Interleukin-15-Stimulated Natural Killer Cells Clear HIV-1-Infected Cells following Latency Reversal Ex Vivo

The potential and promise of IL-15 in immuno-oncogenic therapies

(2017) Tanya O. Robinson et al.   IMMUNOLOGY LETTERS

CD56bright NK cells exhibit potent antitumor responses following IL-15 priming

(2017) Julia A. Wagner, Maximillian Rosario, Rizwan Romee, Melissa M. Berrien-Elliott, Stephanie E. Schneider, Jeffrey W. Leong, Ryan P. Sullivan, Brea A. Jewell, Michelle Becker-Hapak, Timothy Schappe, Sara Abdel-Latif, Aaron R. Ireland, Devika Jaishankar, Justin A. King, Ravi Vij, Dennis Clement, Jodie Goodridge, Karl-Johan Malmberg, Hing C. Wong, Todd A. Fehniger   JOURNAL OF CLINICAL INVESTIGATION

ALT-803 Transiently Reduces Simian Immunodeficiency Virus Replication in the Absence of Antiretroviral Treatment

(2017) Amy L. Ellis-Connell et al.   JOURNAL OF VIROLOGY

Control of the HIV-1 DNA Reservoir Is Associated In Vivo and In Vitro with NKp46/NKp30 (CD335 CD337) Inducibility and Interferon Gamma Production by Transcriptionally Unique NK Cells

(2017) Francesco Marras et al.   JOURNAL OF VIROLOGY

Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR show long-term persistence and potent antitumor activity

(2017) E Liu et al.   LEUKEMIA

Natural killer cells migrate into and control simian immunodeficiency virus replication in lymph node follicles in African green monkeys

(2017) Nicolas Huot et al.   NATURE MEDICINE

Natural killer cells unleashed: Checkpoint receptor blockade and BiKE/TriKE utilization in NK-mediated anti-tumor immunotherapy

(2017) Zachary B. Davis et al.   SEMINARS IN IMMUNOLOGY

The histone deacetylase inhibitor SAHA simultaneously reactivates HIV-1 from latency and up-regulates NKG2D ligands sensitizing for natural killer cell cytotoxicity

(2017) Maria Giovanna Desimio et al.   VIROLOGY

HIV-1 adaptation to NK cell-mediated immune pressure

(2017) Marjet Elemans et al.   PLoS Pathogens

Increased NK cell immunity in a transgenic mouse model of NKp46 overexpression

(2017) Ariella Glasner et al.   Scientific Reports

NKG2D Acts as a Co-Receptor for Natural Killer Cell-Mediated Anti-HIV-1 Antibody-Dependent Cellular Cytotoxicity

(2016) Matthew S. Parsons et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

A Novel Toll-Like Receptor 9 Agonist, MGN1703, Enhances HIV-1 Transcription and NK Cell-Mediated Inhibition of HIV-1-Infected Autologous CD4+T Cells

(2016) Rasmus Offersen et al.   JOURNAL OF VIROLOGY

Chimeric Antigen Receptor T Cells Guided by the Single-Chain Fv of a Broadly Neutralizing Antibody Specifically and Effectively Eradicate Virus Reactivated from Latency in CD4 + T Lymphocytes Isolated from HIV-1-Infected Individuals Receiving Suppressive Combined Antiretroviral Therapy

(2016) Bingfeng Liu et al.   JOURNAL OF VIROLOGY

CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles

(2016) Yew Ann Leong et al.   NATURE IMMUNOLOGY

Targeting natural killer cells in cancer immunotherapy

(2016) Camille Guillerey et al.   NATURE IMMUNOLOGY

Elimination of HIV-1-infected cells by broadly neutralizing antibodies

(2016) Timothée Bruel et al.   Nature Communications

Shocking HIV out of hiding

(2016) Thomas A. Rasmussen et al.   Current Opinion in HIV and AIDS

Preclinical shock strategies to reactivate latent HIV-1

(2016) Gilles Darcis et al.   Current Opinion in HIV and AIDS

HIV Latency-Reversing Agents Have Diverse Effects on Natural Killer Cell Function

(2016) Carolina Garrido et al.   Frontiers in Immunology

Lysis of HIV-1-infected autologous CD4+ primary T cells by interferon-alpha-activated NK cells requires NKp46 and NKG2D

(2015) Costin Tomescu et al.   AIDS

Recombinant human heterodimeric IL-15 complex displays extensive and reproducible N- and O-linked glycosylation

(2015) M. Thaysen-Andersen et al.   GLYCOCONJUGATE JOURNAL

Expanded Cytotoxic T-cell Lymphocytes Target the Latent HIV Reservoir

(2015) Julia A. Sung et al.   JOURNAL OF INFECTIOUS DISEASES

Innate Immune Activity Correlates with CD4 T Cell-Associated HIV-1 DNA Decline during Latency-Reversing Treatment with Panobinostat

(2015) Rikke Olesen et al.   JOURNAL OF VIROLOGY

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

(2015) Kai Deng et al.   NATURE

Therapeutic approaches to enhance natural killer cell cytotoxicity against cancer: the force awakens

(2015) Richard W. Childs et al.   NATURE REVIEWS DRUG DISCOVERY

The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo

(2015) Ole S. Søgaard et al.   PLoS Pathogens

Comparison of the Superagonist Complex, ALT-803, to IL15 as Cancer Immunotherapeutics in Animal Models

(2015) P. R. Rhode et al.   Cancer Immunology Research

HIV-1 Vaccine-Induced C1 and V2 Env-Specific Antibodies Synergize for Increased Antiviral Activities

(2014) Justin Pollara et al.   JOURNAL OF VIROLOGY

Natural killer cell responses to dendritic cells infected by the ANRS HIV-1 vaccine candidate, MVA HIV

(2014) Jean-Saville Cummings et al.   VACCINE

Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial

(2014) Thomas A Rasmussen et al.   Lancet HIV

Influence of In Vitro IL-2 or IL-15 Alone or in Combination with Hsp-70-Derived 14-mer Peptide (TKD) on the Expression of NK Cell Activatory and Inhibitory Receptors

(2013) Ilona Hromadnikova et al.   MEDIATORS OF INFLAMMATION

Stimulation of HIV-1-Specific Cytolytic T Lymphocytes Facilitates Elimination of Latent Viral Reservoir after Virus Reactivation

(2012) Liang Shan et al.   IMMUNITY

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

(2012) N. M. Archin et al.   NATURE

HIV-1 adaptation to NK-cell-mediated immune pressure

(2011) Galit Alter et al.   NATURE

Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety

(2010) V Hoyos et al.   LEUKEMIA

Natural killer cell–directed therapies: moving from unexpected results to successful strategies

(2008) Magali Terme et al.   NATURE IMMUNOLOGY

The lymph node in HIV pathogenesis

(2008) Michael M. Lederman et al.   SEMINARS IN IMMUNOLOGY

Lysis of Endogenously Infected CD4+ T Cell Blasts by rIL-2 Activated Autologous Natural Killer Cells from HIV-Infected Viremic Individuals

(2008) Manuela Fogli et al.   PLoS Pathogens