Phosphorylation Signaling in APP Processing in Alzheimer’s Disease

The secreted APP ectodomain sAPPα, but not sAPPβ, protects neurons against Aβ oligomer-induced dendritic spine loss and increased tau phosphorylation

(2019) Christian Tackenberg et al.   Molecular Brain

Post Translational Modulation of β-Amyloid Precursor Protein Trafficking to the Cell Surface Alters Neuronal Iron Homeostasis

(2019) Andrew Tsatsanis et al.   NEUROCHEMICAL RESEARCH

Clinical and biological effects of long-term lithium treatment in older adults with amnestic mild cognitive impairment: randomised clinical trial

(2019) Orestes V. Forlenza et al.   BRITISH JOURNAL OF PSYCHIATRY

Par3 regulates polarized convergence between APP and BACE1 in hippocampal neurons

(2019) Miao Sun et al.   NEUROBIOLOGY OF AGING

Rho‐associated coiled‐coil kinase 1 activation mediates amyloid precursor protein site‐specific Ser655 phosphorylation and triggers amyloid pathology

(2019) Yong‐Bo Hu et al.   AGING CELL

Death-Associated Protein Kinase 1 Phosphorylation in Neuronal Cell Death and Neurodegenerative Disease

(2019) Nami Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chronic Dyrk1 Inhibition Delays the Onset of AD-Like Pathology in 3xTg-AD Mice

(2019) R. Velazquez et al.   MOLECULAR NEUROBIOLOGY

Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease

(2019) Christopher H. van Dyck et al.   JAMA Neurology

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Phosphorylation of the amyloid precursor protein (APP) at Ser-675 promotes APP processing involving meprin β

(2019) Preeti Kumaran Menon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation

(2019) Woo Shik Shin et al.   Alzheimers Research & Therapy

The effects of insulin and insulin-like growth factor I on amyloid precursor protein phosphorylation in in vitro and in vivo models of Alzheimer's disease

(2019) Bhumsoo Kim et al.   NEUROBIOLOGY OF DISEASE

Targeting Fyn Kinase in Alzheimer’s Disease

(2018) Haakon B. Nygaard   BIOLOGICAL PSYCHIATRY

The Conundrum of GSK3 Inhibitors: Is it the Dawn of a New Beginning?

(2018) Ratan V. Bhat et al.   JOURNAL OF ALZHEIMERS DISEASE

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

(2018) Erika N. Cline et al.   JOURNAL OF ALZHEIMERS DISEASE

Intranasal insulin in Alzheimer’s dementia or mild cognitive impairment: a systematic review

(2018) Konstantinos Ioannis Avgerinos et al.   JOURNAL OF NEUROLOGY

CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer’s Disease

(2018) Yang-Ping Shentu et al.   Cell Reports

TREM2 — a key player in microglial biology and Alzheimer disease

(2018) Tyler K. Ulland et al.   Nature Reviews Neurology

Death-Associated Protein Kinase 1 As A Promising Drug Target In Cancer and Alzheimer’s Disease

(2018) Dongmei Chen et al.   Recent Patents on Anti-Cancer Drug Discovery

Alzheimer's disease

(2017) C. A. Lane et al.   EUROPEAN JOURNAL OF NEUROLOGY

Protein Phosphorylation is a Key Mechanism in Alzheimer’s Disease

(2017) Joana Oliveira et al.   JOURNAL OF ALZHEIMERS DISEASE

Recent Progress in Alzheimer’s Disease Research, Part 1: Pathology

(2017) Francis T. Hane et al.   JOURNAL OF ALZHEIMERS DISEASE

Recent Progress in Alzheimer’s Disease Research, Part 2: Genetics and Epidemiology

(2017) Morgan Robinson et al.   JOURNAL OF ALZHEIMERS DISEASE

Role of Glutamate and NMDA Receptors in Alzheimer’s Disease

(2017) Rui Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

The Role of ADAM10 in Alzheimer’s Disease

(2017) Xiang-Zhen Yuan et al.   JOURNAL OF ALZHEIMERS DISEASE

Not just amyloid: physiological functions of the amyloid precursor protein family

(2017) Ulrike C. Müller et al.   NATURE REVIEWS NEUROSCIENCE

Par3 and aPKC regulate BACE1 endosome-to-TGN trafficking through PACS1

(2017) Miao Sun et al.   NEUROBIOLOGY OF AGING

Polo-like kinase 2 phosphorylation of amyloid precursor protein regulates activity-dependent amyloidogenic processing

(2017) Yeunkum Lee et al.   NEUROPHARMACOLOGY

Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson’s disease

(2017) Zhong-Can Chen et al.   Science Signaling

Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson’s disease

(2017) Zhong-Can Chen et al.   Science Signaling

An Aberrant Phosphorylation of Amyloid Precursor Protein Tyrosine Regulates Its Trafficking and the Binding to the Clathrin Endocytic Complex in Neural Stem Cells of Alzheimer's Disease Patients

(2017) Ebbe T. Poulsen et al.   Frontiers in Molecular Neuroscience

NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease

(2016) Viviana Triaca et al.   AGING CELL

Death-associated protein kinase 1 phosphorylates NDRG2 and induces neuronal cell death

(2016) Mi-Hyeon You et al.   CELL DEATH AND DIFFERENTIATION

Membrane tethering of APP c-terminal fragments is a prerequisite for T668 phosphorylation preventing nuclear sphere generation

(2016) Hassan Bukhari et al.   CELLULAR SIGNALLING

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Inhibition of death-associated protein kinase 1 attenuates the phosphorylation and amyloidogenic processing of amyloid precursor protein

(2016) Byeong Mo Kim et al.   HUMAN MOLECULAR GENETICS

Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-β levels in brain

(2016) Benjamin W. Henderson et al.   JOURNAL OF NEUROCHEMISTRY

Restoring Soluble Amyloid Precursor Protein α Functions as a Potential Treatment for Alzheimer's Disease

(2016) Ahsan Habib et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Age, APOE and sex: Triad of risk of Alzheimer’s disease

(2016) Brandalyn C. Riedel et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery

(2016) William A. Banks   NATURE REVIEWS DRUG DISCOVERY

Extensive nuclear sphere generation in the human Alzheimer's brain

(2016) Katharina Kolbe et al.   NEUROBIOLOGY OF AGING

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Structural basis of human γ-secretase assembly

(2015) Linfeng Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Y682G Mutation of Amyloid Precursor Protein Promotes Endo-Lysosomal Dysfunction by Disrupting APP–SorLA Interaction

(2015) Luca Rosario La Rosa et al.   Frontiers in Cellular Neuroscience

Alzheimer's disease

(2015) Colin L. Masters et al.   Nature Reviews Disease Primers

Enhancement of BACE1 Activity by p25/Cdk5-Mediated Phosphorylation in Alzheimer’s Disease

(2015) Woo-Joo Song et al.   PLoS One

Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers

(2014) Christiane Reitz et al.   BIOCHEMICAL PHARMACOLOGY

Targeting TNF: a therapeutic strategy for Alzheimer's disease

(2014) Xin Cheng et al.   DRUG DISCOVERY TODAY

Phosphorylation of Amyloid Precursor Protein at Threonine 668 Is Essential for Its Copper-responsive Trafficking in SH-SY5Y Neuroblastoma Cells

(2014) Karla M. Acevedo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trafficking regulation of proteins in Alzheimer’s disease

(2014) Shangtong Jiang et al.   Molecular Neurodegeneration

Three-dimensional structure of human γ-secretase

(2014) Peilong Lu et al.   NATURE

SAP97-mediated ADAM10 trafficking from Golgi outposts depends on PKC phosphorylation

(2014) C Saraceno et al.   Cell Death & Disease

Fyn kinase inhibition as a novel therapy for Alzheimer’s disease

(2014) Haakon B Nygaard et al.   Alzheimers Research & Therapy

Truncated and modified amyloid-beta species

(2014) Markus P Kummer et al.   Alzheimers Research & Therapy

A review on cholinesterase inhibitors for Alzheimer’s disease

(2013) Preet Anand et al.   ARCHIVES OF PHARMACAL RESEARCH

A new molecular explanation for age-related neurodegeneration: The Tyr682 residue of amyloid precursor protein

(2013) Carmela Matrone   BIOESSAYS

Sorting receptor SORLA - a trafficking path to avoid Alzheimer disease

(2013) T. E. Willnow et al.   JOURNAL OF CELL SCIENCE

Pharmacologic Inhibition of ROCK2 Suppresses Amyloid-  Production in an Alzheimer's Disease Mouse Model

(2013) J. H. Herskowitz et al.   JOURNAL OF NEUROSCIENCE

An Intracellular Threonine of Amyloid-β Precursor Protein Mediates Synaptic Plasticity Deficits and Memory Loss

(2013) Franco Lombino et al.   PLoS One

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance

(2012) Carmela Matrone et al.   AGING CELL

sAPPα rescues deficits in amyloid precursor protein knockout mice following focal traumatic brain injury

(2012) Frances Corrigan et al.   JOURNAL OF NEUROCHEMISTRY

JNK3 Perpetuates Metabolic Stress Induced by Aβ Peptides

(2012) Sung Ok Yoon et al.   NEURON

Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation

(2012) Demian Obregon et al.   Nature Communications

Peptidyl-prolyl cis–trans isomerase Pin1 in ageing, cancer and Alzheimer disease

(2011) Tae Ho Lee et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Identification and biology of β-secretase

(2011) Patty C. Kandalepas et al.   JOURNAL OF NEUROCHEMISTRY

Proteolytic processing of Alzheimer’s β-amyloid precursor protein

(2011) Han Zhang et al.   JOURNAL OF NEUROCHEMISTRY

APP is Phosphorylated by TrkA and Regulates NGF/TrkA Signaling

(2011) C. Matrone et al.   JOURNAL OF NEUROSCIENCE

The Loss of c-Jun N-Terminal Protein Kinase Activity Prevents the Amyloidogenic Cleavage of Amyloid Precursor Protein and the Formation of Amyloid Plaques In Vivo

(2011) S. Mazzitelli et al.   JOURNAL OF NEUROSCIENCE

Biology and pathophysiology of the amyloid precursor protein

(2011) Hui Zheng et al.   Molecular Neurodegeneration

Effect of glycogen synthase kinase 3 β-mediated presenilin 1 phosphorylation on amyloid β production is negatively regulated by insulin receptor cleavage

(2011) M. Maesako et al.   NEUROSCIENCE

APP processing in Alzheimer's disease

(2011) Yun-wu Zhang et al.   Molecular Brain

Rho Kinase II Phosphorylation of the Lipoprotein Receptor LR11/SORLA Alters Amyloid-β Production

(2010) Jeremy H. Herskowitz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dyrk1A-mediated phosphorylation of Presenilin 1: a functional link between Down syndrome and Alzheimer’s disease

(2010) Young Shin Ryu et al.   JOURNAL OF NEUROCHEMISTRY

The secretases: enzymes with therapeutic potential in Alzheimer disease

(2010) Bart De Strooper et al.   Nature Reviews Neurology

Tyr682 in the Intracellular Domain of APP Regulates Amyloidogenic APP Processing In Vivo

(2010) Alessia P. M. Barbagallo et al.   PLoS One

S655 phosphorylation enhances APP secretory traffic

(2009) Sandra Isabel Vieira et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The interactome of the amyloid β precursor protein family members is shaped by phosphorylation of their intracellular domains

(2009) Robert Tamayev et al.   Molecular Neurodegeneration

Targeting protein kinases in central nervous system disorders

(2009) Laura K. Chico et al.   NATURE REVIEWS DRUG DISCOVERY

JNK regulates APP cleavage and degradation in a model of Alzheimer's disease

(2009) Alessio Colombo et al.   NEUROBIOLOGY OF DISEASE

Phosphorylation of amyloid precursor protein (APP) at Tyr687 regulates APP processing by α- and γ-secretase

(2008) Keita Takahashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phosphorylation of β-amyloid precursor protein (APP) cytoplasmic tail facilitates amyloidogenic processing during apoptosis

(2008) Chhinder P. Sodhi et al.   BRAIN RESEARCH

Regulation of FE65 Nuclear Translocation and Function by Amyloid β-Protein Precursor in Osmotically Stressed Cells

(2008) Tadashi Nakaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Amyloid β-Protein Precursor by Phosphorylation and Protein Interactions

(2008) Toshiharu Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease β-amyloid production

(2008) Kavon Rezai-Zadeh et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Tumor Necrosis Factor-α–elicited Stimulation of γ-Secretase Is Mediated by c-Jun N-terminal Kinase-dependent Phosphorylation of Presenilin and Nicastrin

(2008) Lan-Hsin Kuo et al.   MOLECULAR BIOLOGY OF THE CELL

Sodium selenite inhibits γ-secretase activity through activation of ERK

(2008) Ying-Tsen Tung et al.   NEUROSCIENCE LETTERS

Phosphorylation of thr668 in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3)

(2003) Claire L. Standen et al.   JOURNAL OF NEUROCHEMISTRY