Macroalgae as a Valuable Source of Naturally Occurring Bioactive Compounds for the Treatment of Alzheimer’s Disease

Chemical characterization of sulfated polysaccharides from Gracilaria gracilis and Ulva lactuca and their radical scavenging, metal chelating, and cholinesterase inhibitory activities

(2019) Tosin A. Olasehinde et al.   INTERNATIONAL JOURNAL OF FOOD PROPERTIES

Aqueous–ethanol extracts of some South African seaweeds inhibit beta‐amyloid aggregation, cholinesterases, and beta‐secretase activities in vitro

(2019) Tosin A. Olasehinde et al.   JOURNAL OF FOOD BIOCHEMISTRY

Chlorella sorokiniana and Chlorella minutissima exhibit antioxidant potentials, inhibit cholinesterases and modulate disaggregation of β-amyloid fibrils

(2019) Tosin A. Olasehinde et al.   ELECTRONIC JOURNAL OF BIOTECHNOLOGY

Neuroprotective effects of some seaweeds against Zn – induced neuronal damage in HT-22 cells via modulation of redox imbalance, inhibition of apoptosis and acetylcholinesterase activity

(2019) Tosin A. Olasehinde et al.   METABOLIC BRAIN DISEASE

Eckmaxol, a Phlorotannin Extracted from Ecklonia maxima, Produces Anti-β-amyloid Oligomer Neuroprotective Effects Possibly via Directly Acting on Glycogen Synthase Kinase 3β

(2018) Jialing Wang et al.   ACS Chemical Neuroscience

Comparative study of selective in vitro and in silico BACE1 inhibitory potential of glycyrrhizin together with its metabolites, 18α- and 18β-glycyrrhetinic acid, isolated from Hizikia fusiformis

(2018) Aditi Wagle et al.   ARCHIVES OF PHARMACAL RESEARCH

Upgrading the antioxidant properties of fucoidan and alginate from Cystoseira trinodis by fungal fermentation or enzymatic pretreatment of the seaweed biomass

(2018) Awatief F. Hifney et al.   FOOD CHEMISTRY

Use of the brown seaweed Sargassum latifolium in the design of alginate-fucoidan based films with natural antioxidant properties and kinetic modeling of moisture sorption and polyphenolic release

(2018) Mohamed Gomaa et al.   FOOD HYDROCOLLOIDS

Microwave assisted extraction of phenolic compounds from four economic brown macroalgae species and evaluation of their antioxidant activities and inhibitory effects on α-amylase, α-glucosidase, pancreatic lipase and tyrosinase

(2018) Yuan Yuan et al.   FOOD RESEARCH INTERNATIONAL

Extraction and characterization of an alginate from the Iranian brown seaweed Nizimuddinia zanardini

(2018) Roya Abka Khajouei et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Neuroprotective effects of fucoxanthin and its derivative fucoxanthinol from the phaeophyte Undaria pinnatifida attenuate oxidative stress in hippocampal neurons

(2018) Md. Mohibbullah et al.   JOURNAL OF APPLIED PHYCOLOGY

Moringa oleifera supplemented diet modulates nootropic-related biomolecules in the brain of STZ-induced diabetic rats treated with acarbose

(2018) Ganiyu Oboh et al.   METABOLIC BRAIN DISEASE

In vitro protective activity of South Australian marine sponge and macroalgae extracts against amyloid beta (Aβ 1–42 ) induced neurotoxicity in PC-12 cells

(2018) Mousa Alghazwi et al.   NEUROTOXICOLOGY AND TERATOLOGY

Bioactive compounds from marine macroalgae and their hypoglycemic benefits

(2018) Chao Zhao et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Phlorotannin-rich fraction from Ishige foliacea brown seaweed prevents the scopolamine-induced memory impairment via regulation of ERK-CREB-BDNF pathway

(2018) Min Young Um et al.   Journal of Functional Foods

Fucoidan inhibits amyloid-β-induced toxicity in transgenic Caenorhabditis elegans by reducing the accumulation of amyloid-β and decreasing the production of reactive oxygen species

(2018) Xuelian Wang et al.   Food & Function

Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects

(2018) Rudimar L. Frozza et al.   Frontiers in Neuroscience

Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease

(2018) Fuyuki Kametani et al.   Frontiers in Neuroscience

Anti-neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer's Disease

(2018) Bushra Shal et al.   Frontiers in Pharmacology

Phloroglucinol ameliorates cognitive impairments by reducing the amyloid β peptide burden and pro-inflammatory cytokines in the hippocampus of 5XFAD mice

(2018) Eun-Jeong Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

In vitro and in silico evaluation of fucosterol from Sargassum horridum as potential human acetylcholinesterase inhibitor

(2018) E. S. Castro-Silva et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Fucosterol exerts protection against amyloid β-induced neurotoxicity, reduces intracellular levels of amyloid β and enhances the mRNA expression of neuroglobin in amyloid β-induced SH-SY5Y cells

(2018) Sook Yee Gan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Fucosterol from an Edible Brown Alga Ecklonia stolonifera Prevents Soluble Amyloid Beta-Induced Cognitive Dysfunction in Aging Rats

(2018) Jeong Oh et al.   Marine Drugs

Comparative study on neuroprotective activities of fucoidans from Fucus vesiculosus and Undaria pinnatifida

(2018) Mousa Alghazwi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Extraction of proteins from two marine macroalgae, Ulva sp. and Gracilaria sp., for food application, and evaluating digestibility, amino acid composition and antioxidant properties of the protein concentrates

(2018) Meital Kazir et al.   FOOD HYDROCOLLOIDS

In vitro amoebicidal and antioxidant activities of some Tunisian seaweeds

(2017) Olfa Chiboub et al.   EXPERIMENTAL PARASITOLOGY

Cytoprotective effect of seaweeds with high antioxidant activity from the Peniche coast (Portugal)

(2017) Susete Pinteus et al.   FOOD CHEMISTRY

Proximate composition, phenolic content and in vitro antioxidant activity of aqueous extracts of the seaweeds Ascophyllum nodosum , Bifurcaria bifurcata and Fucus vesiculosus . Effect of addition of the extracts on the oxidative stability of canola oil under accelerated storage conditions

(2017) Rubén Agregán et al.   FOOD RESEARCH INTERNATIONAL

Characterization of dietary fucoxanthin from Himanthalia elongata brown seaweed

(2017) Gaurav Rajauria et al.   FOOD RESEARCH INTERNATIONAL

Isolation of fucoidan from Sargassum polycystum brown algae: Structural characterization, in vitro antioxidant and anticancer activity

(2017) Subramanian Palanisamy et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Hypolipidaemic and antioxidant capacities of polysaccharides obtained from Laminaria japonica by different extraction media in diet-induced mouse model

(2017) Yujing Yao et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY

Fucoxanthin Inhibits β-Amyloid Assembly and Attenuates β-Amyloid Oligomer-Induced Cognitive Impairments

(2017) Siying Xiang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

An ethanol extract from the phaeophyte Undaria pinnatifida improves learning and memory impairment and dendritic spine morphology in hippocampal neurons

(2017) Ji-Young Choi et al.   JOURNAL OF APPLIED PHYCOLOGY

Cholinergic modulation of the hippocampal region and memory function

(2017) Juhee Haam et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid and Tau Pathology in Normal Cognitive Aging

(2017) Emilie T. Reas   JOURNAL OF NEUROSCIENCE

Extraction and Identification of Phlorotannins from the Brown Alga, Sargassum fusiforme (Harvey) Setchell

(2017) Yajing Li et al.   Marine Drugs

Protective Effects of Fucoidan on Aβ25–35 and d-Gal-Induced Neurotoxicity in PC12 Cells and d-Gal-Induced Cognitive Dysfunction in Mice

(2017) Hengyun Wei et al.   Marine Drugs

Therapeutic Potentials of Microalgae in the Treatment of Alzheimer’s Disease

(2017) Tosin Olasehinde et al.   MOLECULES

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

An extract of the marine alga Alaria esculenta modulates α-synuclein folding and amyloid formation

(2017) James C. Giffin et al.   NEUROSCIENCE LETTERS

Fucoxanthin, a Marine Carotenoid, Attenuates β-Amyloid Oligomer-Induced Neurotoxicity Possibly via Regulating the PI3K/Akt and the ERK Pathways in SH-SY5Y Cells

(2017) Jiajia Lin et al.   Oxidative Medicine and Cellular Longevity

Gelidiella acerosa protects against Aβ 25–35-induced toxicity and memory impairment in Swiss Albino mice: an in vivo report

(2017) Syad Arif Nisha et al.   PHARMACEUTICAL BIOLOGY

Antioxidant properties of phlorotannins from brown seaweed Cystoseira trinodis (Forsskål) C. Agardh

(2017) R. Sathya et al.   Arabian Journal of Chemistry

Fucoxanthin prevents H2O2-induced neuronal apoptosis via concurrently activating the PI3-K/Akt cascade and inhibiting the ERK pathway

(2017) Jie Yu et al.   Food & Nutrition Research

Fucoxanthin provides neuroprotection in models of traumatic brain injury via the Nrf2-ARE and Nrf2-autophagy pathways

(2017) Li Zhang et al.   Scientific Reports

Structural elucidation and protective role of a polysaccharide from Sargassum fusiforme on ameliorating learning and memory deficiencies in mice

(2016) Pei Hu et al.   CARBOHYDRATE POLYMERS

Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

(2016) Yu Yamazaki et al.   CNS DRUGS

Kinetics and molecular docking studies of fucosterol and fucoxanthin, BACE1 inhibitors from brown algae Undaria pinnatifida and Ecklonia stolonifera

(2016) Hyun Ah Jung et al.   FOOD AND CHEMICAL TOXICOLOGY

Antioxidant activities of crude extracts of fucoidan extracted from Sargassum glaucescens by a compressional-puffing-hydrothermal extraction process

(2016) Chun-Yung Huang et al.   FOOD CHEMISTRY

Industrial optimization of fucoidan extraction from Sargassum sp. and its potential antioxidant and emulsifying activities

(2016) Awatief F. Hifney et al.   FOOD HYDROCOLLOIDS

Identification and characterization of phenolic antioxidant compounds from brown Irish seaweed Himanthalia elongata using LC-DAD–ESI-MS/MS

(2016) Gaurav Rajauria et al.   Innovative Food Science & Emerging Technologies

Neuroprotective activities of natural products from marine macroalgae during 1999–2015

(2016) Mousa Alghazwi et al.   JOURNAL OF APPLIED PHYCOLOGY

The pigments of kelps (Ochrophyta) as part of the flexible response to highly variable marine environments

(2016) Fátima Fernandes et al.   JOURNAL OF APPLIED PHYCOLOGY

Algae as nutritional and functional food sources: revisiting our understanding

(2016) Mark L. Wells et al.   JOURNAL OF APPLIED PHYCOLOGY

Fucoxanthin, a Marine Carotenoid, Reverses Scopolamine-Induced Cognitive Impairments in Mice and Inhibits Acetylcholinesterase in Vitro

(2016) Jiajia Lin et al.   Marine Drugs

Antimicrobial Action of Compounds from Marine Seaweed

(2016) María Pérez et al.   Marine Drugs

Neuroprotective effect of the marine macroalgaGelidiella acerosa: identification of active compounds through bioactivity-guided fractionation

(2016) Arif Nisha Syad et al.   PHARMACEUTICAL BIOLOGY

Bioactive extracts of red seaweeds Pterocladiella capillacea and Osmundaria obtusiloba (Floridophyceae: Rhodophyta) with antioxidant and bacterial agglutination potential

(2016) Daniel Barroso de Alencar et al.   Asian Pacific Journal of Tropical Medicine

Identification and efficient extraction method of phlorotannins from the brown seaweed Macrocystis pyrifera using an orthogonal experimental design

(2016) A. Leyton et al.   Algal Research-Biomass Biofuels and Bioproducts

Phlorofucofuroeckol Improves Glutamate-Induced Neurotoxicity through Modulation of Oxidative Stress-Mediated Mitochondrial Dysfunction in PC12 Cells

(2016) Jwa-Jin Kim et al.   PLoS One

The Edible Red Alga Porphyra yezoensis Promotes Neuronal Survival and Cytoarchitecture in Primary Hippocampal Neurons

(2015) Md. Mohibbullah et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Anti-Alzheimers and anti-inflammatory activities of a glycoprotein purified from the edible brown alga Undaria pinnatifida

(2015) S.M. Rafiquzzaman et al.   FOOD RESEARCH INTERNATIONAL

Multifunctional Activity of Polyphenolic Compounds Associated with a Potential for Alzheimer's Disease Therapy fromEcklonia cava

(2015) Byoung Wook Choi et al.   PHYTOTHERAPY RESEARCH

Antiaggregation Potential of Padina gymnospora against the Toxic Alzheimer’s Beta-Amyloid Peptide 25–35 and Cholinesterase Inhibitory Property of Its Bioactive Compounds

(2015) Balakrishnan Shanmuganathan et al.   PLoS One

Biological activities of two macroalgae from Adriatic coast of Montenegro

(2015) Marijana Kosanić et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Phloroglucinol Attenuates the Cognitive Deficits of the 5XFAD Mouse Model of Alzheimer’s Disease

(2015) Eun-Jeong Yang et al.   PLoS One

Advances in algal drug research with emphasis on enzyme inhibitors

(2014) Kannan R.R. Rengasamy et al.   BIOTECHNOLOGY ADVANCES

Phenolic profiles, antioxidant capacity, and acetylcholinesterase inhibitory activity of eight South African seaweeds

(2014) Kannan R. R. Rengasamy et al.   JOURNAL OF APPLIED PHYCOLOGY

Essential Oil from Lemon Peels Inhibit Key Enzymes Linked to Neurodegenerative Conditions and Pro-oxidant Induced Lipid Peroxidation

(2014) Ganiyu Oboh et al.   Journal of Oleo Science

Anticancer Effects of Different Seaweeds on Human Colon and Breast Cancers

(2014) Ghislain Moussavou et al.   Marine Drugs

Amyloid-Beta: A Crucial Factor in Alzheimer's Disease

(2014) Saeed Sadigh-Eteghad et al.   MEDICAL PRINCIPLES AND PRACTICE

Assessment of anti-amyloidogenic activity of marine red algaG. acerosaagainst Alzheimer’s beta-amyloid peptide 25–35

(2014) Arif Nisha Syad et al.   NEUROLOGICAL RESEARCH

High Activities of BACE1 in Brains with Mild Cognitive Impairment

(2013) Xin Cheng et al.   AMERICAN JOURNAL OF PATHOLOGY

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Oxidative Stress and the Pathogenesis of Alzheimer's Disease

(2013) Yan Zhao et al.   Oxidative Medicine and Cellular Longevity

BACE1 in Alzheimer's disease

(2012) M. Sathya et al.   CLINICA CHIMICA ACTA

Antioxidant Activity of Hawaiian Marine Algae

(2012) Dovi Kelman et al.   Marine Drugs

Current and future treatments for Alzheimer’s disease

(2012) Konstantina G. Yiannopoulou et al.   Therapeutic Advances in Neurological Disorders

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

Anatabine lowers Alzheimer's Aβ production in vitro and in vivo

(2011) Daniel Paris et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuroprotective Effects of Marine Algae

(2011) Ratih Pangestuti et al.   Marine Drugs

A review of antihypertensive and antioxidant activities in macroalgae

(2010) Michelle S. Tierney et al.   BOTANICA MARINA

Review Article: Genetics of Alzheimer Disease

(2010) Lynn M. Bekris et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Late onset Alzheimer’s disease in older people

(2010) Ahmet Turan Isik   Clinical Interventions in Aging

Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases

(2009) Xiao-xia Dong et al.   ACTA PHARMACOLOGICA SINICA

The Role of Apolipoprotein E in Alzheimer's Disease

(2009) Jungsu Kim et al.   NEURON