Phosphorylation of CDK9 at Ser175 Enhances HIV Transcription and Is a Marker of Activated P-TEFb in CD4+ T Lymphocytes
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Title
Phosphorylation of CDK9 at Ser175 Enhances HIV Transcription and Is a Marker of Activated P-TEFb in CD4+ T Lymphocytes
Authors
Keywords
Phosphorylation, T cells, Flow cytometry, HIV, Memory T cells, Immunoprecipitation, T cell receptors, Acetylation
Journal
PLoS Pathogens
Volume 9, Issue 5, Pages e1003338
Publisher
Public Library of Science (PLoS)
Online
2013-05-03
DOI
10.1371/journal.ppat.1003338
References
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Note: Only part of the references are listed.- BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism
- (2013) Daniela Boehm et al. CELL CYCLE
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- (2012) Jonathan Karn et al. CURRENT HIV RESEARCH
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- (2012) Min Liu et al. MOLECULAR CELL
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- (2012) Koh Fujinaga et al. NUCLEIC ACIDS RESEARCH
- The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation
- (2012) Zichong Li et al. NUCLEIC ACIDS RESEARCH
- Reactivation of Latent HIV-1 by Inhibition of BRD4
- (2012) Jian Zhu et al. Cell Reports
- Two-pronged Binding with Bromodomain-containing Protein 4 Liberates Positive Transcription Elongation Factor b from Inactive Ribonucleoprotein Complexes
- (2011) Sebastian Schröder et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Epigenetic displacement of HP1 from heterochromatin by HIV-1 Vpr causes premature sister chromatid separation
- (2011) Mari Shimura et al. JOURNAL OF CELL BIOLOGY
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- T-Cell Receptor Signaling Enhances Transcriptional Elongation from Latent HIV Proviruses by Activating P-TEFb through an ERK-Dependent Pathway
- (2011) Young Kyeung Kim et al. JOURNAL OF MOLECULAR BIOLOGY
- Epigenetic Silencing of HIV-1 by the Histone H3 Lysine 27 Methyltransferase Enhancer of Zeste 2
- (2011) J. Friedman et al. JOURNAL OF VIROLOGY
- Chromatin Reassembly Factors Are Involved in Transcriptional Interference Promoting HIV Latency
- (2011) E. Gallastegui et al. JOURNAL OF VIROLOGY
- Regulation of Cyclin T1 and HIV-1 Replication by MicroRNAs in Resting CD4+ T Lymphocytes
- (2011) K. Chiang et al. JOURNAL OF VIROLOGY
- Protein Phosphatase-1 Activates CDK9 by Dephosphorylating Ser175
- (2011) Tatiana Ammosova et al. PLoS One
- Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin
- (2011) N. He et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Repressive LTR Nucleosome Positioning by the BAF Complex Is Required for HIV Latency
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- Establishment of HIV Latency in Primary CD4+ Cells Is due to Epigenetic Transcriptional Silencing and P-TEFb Restriction
- (2010) M. Tyagi et al. JOURNAL OF VIROLOGY
- Studies of HIV-1 latency in an ex vivo model that uses primary central memory T cells
- (2010) Alberto Bosque et al. METHODS
- HIV-1 Tat and Host AFF4 Recruit Two Transcription Elongation Factors into a Bifunctional Complex for Coordinated Activation of HIV-1 Transcription
- (2010) Nanhai He et al. MOLECULAR CELL
- HIV-1 Tat Assembles a Multifunctional Transcription Elongation Complex and Stably Associates with the 7SK snRNP
- (2010) Bijan Sobhian et al. MOLECULAR CELL
- Crystal structure of HIV-1 Tat complexed with human P-TEFb
- (2010) Tahir H. Tahirov et al. NATURE
- RNA-mediated displacement of an inhibitory snRNP complex activates transcription elongation
- (2010) Iván D'Orso et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The Mechanism of Release of P-TEFb and HEXIM1 from the 7SK snRNP by Viral and Cellular Activators Includes a Conformational Change in 7SK
- (2010) Brian J. Krueger et al. PLoS One
- Establishment of HIV-1 latency in resting CD4+ T cells depends on chemokine-induced changes in the actin cytoskeleton
- (2010) P. U. Cameron et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- HIV Persistence and the Prospect of Long-Term Drug-Free Remissions for HIV-Infected Individuals
- (2010) D. Trono et al. SCIENCE
- Epigenetic regulation of HIV latency
- (2010) Shweta Hakre et al. Current Opinion in HIV and AIDS
- The molecular biology of HIV latency: breaking and restoring the Tat-dependent transcriptional circuit
- (2010) Jonathan Karn Current Opinion in HIV and AIDS
- Mechanisms of HIV Latency: an Emerging Picture of Complexity
- (2010) David M. Margolis Current HIV/AIDS Reports
- Acetylation of cyclin T1 regulates the equilibrium between active and inactive P-TEFb in cells
- (2009) Sungyoo Cho et al. EMBO JOURNAL
- Characterization of Cdk9 T-loop phosphorylation in resting and activated CD4+ T lymphocytes
- (2009) Rajesh Ramakrishnan et al. JOURNAL OF LEUKOCYTE BIOLOGY
- HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
- (2009) Nicolas Chomont et al. NATURE MEDICINE
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- (2009) Mayte Coiras et al. NATURE REVIEWS MICROBIOLOGY
- A capping-independent function of MePCE in stabilizing 7SK snRNA and facilitating the assembly of 7SK snRNP
- (2009) Y. Xue et al. NUCLEIC ACIDS RESEARCH
- The Challenge of Finding a Cure for HIV Infection
- (2009) D. D. Richman et al. SCIENCE
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- (2009) Jana Blazkova et al. PLoS Pathogens
- Epigenetic Regulation of HIV-1 Latency by Cytosine Methylation
- (2009) Steven E. Kauder et al. PLoS Pathogens
- Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells
- (2008) A. Bosque et al. BLOOD
- The multi-tasking P-TEFb complex
- (2008) Vanessa Brès et al. CURRENT OPINION IN CELL BIOLOGY
- The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation
- (2008) Sonja Baumli et al. EMBO JOURNAL
- The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes
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- Epigenetic Silencing of Human Immunodeficiency Virus (HIV) Transcription by Formation of Restrictive Chromatin Structures at the Viral Long Terminal Repeat Drives the Progressive Entry of HIV into Latency
- (2008) R. Pearson et al. JOURNAL OF VIROLOGY
- Transient-mediated fate determination in a transcriptional circuit of HIV
- (2008) Leor S Weinberger et al. NATURE GENETICS
- HIV rebounds from latently infected cells, rather than from continuing low-level replication
- (2008) B. Joos et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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