Macrophages derived exosomes deliver miR-223 to epithelial ovarian cancer cells to elicit a chemoresistant phenotype

Metabolic features of macrophages in inflammatory diseases and cancer

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Hypoxia-induced exosomes contribute to a more aggressive and chemoresistant ovarian cancer phenotype: a novel mechanism linking STAT3/Rab proteins

(2018) Kalpana Deepa Priya Dorayappan et al.   ONCOGENE

C/EBPβ enhances platinum resistance of ovarian cancer cells by reprogramming H3K79 methylation

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Mutation in the FGFR1 tyrosine kinase domain or inactivation of PTEN is associated with acquired resistance to FGFR inhibitors in FGFR1-driven leukemia/lymphomas

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The contribution of tumor-associated macrophages in glioma neo-angiogenesis and implications for anti-angiogenic strategies

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Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1

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The role of exosomes in cancer metastasis

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Herpesviruses shape tumour microenvironment through exosomal transfer of viral microRNAs

(2017) Ohad Yogev et al.   PLoS Pathogens

The biological significance and clinical applications of exosomes in ovarian cancer

(2016) Kalpana Deepa Priya Dorayappan et al.   GYNECOLOGIC ONCOLOGY

Comprehensive Proteomic Analysis of Mesenchymal Stem Cell Exosomes Reveals Modulation of Angiogenesis via Nuclear Factor-KappaB Signaling

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Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction

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Bioconjugated Manganese Dioxide Nanoparticles Enhance Chemotherapy Response by Priming Tumor-Associated Macrophages toward M1-like Phenotype and Attenuating Tumor Hypoxia

(2015) Manli Song et al.   ACS Nano

Berberine Sensitizes Human Ovarian Cancer Cells to Cisplatin Through miR-93/PTEN/Akt Signaling Pathway

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MiR-223 promotes the cisplatin resistance of human gastric cancer cells via regulating cell cycle by targeting FBXW7

(2015) Xiaoying Zhou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

miR-186 regulation of Twist1 and ovarian cancer sensitivity to cisplatin

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Macrophages are recruited to hypoxic tumor areas and acquire a Pro-Angiogenic M2-Polarized phenotype via hypoxic cancer cell derived cytokines Oncostatin M and Eotaxin

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Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

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The sensitivity of gastric cancer to trastuzumab is regulated by the miR-223/FBXW7 pathway

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Increased metabolites of 5-lipoxygenase from hypoxic ovarian cancer cells promote tumor-associated macrophage infiltration

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Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis

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Cisplatin-induced caspase activation mediates PTEN cleavage in ovarian cancer cells: a potential mechanism of chemoresistance

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MicroRNA-216a/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer

(2013) Hongping Xia et al.   HEPATOLOGY

Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis

(2013) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNAs Transfer from Human Macrophages to Hepato-Carcinoma Cells and Inhibit Proliferation

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Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

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MicroRNA-mediated control of macrophages and its implications for cancer

(2013) Mario Leonardo Squadrito et al.   TRENDS IN IMMUNOLOGY

Nanoparticle analysis of circulating cell-derived vesicles in ovarian cancer patients

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Hypoxic enhancement of exosome release by breast cancer cells

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Hypoxia-Inducible Factors in Physiology and Medicine

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TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice

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Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy

(2011) David G. DeNardo et al.   Cancer Discovery

The GTPase RAB20 is a HIF target with mitochondrial localization mediating apoptosis in hypoxia

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Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy

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Potential role of miR-9 and miR-223 in recurrent ovarian cancer

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The role of PTEN signaling perturbations in cancer and in targeted therapy

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