Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq

ToxPi Graphical User Interface 2.0: Dynamic exploration, visualization, and sharing of integrated data models

(2018) Skylar W. Marvel et al.   BMC BIOINFORMATICS

Mechanism of valproic acid-induced Fanconi syndrome involves mitochondrial dysfunction and oxidative stress in rat kidney

(2018) Reza Heidari et al.   NEPHROLOGY

A hybrid gene selection approach to create the S1500+ targeted gene sets for use in high-throughput transcriptomics

(2018) Deepak Mav et al.   PLoS One

Drug-Induced Liver Injury: Cascade of Events Leading to Cell Death, Apoptosis or Necrosis

(2017) Andrea Iorga et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling

(2017) Joanne M. Yeakley et al.   PLoS One

Mechanism of isoniazid-induced hepatotoxicity: then and now

(2016) Imir Metushi et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

A chemical–biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives

(2016) Fabian A. Grimm et al.   GREEN CHEMISTRY

Hepatotoxicity mechanisms of isoniazid: A mini-review

(2015) Hozeifa M. Hassan et al.   JOURNAL OF APPLIED TOXICOLOGY

High-Throughput Tag-Sequencing Analysis of Early Events Induced by Ochratoxin A in HepG-2 Cells

(2015) Yu Zhang et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Strategies, models and biomarkers in experimental non-alcoholic fatty liver disease research

(2015) Joost Willebrords et al.   PROGRESS IN LIPID RESEARCH

Sodium valproate induces mitochondrial respiration dysfunction in HepG2 in vitro cell model

(2015) Tuomas Komulainen et al.   TOXICOLOGY

Application of RPTEC/TERT1 cells for investigation of repeat dose nephrotoxicity: A transcriptomic study

(2015) Lydia Aschauer et al.   TOXICOLOGY IN VITRO

Transcriptomics hit the target: Monitoring of ligand-activated and stress response pathways for chemical testing

(2015) Alice Limonciel et al.   TOXICOLOGY IN VITRO

Design Principles of Concentration-Dependent Transcriptome Deviations in Drug-Exposed Differentiating Stem Cells

(2014) Tanja Waldmann et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease

(2014) Edgar Dawkins et al.   JOURNAL OF NEUROCHEMISTRY

Epiregulin: Roles in normal physiology and cancer

(2014) David J. Riese et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A Review of the Evidence that Ochratoxin A Is an Nrf2 Inhibitor: Implications for Nephrotoxicity and Renal Carcinogenicity

(2014) Alice Limonciel et al.   Toxins

Transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models

(2013) Tatyana Y. Doktorova et al.   CARCINOGENESIS

Delineation of the Key Aspects in the Regulation of Epithelial Monolayer Formation

(2013) L. Aschauer et al.   MOLECULAR AND CELLULAR BIOLOGY

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Alpha-fetoprotein: a renaissance

(2013) A. A. Terentiev et al.   TUMOR BIOLOGY

Oxidative stress induced by potassium bromate exposure results in altered tight junction protein expression in renal proximal tubule cells

(2012) Alice Limonciel et al.   ARCHIVES OF TOXICOLOGY

An overview of transcriptional regulation in response to toxicological insult

(2012) Paul Jennings et al.   ARCHIVES OF TOXICOLOGY

ToxPi GUI: an interactive visualization tool for transparent integration of data from diverse sources of evidence

(2012) D. M. Reif et al.   BIOINFORMATICS

Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress

(2012) Anja Wilmes et al.   Journal of Proteomics

A label-free, impedance-based real time assay to identify drug-induced toxicities and differentiate cytostatic from cytotoxic effects

(2012) S. Kustermann et al.   TOXICOLOGY IN VITRO

Beneficial Role of Nrf2 in Regulating NADPH Generation and Consumption

(2011) Kai Connie Wu et al.   TOXICOLOGICAL SCIENCES

Lactate is an ideal non-invasive marker for evaluating temporal alterations in cell stress and toxicity in repeat dose testing regimes

(2011) Alice Limonciel et al.   TOXICOLOGY IN VITRO

Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood

(2010) Shruta S. Dadarkar et al.   JOURNAL OF APPLIED TOXICOLOGY

Identification and dissection of the Nrf2 mediated oxidative stress pathway in human renal proximal tubule toxicity

(2010) Anja Wilmes et al.   TOXICOLOGY IN VITRO

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion

(2009) Paul Jennings et al.   TOXICOLOGY IN VITRO

Effect of ochratoxin A on redox-regulated transcription factors, antioxidant enzymes and glutathione-S-transferase in cultured kidney tubulus cells

(2008) C. Boesch-Saadatmandi et al.   FOOD AND CHEMICAL TOXICOLOGY

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY