Review
Pharmacology & Pharmacy
Yulai Zeng, Shuyu Hu, Yi Luo, Kang He
Summary: Hepatocellular carcinoma (HCC) is a common cancer with unsatisfactory early diagnosis and treatment. Exosomes, containing various components, play a crucial role in the development and prognosis of HCC. Biomarkers in exosomes show potential for novel diagnostic and prognostic tools for HCC.
Article
Cell Biology
Ting Zhan, Xueting Cheng, Qingxi Zhu, Zheng Han, Kejing Zhu, Jie Tan, Men Liu, Wei Chen, Xiaoli Chen, Xiaohong Chen, Xia Tian, Xiaodong Huang
Summary: There is evidence that LOC105369504, a long non-coding RNA, plays an important role in the emergence, progression, and metastasis of colorectal cancer. It binds directly to the protein PSPC1 and regulates its stability through the ubiquitin-proteasome pathway, leading to suppression of tumor growth and metastasis in colorectal cancer cells.
CELL DEATH DISCOVERY
(2023)
Article
Oncology
Qi-Nian Wu, Xiao-Jing Luo, Jia Liu, Yun-Xin Lu, Yun Wang, Jingjing Qi, Ze-Xian Liu, Qi-Tao Huang, Ze-Kun Liu, Jia-Bin Lu, Ying Jin, Heng-Ying Pu, Pei-Shan Hu, Jia-Bo Zheng, Zhao-Lei Zeng, Huai-Qiang Ju, Dan Xie, Qi Zhao, Ruihua Xu
Summary: This study identified a novel colorectal cancer biomarker and therapeutic target, MNX1-AS1, a long noncoding RNA that drives proliferation through the MYC/MNX1-AS1/YB1 signaling pathway. These findings suggest that the MYC-MNX1-AS1-YB1 axis could potentially serve as a biomarker and therapeutic target in colorectal cancer.
Article
Medicine, Research & Experimental
Jia-Qi Sheng, Mu-Ru Wang, Dan Fang, Lian Liu, Wen-Jie Huang, De-An Tian, Xing-Xing He, Pei-Yuan Li
Summary: Long noncoding RNA NBR2 acts as a tumor suppressor gene in hepatocellular carcinoma, inhibiting cell proliferation, invasion, and migration, as well as promoting proliferation by repressing autophagy. The study provides a novel treatment strategy for hepatocellular carcinoma.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Ba Da Yun, Ye Ji Choi, Seung Wan Son, Gabriel Adelman Cipolla, Fernanda Costa Brandao Berti, Danielle Malheiros, Tae-Jin Oh, Hyo Jeong Kuh, Soo Young Choi, Jong Kook Park
Summary: Circular RNAs and long noncoding RNAs are differentially expressed in gastrointestinal cancers. They regulate cellular activities by interacting with microRNAs and proteins, and are transported in exosomes to facilitate cell-cell communication within the cancer microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Chen Yang, Yiwen Zang, Siqi Wu, Quan Zhou, Yuxi Ou, Qiang Ding, Hao Wang, Zuquan Xiong
Summary: This study demonstrates that the circFTO/miR-514b-3p/DUSP4 axis plays an important role in the development of ccRCC and may serve as a potential biomarker and therapeutic target.
CELL DEATH DISCOVERY
(2022)
Review
Cell & Tissue Engineering
Lukasz Pulik, Bartosz Mierzejewski, Aleksandra Sibilska, Iwona Grabowska, Maria Anna Ciemerych, Pawel Legosz, Edyta Brzoska
Summary: Heterotopic ossification is the formation of bone in non-osseous tissues, and it can be caused by genetic or non-genetic factors. TGF beta 1, BMPs, activin A, and other factors are known to induce HO. Dysregulation of noncoding RNAs may also play a role in the development of HO.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Multidisciplinary Sciences
Heping Zhang, Jingfang Wang, Taoyuan Yu, Jingmin Wang, Jun Lu, Zongyang Yu
Summary: This study demonstrates that silencing long non-coding RNA cancer susceptibility candidate 9 can significantly inhibit the proliferation and invasion of CRC cells. miR-542-3p and integrin-linked kinase play a negative regulatory role in this process.
Review
Biochemistry & Molecular Biology
Jianmin Zhang, Zhenzhen Liu, Yongqiang Liu, Yajing Shi, Feng Chen, Yufang Leng
Summary: Intestinal ischemia-reperfusion injury is a common clinical condition with unclear mechanisms. Recent studies have shown that noncoding RNAs play an important role in the pathogenesis of this condition. This paper discusses the expression, function, and mechanism of noncoding RNAs during intestinal ischemia-reperfusion, including various aspects such as cell proliferation, autophagy, oxidative stress, apoptosis, and iron death. However, further research is needed to investigate the unknown mechanisms between noncoding RNAs and intestinal ischemia-reperfusion.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Endocrinology & Metabolism
Mengqi Chang, Shenzhong Jiang, Xiaopeng Guo, Jun Gao, Peng Liu, Xinjie Bao, Ming Feng, Renzhi Wang
Summary: Exosomes are small vesicles that carry various molecules, including RNAs, and play important roles in cell communication and drug delivery. In this review, the impact of exosomal RNAs on pituitary adenoma and their potential as clinical therapies are discussed. Potential biomarkers and therapeutic applications of exosomes in pituitary adenoma are examined.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Yun Bai, Meijuan Ding, Dan Lu, Yiwen Li, Shuai Yao, Lei Wang, Hui Li, Guanghua Cui, Xue Li, Xiaoke Sun, Yu Yang
Summary: The study identified lncRNA AC007639.1 as overexpressed in hepatocellular carcinoma, and knocking it down promoted cancer cell death, slowed down xenograft tumor growth, and increased p53 expression while decreasing angiopoietin-like 4 expression in HCC cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kaisa Cui, Liang Gong, Han Zhang, Ying Chen, Bingxin Liu, Zhicheng Gong, Jiuming Li, Yuanben Wang, Shengbai Sun, Yajun Li, Qiang Zhang, Yulin Cao, Qilin Li, Bojian Fei, Zhaohui Huang
Summary: This study reveals that the RNA exosome gene (EXOSC8) promotes colorectal cancer (CRC) tumorigenesis by regulating cancer-related ribosome biogenesis in CRC. Silencing of EXOSC8 decreases levels of nucleolar proteins and proliferation markers, as well as rRNA/DNA and global protein syntheses. EXOSC8 knockdown triggers ribosomal stress, releasing nucleolar protein RPL5/11 into the nucleoplasm and hijacking Mdm2 to block its E3 ubiquitin ligase function, thereby releasing and activating p53. EXOSC8 may serve as a potential therapeutic target in CRC.
Article
Biotechnology & Applied Microbiology
Chuandong Cheng, Yongfei Dong, Xiaoyu Ru, Yanghua Xia, Ying Ji
Summary: Recent studies have shown that in glioma, ANCR and EZH2 are upregulated while PTEN is downregulated. The positive correlation between ANCR and EZH2, as well as the negative correlation between PTEN and ANCR/EZH2 expression, were observed. Inhibition of ANCR, reduction of EZH2, or elevation of PTEN have been found to have beneficial effects on suppressing glioma cell growth.
CANCER GENE THERAPY
(2021)
Article
Oncology
Ya-Sian Chang, Ya-Ting Lee, Ju-Chen Yen, Yuli C. C. Chang, Li-Li Lin, Wen-Ling Chan, Wei-Chiao Chang, Shyr-Yi Lin, Jan-Gowth Chang
Summary: This study identified the crucial role of NTT in hepatocellular carcinoma by regulating MYB-mediated target genes, suggesting its potential as a novel therapeutic target for HCC.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Mandana Ameli-Mojarad, Melika Ameli-Mojarad, Mahrooyeh Hadizadeh, Chris Young, Hosna Babini, Ehsan Nazemalhosseini-Mojarad, Maziar Ashrafian Bonab
Summary: Colorectal cancer is the third most common type of cancer worldwide, with late detection contributing to a significant portion of annual mortality. Non-coding RNA circRNAs are being investigated as potential targets for diagnostic and prognostic detection of CRC, playing important roles in the molecular mechanisms of CRC development and progression.
CANCER CELL INTERNATIONAL
(2021)
Article
Chemistry, Analytical
Hua He, Guangyong Qin, Simin Bi, Zhenzhen Feng, Jian Mao, Xin Guan, Minmin Xue, Zhirui Wang, Xiaojuan Wang, Daoyong Yu, Fang Huang
Summary: This study develops a deep-learning-enhanced diffusion imaging assay to measure the local-density effects on ligand-receptor interactions in the plasma membrane of live cells. The assay allows for spatially resolved measurements of receptor diffusion coefficient and reveals the density-dependent regulation of chemokine receptor CXCR4 interactions with different ligands. This research provides new insights into density-dependent receptor regulation and offers an unprecedented assay applicable to various receptors in live cells.
ANALYTICAL CHEMISTRY
(2023)
Article
Infectious Diseases
Yi Guo, Hao Wang, Mingzhong Xiao, Xin Guan, Yanshou Lei, Tingyue Diao, Pinpin Long, Rui Zeng, Xuefeng Lai, Hao Cai, Yutong You, Yuying Wen, Wenhui Li, Xi Wang, Yufei Wang, Qinlin Chen, Yuchan Yang, Yutong Qiu, Jishuai Chen, Huidan Zeng, Wei Ni, Youyun Zhao, Kani Ouyang, Jingzhi Wang, Qi Wang, Li Liu, Lulu Song, Youjie Wang, Huan Guo, Xiaodong Li, Tangchun Wu, Yu Yuan
Summary: This study aimed to describe the long-term outcomes and ongoing pathophysiological alterations among COVID-19 survivors. A longitudinal cohort of 208 convalescents were followed up at different time points. Most convalescents showed improved physical and psychological health, but a small proportion still had sequelae symptoms, residual lung lesions, exercise impairment, and mental health disorders at 18.5 months.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Chemistry, Multidisciplinary
Jian Mao, Minmin Xue, Xin Guan, Qian Wang, Zhirui Wang, Guangyong Qin, Hua He
Summary: In this study, near-infrared CDs with a maximum emission of around 750 nm were designed and synthesized by weaving a nitrogen-doped aromatic backbone with surplus carboxyl groups on the surface. The NIR-CDs can be conjugated to monovalent antibody fragments for labeling and imaging of cellular receptors, and they exhibit improved signal-to-noise ratio and localization precision compared to visible CDs. Fluorescent burst analysis allows for accurate counting of cellular receptors at nanoscale resolution. Using NIR-CDs-based SMLM, oligomerization and internalization of programmed cell death-ligand 1 by a small molecule inhibitor for checkpoint blockade were demonstrated. The NIR-CDs can serve as a generally applicable probe for quantitative nanoscopy in chemistry and biology.
Review
Chemistry, Multidisciplinary
Xin Guan, Haijuan Li, Limei Chen, Guohua Qi, Yongdong Jin
Summary: A glass capillary-based nanopore (G-nanopore) with tapered tip and flexible surface modifications provides a powerful sensing platform for diverse biological measurements. It enables noninvasive single molecule and subcellular single cell detections and shows potential for cancer diagnosis and treatment applications. However, current bottlenecks limit its widespread use in clinical applications.
Article
Medical Laboratory Technology
Huijie Wang, Guangtao Xia, Xin Guan, Li Wang, Lei Qin, Min Fu
Summary: The study aimed to detect the expression level of nuclear factor erythroid 2-related factor 2 (Nrf2) in the serum of rheumatoid arthritis (RA) patients and investigate its correlation with disease activity, pro-inflammatory factors, clinical characteristics, and changes after treatment. The results showed that Nrf2 levels were significantly elevated in the serum of RA patients, along with increased levels of malondialdehyde (MDA). Nrf2 levels were positively correlated with disease activity and pro-inflammatory factor levels. Nrf2 may serve as a potential indicator to monitor disease activity and prognosis in RA patients.
CLINICAL BIOCHEMISTRY
(2023)
Article
Engineering, Environmental
Shuai Bai, Lingbo Yu, Xinchun Guan, Hui Li, Jinping Ou
Summary: The effects of nano-SiO2 (NS) and nano-TiO2 (NT) on the microstructure, strength, and chloride diffusivity of frozen cement paste were compared. It was found that NS effectively compensated for hydration loss by increasing C-S-H gel content and degree of hydration, while NT had little effect on hydration loss compensation. Both NS and NT improved the frost-damaged pore structures, but NS had a better improvement effect. NS and NT had similar enhancement effects on strength, but NS had a much better improvement effect on chloride diffusivity. In conclusion, NS promoted cement hydration and optimized pore structure through pozzolanic effect, while NT mainly improved pore structure through nano-filling effect in the early-age frozen cement paste.
COLD REGIONS SCIENCE AND TECHNOLOGY
(2023)
Article
Physics, Applied
Suxia Xie, Siyi Sun, Zhijian Li, Jingcheng Yang, Weiwei Shen, Xin Guan
Summary: We studied an all-dielectric metasurface composed of one transverse nanohole and two identical vertical nanoholes, which supports both symmetry-protected and accidental bound states in the continuum (BICs). By destructive interference between the surface states from the transverse nanohole and the identical vertical nanoholes, two symmetry-protected BICs emerge, which can be turned into quasi-BICs by adjusting the electric field polarization direction. The accidental BICs come from destructive interference from different radiation channels, which are less influenced by the in-plane structural parameters symmetry. All three BICs in the metasurface have ultra-high Q-factors (exceeding 10(6), 10(4), and 10(6), respectively), making them highly valuable in biosensor applications. Furthermore, the metasurface exhibits outstanding ultra-slow light properties at BICs, with a group index of about 10(6), enabling the development of new generation flat-optics slow light devices.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Hongyan Li, Nan Ge, Xin Guan, Chao Han, Ying Li, Liming Shen, Mengmeng Chen, Bingqiang Zhang, Chao Qu, Wei Zou
Summary: This study aimed to determine the effects of the ER-alpha 36 modulator SNG162 on GBM growth and invasion. The results showed that SNG162 could inhibit the growth and invasion of GBM by suppressing the expression of ER-alpha 36, suggesting that it could be a potential therapeutic agent for GBM.
Review
Pharmacology & Pharmacy
Qiran Wei, Jiting Zhou, Hongchao Li, Luying Wang, Yao Wu, Aixia Ma, Xin Guan
Summary: This study conducted a large-scale meta-analysis and subgroup analysis to compare the effect of fixed-dose combination (FDC) therapy with that of free-equivalent combination (FEC) therapy on medication adherence. The results showed that FDC significantly improved medication compliance compared to FEC. Subgroup analyses also revealed differences in the impact of FDC on different disease types, evaluation periods, and compliance indicators.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Xin Guan, Yushan Zhao, Charles Okanda Nyatega, Qiang Li
Summary: Accurate segmentation of brain tumors from MRI is crucial for clinical decisions and surgical planning. Traditional CNN models that use information from a single view or one by one are not effective for tumor segmentation. To address this issue, we propose a hierarchical multi-view convolution method that decomposes the standard 3D convolution into axial, coronal, and sagittal views to provide complementary features. Evaluation results show that compared to the baseline network, the proposed method achieves improvements of 1.74%, 0.5%, and 2.19% in tumor segmentation accuracy.
Article
Medicine, General & Internal
Jingjing Lyu, Xin Guan, Yuhan Zhou, Huan Guo, Shanshan Cheng, Chaolong Wang
Summary: The study aims to develop cost-effective models to identify high-risk individuals for early diagnosis of hepatobiliary and pancreatic cancers. Based on a 6-year follow-up study, the researchers identified incident cases of hepatocellular carcinoma, biliary tract cancer, and pancreatic cancer, and constructed clinical risk scores. These models have shown high utility in stratifying high-risk individuals.
JOURNAL OF EVIDENCE BASED MEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Lv Ke, Ting Yang, Chenyu Liang, Xin Guan, Tian Li, Yang Jiao, Daoyuan Tang, Donghui Huang, Shihang Li, Shenghui Zhang, Xinjian He, Huan Xu
Summary: In this study, electroactive and antibacterial poly(lactic acid) nanofibrous membranes (NFMs) were fabricated using a facile method. Microwave-assisted doping was employed to produce zinc-doped titanium dioxide nanoparticles, which greatly improved the properties of the PLA nanofibers. The composite NFMs showed enhanced filtration performance and antibacterial activity compared to pure PLA, making them promising for healthcare applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Oncology
Fei Wen, Xin Guan, Hai-Xia Qu, Xiang-Jun Jiang
Summary: In this study, a gastric cancer predictive model was established using RNA-seq data, and several genes in the model were found to be associated with the prognosis of gastric cancer. These genes have the potential to serve as auxiliary markers in the clinical diagnosis of gastric cancer.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2023)
Article
Engineering, Environmental
Long Li, Jiangnan Wang, Hongchao Li, Xin Guan, Kang Li, Bing Zhang, Xueqin Li, Jinli Zhang
Summary: In this study, mixed-dimensional fillers of NiCo-layered double hydroxide-decorated polypyrrole nanotubes (PNT@NiCo-LDH) were synthesized and incorporated into Pebax MH 1657 (Pebax) matrix to fabricate mixed matrix membranes (MMMs) for efficient CO2 separation. PNT@NiCo-LDH played a vital role in constructing 1D/2D/3D CO2 transport pathways in MMMs and accelerating CO2 selective transport. The prepared MMMs exhibited excellent CO2 separation performance.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Review
Endocrinology & Metabolism
Hua Fan, Shikun Bai, Xin Guan, Wen Ma, Yu Fu, Xuan Zhang, Lili Deng, Jing Tian
Summary: A systematic literature search found that patients with concurrent SCLC and DM using metformin had significantly longer overall survival (OS) and disease-free survival (DFS) compared to those without metformin usage.
MINERVA ENDOCRINOLOGY
(2023)
