Trafficking regulation of proteins in Alzheimer’s disease

Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer’s disease

(2013) Elena Marcello et al.   JOURNAL OF CLINICAL INVESTIGATION

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Activity-Induced Convergence of APP and BACE-1 in Acidic Microdomains via an Endocytosis-Dependent Pathway

(2013) Utpal Das et al.   NEURON

GPR3 Stimulates Aβ Production via Interactions with APP and β-Arrestin2

(2013) Christopher D. Nelson et al.   PLoS One

β-Arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology

(2012) Xiaosong Liu et al.   CELL RESEARCH

CutA Divalent Cation Tolerance Homolog (Escherichia coli) (CUTA) Regulates β-Cleavage of β-Amyloid Precursor Protein (APP) through Interacting with β-Site APP Cleaving Protein 1 (BACE1)

(2012) Yingjun Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Retention in Endoplasmic Reticulum 1 (RER1) Modulates Amyloid-β (Aβ) Production by Altering Trafficking of γ-Secretase and Amyloid Precursor Protein (APP)

(2012) Hyo-Jin Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The neuropeptide PACAP38 induces dendritic spine remodeling through ADAM10-N-cadherin signaling pathway

(2012) F. Gardoni et al.   JOURNAL OF CELL SCIENCE

Intracellular Amyloid Precursor Protein Sorting and Amyloid-  Secretion Are Regulated by Src-Mediated Phosphorylation of Mint2

(2012) J. Chaufty et al.   JOURNAL OF NEUROSCIENCE

FBL2 Regulates Amyloid Precursor Protein (APP) Metabolism by Promoting Ubiquitination-Dependent APP Degradation and Inhibition of APP Endocytosis

(2012) T. Watanabe et al.   JOURNAL OF NEUROSCIENCE

GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production

(2012) Jeremy H. Herskowitz et al.   MOLECULAR BIOLOGY OF THE CELL

LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer’s disease

(2012) Julie Brodeur et al.   Molecular Neurodegeneration

Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing

(2012) Yonghao Zhao et al.   Molecular Neurodegeneration

The location and trafficking routes of the neuronal retromer and its role in amyloid precursor protein transport

(2012) Akhil Bhalla et al.   NEUROBIOLOGY OF DISEASE

Ubiquilin-1 regulates amyloid precursor protein maturation and degradation by stimulating K63-linked polyubiquitination of lysine 688

(2012) A. El Ayadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Meta-analysis of the Association Between Variants in SORL1 and Alzheimer Disease

(2011) Christiane Reitz   ARCHIVES OF NEUROLOGY

Arc/Arg3.1 Regulates an Endosomal Pathway Essential for Activity-Dependent β-Amyloid Generation

(2011) Jing Wu et al.   CELL

Interaction between amyloid precursor protein and Nogo receptors regulates amyloid deposition

(2011) Xiangdong Zhou et al.   FASEB JOURNAL

Structural features of the KPI domain control APP dimerization, trafficking, and processing

(2011) Naouel Ben Khalifa et al.   FASEB JOURNAL

Down-regulation of the ATP-binding Cassette Transporter 2 (Abca2) Reduces Amyloid-β Production by Altering Nicastrin Maturation and Intracellular Localization

(2011) Vasiliki Michaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VPS35 haploinsufficiency increases Alzheimer’s disease neuropathology

(2011) Lei Wen et al.   JOURNAL OF CELL BIOLOGY

Alzheimer's disease: synapses gone cold

(2011) Robert M Koffie et al.   Molecular Neurodegeneration

Biology and pathophysiology of the amyloid precursor protein

(2011) Hui Zheng et al.   Molecular Neurodegeneration

ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

(2011) R. Sannerud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APP processing in Alzheimer's disease

(2011) Yun-wu Zhang et al.   Molecular Brain

Thousands of Rab GTPases for the Cell Biologist

(2011) Yoan Diekmann et al.   PLoS Computational Biology

Evolution of Mannose 6-Phosphate Receptors (MPR300 and 46): Lysosomal Enzyme Sorting Proteins

(2010) S. Nadimpalli et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing

(2010) Hirokazu Okada et al.   FASEB JOURNAL

Ubiquitin Regulates GGA3-mediated Degradation of BACE1

(2010) Eugene L. Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Arginine Stretch Limits ADAM10 Exit from the Endoplasmic Reticulum

(2010) Elena Marcello et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alpha-secretase in Alzheimer’s disease: molecular identity, regulation and therapeutic potential

(2010) Stefan F. Lichtenthaler   JOURNAL OF NEUROCHEMISTRY

The Disintegrin/Metalloproteinase ADAM10 Is Essential for the Establishment of the Brain Cortex

(2010) E. Jorissen et al.   JOURNAL OF NEUROSCIENCE

Diabetes-Associated SorCS1 Regulates Alzheimer's Amyloid-  Metabolism: Evidence for Involvement of SorL1 and the Retromer Complex

(2010) R. F. Lane et al.   JOURNAL OF NEUROSCIENCE

Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated

(2010) Sandra I Vieira et al.   Molecular Neurodegeneration

Inhibition of neuronal calcium oscillations by cell surface APP phosphorylated on T668

(2010) Susana Ferrao Santos et al.   NEUROBIOLOGY OF AGING

Activation and intrinsic  -secretase activity of presenilin 1

(2010) K. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular Trafficking of Presenilin 1 Is Regulated by β-Amyloid Precursor Protein and Phospholipase D1

(2009) Yun Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduced Amyloid Deposition in Mice Overexpressing RTN3 Is Adversely Affected by Preformed Dystrophic Neurites

(2009) Q. Shi et al.   JOURNAL OF NEUROSCIENCE

S655 phosphorylation enhances APP secretory traffic

(2009) Sandra Isabel Vieira et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The Orphan G Protein-Coupled Receptor 3 Modulates Amyloid-Beta Peptide Generation in Neurons

(2009) A. Thathiah et al.   SCIENCE

Assembly, Maturation, and Trafficking of the γ-Secretase Complex in Alzheimers Disease

(2008) Daniel Dries et al.   Current Alzheimer Research

Intracellular trafficking of LRP9 is dependent on two acidic cluster/dileucine motifs

(2008) Rémi Boucher et al.   HISTOCHEMISTRY AND CELL BIOLOGY

A Novel Sorting Nexin Modulates Endocytic Trafficking and α-Secretase Cleavage of the Amyloid Precursor Protein

(2008) Susanne Schöbel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Amyloid β-Protein Precursor by Phosphorylation and Protein Interactions

(2008) Toshiharu Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adaptor Protein Sorting Nexin 17 Regulates Amyloid Precursor Protein Trafficking and Processing in the Early Endosomes

(2008) Jiyeon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sortilin-related Receptor with A-type Repeats (SORLA) Affects the Amyloid Precursor Protein-dependent Stimulation of ERK Signaling and Adult Neurogenesis

(2008) Michael Rohe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Acidic Dileucine Signals in LRP9 that Interact with Both GGAs and AP-1/AP-2

(2008) Balraj Doray et al.   TRAFFIC

Mint3/X11γ Is an ADP-Ribosylation Factor-dependent Adaptor that Regulates the Traffic of the Alzheimer's Precursor Protein from the Trans-Golgi Network

(2007) Punya Shrivastava-Ranjan et al.   MOLECULAR BIOLOGY OF THE CELL