Role of T cell-derived exosomes in immunoregulation

Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

(2018) Tian Tian et al.   BIOMATERIALS

Proinflammatory role of blister fluid-derived exosomes in bullous pemphigoid

(2018) Hui Fang et al.   JOURNAL OF PATHOLOGY

Long Non-Coding RNA HOXA Transcript Antisense RNA Myeloid-Specific 1–HOXA1 Axis Downregulates the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells in Lung Cancer

(2018) Xinyu Tian et al.   Frontiers in Immunology

Roles of Macrophage Exosomes in Immune Response to Calcium Oxalate Monohydrate Crystals

(2018) Nilubon Singhto et al.   Frontiers in Immunology

Identification of non-invasive miRNAs biomarkers for prostate cancer by deep sequencing analysis of urinary exosomes

(2017) Marta Rodríguez et al.   Molecular Cancer

Exosomes derived from gemcitabine-resistant cells transfer malignant phenotypic traits via delivery of miRNA-222-3p

(2017) Feng Wei et al.   Molecular Cancer

Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment

(2017) Sadna Budhu et al.   Science Signaling

The HBx gene of hepatitis B virus can influence hepatic microenvironment via exosomes by transferring its mRNA and protein

(2017) Neetu Rohit Kapoor et al.   VIRUS RESEARCH

Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment

(2017) Sadna Budhu et al.   Science Signaling

Serum exosomes as predictors of clinical response to ipilimumab in metastatic melanoma

(2017) Marco Tucci et al.   OncoImmunology

ICOS Promotes the Function of CD4+Effector T Cells during Anti-OX40–Mediated Tumor Rejection

(2016) Todd C. Metzger et al.   CANCER RESEARCH

The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes

(2016) Shu Wen Wen et al.   CANCER RESEARCH

CD40L expression by CD4+but not CD8+T cells regulates antiviral immune responses in acute LCMV infection in mice

(2016) Sibel Durlanik et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4+T-cell responses

(2016) Yingping Xu et al.   IMMUNOLOGY

c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes

(2016) Rachel M. DeRita et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Exosomes derived from dendritic cells improve cardiac function via activation of CD4+ T lymphocytes after myocardial infarction

(2016) Haibo Liu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis

(2015) Yan Li et al.   CELL RESEARCH

Macrophages play an essential role in antigen-specific immune suppression mediated by T CD8+cell-derived exosomes

(2015) Katarzyna Nazimek et al.   IMMUNOLOGY

Acquisition of new tumor cell properties by MSC-derived exosomes

(2015) YUANYUAN YANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Exosomes from Dendritic Cells Loaded with Chaperone-Rich Cell Lysates Elicit a Potent T Cell Immune Response Against Intracranial Glioma in Mice

(2015) Ning Bu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

(2015) Sonia A. Melo et al.   NATURE

Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio

(2015) Tianzhi Yang et al.   PHARMACEUTICAL RESEARCH

Improved Characterization of EV Preparations Based on Protein to Lipid Ratio and Lipid Properties

(2015) Xabier Osteikoetxea et al.   PLoS One

Human CD4+CD39+regulatory T cells produce adenosine upon co-expression of surface CD73 or contact with CD73+exosomes or CD73+cells

(2014) P. J. Schuler et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 Cells

(2014) Isobel S. Okoye et al.   IMMUNITY

Th17/Treg Cells Imbalance and GITRL Profile in Patients with Hashimoto’s Thyroiditis

(2014) Yingzhao Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosomes Derived from Burkitt's Lymphoma Cell Lines Induce Proliferation, Differentiation, and Class-Switch Recombination in B Cells

(2014) C. Gutzeit et al.   JOURNAL OF IMMUNOLOGY

CD47-dependent immunomodulatory and angiogenic activities of extracellular vesicles produced by T cells

(2014) Sukhbir Kaur et al.   MATRIX BIOLOGY

Exosomes in human semen carry a distinctive repertoire of small non-coding RNAs with potential regulatory functions

(2014) L. Vojtech et al.   NUCLEIC ACIDS RESEARCH

Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes

(2014) J P Webber et al.   ONCOGENE

Anti-VEGF-A Affects the Angiogenic Properties of Tumor-Derived Microparticles

(2014) Michal Munster et al.   PLoS One

Exosomes from IL-1β stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes

(2014) Tomohiro Kato et al.   ARTHRITIS RESEARCH & THERAPY

Regulatory T Cell-Derived Exosomes: Possible Therapeutic and Diagnostic Tools in Transplantation

(2014) Akansha Agarwal et al.   Frontiers in Immunology

Exosomes as new vesicular lipid transporters involved in cell–cell communication and various pathophysiologies

(2013) Michel Record et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

CD169 mediates the capture of exosomes in spleen and lymph node

(2013) S. C. Saunderson et al.   BLOOD

CD4+CD25+ regulatory T cells-derived exosomes prolonged kidney allograft survival in a rat model

(2013) Xuesong Yu et al.   CELLULAR IMMUNOLOGY

CD73 expression on extracellular vesicles derived from CD4+CD25+Foxp3+T cells contributes to their regulatory function

(2013) Lesley Ann Smyth et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity

(2013) Krzysztof Bryniarski et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Exosome Secretion Is Enhanced by Invadopodia and Drives Invasive Behavior

(2013) Daisuke Hoshino et al.   Cell Reports

Hijacking Multivesicular Bodies Enables Long-Term and Exosome-Mediated Long-Distance Action of Anthrax Toxin

(2013) Laurence Abrami et al.   Cell Reports

Circulating Microparticles as Disease-Specific Biomarkers of Severity of Inflammation in Patients With Hepatitis C or Nonalcoholic Steatohepatitis

(2012) Miroslaw Kornek et al.   GASTROENTEROLOGY

Toward tailored exosomes: The exosomal tetraspanin web contributes to target cell selection

(2012) Sanyukta Rana et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Exosomes: New players in cell–cell communication

(2012) Claudia Bang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Activated T Cell Exosomes Promote Tumor Invasion via Fas Signaling Pathway

(2012) Z. Cai et al.   JOURNAL OF IMMUNOLOGY

Immune Surveillance Properties of Human NK Cell-Derived Exosomes

(2012) L. Lugini et al.   JOURNAL OF IMMUNOLOGY

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells

(2012) Shayne A. Bellingham et al.   NUCLEIC ACIDS RESEARCH

Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions

(2012) Esther N. M. Nolte-’t Hoen et al.   NUCLEIC ACIDS RESEARCH

Activated Human T Cells Secrete Exosomes That Participate in IL-2 Mediated Immune Response Signaling

(2012) Jessica Wahlgren et al.   PLoS One

Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes

(2011) A. Montecalvo et al.   BLOOD

Immunosuppressive exosomes from TGF-β1 gene-modified dendritic cells attenuate Th17-mediated inflammatory autoimmune disease by inducing regulatory T cells

(2011) Zhijian Cai et al.   CELL RESEARCH

CD4+ T cell-released exosomes inhibit CD8+ cytotoxic T-lymphocyte responses and antitumor immunity

(2011) Haifeng Zhang et al.   Cellular & Molecular Immunology

Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor- 1

(2011) M. J. Szczepanski et al.   HAEMATOLOGICA

Increased Frequency of Follicular Helper T Cells in Patients with Autoimmune Thyroid Disease

(2011) Chenlu Zhu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cancer Exosomes Express CD39 and CD73, Which Suppress T Cells through Adenosine Production

(2011) A. Clayton et al.   JOURNAL OF IMMUNOLOGY

ExoCarta 2012: database of exosomal proteins, RNA and lipids

(2011) S. Mathivanan et al.   NUCLEIC ACIDS RESEARCH

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

(2011) María Mittelbrunn et al.   Nature Communications

Contribution of MyD88 to the Tumor Exosome-Mediated Induction of Myeloid Derived Suppressor Cells

(2010) Yuelong Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

Dendritic Cells Recruit T Cell Exosomes via Exosomal LFA-1 Leading to Inhibition of CD8+ CTL Responses through Downregulation of Peptide/MHC Class I and Fas Ligand-Mediated Cytotoxicity

(2010) Y. Xie et al.   JOURNAL OF IMMUNOLOGY

The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation

(2010) Hua-Chen Chang et al.   NATURE IMMUNOLOGY

Proinflammatory exosomes in bronchoalveolar lavage fluid of patients with sarcoidosis

(2010) K. R. Qazi et al.   THORAX

Noncytotoxic Suppression of Human Immunodeficiency Virus Type 1 Transcription by Exosomes Secreted from CD8+ T Cells

(2009) A. Tumne et al.   JOURNAL OF VIROLOGY

ExoCarta: A compendium of exosomal proteins and RNA

(2009) Suresh Mathivanan et al.   PROTEOMICS

Induction of myeloid-derived suppressor cells by tumor exosomes

(2008) Xiaoyu Xiang et al.   INTERNATIONAL JOURNAL OF CANCER

B lymphocytes and macrophages release cell membrane deposited C3-fragments on exosomes with T cell response-enhancing capacity☆

(2008) Krisztián Papp et al.   MOLECULAR IMMUNOLOGY

Dendritic Cells Release HLA-B-Associated Transcript-3 Positive Exosomes to Regulate Natural Killer Function

(2008) Venkateswara Rao Simhadri et al.   PLoS One