Mechanism of isoniazid-induced hepatotoxicity: then and now

T Cell–Mediated Hypersensitivity Reactions to Drugs

(2015) Rebecca Pavlos et al.   Annual Review of Medicine

The Combination of Anti-CTLA-4 and PD1–/– Mice Unmasks the Potential of Isoniazid and Nevirapine To Cause Liver Injury

(2015) Alastair Mak et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study

(2015) Naga Chalasani et al.   GASTROENTEROLOGY

Treatment of PD-1−/−mice with amodiaquine and anti-CTLA4 leads to liver injury similar to idiosyncratic liver injury in patients

(2015) Imir G. Metushi et al.   HEPATOLOGY

Evolving models of the immunopathogenesis of T cell–mediated drug allergy: The role of host, pathogens, and drug response

(2015) Katie D. White et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Comprehensive genome-wide evaluation of lapatinib-induced liver injury yields a single genetic signal centered on known risk allele HLA-DRB1*07:01

(2015) L R Parham et al.   PHARMACOGENOMICS JOURNAL

IgG3 Is the Dominant Subtype of Anti-isoniazid Antibodies in Patients with Isoniazid-Induced Liver Failure

(2014) Imir G. Metushi et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin

(2014) Xiaoli Meng et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Mild Isoniazid-Induced Liver Injury in Humans Is Associated with an Increase in Th17 Cells and T Cells Producing IL-10

(2014) Imir G. Metushi et al.   CHEMICAL RESEARCH IN TOXICOLOGY

N-acetyltransferase 2 (NAT2) genotype as a risk factor for development of drug-induced liver injury relating to antituberculosis drug treatment in a mixed-ethnicity patient group

(2014) Ching-Soon Ng et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Recent progress in genetic variation and risk of antituberculosis drug-induced liver injury

(2014) Yi-Shin Huang   Journal of the Chinese Medical Association

Regulatory T cells modulate granulomatous inflammation in an HLA-DP2 transgenic murine model of beryllium-induced disease

(2014) D. G. Mack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Systems Biology Approach Utilizing a Mouse Diversity Panel Identifies Genetic Differences Influencing Isoniazid-Induced Microvesicular Steatosis

(2014) Rachel J. Church et al.   TOXICOLOGICAL SCIENCES

Detection of anti-isoniazid and anti-cytochrome P450 antibodies in patients with isoniazid-induced liver failure

(2013) Imir G. Metushi et al.   HEPATOLOGY

Isoniazid-induced liver injury and immune response in mice

(2013) Imir G. Metushi et al.   Journal of Immunotoxicology

Lack of liver injury in Wistar rats treated with the combination of isoniazid and rifampicin

(2013) Imir G. Metushi et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy

(2013) Feng Li et al.   NATURE MEDICINE

Direct Oxidation and Covalent Binding of Isoniazid to Rodent Liver and Human Hepatic Microsomes: Humans Are More Like Mice than Rats

(2012) Imir G. Metushi et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States

(2011) Antonia F. Stepan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A Fresh Look at the Mechanism of Isoniazid-Induced Hepatotoxicity

(2011) I G Metushi et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome

(2011) Tai-Ming Ko et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TNF-α genetic polymorphism −308G/A and antituberculosis drug-induced hepatitis

(2011) Sang-Heon Kim et al.   LIVER INTERNATIONAL

Role of IL-17 and Th17 Cells in Liver Diseases

(2010) Linda Hammerich et al.   Clinical & Developmental Immunology

Biology of interleukin-10

(2010) Robert Sabat et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Influence of glutathione S-transferase M1 and T1 homozygous null mutations on the risk of antituberculosis drug-induced hepatotoxicity in a Caucasian population

(2010) Virginia Leiro et al.   LIVER INTERNATIONAL

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury

(2010) Jonathan B Singer et al.   NATURE GENETICS

A Zone Classification System for Risk Assessment of Idiosyncratic Drug Toxicity Using Daily Dose and Covalent Binding

(2009) S. Nakayama et al.   DRUG METABOLISM AND DISPOSITION

Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa

(2009) S A Khader et al.   Mucosal Immunology