Targeting arginase-II protects mice from high-fat-diet-induced hepatic steatosis through suppression of macrophage inflammation

Arginase 2 deficiency results in spontaneous steatohepatitis: A novel link between innate immune activation and hepatic de novo lipogenesis

(2015) Laura A. Navarro et al.   JOURNAL OF HEPATOLOGY

ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis

(2014) Yuyan Xiong et al.   Autophagy

Characterization of Distinct Subpopulations of Hepatic Macrophages in HFD/Obese Mice

(2014) Hidetaka Morinaga et al.   DIABETES

Arginase Inhibition Ameliorates Hepatic Metabolic Abnormalities in Obese Mice

(2014) Jiyoung Moon et al.   PLoS One

Functions of Arginase Isoforms in Macrophage Inflammatory Responses: Impact on Cardiovascular Diseases and Metabolic Disorders

(2014) Zhihong Yang et al.   Frontiers in Immunology

Mulberry Anthocyanins Inhibit Oleic Acid Induced Lipid Accumulation by Reduction of Lipogenesis and Promotion of Hepatic Lipid Clearance

(2013) Jia-Jen Chang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Nonalcoholic Fatty Liver Disease: A Novel Cardiometabolic Risk Factor for Type 2 Diabetes and Its Complications

(2013) Giovanni Targher et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Arginase inhibition mediates renal tissue protection in diabetic nephropathy by a nitric oxide synthase 3-dependent mechanism

(2013) Hanning You et al.   KIDNEY INTERNATIONAL

Obesity Notches up fatty liver

(2013) Michael P Czech   NATURE MEDICINE

Arginase‐II Induces Vascular Smooth Muscle Cell Senescence and Apoptosis Through p66Shc and p53 Independently of Its l ‐Arginine Ureahydrolase Activity: Implications for Atherosclerotic Plaque Vulnerability

(2013) Yuyan Xiong et al.   Journal of the American Heart Association

Glucose-6-phosphate dehydrogenase regulation in the hepatopancreas of the anoxia-tolerant marine mollusc,Littorina littorea

(2013) Judeh L. Lama et al.   PeerJ

Positive crosstalk between arginase-II and S6K1 in vascular endothelial inflammation and aging

(2012) Gautham Yepuri et al.   AGING CELL

Mechanism of AMPK Suppression of LXR-dependent Srebp-1c Transcription

(2012) Fuichi Yap et al.   International Journal of Biological Sciences

Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis

(2012) Xiu‐Fen Ming et al.   Journal of the American Heart Association

Immunohistochemical study of arginase 1 and 2 in various tissues of rats

(2011) Sungyoung Choi et al.   ACTA HISTOCHEMICA

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

(2011) Yu Li et al.   Cell Metabolism

A selective estrogen receptor α agonist ameliorates hepatic steatosis in the male aromatase knockout mouse

(2011) Jenny D Y Chow et al.   JOURNAL OF ENDOCRINOLOGY

Inflammatory Signals shift from adipose to liver during high fat feeding and influence the development of steatohepatitis in mice

(2011) Michaela C Stanton et al.   Journal of Inflammation-London

Genetic control ofde novolipogenesis: role in diet-induced obesity

(2010) Maggie S. Strable et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

C-C Chemokine Receptor 2 (CCR2) Regulates the Hepatic Recruitment of Myeloid Cells That Promote Obesity-Induced Hepatic Steatosis

(2010) A. E. Obstfeld et al.   DIABETES

Inflammatory Mediators of Hepatic Steatosis

(2010) Elizabeth Hijona et al.   MEDIATORS OF INFLAMMATION

Macrophage Plasticity in Experimental Atherosclerosis

(2010) Jamila Khallou-Laschet et al.   PLoS One

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

(2010) Shijie Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

(2009) R. J. Shaw   Acta Physiologica

Arginase Activity Mediates Retinal Inflammation in Endotoxin-Induced Uveitis

(2009) Wenbo Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance

(2009) W. Huang et al.   DIABETES

Adiponectin: A Key Adipokine in Alcoholic Fatty Liver

(2009) Min You et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Hepatic Lipid Partitioning and Liver Damage in Nonalcoholic Fatty Liver Disease

(2009) Zheng Zheng Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

(2008) Justin I. Odegaard et al.   Cell Metabolism

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

(2008) Thomas Porstmann et al.   Cell Metabolism

Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

(2008) David Patsouris et al.   Cell Metabolism

Selective versus Total Insulin Resistance: A Pathogenic Paradox

(2008) Michael S. Brown et al.   Cell Metabolism

Molecular Mechanisms and Therapeutic Targets in Steatosis and Steatohepatitis

(2008) N. Anderson et al.   PHARMACOLOGICAL REVIEWS