A Snapshot of The Tumor Microenvironment in Colorectal Cancer: The Liquid Biopsy

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Tumor Extracellular Matrix Remodeling: New Perspectives as a Circulating Tool in the Diagnosis and Prognosis of Solid Tumors

(2019) Marta Giussani et al.   Cells

Circulating Tumour Cells (CTC), Head and Neck Cancer and Radiotherapy; Future Perspectives

(2019) Vanathi Perumal et al.   Cancers

Cancer-associated fibroblasts in gastrointestinal cancer

(2019) Hiroki Kobayashi et al.   Nature Reviews Gastroenterology & Hepatology

Exosomes in the tumor microenvironment as mediators of cancer therapy resistance

(2019) Irene Li et al.   Molecular Cancer

Effects of exosomes on pre-metastatic niche formation in tumors

(2019) Yaxin Guo et al.   Molecular Cancer

Collagens and Cancer associated fibroblasts in the reactive stroma and its relation to Cancer biology

(2019) Neel I. Nissen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Macrophages derived exosomes deliver miR-223 to epithelial ovarian cancer cells to elicit a chemoresistant phenotype

(2019) Xiaolan Zhu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Oral mucosal mesenchymal stem cell‑derived exosomes: A potential therapeutic target in oral premalignant lesions

(2019) Wenwen Li et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Colorectal cancer exosomes induce lymphatic network remodeling in lymph nodes

(2019) Bo Sun et al.   INTERNATIONAL JOURNAL OF CANCER

Exosome-transferred lncRNAs at the core of cancer bone lesions

(2019) Nicolas Léveillé et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Clinical utility of circulating tumor DNA for colorectal cancer

(2019) Hiroki Osumi et al.   CANCER SCIENCE

Mesenchymal stem cell exosomes: a two-edged sword in cancer therapy

(2019) Faezeh Vakhshiteh et al.   International Journal of Nanomedicine

Loss of exosomal miR-3188 in cancer-associated fibroblasts contributes to HNC progression

(2019) Xiaoning Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Extracellular vesicles in the tumor microenvironment: old stories, but new tales

(2019) Liu Han et al.   Molecular Cancer

CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer

(2019) J. L. Hu et al.   Molecular Cancer

Snail1-dependent cancer-associated fibroblasts induce epithelial-mesenchymal transition in lung cancer cells via exosomes

(2019) J You et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Exosomal micro RNA s derived from colon cancer cells promote tumor progression by suppressing fibroblast TP 53 expression

(2019) Shunsuke Yoshii et al.   CANCER SCIENCE

Exosomal miRNA-106b from cancer-associated fibroblast promotes gemcitabine resistance in pancreatic cancer

(2019) Yuan Fang et al.   EXPERIMENTAL CELL RESEARCH

Exosomal transfer of miR‐124 inhibits normal fibroblasts to cancer‐associated fibroblasts transition by targeting sphingosine kinase 1 in ovarian cancer

(2019) Yuyang Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Exosomal transfer of p-STAT3 promotes acquired 5-FU resistance in colorectal cancer cells

(2019) Qian Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Macrophage-derived exosomal microRNA-501-3p promotes progression of pancreatic ductal adenocarcinoma through the TGFBR3-mediated TGF-β signaling pathway

(2019) Zi Yin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cancer‑associated fibroblast‑derived exosomal miR‑382‑5p promotes the migration and invasion of oral squamous cell carcinoma

(2019) Li‑Ping Sun et al.   ONCOLOGY REPORTS

The multifaceted role of mesenchymal stem cells in cancer

(2019) Michael Timaner et al.   SEMINARS IN CANCER BIOLOGY

ELK3 expressed in lymphatic endothelial cells promotes breast cancer progression and metastasis through exosomal miRNAs

(2019) Kwang-Soo Kim et al.   Scientific Reports

Functions of Exosomes in the Triangular Relationship between the Tumor, Inflammation, and Immunity in the Tumor Microenvironment

(2019) Tiantian Wang et al.   Journal of Immunology Research

Ontogeny of Tumor-Associated Macrophages

(2019) Marie Laviron et al.   Frontiers in Immunology

Accuracy of Tumour-Associated Circulating Endothelial Cells as a Screening Biomarker for Clinically Significant Prostate Cancer

(2019) Sebastian Chakrit Bhakdi et al.   Cancers

Anti-angiogenesis triggers exosomes release from endothelial cells to promote tumor vasculogenesis

(2019) Ye Zeng et al.   Journal of Extracellular Vesicles

Long noncoding RNA CCAL transferred from fibroblasts by exosomes promotes chemoresistance of colorectal cancer cells

(2019) Xuan Deng et al.   INTERNATIONAL JOURNAL OF CANCER

Enhancement of therapeutic potential of mesenchymal stem cell-derived extracellular vesicles

(2019) Kyong-Su Park et al.   Stem Cell Research & Therapy

A Novel Type of Blood Biomarker: Distinct Changes of Cytokine-Induced STAT Phosphorylation in Blood T Cells Between Colorectal Cancer Patients and Healthy Individuals

(2019) Yun et al.   Cancers

Drug-resistant endothelial cells facilitate progression, EMT and chemoresistance in nasopharyngeal carcinoma via exosomes

(2019) Limin Huang et al.   CELLULAR SIGNALLING

Cancer-derived exosomes trigger endothelial to mesenchymal transition followed by the induction of cancer-associated fibroblasts

(2018) Ju Hun Yeon et al.   Acta Biomaterialia

Altered monocyte differentiation and macrophage polarization patterns in patients with breast cancer

(2018) Chih-Hsing Hung et al.   BMC CANCER

Phase II study of bevacizumab, cisplatin, and docetaxel plus maintenance bevacizumab as first-line treatment for patients with advanced non-squamous non-small-cell lung cancer combined with exploratory analysis of circulating endothelial cells: Thoracic Oncology Research Group (TORG)1016

(2018) Satoshi Ikeda et al.   BMC CANCER

Colorectal cancer cell–derived exosomes containing miR-10b regulate fibroblast cells via the PI3K/Akt pathway

(2018) Guangyao Dai et al.   BULLETIN DU CANCER

New insights into the biological impacts of immune cell-derived exosomes within the tumor environment

(2018) Meng Shen et al.   CANCER LETTERS

A novel stromal lncRNA signature reprograms fibroblasts to promote the growth of oral squamous cell carcinoma via LncRNA-CAF/interleukin-33

(2018) Liang Ding et al.   CARCINOGENESIS

When worlds collide: Th17 and Treg cells in cancer and autoimmunity

(2018) Hannah M. Knochelmann et al.   Cellular & Molecular Immunology

Exosomes from mesenchymal stromal cells enhance imatinib-induced apoptosis in human leukemia cells via activation of caspase signaling pathway

(2018) Ying Liu et al.   CYTOTHERAPY

Potential roles of tumor-derived exosomes in angiogenesis

(2018) Nils Ludwig et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Horizontal transfer of exosomal CXCR4 promotes murine hepatocarcinoma cell migration, invasion and lymphangiogenesis

(2018) Min Li et al.   GENE

Role of T cell-derived exosomes in immunoregulation

(2018) Jian Lu et al.   IMMUNOLOGIC RESEARCH

Exosomes from heat-stressed tumour cells inhibit tumour growth by converting regulatory T cells to Th17 cells via IL-6

(2018) Danfeng Guo et al.   IMMUNOLOGY

Exosomes derived from exhausted CD8+ T cells impaired the anticancer function of normal CD8+ T cells

(2018) Xiaochen Wang et al.   JOURNAL OF MEDICAL GENETICS

Proteomic Analysis of Cancer-Associated Fibroblasts Reveals a Paracrine Role for MFAP5 in Human Oral Tongue Squamous Cell Carcinoma

(2018) Simona Principe et al.   JOURNAL OF PROTEOME RESEARCH

Circulating endothelial cells and microparticles as diagnostic and prognostic biomarkers in small-cell lung cancer

(2018) Fadi Najjar et al.   LUNG CANCER

Human cancer cells suppress behaviors of endothelial progenitor cells through miR-21 targeting IL6R

(2018) Wenbin Wang et al.   MICROVASCULAR RESEARCH

The influence of tumour-derived extracellular vesicles on local and distal metastatic dissemination

(2018) Laura Nogués et al.   MOLECULAR ASPECTS OF MEDICINE

Emerging role of exosome-derived long non-coding RNAs in tumor microenvironment

(2018) Zhenqiang Sun et al.   Molecular Cancer

Exosomes Induce Fibroblast Differentiation into Cancer-Associated Fibroblasts through TGFβ Signaling

(2018) Cassandra Ringuette Goulet et al.   MOLECULAR CANCER RESEARCH

Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: in vitro and in vivo evaluations

(2018) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells

(2018) Wei Yan et al.   NATURE CELL BIOLOGY

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Exosome-mediated transfer of lncRUNX2-AS1 from multiple myeloma cells to MSCs contributes to osteogenesis

(2018) Bingzong Li et al.   ONCOGENE

Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A

(2018) Kyoko Hashimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosome and mesenchymal stem cell cross-talk in the tumor microenvironment

(2018) Theresa L. Whiteside   SEMINARS IN IMMUNOLOGY

Size-Based Enrichment Technologies for Non-cancerous Tumor-Derived Cells in Blood

(2018) Jamie Mong et al.   TRENDS IN BIOTECHNOLOGY

Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19

(2018) Jing Ren et al.   Theranostics

Exosomes Released by Gastric Cancer Cells Induce Transition of Pericytes Into Cancer-Associated Fibroblasts

(2018) Xiaofei Ning et al.   MEDICAL SCIENCE MONITOR

Diagnostic value of peripheral blood immune profiling in colorectal cancer

(2018) Joungbum Choi et al.   Annals of Surgical Treatment and Research

A multicenter phase II trial of neoadjuvant letrozole plus low-dose cyclophosphamide in postmenopausal patients with estrogen receptor-positive breast cancer (JBCRG-07): therapeutic efficacy and clinical implications of circulating endothelial cells

(2018) Takayuki Ueno et al.   Cancer Medicine

Exosomes in cancer: small vesicular transporters for cancer progression and metastasis, biomarkers in cancer therapeutics

(2018) Atefe Abak et al.   PeerJ

M1 Macrophage-Derived Nanovesicles Potentiate the Anticancer Efficacy of Immune Checkpoint Inhibitors

(2018) Yeon Woong Choo et al.   ACS Nano

Exosomes from BM-MSCs increase the population of CSCs via transfer of miR-142-3p

(2018) Hongdan Li et al.   BRITISH JOURNAL OF CANCER

Transfer of miRNA in Macrophage-Derived Exosomes Induces Drug Resistance in Pancreatic Adenocarcinoma

(2018) Yoav Binenbaum et al.   CANCER RESEARCH

Colorectal cancer-derived small extracellular vesicles establish an inflammatory premetastatic niche in liver metastasis

(2018) Yingkuan Shao et al.   CARCINOGENESIS

Exosomal miR-27a Derived from Gastric Cancer Cells Regulates the Transformation of Fibroblasts into Cancer-Associated Fibroblasts

(2018) Jingya Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Brain microvascular endothelial cell exosome–mediated S100A16 up-regulation confers small-cell lung cancer cell survival in brain

(2018) Zhi-Hua Xu et al.   FASEB JOURNAL

Prodrug suicide gene therapy for cancer targeted intracellular by mesenchymal stem cell exosomes

(2018) Altanerova Ursula et al.   INTERNATIONAL JOURNAL OF CANCER

Blood-Based Cancer Biomarkers in Liquid Biopsy: A Promising Non-Invasive Alternative to Tissue Biopsy

(2018) José Marrugo-Ramírez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Loss of exosomal miR-148b from cancer-associated fibroblasts promotes endometrial cancer cell invasion and cancer metastasis

(2018) Bi-Lan Li et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Exosomes derived from mesenchymal stem cells enhance radiotherapy-induced cell death in tumor and metastatic tumor foci

(2018) Virgínea de Araujo Farias et al.   Molecular Cancer

Differential distribution and enrichment of non-coding RNAs in exosomes from normal and Cancer-associated fibroblasts in colorectal cancer

(2018) Mercedes Herrera et al.   Molecular Cancer

Shedding of bevacizumab in tumour cells-derived extracellular vesicles as a new therapeutic escape mechanism in glioblastoma

(2018) Thomas Simon et al.   Molecular Cancer

Cervical squamous cell carcinoma-secreted exosomal miR-221-3p promotes lymphangiogenesis and lymphatic metastasis by targeting VASH1

(2018) Chen-Fei Zhou et al.   ONCOGENE

Exosomal miR-1228 from cancer-associated fibroblasts promotes cell migration and invasion of osteosarcoma by directly targeting SCAI.

(2018) JIAN-WEI WANG et al.   ONCOLOGY RESEARCH

Potential Effect of Exosomes Derived from Cancer Stem Cells and MSCs on Progression of DEN-Induced HCC in Rats

(2018) Faisal A. Alzahrani et al.   Stem Cells International

A New Approach for Loading Anticancer Drugs Into Mesenchymal Stem Cell-Derived Exosome Mimetics for Cancer Therapy

(2018) Senthilkumar Kalimuthu et al.   Frontiers in Pharmacology

Latest development of liquid biopsy

(2018) Alvin Ho-Kwan Cheung et al.   Journal of Thoracic Disease

Cancer-associated fibroblasts contribute to oral cancer cells proliferation and metastasis via exosome-mediated paracrine miR-34a-5p

(2018) Yao-yin Li et al.   EBioMedicine

Predictive role of UCA1-containing exosomes in cetuximab-resistant colorectal cancer

(2018) Ying-nan Yang et al.   Cancer Cell International

M2 Macrophage-Derived Exosomes Promote Cell Migration and Invasion in Colon Cancer

(2018) Jingqin Lan et al.   CANCER RESEARCH

Liquid Biopsy for the Management of Patients with Colorectal Cancer

(2018) Takeshi Yamada et al.   DIGESTION

Effect of mesenchymal stem cells-derived exosomes on tumor microenvironment: Tumor progression versus tumor suppression

(2018) Samaneh Shojaei et al.   JOURNAL OF CELLULAR PHYSIOLOGY

APC-activated long noncoding RNA inhibits colorectal carcinoma pathogenesis through reduction of exosome production

(2018) Feng-Wei Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatocellular carcinoma-derived exosomal miRNA-21 contributes to tumor progression by converting hepatocyte stellate cells to cancer-associated fibroblasts

(2018) Yuan Zhou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Melanoma cell-secreted exosomal miR-155-5p induce proangiogenic switch of cancer-associated fibroblasts via SOCS1/JAK2/STAT3 signaling pathway

(2018) Xiaocheng Zhou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Exosomes Derived from Human Primary and Metastatic Colorectal Cancer Cells Contribute to Functional Heterogeneity of Activated Fibroblasts by Reprogramming Their Proteome

(2018) Alin Rai et al.   PROTEOMICS

Liquid biopsy in ovarian cancer: the potential of circulating miRNAs and exosomes

(2018) Lydia Giannopoulou et al.   Translational Research

Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis

(2018) Zhicheng Zeng et al.   Nature Communications

Diverse Long RNAs Are Differentially Sorted into Extracellular Vesicles Secreted by Colorectal Cancer Cells

(2018) Scott A. Hinger et al.   Cell Reports

Exosomes Released from Tumor-Associated Macrophages Transfer miRNAs That Induce a Treg/Th17 Cell Imbalance in Epithelial Ovarian Cancer

(2018) Jieru Zhou et al.   Cancer Immunology Research

Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells

(2017) Peiming Zheng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Regulated Polarization of Tumor-Associated Macrophages by miR-145 via Colorectal Cancer–Derived Extracellular Vesicles

(2017) Haruka Shinohara et al.   JOURNAL OF IMMUNOLOGY

Exo-MFA – A 13C metabolic flux analysis framework to dissect tumor microenvironment-secreted exosome contributions towards cancer cell metabolism

(2017) Abhinav Achreja et al.   METABOLIC ENGINEERING

Reduced adipogenesis after lung tumor exosomes priming in human mesenchymal stem cells via TGFβ signaling pathway

(2017) Shihua Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Exosomes from M1-Polarized Macrophages Potentiate the Cancer Vaccine by Creating a Pro-inflammatory Microenvironment in the Lymph Node

(2017) Lifang Cheng et al.   MOLECULAR THERAPY

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

Aberrant low expression of p85α in stromal fibroblasts promotes breast cancer cell metastasis through exosome-mediated paracrine Wnt10b

(2017) Y Chen et al.   ONCOGENE

Exosomes Derived From Hypoxic Colorectal Cancer Cells Promote Angiogenesis Through Wnt4-Induced β-Catenin Signaling in Endothelial Cells

(2017) Zhe Huang et al.   ONCOLOGY RESEARCH

Exosomes Derived from Irradiated Esophageal Carcinoma-Infiltrating T Cells Promote Metastasis by Inducing the Epithelial–Mesenchymal Transition in Esophageal Cancer Cells

(2017) Hua Min et al.   PATHOLOGY & ONCOLOGY RESEARCH

UBR2 Enriched in p53 Deficient Mouse Bone Marrow Mesenchymal Stem Cell-Exosome Promoted Gastric Cancer Progression via Wnt/β-Catenin Pathway

(2017) Jiahui Mao et al.   STEM CELLS

MicroRNA-100 shuttled by mesenchymal stem cell-derived exosomes suppresses in vitro angiogenesis through modulating the mTOR/HIF-1α/VEGF signaling axis in breast cancer cells

(2017) Katayoon Pakravan et al.   CELLULAR ONCOLOGY

Maintenance of cancer stemness by miR-196b-5p contributes to chemoresistance of colorectal cancer cells via activating STAT3 signaling pathway

(2017) Dong Ren et al.   Oncotarget

Prognostic value of circulating endothelial cells in metastatic colorectal cancer

(2017) Nuh N. Rahbari et al.   Oncotarget

Circulating exosomal microRNA-203 is associated with metastasis possibly via inducing tumor-associated macrophages in colorectal cancer

(2017) Yuki Takano et al.   Oncotarget

Cancer-associated fibroblasts release exosomal microRNAs that dictate an aggressive phenotype in breast cancer

(2017) Elvira Donnarumma et al.   Oncotarget

Exosomes Derived From Natural Killer Cells Exert Therapeutic Effect in Melanoma

(2017) Liya Zhu et al.   Theranostics

Exosomes from metastatic cancer cells transfer amoeboid phenotype to non-metastatic cells and increase endothelial permeability: their emerging role in tumor heterogeneity

(2017) Odessa Schillaci et al.   Scientific Reports

A randomized phase 3 study on the optimization of the combination of bevacizumab with FOLFOX/OXXEL in the treatment of patients with metastatic colorectal cancer-OBELICS (Optimization of BEvacizumab scheduLIng within Chemotherapy Scheme)

(2016) Antonio Avallone et al.   BMC CANCER

Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA

(2016) Le Qu et al.   CANCER CELL

Circulating Cancer-Associated Macrophage-Like Cells Differentiate Malignant Breast Cancer and Benign Breast Conditions

(2016) D. L. Adams et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Mesenchymal Stem Cell–Derived Exosomes Stimulate Cycling Quiescence and Early Breast Cancer Dormancy in Bone Marrow

(2016) Sarah A. Bliss et al.   CANCER RESEARCH

The emerging roles of exosomes in tumor–stroma interaction

(2016) Hailong Fu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Lung tumor exosomes induce a pro-inflammatory phenotype in mesenchymal stem cells via NFκB-TLR signaling pathway

(2016) Xiaoxia Li et al.   Journal of Hematology & Oncology

Exosomes derived from human mesenchymal stem cells promote gastric cancer cell growth and migration via the activation of the Akt pathway

(2016) Hongbing Gu et al.   Molecular Medicine Reports

Melanosomes foster a tumour niche by activating CAFs

(2016) Susana García-Silva et al.   NATURE CELL BIOLOGY

Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells

(2016) K E Richards et al.   ONCOGENE

Colorectal cancer cell-derived microRNA200 modulates the resistance of adjacent blood endothelial barriers in vitro

(2016) Silvio Holzner et al.   ONCOLOGY REPORTS

Tumor-derived circulating endothelial cell clusters in colorectal cancer

(2016) I. Cima et al.   Science Translational Medicine

Exosome-mediated delivery of miR-9 induces cancer-associated fibroblast-like properties in human breast fibroblasts

(2016) S Baroni et al.   Cell Death & Disease

Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1

(2016) Chi Lam Au Yeung et al.   Nature Communications

Colorectal cancer cell-derived extracellular vesicles induce phenotypic alteration of T cells into tumor-growth supporting cells with transforming growth factor-β1-mediated suppression

(2016) Nami Yamada et al.   Oncotarget

Cytoskeleton-centric protein transportation by exosomes transforms tumor-favorable macrophages

(2016) Zhipeng Chen et al.   Oncotarget

Clinical relevance of circulating mucosal-associated invariant T cell levels and their anti-cancer activity in patients with mucosal-associated cancer

(2016) Eun Jeong Won et al.   Oncotarget

Exosomes from human colorectal cancer induce a tumor-like behavior in colonic mesenchymal stromal cells

(2016) Luana Lugini et al.   Oncotarget

Podoplanin is a component of extracellular vesicles that reprograms cell-derived exosomal proteins and modulates lymphatic vessel formation

(2016) Patricia Carrasco-Ramírez et al.   Oncotarget

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

(2016) Hongyun Zhao et al.   eLife

Cells release subpopulations of exosomes with distinct molecular and biological properties

(2016) Eduard Willms et al.   Scientific Reports

Excessive collagen turnover products are released during colorectal cancer progression and elevated in serum from metastatic colorectal cancer patients

(2016) S. N. Kehlet et al.   Scientific Reports

Human adipose mesenchymal stem cell-derived exosomal-miRNAs are critical factors for inducing anti-proliferation signalling to A2780 and SKOV-3 ovarian cancer cells

(2016) Abu Musa Md Talimur Reza et al.   Scientific Reports

Macrophage-secreted Exosomes Delivering miRNA-21 Inhibitor can Regulate BGC-823 Cell Proliferation

(2015) Jian-Jun Wang et al.   Asian Pacific Journal of Cancer Prevention

Circulating tumor cells (CTC) and KRAS mutant circulating free DNA (cfDNA) detection in peripheral blood as biomarkers in patients diagnosed with exocrine pancreatic cancer

(2015) Julie Earl et al.   BMC CANCER

Identification of Cancer-Associated Fibroblasts in Circulating Blood from Patients with Metastatic Breast Cancer

(2015) Z. Ao et al.   CANCER RESEARCH

Exosomes derived from human mesenchymal stem cells confer drug resistance in gastric cancer

(2015) Runbi Ji et al.   CELL CYCLE

Circulating Endothelial Cells and Their Subpopulations: Role as Predictive Biomarkers in Antiangiogenic Therapy for Colorectal Cancer

(2015) Mariangela Manzoni et al.   Clinical Colorectal Cancer

Loss of miR-200 family in 5-fluorouracil resistant colon cancer drives lymphendothelial invasiveness in vitro

(2015) D. Senfter et al.   HUMAN MOLECULAR GENETICS

Increased pre-surgical numbers of endothelial progenitor cells and circulating endothelial cells in colorectal cancer fail to predict outcome

(2015) K. S. Ramcharan et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Lung cancer exosomes initiate global long non-coding RNA changes in mesenchymal stem cells

(2015) SHIHUA WANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma

(2015) Guohua Lou et al.   Journal of Hematology & Oncology

M-Trap: Exosome-Based Capture of Tumor Cells as a New Technology in Peritoneal Metastasis

(2015) Alexandre de la Fuente et al.   JNCI-Journal of the National Cancer Institute

CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA

(2015) Alice Conigliaro et al.   Molecular Cancer

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Investigation of the roles of exosomes in colorectal cancer liver metastasis

(2015) XIA WANG et al.   ONCOLOGY REPORTS

Stroma derived COL6A3 is a potential prognosis marker of colorectal carcinoma revealed by quantitative proteomics

(2015) Jie Qiao et al.   Oncotarget

Circulating and tumor-infiltrating Tim-3 in patients with colorectal cancer

(2015) Benling Xu et al.   Oncotarget

Extracellular vesicles derived from renal cancer stem cells induce a pro-tumorigenic phenotype in mesenchymal stromal cells

(2015) Rafael Soares Lindoso et al.   Oncotarget

Cancer exosomes trigger mesenchymal stem cell differentiation into pro-angiogenic and pro-invasive myofibroblasts

(2015) Ridwana Chowdhury et al.   Oncotarget

Endothelial exosomes contribute to the antitumor response during breast cancer neoadjuvant chemotherapy via microRNA transfer

(2015) Nicolas Bovy et al.   Oncotarget

M-Trap: Exosome-Based Capture of Tumor Cells as a New Technology in Peritoneal Metastasis

(2015) Alexandre de la Fuente et al.   JNCI-Journal of the National Cancer Institute

Fibroblast-Derived Exosomes Contribute to Chemoresistance through Priming Cancer Stem Cells in Colorectal Cancer

(2015) Yibing Hu et al.   PLoS One

A Novel Strategy for Detection and Enumeration of Circulating Rare Cell Populations in Metastatic Cancer Patients Using Automated Microfluidic Filtration and Multiplex Immunoassay

(2015) Mark Jesus M. Magbanua et al.   PLoS One

Serum endostatin levels are elevated in colorectal cancer and correlate with invasion and systemic inflammatory markers

(2014) T Kantola et al.   BRITISH JOURNAL OF CANCER

A five-microRNA panel in plasma was identified as potential biomarker for early detection of gastric cancer

(2014) C Zhu et al.   BRITISH JOURNAL OF CANCER

Endothelial CD276 (B7-H3) expression is increased in human malignancies and distinguishes between normal and tumour-derived circulating endothelial cells

(2014) J Kraan et al.   BRITISH JOURNAL OF CANCER

Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways

(2014) Mirjam C. Boelens et al.   CELL

MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 Cells

(2014) Isobel S. Okoye et al.   IMMUNITY

Combined evaluation of a panel of protein and miRNA serum-exosome biomarkers for pancreatic cancer diagnosis increases sensitivity and specificity

(2014) Bindhu Madhavan et al.   INTERNATIONAL JOURNAL OF CANCER

Correction: Colorectal Cancer Stem Cells Are Enriched in Xenogeneic Tumors Following Chemotherapy

(2014) Scott J. Dylla et al.   PLoS One

Exosomes Derived from Mesenchymal Stem Cells Suppress Angiogenesis by Down-Regulating VEGF Expression in Breast Cancer Cells

(2014) Jong-Kuen Lee et al.   PLoS One

CD4+ T Cells Expressing Latency-Associated Peptide and Foxp3 Are an Activated Subgroup of Regulatory T Cells Enriched in Patients with Colorectal Cancer

(2014) Jayashri Mahalingam et al.   PLoS One

Discovery and Validation of New Potential Biomarkers for Early Detection of Colon Cancer

(2014) Xavier Solé et al.   PLoS One

Egr-1 Activation by Cancer-Derived Extracellular Vesicles Promotes Endothelial Cell Migration via ERK1/2 and JNK Signaling Pathways

(2014) Yae Jin Yoon et al.   PLoS One

Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells

(2014) M. Ono et al.   Science Signaling

Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

(2014) C. Bettegowda et al.   Science Translational Medicine

Endothelial cells require miR-214 to secrete exosomes that suppress senescence and induce angiogenesis in human and mouse endothelial cells

(2013) B. W. M. van Balkom et al.   BLOOD

The pre-metastatic niche: finding common ground

(2013) Jaclyn Sceneay et al.   CANCER AND METASTASIS REVIEWS

Tumor-Stroma Interaction: Revealing Fibroblast-Secreted Exosomes as Potent Regulators of Wnt-Planar Cell Polarity Signaling in Cancer Metastasis

(2013) V. Luga et al.   CANCER RESEARCH

Mobilization of Viable Tumor Cells Into the Circulation During Radiation Therapy

(2013) Olga A. Martin et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

BM mesenchymal stromal cell–derived exosomes facilitate multiple myeloma progression

(2013) Aldo M. Roccaro et al.   JOURNAL OF CLINICAL INVESTIGATION

Exosomes from human adipose-derived mesenchymal stem cells promote migration through Wnt signaling pathway in a breast cancer cell model

(2013) Ruizhu Lin et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules

(2013) Anand Ramteke et al.   MOLECULAR CARCINOGENESIS

Influence of tumour micro-environment heterogeneity on therapeutic response

(2013) Melissa R. Junttila et al.   NATURE

Liquid biopsy: monitoring cancer-genetics in the blood

(2013) Emily Crowley et al.   Nature Reviews Clinical Oncology

Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer

(2013) Sarah-Jane Dawson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Activated T Cell Exosomes Promote Tumor Invasion via Fas Signaling Pathway

(2012) Z. Cai et al.   JOURNAL OF IMMUNOLOGY

Immune Surveillance Properties of Human NK Cell-Derived Exosomes

(2012) L. Lugini et al.   JOURNAL OF IMMUNOLOGY

Exosome removal as a therapeutic adjuvant in cancer

(2012) Annette M Marleau et al.   Journal of Translational Medicine

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Gastric Cancer Exosomes Trigger Differentiation of Umbilical Cord Derived Mesenchymal Stem Cells to Carcinoma-Associated Fibroblasts through TGF-β/Smad Pathway

(2012) Jianmei Gu et al.   PLoS One

Circulating fibroblast-like cells in men with metastatic prostate cancer

(2012) Michelle L. Jones et al.   PROSTATE

Circulating Tumor Cells and Circulating Tumor DNA

(2011) Catherine Alix-Panabières et al.   Annual Review of Medicine

Exosomes from ovarian cancer cells induce adipose tissue-derived mesenchymal stem cells to acquire the physical and functional characteristics of tumor-supporting myofibroblasts

(2011) Jung Ah Cho et al.   GYNECOLOGIC ONCOLOGY

Cancer Exosomes Express CD39 and CD73, Which Suppress T Cells through Adenosine Production

(2011) A. Clayton et al.   JOURNAL OF IMMUNOLOGY

MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins

(2011) Kasey C. Vickers et al.   NATURE CELL BIOLOGY

Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma

(2011) J. D. Arroyo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detection and isolation of cell-derived microparticles are compromised by protein complexes resulting from shared biophysical parameters

(2010) B. Gyorgy et al.   BLOOD

Relevance of circulating tumor cells, extracellular nucleic acids, and exosomes in breast cancer

(2010) Anne M. Friel et al.   BREAST CANCER RESEARCH AND TREATMENT

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

Cancer Exosomes Trigger Fibroblast to Myofibroblast Differentiation

(2010) J. Webber et al.   CANCER RESEARCH

Prognostic significance of circulating tumor cells in patients with metastatic colorectal cancer

(2009) S. J. Cohen et al.   ANNALS OF ONCOLOGY

Colorectal cancer cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endothelial cells

(2009) Bok Hong et al.   BMC GENOMICS