Use of transcriptomics in understanding mechanisms of drug-induced toxicity

Gene Expression Profiles in Peripheral Blood Mononuclear Cells Can Distinguish Patients with Non-Small Cell Lung Cancer from Patients with Nonmalignant Lung Disease

(2009) M. K. Showe et al.   CANCER RESEARCH

Omic profiling for drug safety assessment: current trends and public–private partnerships

(2009) William M. Gallagher et al.   DRUG DISCOVERY TODAY

Blood-based transcriptomics: leukemias and beyond

(2009) Andrea Staratschek-Jox et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans

(2009) A. H. Harrill et al.   GENOME RESEARCH

Acetaminophen dosing of humans results in blood transcriptome and metabolome changes consistent with impaired oxidative phosphorylation

(2009) Rick D. Fannin et al.   HEPATOLOGY

Orphan Transporter SLC6A18 Is Renal Neutral Amino Acid Transporter B0AT3

(2009) Dustin Singer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Population-Based Discovery of Toxicogenomics Biomarkers for Hepatotoxicity Using a Laboratory Strain Diversity Panel

(2009) Alison H. Harrill et al.   TOXICOLOGICAL SCIENCES

Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion

(2009) Paul Jennings et al.   TOXICOLOGY IN VITRO

Transcriptomic Analysis of Nephrotoxicity Induced by Cephaloridine, a Representative Cephalosporin Antibiotic

(2008) Masatomo Rokushima et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Integrated Pathway Analysis of Rat Urine Metabolic Profiles and Kidney Transcriptomic Profiles To Elucidate the Systems Toxicology of Model Nephrotoxicants

(2008) Ethan Yixun Xu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

An overview of drug-induced acute kidney injury

(2008) Neesh Pannu et al.   CRITICAL CARE MEDICINE

Simultaneous application of t-test and fold change criteria to identify acetaminophen and carbon tetrachloride affected genes in mice liver

(2008) Sanjeev Noel et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Systems biology and functional genomics approaches for the identification of cellular responses to drug toxicity

(2008) Alison Hege Harrill et al.   Expert Opinion on Drug Metabolism & Toxicology

Causes, Clinical Features, and Outcomes From a Prospective Study of Drug-Induced Liver Injury in the United States

(2008) Naga Chalasani et al.   GASTROENTEROLOGY

In vitro gene expression analysis of hepatotoxic drugs in rat primary hepatocytes

(2008) Hiromi Suzuki et al.   JOURNAL OF APPLIED TOXICOLOGY

In vitro gene expression analysis of nephrotoxic drugs in rat primary renal cortical tubular cells

(2008) Hiromi Suzuki et al.   JOURNAL OF APPLIED TOXICOLOGY

Differential gene expression analysis of a known hepatotoxin, N-acetyl-p-amino-phenol (APAP) as compared to its non-toxic analog, N-acetyl-m-amino-phenol (AMAP) in mouse liver

(2008) Priyanka Priyadarsiny et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Parallelogram Approach Using Rat-Human In Vitro and Rat In Vivo Toxicogenomics Predicts Acetaminophen-induced Hepatotoxicity in Humans

(2008) Anne S. Kienhuis et al.   TOXICOLOGICAL SCIENCES

Coexposure of Mice to Trovafloxacin and Lipopolysaccharide, a Model of Idiosyncratic Hepatotoxicity, Results in a Unique Gene Expression Profile and Interferon Gamma–Dependent Liver Injury

(2008) Patrick J. Shaw et al.   TOXICOLOGICAL SCIENCES

Gene expression profiles of murine fatty liver induced by the administration of methotrexate

(2008) Min-Ho Lee et al.   TOXICOLOGY

A toxicogenomics approach for early assessment of potential non-genotoxic hepatocarcinogenicity of chemicals in rats

(2008) Takeki Uehara et al.   TOXICOLOGY

Response of human renal tubular cells to cyclosporine and sirolimus: A toxicogenomic study

(2008) Nicolas Pallet et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Use of toxicogenomics to understand mechanisms of drug-induced hepatotoxicity during drug discovery and development

(2008) Eric A.G. Blomme et al.   TOXICOLOGY LETTERS

Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype

(2008) Edward K Lobenhofer et al.   GENOME BIOLOGY

Analysis of Functional Groups of Differentially Expressed Genes in the Peripheral Blood of Patients with Cervical Cancer Undergoing Concurrent Chemoradiation Treatment

(2007) Angel Chao et al.   RADIATION RESEARCH

PPARα: Mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators

(2007) Frank J. Gonzalez et al.   TOXICOLOGY

Evaluation of the effects of serial phlebotomy on the transcriptome of major tissues and on the response to toxicants in rats

(2007) Eric A.G. Blomme et al.   TOXICOLOGY LETTERS