Protein Phosphorylation is a Key Mechanism in Alzheimer’s Disease

Patología vascular: ¿causa o efecto en la enfermedad de Alzheimer?

(2018) S. Rius-Pérez et al.   NEUROLOGIA

Binding of Hsp90 to Tau Promotes a Conformational Change and Aggregation of Tau Protein

(2017) Elena Tortosa et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's Disease: From Mitochondrial Perturbations to Mitochondrial Medicine

(2016) Susana Cardoso et al.   BRAIN PATHOLOGY

The amyloid cascade hypothesis: are we poised for success or failure?

(2016) Eric Karran et al.   JOURNAL OF NEUROCHEMISTRY

Altered protein phosphorylation as a resource for potential AD biomarkers

(2016) Ana Gabriela Henriques et al.   Scientific Reports

Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis

(2015) Kirsten L. Viola et al.   ACTA NEUROPATHOLOGICA

Neurodegenerative Diseases: Expanding the Prion Concept

(2015) Lary C. Walker et al.   Annual Review of Neuroscience

Protein phosphatase 1 is a key player in nuclear events

(2015) Sandra Rebelo et al.   CELLULAR SIGNALLING

The metabolism hypothesis of Alzheimer’s disease: from the concept of central insulin resistance and associated consequences to insulin therapy

(2015) Katrin Morgen et al.   JOURNAL OF NEURAL TRANSMISSION

The effect of Aβ and PKC on actin network remodelling

(2015) A. G. Henriques et al.   MICROSCOPY AND MICROANALYSIS

Dual-specificity phosphatases: critical regulators with diverse cellular targets

(2015) Kate I. Patterson et al.   BIOCHEMICAL JOURNAL

Highly potent soluble amyloid-β seeds in human Alzheimer brain but not cerebrospinal fluid

(2014) Sarah K. Fritschi et al.   BRAIN

The N-terminal fragment of the β-amyloid precursor protein of Alzheimer's disease (N-APP) binds to phosphoinositide-rich domains on the surface of hippocampal neurons

(2014) Edgar Dawkins et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives

(2013) Russell H. Swerdlow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Innate Immunity in Alzheimer’s Disease: A Complex Affair

(2013) Marie-Victoire Guillot-Sestier et al.   CNS & Neurological Disorders-Drug Targets

Isomerase Pin1 Stimulates Dephosphorylation of Tau Protein at Cyclin-dependent Kinase (Cdk5)-dependent Alzheimer Phosphorylation Sites

(2013) Taeko Kimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prostate-derived Sterile 20-like Kinases (PSKs/TAOKs) Phosphorylate Tau Protein and Are Activated in Tangle-bearing Neurons in Alzheimer Disease

(2013) Ignatius A. Tavares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global Analysis of Phosphorylation of Tau by the Checkpoint Kinases Chk1 and Chk2 in vitro

(2013) Jhoana Mendoza et al.   JOURNAL OF PROTEOME RESEARCH

Maintaining genome stability in the nervous system

(2013) Peter J McKinnon   NATURE NEUROSCIENCE

The case for soluble Aβ oligomers as a drug target in Alzheimer's disease

(2013) Franz Hefti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The role of APP and BACE1 trafficking in APP processing and amyloid-β generation

(2013) Xiaojie Zhang et al.   Alzheimers Research & Therapy

Amyloid β-protein oligomers and Alzheimer’s disease

(2013) Eric Y Hayden et al.   Alzheimers Research & Therapy

Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

(2013) L. Mucke et al.   Cold Spring Harbor Perspectives in Medicine

Neurovascular Dysfunction and Faulty Amyloid  -Peptide Clearance in Alzheimer Disease

(2013) A. P. Sagare et al.   Cold Spring Harbor Perspectives in Medicine

The PP1 binding code: a molecular-lego strategy that governs specificity

(2012) Ewald Heroes et al.   FEBS Journal

Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain

(2012) Sven O. Dahms et al.   JOURNAL OF MOLECULAR BIOLOGY

Protein Phosphatase 1γ Isoforms Linked Interactions in the Brain

(2012) Sara L. C. Esteves et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Nitric Oxide Decreases the Enzymatic Activity of Insulin Degrading Enzyme in APP/PS1 Mice

(2012) Markus P. Kummer et al.   Journal of Neuroimmune Pharmacology

Protein Phosphatase 1α Interacting Proteins in the Human Brain

(2012) Sara L.C. Esteves et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Epidermal growth factor receptor is a preferred target for treating Amyloid- -induced memory loss

(2012) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease

(2012) Sascha Weggen et al.   Alzheimers Research & Therapy

Neurochemical biomarkers in Alzheimer’s disease and related disorders

(2012) Mirko Bibl et al.   Therapeutic Advances in Neurological Disorders

The E2 Domains of APP and APLP1 Share a Conserved Mode of Dimerization

(2011) Sangwon Lee et al.   BIOCHEMISTRY

Aberrant phosphorylation in the pathogenesis of Alzheimer's disease

(2011) Sul-Hee Chung   BMB Reports

Alzheimer's dementia begins as a disease of small blood vessels, damaged by oxidative-induced inflammation and dysregulated amyloid metabolism: implications for early detection and therapy

(2011) Vincent T. Marchesi   FASEB JOURNAL

Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau

(2011) Alessia Usardi et al.   FEBS Journal

Prolyl Isomerase Pin1 Promotes Amyloid Precursor Protein (APP) Turnover by Inhibiting Glycogen Synthase Kinase-3β (GSK3β) Activity

(2011) Suk Ling Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics

(2011) Susanne M. Pritchard et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Identification and characterization of a neuronal enriched novel transcript encoding the previously described p60Fe65 isoform

(2011) Sara Catarina Domingues et al.   JOURNAL OF NEUROCHEMISTRY

Alzheimer's disease: synapses gone cold

(2011) Robert M Koffie et al.   Molecular Neurodegeneration

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease

(2011) Sergio T. Ferreira et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Post-translational modifications of tau protein: Implications for Alzheimer's disease

(2011) Ludovic Martin et al.   NEUROCHEMISTRY INTERNATIONAL

The Intracellular Threonine of Amyloid Precursor Protein That Is Essential for Docking of Pin1 Is Dispensable for Developmental Function

(2011) Alessia P. M. Barbagallo et al.   PLoS One

MicroRNAs miR-221 and miR-222: a new level of regulation in aggressive breast cancer

(2011) Maitri Y Shah et al.   Genome Medicine

Monte Carlo Simulations of Tau Proteins: Effect of Phosphorylation

(2010) Y.S. Jho et al.   BIOPHYSICAL JOURNAL

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

The Physiological Relevance of Protein Phosphatase 1 and its Interacting Proteins to Health and Disease

(2010) M. Fardilha et al.   CURRENT MEDICINAL CHEMISTRY

Parkinsonian Neurotoxin 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and α-Synuclein Mutations Promote Tau Protein Phosphorylation at Ser262and Destabilize Microtubule Cytoskeletonin Vitro

(2010) Hamid Y. Qureshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsc70 Rapidly Engages Tau after Microtubule Destabilization

(2010) Umesh K. Jinwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of APP-CTF-AICD domains and interaction with adaptor proteins: signal transduction and/or transcriptional role - relevance for Alzheimer pathology

(2010) Gennaro Schettini et al.   JOURNAL OF NEUROCHEMISTRY

Link Between DYRK1A Overexpression and Several-Fold Enhancement of Neurofibrillary Degeneration With 3-Repeat Tau Protein in Down Syndrome

(2010) Jerzy Wegiel et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Testing the amyloid hypothesis of Alzheimer's disease in vivo

(2010) Sam Gandy   LANCET NEUROLOGY

Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated

(2010) Sandra I Vieira et al.   Molecular Neurodegeneration

Relationship Between Tau Pathology and Neuroinflammation in Alzheimer's Disease

(2010) Maria Jose Metcalfe et al.   MOUNT SINAI JOURNAL OF MEDICINE

Amyloid Precursor Protein Binding Protein-1 Modulates Cell Cycle Progression in Fetal Neural Stem Cells

(2010) Yuyoung Joo et al.   PLoS One

A role for FKBP52 in Tau protein function

(2010) B. Chambraud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's Disease: From Pathology to Therapeutic Approaches

(2009) Roland Jakob-Roetne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Conformational Changes Specific for Pseudophosphorylation at Serine 262 Selectively Impair Binding of Tau to Microtubules

(2009) Daniela Fischer et al.   BIOCHEMISTRY

Animal models reveal role for tau phosphorylation in human disease

(2009) Jürgen Götz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Single domain response regulators: molecular switches with emerging roles in cell organization and dynamics

(2009) Urs Jenal et al.   CURRENT OPINION IN MICROBIOLOGY

Αβ Hinders Nuclear Targeting of AICD and Fe65 in Primary Neuronal Cultures

(2009) A. G. Henriques et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Pin1 affects Tau phosphorylation in response to Aβ oligomers

(2009) Alessandra Bulbarelli et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The interactome of the amyloid β precursor protein family members is shaped by phosphorylation of their intracellular domains

(2009) Robert Tamayev et al.   Molecular Neurodegeneration

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

(2009) Diane P. Hanger et al.   TRENDS IN MOLECULAR MEDICINE

The tau code

(2009) Jesus Avila   Frontiers in Aging Neuroscience

Displacement affinity chromatography of protein phosphatase one (PP1) complexes

(2008) Greg BG Moorhead et al.   BMC BIOCHEMISTRY

Biochemistry of Tau in Alzheimer’s disease and related neurological disorders

(2008) Nicolas Sergeant et al.   Expert Review of Proteomics

Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome

(2008) Fei Liu et al.   FASEB JOURNAL

Phosphorylation Regulates Tau Interactions with Src Homology 3 Domains of Phosphatidylinositol 3-Kinase, Phospholipase Cγ1, Grb2, and Src Family Kinases

(2008) C. Hugh Reynolds et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-221/222 Confers Tamoxifen Resistance in Breast Cancer by Targeting p27Kip1

(2008) Tyler E. Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Building γ-secretase – the bits and pieces

(2008) Dragana Spasic et al.   JOURNAL OF CELL SCIENCE

Neurochemical approaches of cerebrospinal fluid diagnostics in neurodegenerative diseases

(2008) Markus Otto et al.   METHODS

Tumor Necrosis Factor-α–elicited Stimulation of γ-Secretase Is Mediated by c-Jun N-terminal Kinase-dependent Phosphorylation of Presenilin and Nicastrin

(2008) Lan-Hsin Kuo et al.   MOLECULAR BIOLOGY OF THE CELL

Appearance modeling of 11C PiB PET images: Characterizing amyloid deposition in Alzheimer's disease, mild cognitive impairment and healthy aging

(2008) Jurgen Fripp et al.   NEUROIMAGE

Linking Aβ and Tau in Late-Onset Alzheimer's Disease: A Dual Pathway Hypothesis

(2008) Scott A. Small et al.   NEURON

PP1 inhibition by Aβ peptide as a potential pathological mechanism in Alzheimer's disease

(2008) Ana Paula B. Vintém et al.   NEUROTOXICOLOGY AND TERATOLOGY

The microtubule-associated protein tau is phosphorylated by Syk

(2007) Thibaud Lebouvier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Phosphorylation of thr668 in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3)

(2003) Claire L. Standen et al.   JOURNAL OF NEUROCHEMISTRY