Strategies to eradicate HIV from infected patients: elimination of latent provirus reservoirs

HIV Eradication Strategies: Implications for the Central Nervous System

(2019) Rebecca T. Veenhuis et al.   Current HIV/AIDS Reports

The inhibitor apoptosis protein antagonist Debio 1143 Is an attractive HIV-1 latency reversal candidate

(2019) Michael Bobardt et al.   PLoS One

HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation

(2019) Ravindra K. Gupta et al.   NATURE

Adeno-Associated Virus Delivery of Anti-HIV Monoclonal Antibodies Can Drive Long-Term Virologic Suppression

(2019) José M. Martinez-Navio et al.   IMMUNITY

Shifting the HIV Paradigm from Care to Cure: Proceedings from the Caribbean Expert Summit in Barbados, August 2017

(2018) R. Clive Landis et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Novel Latency Reversal Agents for HIV-1 Cure

(2018) Adam M. Spivak et al.   Annual Review of Medicine

Getting the “Kill” into “Shock and Kill”: Strategies to Eliminate Latent HIV

(2018) Youry Kim et al.   Cell Host & Microbe

Astrocytes sustain long-term productive HIV-1 infection without establishment of reactivable viral latency

(2018) Corinne Barat et al.   GLIA

The role of latency reversal agents in the cure of HIV: A review of current data

(2018) Kiandokht Bashiri et al.   IMMUNOLOGY LETTERS

Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells

(2018) Szu-Han Huang et al.   JOURNAL OF CLINICAL INVESTIGATION

The Pathway To Establishing HIV Latency Is Critical to How Latency Is Maintained and Reversed

(2018) Simin D. Rezaei et al.   JOURNAL OF VIROLOGY

Maraviroc Is Associated with Latent HIV-1 Reactivation through NF-κB Activation in Resting CD4+ T Cells from HIV-Infected Individuals on Suppressive Antiretroviral Therapy

(2018) Nadia Madrid-Elena et al.   JOURNAL OF VIROLOGY

Interleukin-15-Stimulated Natural Killer Cells Clear HIV-1-Infected Cells following Latency Reversal Ex Vivo

(2018) Carolina Garrido et al.   JOURNAL OF VIROLOGY

A New Quinoline BRD4 Inhibitor Targets a Distinct Latent HIV-1 Reservoir for Reactivation from Other “Shock” Drugs

(2018) Erik Abner et al.   JOURNAL OF VIROLOGY

Born to run: control of transcription elongation by RNA polymerase II

(2018) Fei Xavier Chen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Measuring integrated HIV DNA ex vivo and in vitro provides insights about how reservoirs are formed and maintained

(2018) Marilia Rita Pinzone et al.   Retrovirology

HIV Reactivation after Partial Protection by Neutralizing Antibodies

(2018) Matthew S. Parsons et al.   TRENDS IN IMMUNOLOGY

Genome scale screening identification of SaCas9/gRNAs for targeting HIV-1 provirus and suppression of HIV-1 infection

(2018) Qiankun Wang et al.   VIRUS RESEARCH

CRISPR-Cas based antiviral strategies against HIV-1

(2018) Gang Wang et al.   VIRUS RESEARCH

Epigenetic regulation of HIV-1 latency: focus on polycomb group (PcG) proteins

(2018) Sheraz Khan et al.   Clinical Epigenetics

Cytokine release syndrome

(2018) Alexander Shimabukuro-Vornhagen et al.   Journal for ImmunoTherapy of Cancer

Barriers for HIV Cure: The Latent Reservoir

(2018) Sergio Castro-Gonzalez et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation

(2018) Homa Rahnamoun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CD32 Expression is not Associated to HIV-DNA content in CD4 cell subsets of individuals with Different Levels of HIV Control

(2018) Marcial García et al.   Scientific Reports

Benzolactam-related compounds promote apoptosis of HIV-infected human cells via protein kinase C–induced HIV latency reversal

(2018) Kouki Matsuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A majority of HIV persistence during antiretroviral therapy is due to infected cell proliferation

(2018) Daniel B. Reeves et al.   Nature Communications

Hematopoietic Stem and Progenitor Cells Are a Distinct HIV Reservoir that Contributes to Persistent Viremia in Suppressed Patients

(2018) Thomas D. Zaikos et al.   Cell Reports

Gene Editing of HIV-1 Co-receptors to Prevent and/or Cure Virus Infection

(2018) Alexander G. Allen et al.   Frontiers in Microbiology

Expanding the Therapeutic Window for CAR T Cell Therapy in Solid Tumors: The Knowns and Unknowns of CAR T Cell Biology

(2018) Keisuke Watanabe et al.   Frontiers in Immunology

Therapeutic Targeting of HIV Reservoirs: How to Give T Cells a New Direction

(2018) Hongbing Yang et al.   Frontiers in Immunology

Human Immunodeficiency Virus and Aging in the Era of Effective Antiretroviral Therapy

(2017) Puja Van Epps et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Interval dosing with the HDAC inhibitor vorinostat effectively reverses HIV latency

(2017) Nancie M. Archin et al.   JOURNAL OF CLINICAL INVESTIGATION

Sequential Vacc-4x and romidepsin during combination antiretroviral therapy (cART): Immune responses to Vacc-4x regions on p24 and changes in HIV reservoirs

(2017) G. Tapia et al.   JOURNAL OF INFECTION

Current status of HIV/AIDS in the ART era

(2017) Kazuhisa Yoshimura   JOURNAL OF INFECTION AND CHEMOTHERAPY

Perspectives on Human Immunodeficiency Virus (HIV) Cure: HIV Persistence in Tissue

(2017) Eli A. Boritz et al.   JOURNAL OF INFECTIOUS DISEASES

Proviral Latency, Persistent Human Immunodeficiency Virus Infection, and the Development of Latency Reversing Agents

(2017) David M. Margolis et al.   JOURNAL OF INFECTIOUS DISEASES

Humoral and Innate Antiviral Immunity as Tools to Clear Persistent HIV Infection

(2017) Guido Ferrari et al.   JOURNAL OF INFECTIOUS DISEASES

HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency

(2017) George N. Llewellyn et al.   JOURNAL OF NEUROVIROLOGY

Maintenance of the HIV Reservoir Is Antagonized by Selective BCL2 Inhibition

(2017) Nathan W. Cummins et al.   JOURNAL OF VIROLOGY

Quiescence Promotes Latent HIV Infection and Resistance to Reactivation from Latency with Histone Deacetylase Inhibitors

(2017) Mark M. Painter et al.   JOURNAL OF VIROLOGY

Toll-Like Receptor 7 Agonist GS-9620 Induces HIV Expression and HIV-Specific Immunity in Cells from HIV-Infected Individuals on Suppressive Antiretroviral Therapy

(2017) Angela Tsai et al.   JOURNAL OF VIROLOGY

Relationship between Measures of HIV Reactivation and Decline of the Latent Reservoir under Latency-Reversing Agents

(2017) Janka Petravic et al.   JOURNAL OF VIROLOGY

Elimination of cancer stem cells and reactivation of latent HIV-1 via AMPK activation: Common mechanism of action linking inhibition of tumorigenesis and the potential eradication of HIV-1

(2017) Jahahreeh Finley   MEDICAL HYPOTHESES

In Vivo Excision of HIV-1 Provirus by saCas9 and Multiplex Single-Guide RNAs in Animal Models

(2017) Chaoran Yin et al.   MOLECULAR THERAPY

CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses

(2017) Benjamin Descours et al.   NATURE

HIV integration sites in latently infected cell lines: evidence of ongoing replication

(2017) Jori Symons et al.   Retrovirology

A mature macrophage is a principal HIV-1 cellular reservoir in humanized mice after treatment with long acting antiretroviral therapy

(2017) Mariluz Araínga et al.   Retrovirology

HIV Latency: Should We Shock or Lock?

(2017) Gilles Darcis et al.   TRENDS IN IMMUNOLOGY

Targeted Immune Interventions for an HIV-1 Cure

(2017) Matthieu Perreau et al.   TRENDS IN MOLECULAR MEDICINE

The Human Immunodeficiency Virus 1 ASP RNA promotes viral latency by recruiting the Polycomb Repressor Complex 2 and promoting nucleosome assembly

(2017) Juan C. Zapata et al.   VIROLOGY

Synergistic reactivation of latent HIV-1 provirus by PKA activator dibutyryl-cAMP in combination with an HDAC inhibitor

(2017) Hoyong Lim et al.   VIRUS RESEARCH

Multiple Histone Lysine Methyltransferases Are Required for the Establishment and Maintenance of HIV-1 Latency

(2017) Kien Nguyen et al.   mBio

BET inhibitors RVX-208 and PFI-1 reactivate HIV-1 from latency

(2017) Panpan Lu et al.   Scientific Reports

Systems analysis of latent HIV reversal reveals altered stress kinase signaling and increased cell death in infected T cells

(2017) Linda E. Fong et al.   Scientific Reports

Reactivation of HIV-1 from Latency by an Ingenol Derivative from Euphorbia Kansui

(2017) Pengfei Wang et al.   Scientific Reports

Dendritic cells as natural latency reversing agent: A wake-up call for HIV-1

(2017) T. van Montfort et al.   Virulence

In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and "kill" in strategy for virus eradication

(2017) Matthew D. Marsden et al.   PLoS Pathogens

The therapeutic landscape of HIV-1 via genome editing

(2017) Alexander Kwarteng et al.   AIDS Research and Therapy

Eradication of HIV-1 latent reservoirs through therapeutic vaccination

(2017) Joshua Pankrac et al.   AIDS Research and Therapy

A Novel Bromodomain Inhibitor Reverses HIV-1 Latency through Specific Binding with BRD4 to Promote Tat and P-TEFb Association

(2017) Huachao Huang et al.   Frontiers in Microbiology

The Molecular Basis for Human Immunodeficiency Virus Latency

(2017) Uri Mbonye et al.   Annual Review of Virology

Endogenous Retroviruses: With Us and against Us

(2017) Thomas J. Meyer et al.   Frontiers in Chemistry

A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter

(2017) Jun Wu et al.   Scientific Reports

A clue to unprecedented strategy to HIV eradication: “Lock-in and apoptosis”

(2017) Hiroshi Tateishi et al.   Scientific Reports

Connecting HIV-1 integration and transcription: a step toward new treatments

(2016) Bojana Lucic et al.   FEBS LETTERS

Current views on HIV-1 latency, persistence, and cure

(2016) Zora Melkova et al.   FOLIA MICROBIOLOGICA

HIV-specific CD8+ T cells and HIV eradication

(2016) R. Brad Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

Modulation of apoptosis and viral latency – an axis to be well understood for successful cure of human immunodeficiency virus

(2016) Uddhav Timilsina et al.   JOURNAL OF GENERAL VIROLOGY

HIV Provirus Stably Reproduces Parental Latent and Induced Transcription Phenotypes Regardless of the Chromosomal Integration Site

(2016) Farhad B. Hashemi et al.   JOURNAL OF VIROLOGY

Promising Role of Toll-Like Receptor 8 Agonist in Concert with Prostratin for Activation of Silent HIV

(2016) M. A. Rochat et al.   JOURNAL OF VIROLOGY

A Minor Subset of Super Elongation Complexes Plays a Predominant Role in Reversing HIV-1 Latency

(2016) Zichong Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Development of an Attenuated Tat Protein as a Highly-effective Agent to Specifically Activate HIV-1 Latency

(2016) Guannan Geng et al.   MOLECULAR THERAPY

Elimination of Latently HIV-infected Cells from Antiretroviral Therapy-suppressed Subjects by Engineered Immune-mobilizing T-cell Receptors

(2016) Hongbing Yang et al.   MOLECULAR THERAPY

HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3

(2016) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

Position effects influence HIV latency reversal

(2016) Heng-Chang Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reactivation of Latent HIV-1 Expression by Engineered TALE Transcription Factors

(2016) Pedro Perdigão et al.   PLoS One

Are T cells the only HIV-1 reservoir?

(2016) Abraham Joseph Kandathil et al.   Retrovirology

Reversal of Latency as Part of a Cure for HIV-1

(2016) Thomas Aagaard Rasmussen et al.   TRENDS IN MICROBIOLOGY

Shutdown of HIV-1 Transcription in T Cells by Nullbasic, a Mutant Tat Protein

(2016) Hongping Jin et al.   mBio

Strategies to target non-T-cell HIV reservoirs

(2016) Jonah B. Sacha et al.   Current Opinion in HIV and AIDS

Tissue reservoirs of HIV

(2016) Joseph K. Wong et al.   Current Opinion in HIV and AIDS

Cell and gene therapy strategies to eradicate HIV reservoirs

(2016) Chelsea Spragg et al.   Current Opinion in HIV and AIDS

Shocking HIV out of hiding

(2016) Thomas A. Rasmussen et al.   Current Opinion in HIV and AIDS

Position effects influence HIV latency reversal

(2016) Heng-Chang Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Which therapeutic strategy will achieve a cure for HIV-1?

(2016) Anthony R Cillo et al.   Current Opinion in Virology

A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes

(2016) R. Brad Jones et al.   PLoS Pathogens

Stem cell transplantation in strategies for curing HIV/AIDS

(2016) Gero Hütter   AIDS Research and Therapy

Temporal proteomic analysis of HIV infection reveals remodelling of the host phosphoproteome by lentiviral Vif variants

(2016) Edward JD Greenwood et al.   eLife

Targeting the Brain Reservoirs: Toward an HIV Cure

(2016) Céline Marban et al.   Frontiers in Immunology

Targeted HIV-1 Latency Reversal Using CRISPR/Cas9-Derived Transcriptional Activator Systems

(2016) Julia K. Bialek et al.   PLoS One

Specific Elimination of Latently HIV-1 Infected Cells Using HIV-1 Protease-Sensitive Toxin Nanocapsules

(2016) Jing Wen et al.   PLoS One

BIRC2/cIAP1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency

(2015) Lars Pache et al.   Cell Host & Microbe

LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes

(2015) Parmit Kumar Singh et al.   GENES & DEVELOPMENT

Ex vivo analysis identifies effective HIV-1 latency–reversing drug combinations

(2015) Gregory M. Laird et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of HIV-1 Latency by Chromatin Structure and Nuclear Architecture

(2015) Marina Lusic et al.   JOURNAL OF MOLECULAR BIOLOGY

Antibody-Dependent Cellular Cytotoxicity against Reactivated HIV-1-Infected Cells

(2015) Wen Shi Lee et al.   JOURNAL OF VIROLOGY

HIV reservoirs as obstacles and opportunities for an HIV cure

(2015) Tae-Wook Chun et al.   NATURE IMMUNOLOGY

Reactivation of latent HIV-1 provirus via targeting protein phosphatase-1

(2015) Mudit Tyagi et al.   Retrovirology

HIV-1 IN/Pol recruits LEDGF/p75 into viral particles

(2015) Belete Desimmie et al.   Retrovirology

Two cellular microRNAs, miR-196b and miR-1290, contribute to HIV-1 latency

(2015) Pengfei Wang et al.   VIROLOGY

Novel RNA Duplex Locks HIV-1 in a Latent State via Chromatin-mediated Transcriptional Silencing

(2015) Chantelle Ahlenstiel et al.   Molecular Therapy-Nucleic Acids

First report on isolation of methyl gallate with antioxidant, anti-HIV-1 and HIV-1 enzyme inhibitory activities from a mushroom (Pholiota adiposa)

(2014) Chang Rong Wang et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Discovery of a Small Molecule Agonist of Phosphatidylinositol 3-Kinase p110α That Reactivates Latent HIV-1

(2014) Geneviève Doyon et al.   PLoS One

Direct non-productive HIV-1 infection in a T-cell line is driven by cellular activation state and NFκB

(2014) Matthew S Dahabieh et al.   Retrovirology

Long-lived reservoirs of HIV-1

(2014) Thomas D. Zaikos et al.   TRENDS IN MICROBIOLOGY

HIV cure research: Advances and prospects

(2014) Caroline P. Passaes et al.   VIROLOGY

Immune Suppression by Neutrophils in HIV-1 Infection: Role of PD-L1/PD-1 Pathway

(2014) Nathan L. Bowers et al.   PLoS Pathogens

From reactivation of latent HIV-1 to elimination of the latent reservoir: The presence of multiple barriers to viral eradication

(2013) Liang Shan et al.   BIOESSAYS

Closing the gap between T-cell life span estimates from stable isotope-labeling studies in mice and humans

(2013) L. Westera et al.   BLOOD

An Integrated Overview of HIV-1 Latency

(2013) Debbie S. Ruelas et al.   CELL

Human dendritic cell subsets

(2013) Matthew Collin et al.   IMMUNOLOGY

High Levels of CD2 Expression Identify HIV-1 Latently Infected Resting Memory CD4+ T Cells in Virally Suppressed Subjects

(2013) M. Iglesias-Ussel et al.   JOURNAL OF VIROLOGY

A Doubly Fluorescent HIV-1 Reporter Shows that the Majority of Integrated HIV-1 Is Latent Shortly after Infection

(2013) M. S. Dahabieh et al.   JOURNAL OF VIROLOGY

Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells

(2013) Xiying Qu et al.   NUCLEIC ACIDS RESEARCH

An Upstream YY1 Binding Site on the HIV-1 LTR Contributes to Latent Infection

(2013) Wendy Bernhard et al.   PLoS One

Dual-acting stapled peptides target both HIV-1 entry and assembly

(2013) Hongtao Zhang et al.   Retrovirology

Dual-color HIV reporters trace a population of latently infected cells and enable their purification

(2013) Vincenzo Calvanese et al.   VIROLOGY

A candidate anti-HIV reservoir compound, auranofin, exerts a selective ‘anti-memory’ effect by exploiting the baseline oxidative status of lymphocytes

(2013) B Chirullo et al.   Cell Death & Disease

Advances in antiretroviral therapy

(2013) Jose R. Arribas et al.   Current Opinion in HIV and AIDS

Therapeutics for HIV-1 reactivation from latency

(2013) Marco Sgarbanti et al.   Current Opinion in Virology

Phosphorylation of CDK9 at Ser175 Enhances HIV Transcription and Is a Marker of Activated P-TEFb in CD4+ T Lymphocytes

(2013) Uri R. Mbonye et al.   PLoS Pathogens

An In-Depth Comparison of Latent HIV-1 Reactivation in Multiple Cell Model Systems and Resting CD4+ T Cells from Aviremic Patients

(2013) Celsa A. Spina et al.   PLoS Pathogens

The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation

(2012) Zichong Li et al.   NUCLEIC ACIDS RESEARCH

Eradication Therapies for HIV Infection: Time to Begin Again

(2011) David M. Margolis   AIDS RESEARCH AND HUMAN RETROVIRUSES

The Suv39H1 methyltransferase inhibitor chaetocin causes induction of integrated HIV-1 without producing a T cell response

(2011) Wendy Bernhard et al.   FEBS LETTERS

New Insights into the Control of HIV-1 Transcription: When Tat Meets the 7SK snRNP and Super Elongation Complex (SEC)

(2011) Nanhai He et al.   Journal of Neuroimmune Pharmacology

Disulfiram Reactivates Latent HIV-1 in a Bcl-2-Transduced Primary CD4+ T Cell Model without Inducing Global T Cell Activation

(2011) S. Xing et al.   JOURNAL OF VIROLOGY

Role of PD-1 in HIV Pathogenesis and as Target for Therapy

(2011) Filippos Porichis et al.   Current HIV/AIDS Reports

HIV reservoirs, latency, and reactivation: Prospects for eradication

(2009) Viktor Dahl et al.   ANTIVIRAL RESEARCH

Determinants of the Establishment of Human Immunodeficiency Virus Type 1 Latency

(2009) A. Duverger et al.   JOURNAL OF VIROLOGY

Transcriptional Interference Antagonizes Proviral Gene Expression to Promote HIV Latency

(2008) Tina Lenasi et al.   Cell Host & Microbe

Factors Controlling Chromatin Organization and Nucleosome Positioning for Establishment and Maintenance of HIV Latency

(2008) Ivan Sadowski et al.   CURRENT HIV RESEARCH

Reversal of HIV-1 latency with anti-microRNA inhibitors

(2008) Hui Zhang   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY