High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability

Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury

(2018) Steven Wink et al.   ARCHIVES OF TOXICOLOGY

Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq

(2018) Alice Limonciel et al.   ARCHIVES OF TOXICOLOGY

Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study

(2018) Catherine C Bell et al.   TOXICOLOGICAL SCIENCES

High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities

(2016) Steven Wink et al.   ARCHIVES OF TOXICOLOGY

Mechanism of isoniazid-induced hepatotoxicity: then and now

(2016) Imir Metushi et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Novel functions for the transcription factor E2F4 in development and disease

(2016) Jenny Hsu et al.   CELL CYCLE

HLA-B*38:02:01predicts carbimazole/methimazole-induced agranulocytosis

(2016) C-L Cheung et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

(2016) Catherine C. Bell et al.   Scientific Reports

Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability

(2016) Delilah F. G. Hendriks et al.   Scientific Reports

Cardioprotective effects of timosaponin B II from Anemarrhenae asphodeloides Bge on isoproterenol-induced myocardial infarction in rats

(2015) Xue-Yang Deng et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Development of novel tools for thein vitroinvestigation of drug-induced liver injury

(2015) Jian Jiang et al.   Expert Opinion on Drug Metabolism & Toxicology

CCAAT/enhancer-binding protein α is required for hepatic outgrowth via the p53 pathway in zebrafish

(2015) Hao Yuan et al.   Scientific Reports

Dose-Response Analysis Using R

(2015) Christian Ritz et al.   PLoS One

A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies

(2014) Sreenivasa C. Ramaiahgari et al.   ARCHIVES OF TOXICOLOGY

Toxicogenomics directory of chemically exposed human hepatocytes

(2014) Marianna Grinberg et al.   ARCHIVES OF TOXICOLOGY

Simultaneous LC-MS/MS Analysis of the Plasma Concentrations of a Cocktail of 5 Cytochrome P450 Substrate Drugs and Their Metabolites

(2014) Shimako Tanaka et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Vascularized and functional human liver from an iPSC-derived organ bud transplant

(2013) Takanori Takebe et al.   NATURE

STAT1 negatively regulates hepatocellular carcinoma cell proliferation

(2013) GUOFU CHEN et al.   ONCOLOGY REPORTS

A Correlation Between the In Vitro Drug Toxicity of Drugs to Cell Lines That Express Human P450s and Their Propensity to Cause Liver Injury in Humans

(2013) Frida Gustafsson et al.   TOXICOLOGICAL SCIENCES

Development of an Adverse Outcome Pathway From Drug-Mediated Bile Salt Export Pump Inhibition to Cholestatic Liver Injury

(2013) Mathieu Vinken et al.   TOXICOLOGICAL SCIENCES

An overview of transcriptional regulation in response to toxicological insult

(2012) Paul Jennings et al.   ARCHIVES OF TOXICOLOGY

Possible roles of DLK1 in the Notch pathway during development and disease

(2012) Farah A. Falix et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Organotypic liver culture models: Meeting current challenges in toxicity testing

(2012) Edward L. LeCluyse et al.   CRITICAL REVIEWS IN TOXICOLOGY

Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress

(2012) Anja Wilmes et al.   Journal of Proteomics

Use of Micropatterned Cocultures to Detect Compounds That Cause Drug-Induced Liver Injury in Humans

(2012) Salman R. Khetani et al.   TOXICOLOGICAL SCIENCES

Diclofenac inhibits tumor necrosis factor-α-induced nuclear factor-κB activation causing synergistic hepatocyte apoptosis

(2011) Lisa Fredriksson et al.   HEPATOLOGY

STAT1 activation regulates proliferation and differentiation of renal progenitors

(2010) Honghe Wang et al.   CELLULAR SIGNALLING

Use of transcriptomics in understanding mechanisms of drug-induced toxicity

(2010) Yuxia Cui et al.   PHARMACOGENOMICS

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

(2009) Ann K Daly et al.   NATURE GENETICS

Characterisation of flucloxacillin and 5-hydroxymethyl flucloxacillin haptenated HSAin vitroandin vivo

(2009) Rosalind E. Jenkins et al.   Proteomics Clinical Applications

Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury

(2008) Jinghai J. Xu et al.   TOXICOLOGICAL SCIENCES