When worlds collide: Th17 and Treg cells in cancer and autoimmunity

High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy

(2018) Carsten Krieg et al.   NATURE MEDICINE

Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis

(2017) Madhav Kishore et al.   IMMUNITY

Pooled Analysis Safety Profile of Nivolumab and Ipilimumab Combination Therapy in Patients With Advanced Melanoma

(2017) Mario Sznol et al.   JOURNAL OF CLINICAL ONCOLOGY

STAT4 and T-bet control follicular helper T cell development in viral infections

(2017) Jason S. Weinstein et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ex-Th17 (Nonclassical Th1) Cells Are Functionally Distinct from Classical Th1 and Th17 Cells and Are Not Constrained by Regulatory T Cells

(2017) Sharee A. Basdeo et al.   JOURNAL OF IMMUNOLOGY

Reversing SKI–SMAD4-mediated suppression is essential for TH17 cell differentiation

(2017) Song Zhang et al.   NATURE

Corrigendum: Is autoimmunity the Achilles' heel of cancer immunotherapy?

(2017) Carl H June et al.   NATURE MEDICINE

Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

(2017) Jedd D. Wolchok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reversal of Autoimmune Toxicity and Loss of Tumor Response by Interleukin-17 Blockade

(2017) Khashayar Esfahani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Altered homeostasis and development of regulatory T cell subsets represent an IL-2R–dependent risk for diabetes in NOD mice

(2017) Connor J. Dwyer et al.   Science Signaling

Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment

(2017) Sadna Budhu et al.   Science Signaling

Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells

(2017) Stephanie Downs-Canner et al.   Nature Communications

Transcription factor Foxo1 is essential for IL-9 induction in T helper cells

(2017) Sakshi Malik et al.   Nature Communications

Altered homeostasis and development of regulatory T cell subsets represent an IL-2R–dependent risk for diabetes in NOD mice

(2017) Connor J. Dwyer et al.   Science Signaling

Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment

(2017) Sadna Budhu et al.   Science Signaling

Secukinumab in Active Rheumatoid Arthritis: A Phase III Randomized, Double-Blind, Active Comparator- and Placebo-Controlled Study

(2017) Francisco J. Blanco et al.   Arthritis & Rheumatology

The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells

(2017) Fabienne Andris et al.   Frontiers in Immunology

Late presentation of generalised bullous pemphigoid-like reaction in a patient treated with pembrolizumab for metastatic melanoma

(2016) Sagun Parakh et al.   AUSTRALASIAN JOURNAL OF DERMATOLOGY

Worse outcome in breast cancer with higher tumor-infiltrating FOXP3+ Tregs : a systematic review and meta-analysis

(2016) Jiafeng Shou et al.   BMC CANCER

Surface Expression of TGFβ Docking Receptor GARP Promotes Oncogenesis and Immune Tolerance in Breast Cancer

(2016) Alessandra Metelli et al.   CANCER RESEARCH

Dermatologic complications of anti-PD-1/PD-L1 immune checkpoint antibodies

(2016) Vincent Sibaud et al.   CURRENT OPINION IN ONCOLOGY

Autoimmune dermatologic toxicities from immune checkpoint blockade with anti-PD-1 antibody therapy: a report on bullous skin eruptions

(2016) George Jour et al.   JOURNAL OF CUTANEOUS PATHOLOGY

Activity of secukinumab, an anti-IL-17A antibody, on brain lesions in RRMS: results from a randomized, proof-of-concept study

(2016) Eva Havrdová et al.   JOURNAL OF NEUROLOGY

Cutaneous adverse events (AEs) of anti-programmed cell death (PD)-1 therapy in patients with metastatic melanoma: A single-institution cohort

(2016) Shelley Ji Eun Hwang et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Anti-PD1-induced psoriasis: a study of 21 patients

(2016) J. Bonigen et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Pembrolizumab for patients with PD-L1-positive advanced gastric cancer (KEYNOTE-012): a multicentre, open-label, phase 1b trial

(2016) Kei Muro et al.   LANCET ONCOLOGY

Clinical and Histologic Features of Lichenoid Mucocutaneous Eruptions Due to Anti–Programmed Cell Death 1 and Anti–Programmed Cell Death Ligand 1 Immunotherapy

(2016) Veronica J. Shi et al.   JAMA Dermatology

Association of Vitiligo With Tumor Response in Patients With Metastatic Melanoma Treated With Pembrolizumab

(2016) Camille Hua et al.   JAMA Dermatology

IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment

(2015) Luciana Benevides et al.   CANCER RESEARCH

Controversies concerning thymus-derived regulatory T cells: fundamental issues and a new perspective

(2015) Masahiro Ono et al.   IMMUNOLOGY AND CELL BIOLOGY

Disturbed Th17/Treg Balance in Patients with Non-small Cell Lung Cancer

(2015) Min-Chao Duan et al.   INFLAMMATION

TIGIT predominantly regulates the immune response via regulatory T cells

(2015) Sema Kurtulus et al.   JOURNAL OF CLINICAL INVESTIGATION

Immune Mechanisms in Arterial Hypertension

(2015) U. Wenzel et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

(2015) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis

(2015) Yonghao Cao et al.   Science Translational Medicine

Baseline circulating IL-17 predicts toxicity while TGF-β1 and IL-10 are prognostic of relapse in ipilimumab neoadjuvant therapy of melanoma

(2015) Ahmad A. Tarhini et al.   Journal for ImmunoTherapy of Cancer

A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy

(2015) Robert D. Leone et al.   Computational and Structural Biotechnology Journal

IL-1β promotes Th17 differentiation by inducing alternative splicing of FOXP3

(2015) Reiner K. W. Mailer et al.   Scientific Reports

Th17 and regulatory T cell balance in autoimmune and inflammatory diseases

(2014) Mélissa Noack et al.   AUTOIMMUNITY REVIEWS

Control of the Inheritance of Regulatory T Cell Identity by a cis Element in the Foxp3 Locus

(2014) Yongqiang Feng et al.   CELL

Emerging role of IL-17 and Th17 cells in systemic lupus erythematosus

(2014) Jérôme C. Martin et al.   CLINICAL IMMUNOLOGY

T Follicular Helper Cell Differentiation, Function, and Roles in Disease

(2014) Shane Crotty   IMMUNITY

Induction of IL-17+ T Cell Trafficking and Development by IFN- : Mechanism and Pathological Relevance in Psoriasis

(2014) I. Kryczek et al.   JOURNAL OF IMMUNOLOGY

IL-23 Promotes Maintenance but Not Commitment to the Th17 Lineage

(2014) G. L. Stritesky et al.   JOURNAL OF IMMUNOLOGY

The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells

(2014) Frédérique Végran et al.   NATURE IMMUNOLOGY

TH9 cells that express the transcription factor PU.1 drive T cell–mediated colitis via IL-9 receptor signaling in intestinal epithelial cells

(2014) Katharina Gerlach et al.   NATURE IMMUNOLOGY

An Increased Abundance of Tumor-Infiltrating Regulatory T Cells Is Correlated with the Progression and Prognosis of Pancreatic Ductal Adenocarcinoma

(2014) Yichen Tang et al.   PLoS One

Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer

(2014) E. Tran et al.   SCIENCE

Th17 Cells in Cancer: The Ultimate Identity Crisis

(2014) Stefanie R. Bailey et al.   Frontiers in Immunology

Utilizing Regulatory T Cells Against Rheumatoid Arthritis

(2014) Mohammad Haque et al.   Frontiers in Oncology

Essentials of Th17 cell commitment and plasticity

(2013) P. Muranski et al.   BLOOD

Systematic Analysis of Donor and Isolation Factor's Impact on Human Islet Yield and Size Distribution

(2013) Y. Wang et al.   CELL TRANSPLANTATION

Th9 cell development requires a BATF-regulated transcriptional network

(2013) Rukhsana Jabeen et al.   JOURNAL OF CLINICAL INVESTIGATION

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

(2013) Markus Kleinewietfeld et al.   NATURE

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

(2013) Noriko Komatsu et al.   NATURE MEDICINE

Correlations between Psoriasis and Inflammatory Bowel Diseases

(2013) Nevena Skroza et al.   Biomed Research International

Brief Report: Inhibition of interleukin-6 function corrects Th17/Treg cell imbalance in patients with rheumatoid arthritis

(2012) Maxime Samson et al.   ARTHRITIS AND RHEUMATISM

New insights of T cells in the pathogenesis of psoriasis

(2012) Yihua Cai et al.   Cellular & Molecular Immunology

CD4+T Cells: Differentiation and Functions

(2012) Rishi Vishal Luckheeram et al.   Clinical & Developmental Immunology

Distinctive features of classic and nonclassic (Th17 derived) human Th1 cells

(2012) Laura Maggi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-22 from T Cells: Better Late than Never

(2012) Kenya Honda   IMMUNITY

Th22 Cells Are an Important Source of IL-22 for Host Protection against Enteropathogenic Bacteria

(2012) Rajatava Basu et al.   IMMUNITY

The Emerging Role of IL-17 in the Pathogenesis of Psoriasis: Preclinical and Clinical Findings

(2012) David A. Martin et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation

(2012) N. Bollig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory T cell migration during an immune response

(2012) Yaozhong Ding et al.   TRENDS IN IMMUNOLOGY

Clinical Impact of Different Classes of Infiltrating T Cytotoxic and Helper Cells (Th1, Th2, Treg, Th17) in Patients with Colorectal Cancer

(2011) Marie Tosolini et al.   CANCER RESEARCH

Th17 Cells Are Long Lived and Retain a Stem Cell-like Molecular Signature

(2011) Pawel Muranski et al.   IMMUNITY

Foxp3+ Regulatory T Cells of Psoriasis Patients Easily Differentiate into IL-17A-Producing Cells and Are Found in Lesional Skin

(2011) H. Jorn Bovenschen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells

(2011) Wataru Ise et al.   NATURE IMMUNOLOGY

IL-17C regulates the innate immune function of epithelial cells in an autocrine manner

(2011) Vladimir Ramirez-Carrozzi et al.   NATURE IMMUNOLOGY

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

(2011) Xiang-Ping Yang et al.   NATURE IMMUNOLOGY

Th1/Th17 Cell Induction and Corresponding Reduction in ATP Consumption following Vaccination with the Novel Mycobacterium tuberculosis Vaccine MVA85A

(2011) Kristin L. Griffiths et al.   PLoS One

Human TH17 Cells Are Long-Lived Effector Memory Cells

(2011) I. Kryczek et al.   Science Translational Medicine

Deciphering the role of Th17 cells in human disease

(2011) Cailin Moira Wilke et al.   TRENDS IN IMMUNOLOGY

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Suppression of experimental allergic encephalomyelitis by intraventricular administration of interferon-gamma in Lewis rats

(2010) J. A. C. VOORTHUIS et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Interferon-Regulatory Factor 4 Is Essential for the Developmental Program of T Helper 9 Cells

(2010) Valérie Staudt et al.   IMMUNITY

Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells

(2010) Hsin-Jung Wu et al.   IMMUNITY

IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice

(2010) John S. Cho et al.   JOURNAL OF CLINICAL INVESTIGATION

Naive tumor-specific CD4+T cells differentiated in vivo eradicate established melanoma

(2010) Ying Xie et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Th17 Cells Are the Dominant T Cell Subtype Primed by Shigella flexneri Mediating Protective Immunity

(2010) Gernot Sellge et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: IL-23 Receptor Deficiency Prevents the Development of Lupus Nephritis in C57BL/6-lpr/lpr Mice

(2010) V. C. Kyttaris et al.   JOURNAL OF IMMUNOLOGY

A role for the transcription factor Helios in human CD4+CD25+ regulatory T cells

(2010) Derese Getnet et al.   MOLECULAR IMMUNOLOGY

Targeting IL-17 and Th17 Cells in Rheumatoid Arthritis

(2010) Sujata Sarkar et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells

(2010) J. J. O'Shea et al.   SCIENCE

The Emerging Toxicity Profiles of Anti–CTLA-4 Antibodies Across Clinical Indications

(2010) Anna Maria Di Giacomo et al.   SEMINARS IN ONCOLOGY

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Abundant c-Fas-associated death domain-like interleukin-1-converting enzyme inhibitory protein expression determines resistance of T helper 17 cells to activation-induced cell death

(2009) Y. Yu et al.   BLOOD

Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments

(2009) I. Kryczek et al.   BLOOD

The effects of trastuzumab on the CD4+CD25+FoxP3+ and CD4+IL17A+ T-cell axis in patients with breast cancer

(2009) C Horlock et al.   BRITISH JOURNAL OF CANCER

Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin

(2009) C. Johansen et al.   BRITISH JOURNAL OF DERMATOLOGY

Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells

(2009) Natalia Martin-Orozco et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

T Helper 17 Cells Promote Cytotoxic T Cell Activation in Tumor Immunity

(2009) Natalia Martin-Orozco et al.   IMMUNITY

Late Developmental Plasticity in the T Helper 17 Lineage

(2009) Yun Kyung Lee et al.   IMMUNITY

IL-9 as a mediator of Th17-driven inflammatory disease

(2009) Elizabeth C. Nowak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-23 Drives Pathogenic IL-17-Producing CD8+ T Cells

(2009) B. Ciric et al.   JOURNAL OF IMMUNOLOGY

Protumor vs Antitumor Functions of IL-17

(2009) G. Murugaiyan et al.   JOURNAL OF IMMUNOLOGY

TGF-  Promotes Th17 Cell Development through Inhibition of SOCS3

(2009) H. Qin et al.   JOURNAL OF IMMUNOLOGY

Th17 Cytokines Stimulate CCL20 Expression in Keratinocytes In Vitro and In Vivo: Implications for Psoriasis Pathogenesis

(2009) Erin G. Harper et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Circulating Th17, Th22, and Th1 Cells Are Increased in Psoriasis

(2009) Shinji Kagami et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa

(2009) S A Khader et al.   Mucosal Immunology

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

(2009) Mandy J McGeachy et al.   NATURE IMMUNOLOGY

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells

(2009) Sara Trifari et al.   NATURE IMMUNOLOGY

Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells

(2009) Thomas Duhen et al.   NATURE IMMUNOLOGY

IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells

(2009) W. Elyaman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells

(2009) R. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor-specific Th17-polarized cells eradicate large established melanoma

(2008) P. Muranski et al.   BLOOD

Phenotypic Analysis of Prostate-Infiltrating Lymphocytes Reveals TH17 and Treg Skewing

(2008) K. S. Sfanos et al.   CLINICAL CANCER RESEARCH

Regulatory T cells in inflammatory bowel disease

(2008) Elisa K Boden et al.   CURRENT OPINION IN GASTROENTEROLOGY

A Randomized Trial of Ustekinumab, a Human Interleukin-12/23 Monoclonal Antibody, in Patients With Moderate-to-Severe Crohn's Disease

(2008) William J. Sandborn et al.   GASTROENTEROLOGY

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

(2008) Xuexian O. Yang et al.   IMMUNITY

Foxp3 Inhibits RORγt-mediatedIL-17AmRNA Transcription through Direct Interaction with RORγt

(2008) Kenji Ichiyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase I/II Study of Ipilimumab for Patients With Metastatic Melanoma

(2008) Jeffrey S. Weber et al.   JOURNAL OF CLINICAL ONCOLOGY

Deficiency of Th17 cells in hyper IgE syndrome due to mutations inSTAT3

(2008) Cindy S. Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study

(2008) Benjamin M Segal et al.   LANCET NEUROLOGY

Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset

(2008) Marc Veldhoen et al.   NATURE IMMUNOLOGY

IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells

(2008) Valérie Dardalhon et al.   NATURE IMMUNOLOGY

Altered frequency and migration capacity of CD4+CD25+ regulatory T cells in systemic lupus erythematosus

(2008) H.-Y. Lee et al.   RHEUMATOLOGY

Production of IL-12, IL-23 and IL-27p28 by bone marrow-derived conventional dendritic cells rather than macrophages after LPS/TLR4-dependent induction by Salmonella Enteritidis

(2007) Sabine Siegemund et al.   IMMUNOBIOLOGY