Death-Associated Protein Kinase 1 Phosphorylation in Neuronal Cell Death and Neurodegenerative Disease

Role of DAPK1 in neuronal cell death, survival and diseases in the nervous system

(2019) Maryam Sulaiman Alsaadi   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

DAPK1-ERK signal mediates oxygen glucose deprivation reperfusion induced apoptosis in mouse N2a cells

(2018) Wei Xiong et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Death-associated protein kinase (DAPK) family modulators: Current and future therapeutic outcomes

(2018) Ahmed Karam Farag et al.   MEDICINAL RESEARCH REVIEWS

Neuronal Cell Death

(2018) Michael Fricker et al.   PHYSIOLOGICAL REVIEWS

Phosphorylation of Tau by Death-Associated Protein Kinase 1 Antagonizes the Kinase-Induced Cell Apoptosis

(2018) Dong-Xiao Duan et al.   JOURNAL OF ALZHEIMERS DISEASE

MicroRNA-26a/Death-associated protein kinase 1 signaling induces synucleinopathy and dopaminergic neuron degeneration in Parkinson’s disease

(2018) Ying Su et al.   BIOLOGICAL PSYCHIATRY

First-in-class DAPK1/CSF1R dual inhibitors: Discovery of 3,5-dimethoxy-N-(4-(4-methoxyphenoxy)-2-((6-morpholinopyridin-3-yl)amino)pyrimidin-5-yl)benzamide as a potential anti-tauopathies agent

(2018) Ahmed Karam Farag et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals

(2018) Mohamed Elbadawy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuronal Cell Death Mechanisms in Major Neurodegenerative Diseases

(2018) Hao Chi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Death-Associated Protein Kinase 1 As A Promising Drug Target In Cancer and Alzheimer’s Disease

(2018) Dongmei Chen et al.   Recent Patents on Anti-Cancer Drug Discovery

Exploring putative inhibitors of Death Associated Protein Kinase 1 (DAPK1) via targeting Gly- Glu -Leu (G E L) and Pro- Glu -Asn (P E N) substrate recognition motifs

(2017) Pratibha Singh et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

(2017) Q-z Tuo et al.   MOLECULAR PSYCHIATRY

Uncoupling DAPK1 from NMDA receptor GluN2B subunit exerts rapid antidepressant-like effects

(2017) S-X Li et al.   MOLECULAR PSYCHIATRY

Stroke: Tau — a new target in acute brain ischaemia

(2017) Peter Sidaway   Nature Reviews Neurology

Tau exacerbates excitotoxic brain damage in an animal model of stroke

(2017) Mian Bi et al.   Nature Communications

Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae

(2017) Onder Albayram et al.   Nature Communications

PP2A mediates apoptosis or autophagic cell death in multiple myeloma cell lines

(2017) Hang Zhou et al.   Oncotarget

Death-associated protein kinase 1 phosphorylates NDRG2 and induces neuronal cell death

(2016) Mi-Hyeon You et al.   CELL DEATH AND DIFFERENTIATION

Inhibition of death-associated protein kinase 1 attenuates the phosphorylation and amyloidogenic processing of amyloid precursor protein

(2016) Byeong Mo Kim et al.   HUMAN MOLECULAR GENETICS

Regulation of Beclin 1 Protein Phosphorylation and Autophagy by Protein Phosphatase 2A (PP2A) and Death-associated Protein Kinase 3 (DAPK3)

(2016) Nobuyuki Fujiwara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DAPK1 Signaling Pathways in Stroke: from Mechanisms to Therapies

(2016) Shan Wang et al.   MOLECULAR NEUROBIOLOGY

Death-Associated Protein Kinase Activity Is Regulated by Coupled Calcium/Calmodulin Binding to Two Distinct Sites

(2016) Bertrand Simon et al.   STRUCTURE

DANGER is involved in high glucose-induced radioresistance through inhibiting DAPK-mediated anoikis in non-small cell lung cancer

(2016) TaeWoo Kwon et al.   Oncotarget

Function and regulation of tau conformations in the development and treatment of traumatic brain injury and neurodegeneration

(2016) Onder Albayram et al.   Cell and Bioscience

Potential of the Antibody Against cis–Phosphorylated Tau in the Early Diagnosis, Treatment, and Prevention of Alzheimer Disease and Brain Injury

(2016) Kun Ping Lu et al.   JAMA Neurology

Death Associated Protein Kinase 1 (DAPK1): A Regulator of Apoptosis and Autophagy

(2016) Pratibha Singh et al.   Frontiers in Molecular Neuroscience

Programmed Necrosis in the Cross Talk of Cell Death and Inflammation

(2015) Francis Ka-Ming Chan et al.   Annual Review of Immunology

Death Associated Protein Kinase (DAPK) -mediated neurodegenerative mechanisms in nematode excitotoxicity

(2015) John S Del Rosario et al.   BMC NEUROSCIENCE

Novel Cancer Therapeutics with Allosteric Modulation of the Mitochondrial C-Raf-DAPK Complex by Raf Inhibitor Combination Therapy

(2015) Y.-T. Tsai et al.   CANCER RESEARCH

A Novel Mechanism of Spine Damages in Stroke via DAPK1 and Tau

(2015) Lei Pei et al.   CEREBRAL CORTEX

Death-associated protein kinase: A molecule with functional antagonistic duality and a potential role in inflammatory bowel disease (Review)

(2015) SARA STEINMANN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Structural Insight into the Interactions between Death-Associated Protein Kinase 1 and Natural Flavonoids

(2015) Takeshi Yokoyama et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy

(2015) Asami Kondo et al.   NATURE

Identification and Characterization of a Small-Molecule Inhibitor of Death-Associated Protein Kinase 1

(2014) Theis S. Wilbek et al.   CHEMBIOCHEM

DAPK1-p53 Interaction Converges Necrotic and Apoptotic Pathways of Ischemic Neuronal Death

(2014) L. Pei et al.   JOURNAL OF NEUROSCIENCE

Rapid and reversible knockdown of endogenous proteins by peptide-directed lysosomal degradation

(2014) Xuelai Fan et al.   NATURE NEUROSCIENCE

Extrasynaptic NMDA Receptor Involvement in Central Nervous System Disorders

(2014) Matthew P. Parsons et al.   NEURON

Death-associated protein kinase 1 has a critical role in aberrant tau protein regulation and function

(2014) B M Kim et al.   Cell Death & Disease

Fluorescence Linked Enzyme Chemoproteomic Strategy for Discovery of a Potent and Selective DAPK1 and ZIPK Inhibitor

(2013) David A. Carlson et al.   ACS Chemical Biology

Role of DAPK in neuronal cell death

(2013) Yuki Fujita et al.   APOPTOSIS

Regulation of inflammation by DAPK

(2013) Ming-Zong Lai et al.   APOPTOSIS

The DAPK family: a structure–function analysis

(2013) Ruth Shiloh et al.   APOPTOSIS

The DAP-kinase interactome

(2013) Shani Bialik et al.   APOPTOSIS

Protein post-translational modifications and regulation of pluripotency in human stem cells

(2013) Yu-Chieh Wang et al.   CELL RESEARCH

Death Associated Protein Kinases: Molecular Structure and Brain Injury

(2013) Syam Nair et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Oxygen Glucose Deprivation (OGD)/Re-Oxygenation-Induced In Vitro Neuronal Cell Death Involves Mitochondrial Cyclophilin-D/P53 Signaling Axis

(2013) Li-Ping Zhao et al.   NEUROCHEMICAL RESEARCH

Structural and Functional Characterization of the Recombinant Death Domain from Death-Associated Protein Kinase

(2013) Evangelos Dioletis et al.   PLoS One

Mitochondrial Phosphorylation in Apoptosis: Flipping the Death Switch

(2012) Natalie M. Niemi et al.   ANTIOXIDANTS & REDOX SIGNALING

Proline Isomer-Specific Antibodies Reveal the Early Pathogenic Tau Conformation in Alzheimer's Disease

(2012) Kazuhiro Nakamura et al.   CELL

Novel Ser/Thr Protein Phosphatases in Cell Death Regulation

(2012) Haipeng Sun et al.   PHYSIOLOGY

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

DAPK activates MARK1/2 to regulate microtubule assembly, neuronal differentiation and tau toxicity

(2011) P-R Wu et al.   CELL DEATH AND DIFFERENTIATION

GTP binding to the ROC domain of DAP-kinase regulates its function through intramolecular signalling

(2011) Rodrigo Carlessi et al.   EMBO REPORTS

Peptidyl-prolyl cis–trans isomerase Pin1 in ageing, cancer and Alzheimer disease

(2011) Tae Ho Lee et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Death-Associated Protein Kinase 1 Phosphorylates Pin1 and Inhibits Its Prolyl Isomerase Activity and Cellular Function

(2011) Tae Ho Lee et al.   MOLECULAR CELL

A Critical Role for GluN2B-Containing NMDA Receptors in Cortical Development and Function

(2011) Chih-Chieh Wang et al.   NEURON

The roles of amyloid precursor protein (APP) in neurogenesis

(2011) Zhi-dong Zhou et al.   Cell Adhesion & Migration

Structure–activity relationship of novel DAPK inhibitors identified by structure-based virtual screening

(2010) Masako Okamoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY

DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke

(2010) Weihong Tu et al.   CELL

Blocking the Deadly Effects of the NMDA Receptor in Stroke

(2010) Henry G.S. Martin et al.   CELL

Death-associated protein kinase 1 variation and Parkinson’s disease

(2010) J. C. Dachsel et al.   EUROPEAN JOURNAL OF NEUROLOGY

The N-myc downstream regulated gene (NDRG) family: diverse functions, multiple applications

(2010) Veerle Melotte et al.   FASEB JOURNAL

Molecular mechanisms of neurodegeneration in Alzheimer's disease

(2010) L. Crews et al.   HUMAN MOLECULAR GENETICS

Tau protein: Relevance to Parkinson's disease

(2010) Peng Lei et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Protein Phosphatase 2A (PP2A) Holoenzymes Regulate Death-associated Protein Kinase (DAPK) in Ceramide-induced Anoikis

(2010) Ryan C. Widau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Death-Associated Protein Kinase-Mediated Cell Death Modulated by Interaction with DANGER

(2010) B. N. Kang et al.   JOURNAL OF NEUROSCIENCE

The Dependence Receptor UNC5H2/B Triggers Apoptosis via PP2A-Mediated Dephosphorylation of DAP Kinase

(2010) Céline Guenebeaud et al.   MOLECULAR CELL

Post-translational modifications in signal integration

(2010) Yonathan Lissanu Deribe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Autophagy Is Activated by TGF-  and Potentiates TGF- -Mediated Growth Inhibition in Human Hepatocellular Carcinoma Cells

(2009) K. Kiyono et al.   CANCER RESEARCH

DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy

(2009) Einat Zalckvar et al.   EMBO REPORTS

Death-associated protein kinase (DAPK) and signal transduction: fine-tuning of autophagy in Caenorhabditis elegans homeostasis

(2009) Chanhee Kang et al.   FEBS Journal

Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death

(2009) Yao Lin et al.   FEBS Journal

Death-associated protein kinase (DAPK) and signal transduction: regulation in cancer

(2009) Alison M. Michie et al.   FEBS Journal

ERK and cell death: Mechanisms of ERK-induced cell death - apoptosis, autophagy and senescence

(2009) Sebastien Cagnol et al.   FEBS Journal

The alternative splice variant of DAPK-1, s-DAPK-1, induces proteasome-independent DAPK-1 destabilization

(2009) Yao Lin et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Protein phosphatase 2A regulatory subunits and cancer

(2008) Pieter J.A. Eichhorn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Role of JNK1-dependent Bcl-2 Phosphorylation in Ceramide-induced Macroautophagy

(2008) Sophie Pattingre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling

(2008) Adrienne M. Gorman   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL