens

Treatment in vitro with PPARα and PPARγ ligands drives M1-to-M2 polarization of macrophages from T. cruzi-infected mice

(2015) Federico Penas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

(2015) Beth Kelly et al.   CELL RESEARCH

Pro-inflammatory Macrophages Sustain Pyruvate Oxidation through Pyruvate Dehydrogenase for the Synthesis of Itaconate and to Enable Cytokine Expression

(2015) Johannes Meiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nitric oxide synthase in innate and adaptive immunity: an update

(2015) Christian Bogdan   TRENDS IN IMMUNOLOGY

Toxic and therapeutic effects of Nifurtimox and Benznidazol on Trypanosoma cruzi ex vivo infection of human placental chorionic villi explants

(2014) Gemma Rojo et al.   ACTA TROPICA

Metabolic Reprogramming of Macrophages

(2014) Alex J. Freemerman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of IL-12 Production in Human Peripheral Monocytes byTrypanosoma cruziIs Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN-γand CD40-CD40L Interactions

(2014) Lúcia Cristina Jamli Abel et al.   MEDIATORS OF INFLAMMATION

P47phox−/− Mice Are Compromised in Expansion and Activation of CD8+ T Cells and Susceptible to Trypanosoma cruzi Infection

(2014) Monisha Dhiman et al.   PLoS Pathogens

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism

(2012) Arvand Haschemi et al.   Cell Metabolism

Oxidative stress fuels Trypanosoma cruzi infection in mice

(2012) Claudia N. Paiva et al.   JOURNAL OF CLINICAL INVESTIGATION

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

NADPH Phagocyte Oxidase Knockout Mice Control Trypanosoma cruzi Proliferation, but Develop Circulatory Collapse and Succumb to Infection

(2012) Helton C. Santiago et al.   PLoS Neglected Tropical Diseases

NADPH oxidase inhibition ameliorates Trypanosoma cruzi-induced myocarditis during Chagas disease

(2011) Monisha Dhiman et al.   JOURNAL OF PATHOLOGY

Intraphagosomal Peroxynitrite as a Macrophage-derived Cytotoxin against InternalizedTrypanosoma cruzi

(2010) María Noel Alvarez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association of Toll-Like Receptor Signaling and Reactive Oxygen Species: A Potential Therapeutic Target for Posttrauma Acute Lung Injury

(2010) Meng Xiang et al.   MEDIATORS OF INFLAMMATION

The innate immune response to Trypanosoma cruzi infection

(2010) Hisako Kayama et al.   MICROBES AND INFECTION

Impaired Innate Immunity in Tlr4−/− Mice but Preserved CD8+ T Cell Responses against Trypanosoma cruzi in Tlr4-, Tlr2-, Tlr9- or Myd88-Deficient Mice

(2010) Ana-Carolina Oliveira et al.   PLoS Pathogens

In vitro fatty acid enrichment of macrophages alters inflammatory response and net cholesterol accumulation

(2009) Shu Wang et al.   BRITISH JOURNAL OF NUTRITION

Regulation of Macrophage Functions by PPAR-α, PPAR-γ, and LXRs in Mice and Men

(2008) Elena Rigamonti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Peroxiredoxins play a major role in protectingTrypanosoma cruziagainst macrophage- and endogenously-derived peroxynitrite

(2008) Lucía Piacenza et al.   BIOCHEMICAL JOURNAL

Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

(2008) Justin I. Odegaard et al.   Cell Metabolism

Mycobacterium tuberculosislipoprotein-induced association of TLR2 with protein kinase C ζ in lipid rafts contributes to reactive oxygen species-dependent inflammatory signalling in macrophages

(2008) Dong-Min Shin et al.   CELLULAR MICROBIOLOGY

The role of Toll-like receptors 2 and 4 on reactive oxygen species and nitric oxide production by macrophage cells stimulated with root canal pathogens

(2008) L. G. Marcato et al.   Oral microbiology and immunology

Peroxiredoxins from Trypanosoma cruzi: Virulence factors and drug targets for treatment of Chagas disease?

(2007) María Dolores Piñeyro et al.   GENE