Development of an Adverse Outcome Pathway From Drug-Mediated Bile Salt Export Pump Inhibition to Cholestatic Liver Injury

An updated review on drug-induced cholestasis: Mechanisms and investigation of physicochemical properties and pharmacokinetic parameters

(2013) Kyunghee Yang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toxicogenomics for transcription factor-governed molecular pathways: moving on to roles beyond classification and prediction

(2012) Melvin E. Andersen et al.   ARCHIVES OF TOXICOLOGY

Metabolomics reveals an essential role for peroxisome proliferator-activated receptor α in bile acid homeostasis

(2012) Fei Li et al.   JOURNAL OF LIPID RESEARCH

Novel insight into mechanisms of cholestatic liver injury

(2012) Benjamin L Woolbright   WORLD JOURNAL OF GASTROENTEROLOGY

Bile Acids Induce Inflammatory Genes in Hepatocytes

(2011) Katryn Allen et al.   AMERICAN JOURNAL OF PATHOLOGY

Screening of repeated dose toxicity data present in SCC(NF)P/SCCS safety evaluations of cosmetic ingredients

(2011) Mathieu Vinken et al.   ARCHIVES OF TOXICOLOGY

Drug-induced cholestasis

(2011) Manmeet S. Padda et al.   HEPATOLOGY

Effect of bile duct ligation on bile acid composition in mouse serum and liver

(2011) Youcai Zhang et al.   LIVER INTERNATIONAL

Progressive Familial Intrahepatic Cholestasis (PFIC) Type 1, 2, and 3: A Review of the Liver Pathology Findings

(2011) Raffaella Morotti et al.   SEMINARS IN LIVER DISEASE

BSEP inhibition – In vitro screens to assess cholestatic potential of drugs

(2011) Emese Kis et al.   TOXICOLOGY IN VITRO

Oxidative stress is a triggering factor for LPS-induced Mrp2 internalization in the cryopreserved rat and human liver slices

(2010) Shuichi Sekine et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of Breast Cancer Resistance Protein in the Adaptive Response to Cholestasis

(2010) A. Mennone et al.   DRUG METABOLISM AND DISPOSITION

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Itraconazole-Induced Cholestasis: Involvement of the Inhibition of Bile Canalicular Phospholipid Translocator MDR3/ABCB4

(2010) T. Yoshikado et al.   MOLECULAR PHARMACOLOGY

Nuclear receptors as drug targets in cholestasis and drug-induced hepatotoxicity

(2010) Gernot Zollner et al.   PHARMACOLOGY & THERAPEUTICS

Contribution of High Basolateral Bile Salt Efflux to the Lack of Hepatotoxicity in Rat in Response to Drugs Inducing Cholestasis in Human

(2010) Katalin Jemnitz et al.   TOXICOLOGICAL SCIENCES

Interference with Bile Salt Export Pump Function Is a Susceptibility Factor for Human Liver Injury in Drug Development

(2010) Ryan E. Morgan et al.   TOXICOLOGICAL SCIENCES

The Key Events Dose-Response Framework: A Cross-Disciplinary Mode-of-Action Based Approach to Examining Dose-Response and Thresholds

(2009) Elizabeth Julien* et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

De novo bile salt transporter antibodies as a possible cause of recurrent graft failure after liver transplantation: A novel mechanism of cholestasis

(2009) Verena Keitel et al.   HEPATOLOGY

Phenotypic characterization of idiosyncratic drug-induced liver injury: The influence of age and sex

(2009) M. Isabel Lucena et al.   HEPATOLOGY

New molecular insights into the mechanisms of cholestasis

(2009) Martin Wagner et al.   JOURNAL OF HEPATOLOGY

Recurrence of Bile Salt Export Pump Deficiency after Liver Transplantation

(2009) Paloma Jara et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human health safety evaluation of cosmetics in the EU: A legally imposed challenge to science

(2009) M. Pauwels et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mechanisms of Cholestasis

(2008) Gernot Zollner et al.   Clinics in Liver Disease

Novel Orphan Nuclear Receptors-Coregulator Interactions Controlling Anti-Cancer Drug Metabolism

(2008) Radharani Gollamudi et al.   CURRENT DRUG METABOLISM

Use of toxicogenomics to understand mechanisms of drug-induced hepatotoxicity during drug discovery and development

(2008) Eric A.G. Blomme et al.   TOXICOLOGY LETTERS

The current state of serum biomarkers of hepatotoxicity

(2007) Josef Ozer et al.   TOXICOLOGY