Truncated and modified amyloid-beta species

Heme Binding Induces Dimerization and Nitration of Truncated β-Amyloid Peptide Aβ16 Under Oxidative Stress

(2013) Grégory Thiabaud et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A central role for dityrosine crosslinking of Amyloid-β in Alzheimer’s disease

(2013) Youssra K Al-Hilaly et al.   Acta Neuropathologica Communications

The Metalloprotease Meprin β Generates Amino Terminal-truncated Amyloid β Peptide Species

(2012) Jessica Bien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of Amyloid-β Peptide at Serine 8 Attenuates Its Clearance via Insulin-degrading and Angiotensin-converting Enzymes

(2012) Sathish Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyroglutamate Amyloid β (Aβ) Aggravates Behavioral Deficits in Transgenic Amyloid Mouse Model for Alzheimer Disease

(2012) Jessica L. Wittnam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluation of the Performance of Novel Aß Isoforms as Theragnostic Markers in Alzheimer’s Disease: From the Cell to the Patient

(2012) Erik Portelius et al.   Neurodegenerative Diseases

BACE1 Inhibition Induces a Specific Cerebrospinal Fluid β-Amyloid Pattern That Identifies Drug Effects in the Central Nervous System

(2012) Niklas Mattsson et al.   PLoS One

Characterization of cerebrospinal fluid aminoterminally truncated and oxidized amyloid-β peptides

(2012) Mirko Bibl et al.   Proteomics Clinical Applications

Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease

(2011) Sathish Kumar et al.   EMBO JOURNAL

β-Amyloid Peptide Variants in Brains and Cerebrospinal Fluid from Amyloid Precursor Protein (APP) Transgenic Mice

(2011) Heinke Schieb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nitration of Tyrosine 10 Critically Enhances Amyloid β Aggregation and Plaque Formation

(2011) Markus P. Kummer et al.   NEURON

Pyroglutamate-Aβ 3 and 11 colocalize in amyloid plaques in Alzheimer's disease cerebral cortex with pyroglutamate-Aβ 11 forming the central core

(2011) Christopher P. Sullivan et al.   NEUROSCIENCE LETTERS

Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid  -peptides in human cerebrospinal fluid

(2011) A. Halim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cerebrospinal Fluid Tau, p-Tau 181 and Amyloid-β38/40/42 in Frontotemporal Dementias and Primary Progressive Aphasias

(2010) Mirko Bibl et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

Overexpression of Glutaminyl Cyclase, the Enzyme Responsible for Pyroglutamate Aβ Formation, Induces Behavioral Deficits, and Glutaminyl Cyclase Knock-out Rescues the Behavioral Phenotype in 5XFAD Mice

(2010) Sadim Jawhar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

A novel Aβ isoform pattern in CSF reflects γ-secretase inhibition in Alzheimer disease

(2010) Erik Portelius et al.   Alzheimers Research & Therapy

α-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Aβ generation

(2009) Sebastian Jäger et al.   JOURNAL OF NEUROCHEMISTRY

Aminopeptidase A contributes to the N-terminal truncation of amyloid β-peptide

(2009) Jean Sevalle et al.   JOURNAL OF NEUROCHEMISTRY

Alanine-2 Carbonyl is an Oxygen Ligand in Cu2+Coordination of Alzheimer’s Disease Amyloid-β Peptide − Relevance to N-Terminally Truncated Forms

(2009) Simon C. Drew et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reduced levels of IgM autoantibodies against N-truncated pyroglutamate Aβ in plasma of patients with Alzheimer's disease

(2009) Andrea Marcello et al.   NEUROBIOLOGY OF AGING

A novel pathway for amyloid precursor protein processing

(2009) Erik Portelius et al.   NEUROBIOLOGY OF AGING

Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease

(2009) M. Britschgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology

(2008) Stephan Schilling et al.   NATURE MEDICINE

N-truncated amyloid-β oligomers induce learning impairment and neuronal apoptosis

(2007) Ihsen Youssef et al.   NEUROBIOLOGY OF AGING