The Conundrum of GSK3 Inhibitors: Is it the Dawn of a New Beginning?

Treatment of Alzheimer's Disease with the GSK-3 Inhibitor Tideglusib: A Pilot Study

(2018) Teodoro del Ser et al.   JOURNAL OF ALZHEIMERS DISEASE

Pancreas-Specific Delivery of β-Cell Proliferating Small Molecules

(2016) Xueshi Hao et al.   ChemMedChem

Inhibition of DYRK1A and GSK3B induces human β-cell proliferation

(2015) Weijun Shen et al.   Nature Communications

Rats treated with AZD2858, a GSK3 inhibitor, heal fractures rapidly without endochondral bone formation

(2013) Gregor Sisask et al.   BONE

AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans

(2013) Biljana Georgievska et al.   JOURNAL OF NEUROCHEMISTRY

GSK-3β overexpression causes reversible alterations on postsynaptic densities and dendritic morphology of hippocampal granule neurons in vivo

(2013) M Llorens-Martín et al.   MOLECULAR PSYCHIATRY

2012 Alzheimer’s disease facts and figures

(2012)   Alzheimers & Dementia

Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes

(2012) Philip T.T. Ly et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery of Novel Potent and Highly Selective Glycogen Synthase Kinase-3β (GSK3β) Inhibitors for Alzheimer’s Disease: Design, Synthesis, and Characterization of Pyrazines

(2012) Stefan Berg et al.   JOURNAL OF MEDICINAL CHEMISTRY

GSK-3 inhibition by an orally active small molecule increases bone mass in rats

(2011) Richard Marsell et al.   BONE

Tau Protein Is Required for Amyloid  -Induced Impairment of Hippocampal Long-Term Potentiation

(2011) O. A. Shipton et al.   JOURNAL OF NEUROSCIENCE

GSK-3α/β kinases and amyloid production in vivo

(2011) Tomasz Jaworski et al.   NATURE

Role of glycogen synthase kinase-3 in Alzheimer’s disease pathogenesis and glycogen synthase kinase-3 inhibitors

(2010) Jesús Avila et al.   Expert Review of Neurotherapeutics

Altered synaptic plasticity in the mossy fibre pathway of transgenic mice expressing mutant amyloid precursor protein

(2010) Jonathan Witton et al.   Molecular Brain

A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation

(2009) Dominik Paquet et al.   JOURNAL OF CLINICAL INVESTIGATION

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

(2009) Kurt R. Brunden et al.   NATURE REVIEWS DRUG DISCOVERY

A systematic investigation of the protein kinases involved in NMDA receptor-dependent LTD: evidence for a role of GSK-3 but not other serine/threonine kinases

(2009) Stéphane Peineau et al.   Molecular Brain