Effect of mesenchymal stem cells-derived exosomes on tumor microenvironment: Tumor progression versus tumor suppression

Redirecting T Cells to Glypican-3 with 4-1BB Zeta Chimeric Antigen Receptors Results in Th1 Polarization and Potent Antitumor Activity

(2017) Wenpeng Li et al.   HUMAN GENE THERAPY

Induction of Immunogenic Cell Death in Lymphoma Cells by Wharton’s Jelly Mesenchymal Stem Cell Conditioned Medium

(2017) Daniel Hao Lin et al.   Stem Cell Reviews and Reports

MicroRNA-100 shuttled by mesenchymal stem cell-derived exosomes suppresses in vitro angiogenesis through modulating the mTOR/HIF-1α/VEGF signaling axis in breast cancer cells

(2017) Katayoon Pakravan et al.   CELLULAR ONCOLOGY

Tumor-educated mesenchymal stem cells promote pro-metastatic phenotype

(2017) Billy Samuel Hill et al.   Oncotarget

pIL6-TRAIL-engineered umbilical cord mesenchymal/stromal stem cells are highly cytotoxic for myeloma cells both in vitro and in vivo

(2017) Paola Cafforio et al.   Stem Cell Research & Therapy

Inhibition of Bone Marrow-Derived Mesenchymal Stem Cells Homing Towards Triple-Negative Breast Cancer Microenvironment Using an Anti-PDGFRβ Aptamer

(2017) Simona Camorani et al.   Theranostics

Induction of Immunogenic Cell Death in Lymphoma Cells by Wharton’s Jelly Mesenchymal Stem Cell Conditioned Medium

(2017) Daniel Hao Lin et al.   Stem Cell Reviews and Reports

The Immunomodulatory Effects of Mesenchymal Stem Cell Polarization within the Tumor Microenvironment Niche

(2017) Cosette M. Rivera-Cruz et al.   Stem Cells International

Mesenchymal Stem Cell-Derived Extracellular Vesicles: Roles in Tumor Growth, Progression, and Drug Resistance

(2017) Xiaoyan Zhang et al.   Stem Cells International

Cancer prevention from the perspective of global cancer burden patterns

(2017) Hiroki Nagai et al.   Journal of Thoracic Disease

T Cell-Activating Mesenchymal Stem Cells as a Biotherapeutic for HCC

(2017) Arpad Szoor et al.   Molecular Therapy-Oncolytics

Diverse macrophages polarization in tumor microenvironment

(2016) Inmoo Rhee   ARCHIVES OF PHARMACAL RESEARCH

A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion

(2016) Raffaela Fontanella et al.   CANCER LETTERS

Mesenchymal stem cells promote macrophage polarization toward M2b-like cells

(2016) Gyöngyi Kudlik et al.   EXPERIMENTAL CELL RESEARCH

Cancer Stem Cells and Macrophages: Implications in Tumor Biology and Therapeutic Strategies

(2016) Bruno Sainz et al.   MEDIATORS OF INFLAMMATION

Activated human mesenchymal stem/stromal cells suppress metastatic features of MDA-MB-231 cells by secreting IFN-β

(2016) N Yoon et al.   Cell Death & Disease

Activation of mesenchymal stem cells by macrophages promotes tumor progression through immune suppressive effects

(2016) Xiao-hua Jia et al.   Oncotarget

Mesenchymal stem cells promote osteosarcoma cell survival and drug resistance through activation of STAT3

(2016) Bing Tu et al.   Oncotarget

IL-17 Promotes Angiogenic Factors IL-6, IL-8, and Vegf Production via Stat1 in Lung Adenocarcinoma

(2016) Qi Huang et al.   Scientific Reports

In Vivo therapeutic potential of mesenchymal stem cell-derived extracellular vesicles with optical imaging reporter in tumor mice model

(2016) Senthilkumar Kalimuthu et al.   Scientific Reports

Are Mesenchymal Stem Cells So Bloody Great After All?

(2016) Stephanie J. Marfy-Smith et al.   Stem Cells Translational Medicine

Mesenchymal Stem Cells Promote Pancreatic Tumor Growth by Inducing Alternative Polarization of Macrophages

(2016) Esha Mathew et al.   NEOPLASIA

Irradiation enhances susceptibility of tumor cells to the antitumor effects of TNF-α activated adipose derived mesenchymal stem cells in breast cancer model

(2016) Hemn Mohammadpour et al.   Scientific Reports

Human endometrial mesenchymal stem cells exhibit intrinsic anti-tumor properties on human epithelial ovarian cancer cells

(2016) Shixia Bu et al.   Scientific Reports

Pre-activated human mesenchymal stromal cells in combination with doxorubicin synergistically enhance tumor-suppressive activity in mice

(2015) Nara Yoon et al.   CYTOTHERAPY

Adipose-derived mesenchymal stem cells promote cell proliferation and invasion of epithelial ovarian cancer

(2015) Yijing Chu et al.   EXPERIMENTAL CELL RESEARCH

BM-MSCs promote prostate cancer progression via the conversion of normal fibroblasts to cancer-associated fibroblasts

(2015) SIMENG WEN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Genetically engineered mesenchymal stromal cells producing TNFα have tumour suppressing effect on human melanoma xenograft

(2015) Silvia Tyciakova et al.   JOURNAL OF GENE MEDICINE

Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications

(2015) Sweta Rani et al.   MOLECULAR THERAPY

Extracellular Vesicles in Cancer: Exosomes, Microvesicles and the Emerging Role of Large Oncosomes

(2015) Valentina R. Minciacchi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Ectosomes and exosomes: shedding the confusion between extracellular vesicles

(2015) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

Mesenchymal stem cells expressing interleukin-18 suppress breast cancer cells in vitro

(2015) XIAOYI LIU et al.   Experimental and Therapeutic Medicine

Bispecific antibody releasing-mesenchymal stromal cell machinery for retargeting T cells towards acute myeloid leukemia blasts

(2015) R Aliperta et al.   Blood Cancer Journal

Influence of mesenchymal stem cells on metastasis development in mice in vivo

(2015) Aleksandra V Meleshina et al.   Stem Cell Research & Therapy

Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function

(2015) Jian Zhang et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Mesenchymal stem cells deliver synthetic microRNA mimics to glioma cells and glioma stem cells and inhibit their cell migration and self-renewal

(2015) Hae-Kyung Lee et al.   Oncotarget

Extracellular membrane vesicles as a mechanism of cell-to-cell communication: advantages and disadvantages

(2014) Giuseppina Turturici et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Exosome-formed synthetic microRNA-143 is transferred to osteosarcoma cells and inhibits their migration

(2014) Keisuke Shimbo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Biogenesis and secretion of exosomes

(2014) Joanna Kowal et al.   CURRENT OPINION IN CELL BIOLOGY

Exosomes Derived from Mesenchymal Stem Cells Suppress Angiogenesis by Down-Regulating VEGF Expression in Breast Cancer Cells

(2014) Jong-Kuen Lee et al.   PLoS One

Altered MicroRNA Expression Profile in Exosomes during Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells

(2014) Ji-Feng Xu et al.   PLoS One

Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells

(2014) M. Ono et al.   Science Signaling

In vivo Kinetic Biodistribution of Nano-Sized Outer Membrane Vesicles Derived from Bacteria

(2014) Su Chul Jang et al.   Small

Exosomes/miRNAs as mediating cell-based therapy of stroke

(2014) Hongqi Xin et al.   Frontiers in Cellular Neuroscience

Mechanisms of T-Cell Immunosuppression by Mesenchymal Stromal Cells: What Do We Know So Far?

(2014) Rodrigo Haddad et al.   Biomed Research International

Effects of interleukin-18 on natural killer cells: costimulation of activation through Fc receptors for immunoglobulin

(2013) Shivani Srivastava et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth

(2013) Mark Katakowski et al.   CANCER LETTERS

IL-18-Primed Helper NK Cells Collaborate with Dendritic Cells to Promote Recruitment of Effector CD8+ T Cells to the Tumor Microenvironment

(2013) J. L. Wong et al.   CANCER RESEARCH

Multimodal immunogenic cancer cell death as a consequence of anticancer cytotoxic treatments

(2013) H Inoue et al.   CELL DEATH AND DIFFERENTIATION

Paracrine Mechanisms of Mesenchymal Stem Cell-Based Therapy: Current Status and Perspectives

(2013) Xiaoting Liang et al.   CELL TRANSPLANTATION

First-in-Man Phase I Study of GC33, a Novel Recombinant Humanized Antibody Against Glypican-3, in Patients with Advanced Hepatocellular Carcinoma

(2013) A. X. Zhu et al.   CLINICAL CANCER RESEARCH

Exosomes as Intercellular Signaling Organelles Involved in Health and Disease: Basic Science and Clinical Applications

(2013) Chiara Corrado et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

BM mesenchymal stromal cell–derived exosomes facilitate multiple myeloma progression

(2013) Aldo M. Roccaro et al.   JOURNAL OF CLINICAL INVESTIGATION

Exosomes in tumor microenvironment influence cancer progression and metastasis

(2013) Christoph Kahlert et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Exosomes from human adipose-derived mesenchymal stem cells promote migration through Wnt signaling pathway in a breast cancer cell model

(2013) Ruizhu Lin et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

Novel Mechanism of Inhibition of Dendritic Cells Maturation by Mesenchymal Stem Cells via Interleukin-10 and the JAK1/STAT3 Signaling Pathway

(2013) Wen-hua Liu et al.   PLoS One

Microvesicles Derived from Human Umbilical Cord Wharton’s Jelly Mesenchymal Stem Cells Attenuate Bladder Tumor Cell Growth In Vitro and In Vivo

(2013) Shuai Wu et al.   PLoS One

Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis

(2013) Younghun Jung et al.   Nature Communications

Human mesenchymal stem cells creating an immunosuppressive environment and promote breast cancer in mice

(2013) Biljana Ljujic et al.   Scientific Reports

Bone marrow-derived mesenchymal stem cells promote growth and angiogenesis of breast and prostate tumors

(2013) Ting Zhang et al.   Stem Cell Research & Therapy

Dendritic Cells in the Cancer Microenvironment

(2013) Yang Ma et al.   Journal of Cancer

Mesenchymal Stem Cells Migration Homing and Tracking

(2013) Abhishek Sohni et al.   Stem Cells International

Mesenchymal stem cell: An efficient mass producer of exosomes for drug delivery

(2012) Ronne Wee Yeh Yeo et al.   ADVANCED DRUG DELIVERY REVIEWS

Mesenchymal stem cells overexpressing PEDF decrease the angiogenesis of gliomas

(2012) Qiaoshu Wang et al.   BIOSCIENCE REPORTS

Exosomes for drug delivery — a novel application for the mesenchymal stem cell

(2012) Ruenn Chai Lai et al.   BIOTECHNOLOGY ADVANCES

Preactivation of Human MSCs with TNF-α Enhances Tumor-Suppressive Activity

(2012) Ryang Hwa Lee et al.   Cell Stem Cell

Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival

(2012) Tina M. Thornton et al.   International Journal of Biological Sciences

Proteomic Analysis of Exosomes from Mutant KRAS Colon Cancer Cells Identifies Intercellular Transfer of Mutant KRAS

(2012) Michelle Demory Beckler et al.   MOLECULAR & CELLULAR PROTEOMICS

RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells

(2012) B Li et al.   ONCOGENE

Mesenchymal Stem Cell 1 (MSC1)-Based Therapy Attenuates Tumor Growth Whereas MSC2-Treatment Promotes Tumor Growth and Metastasis

(2012) Ruth S. Waterman et al.   PLoS One

Antitumor Activities of Human Placenta-Derived Mesenchymal Stem Cells Expressing Endostatin on Ovarian Cancer

(2012) Lan Zheng et al.   PLoS One

Human Liver Stem Cell-Derived Microvesicles Inhibit Hepatoma Growth in SCID Mice by Delivering Antitumor MicroRNAs

(2012) Valentina Fonsato et al.   STEM CELLS

Human Bone Marrow-Derived Mesenchymal Stem Cells Suppress Human Glioma Growth Through Inhibition of Angiogenesis

(2012) Ivy A.W. Ho et al.   STEM CELLS

Insights into bone marrow-derived mesenchymal stem cells safety for cutaneous repair and regeneration

(2012) Yan Wu et al.   International Wound Journal

Antitumor activity of placenta-derived mesenchymal stem cells producing pigment epithelium-derived factor in a mouse melanoma model

(2012) QIAOLING CHEN et al.   Oncology Letters

Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

(2012) Hina Kalra et al.   PLOS BIOLOGY

Oncogenic extracellular vesicles in brain tumor progression

(2012) Esterina D’Asti et al.   Frontiers in Physiology

Perivascular Human Endometrial Mesenchymal Stem Cells Express Pathways Relevant to Self-Renewal, Lineage Specification, and Functional Phenotype1

(2011) Trimble L.B. Spitzer et al.   BIOLOGY OF REPRODUCTION

Mesenchymal Stem Cells Induce Resistance to Chemotherapy through the Release of Platinum-Induced Fatty Acids

(2011) Jeanine M.L. Roodhart et al.   CANCER CELL

Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo

(2011) Wei Zhu et al.   CANCER LETTERS

A Developmental Taxonomy of Glioblastoma Defined and Maintained by MicroRNAs

(2011) T.-M. Kim et al.   CANCER RESEARCH

Exosomes Released by Melanoma Cells Prepare Sentinel Lymph Nodes for Tumor Metastasis

(2011) J. L. Hood et al.   CANCER RESEARCH

Microvesicles: Messengers and mediators of tumor progression

(2011) Khalid Al-Nedawi et al.   CELL CYCLE

The source of human mesenchymal stromal cells influences their TLR profile as well as their functional properties

(2011) Gordana Raicevic et al.   CELLULAR IMMUNOLOGY

p38 MAPK Contributes to the Growth Inhibition of Leukemic Tumor Cells Mediated by Human Umbilical Cord Mesenchymal Stem Cells

(2011) Kun Tian et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Mesenchymal stem cell migration is regulated by fibronectin through  5 1-integrin-mediated activation of PDGFR-  and potentiation of growth factor signals

(2011) J. Veevers-Lowe et al.   JOURNAL OF CELL SCIENCE

Mesenchymal stem cells as vehicles for targeted delivery of anti-angiogenic protein to solid tumors

(2011) Mahboobe Ghaedi et al.   JOURNAL OF GENE MEDICINE

Proteomic Analysis of Microvesicles Derived from Human Mesenchymal Stem Cells

(2011) Han-Soo Kim et al.   JOURNAL OF PROTEOME RESEARCH

Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs

(2011) Tian Chen et al.   Journal of Translational Medicine

Tumor angiogenesis: molecular pathways and therapeutic targets

(2011) Sara M Weis et al.   NATURE MEDICINE

Concise Review: Mesenchymal Stem Cell Tumor-Homing: Detection Methods in Disease Model Systems

(2011) Michaela R. Reagan et al.   STEM CELLS

Emerging use of stem cells in regenerative medicine

(2010) Adrian K. K. Teo et al.   BIOCHEMICAL JOURNAL

Aquaporins in tumor growth and angiogenesis

(2010) Beatrice Nico et al.   CANCER LETTERS

Human Bone Marrow-Derived MSCs Can Home to Orthotopic Breast Cancer Tumors and Promote Bone Metastasis

(2010) R. H. Goldstein et al.   CANCER RESEARCH

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

CXCL12 (SDF-1)/CXCR4 Pathway in Cancer

(2010) B. A. Teicher et al.   CLINICAL CANCER RESEARCH

Mesenchymal stem cells enhance growth and metastasis of colon cancer

(2010) Kei Shinagawa et al.   INTERNATIONAL JOURNAL OF CANCER

Microvesicles: mediators of extracellular communication during cancer progression

(2010) V. Muralidharan-Chari et al.   JOURNAL OF CELL SCIENCE

Endogenous toll-like receptor ligands and their biological significance

(2010) Li Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

(2010) Dongmei Sun et al.   MOLECULAR THERAPY

B-cell-derived lymphotoxin promotes castration-resistant prostate cancer

(2010) Massimo Ammirante et al.   NATURE

A New Mesenchymal Stem Cell (MSC) Paradigm: Polarization into a Pro-Inflammatory MSC1 or an Immunosuppressive MSC2 Phenotype

(2010) Ruth S. Waterman et al.   PLoS One

Upregulation of PTEN in Glioma Cells by Cord Blood Mesenchymal Stem Cells Inhibits Migration via Downregulation of the PI3K/Akt Pathway

(2010) Venkata Ramesh Dasari et al.   PLoS One

Concise Review: Dissecting a Discrepancy in the Literature: Do Mesenchymal Stem Cells Support or Suppress Tumor Growth?

(2010) Ann H. Klopp et al.   STEM CELLS

Targeting of mesenchymal stem cells to ovarian tumors via an artificial receptor

(2010) Svetlana Komarova et al.   Journal of Ovarian Research

MicroRNA-34a Inhibits Glioblastoma Growth by Targeting Multiple Oncogenes

(2009) Y. Li et al.   CANCER RESEARCH

Therapeutic potential of mesenchymal stromal cells in a mouse breast cancer metastasis model

(2009) Bo Sun et al.   CYTOTHERAPY

Applications of neural and mesenchymal stem cells in the treatment of gliomas

(2009) Thomas Kosztowski et al.   Expert Review of Anticancer Therapy

Targeted delivery of doxorubicin using stealth liposomes modified with transferrin

(2009) XueMing Li et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Emerging functions of microRNAs in glioblastoma

(2009) Sean Lawler et al.   JOURNAL OF NEURO-ONCOLOGY

Mesenchymal Stem Cell-Derived Microvesicles Protect Against Acute Tubular Injury

(2009) S. Bruno et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Human mesenchymal stem cells inhibit cancer cell proliferation by secreting DKK-1

(2009) Y Zhu et al.   LEUKEMIA

Is the intravascular administration of mesenchymal stem cells safe?

(2009) Dario Furlani et al.   MICROVASCULAR RESEARCH

Adult Stromal Cells Derived from Human Adipose Tissue Provoke Pancreatic Cancer Cell Death both In Vitro and In Vivo

(2009) Beatrice Cousin et al.   PLoS One

Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy

(2009) L. S. Sasportas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ExoCarta: A compendium of exosomal proteins and RNA

(2009) Suresh Mathivanan et al.   PROTEOMICS

Concentration-dependent inhibition of angiogenesis by mesenchymal stem cells

(2008) K. Otsu et al.   BLOOD

Gene Therapy Using TRAIL-Secreting Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells against Intracranial Glioma

(2008) S. M. Kim et al.   CANCER RESEARCH

Targeting of the Bmi-1 Oncogene/Stem Cell Renewal Factor by MicroRNA-128 Inhibits Glioma Proliferation and Self-Renewal

(2008) J. Godlewski et al.   CANCER RESEARCH

N-Glycosylation as Novel Strategy to Improve Pharmacokinetic Properties of Bispecific Single-chain Diabodies

(2008) Roland Stork et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic stem-cells for cancer treatment: hopes and hurdles in tactical warfare

(2008) Maarten F Corsten et al.   LANCET ONCOLOGY

Long-term in vivo imaging of human angiogenesis: Critical role of bone marrow-derived mesenchymal stem cells for the generation of durable blood vessels

(2008) Laura Sanz et al.   MICROVASCULAR RESEARCH

Tumor Immunotherapy Using Gene-Modified Human Mesenchymal Stem Cells Loaded into Synthetic Extracellular Matrix Scaffolds

(2008) Marta Compte et al.   STEM CELLS

Molecular mechanisms of p21 and p27 induction by 3-methylcholanthrene, an aryl-hydrocarbon receptor agonist, involved in antiproliferation of human umbilical vascular endothelial cells

(2007) Pai-Huei Pang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Toll-Like Receptors on Human Mesenchymal Stem Cells Drive Their Migration and Immunomodulating Responses

(2007) Suzanne L. Tomchuck et al.   STEM CELLS

Human Leukocyte Antigen-G5 Secretion by Human Mesenchymal Stem Cells Is Required to Suppress T Lymphocyte and Natural Killer Function and to Induce CD4+CD25highFOXP3+Regulatory T Cells

(2007) Zohair Selmani et al.   STEM CELLS