A candidate anti-HIV reservoir compound, auranofin, exerts a selective ‘anti-memory’ effect by exploiting the baseline oxidative status of lymphocytes

Olaquindox-induced apoptosis is suppressed through p38 MAPK and ROS-mediated JNK pathways in HepG2 cells

(2013) Wen-xia Zhao et al.   CELL BIOLOGY AND TOXICOLOGY

Enhancement of Auranofin-Induced Apoptosis in MCF-7 Human Breast Cells by Selenocystine, a Synergistic Inhibitor of Thioredoxin Reductase

(2013) Chaoran Liu et al.   PLoS One

Cadmium Induces Apoptosis in Pancreatic β-Cells through a Mitochondria-Dependent Pathway: The Role of Oxidative Stress-Mediated c-Jun N-Terminal Kinase Activation

(2013) Kai-Chih Chang et al.   PLoS One

Investigational treatment suspension and enhanced cell-mediated immunity at rebound followed by drug-free remission of simian AIDS

(2013) Iart Shytaj et al.   Retrovirology

Altering cell death pathways as an approach to cure HIV infection

(2013) A D Badley et al.   Cell Death & Disease

Superoxide Dismutase in Redox Biology: The Roles of Superoxide and Hydrogen Peroxide

(2012) Garry R. Buettner   Anti-Cancer Agents in Medicinal Chemistry

p38MAPK and ERK1/2 dictate cell death/survival response to different pro-oxidant stimuli via p53 and Nrf2 in neuroblastoma cells SH-SY5Y

(2012) Giuseppe Filomeni et al.   BIOCHEMICAL PHARMACOLOGY

The development of immune-modulating compounds to disrupt HIV latency

(2012) Anna Lisa Remoli et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Therapeutic imprinting of the immune system: towards a remission of AIDS in primates?

(2012) Andrea Savarino et al.   Retrovirology

A Highly Intensified ART Regimen Induces Long-Term Viral Suppression and Restriction of the Viral Reservoir in a Simian AIDS Model

(2012) Iart Luca Shytaj et al.   PLoS Pathogens

Eliminating the HIV Reservoir

(2012) Alain Lafeuillade   Current HIV/AIDS Reports

Gold drug auranofin restricts the viral reservoir in the monkey AIDS model and induces containment of viral load following ART suspension

(2011) Mark G. Lewis et al.   AIDS

HIV reservoirs and the possibility of a cure for HIV infection

(2011) S. Palmer et al.   JOURNAL OF INTERNAL MEDICINE

Elite Controllers Display Higher Activation on Central Memory CD8 T Cells Than HIV Patients Successfully on HAART

(2010) Mariola López et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Maintenance of CD4+ T-cell memory and HIV persistence: keeping memory, keeping HIV

(2010) Nicolas Chomont et al.   Current Opinion in HIV and AIDS

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

(2009) Nicolas Chomont et al.   NATURE MEDICINE

Auranofin inhibits overproduction of pro-inflammatory cytokines, cyclooxygenase expression and PGE2 production in macrophages

(2008) Shinha Han et al.   ARCHIVES OF PHARMACAL RESEARCH

The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidation

(2008) Andrew G. Cox et al.   BIOCHEMICAL PHARMACOLOGY

Gold(I) complexes determine apoptosis with limited oxidative stress in Jurkat T cells

(2008) Maria Pia Rigobello et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A Portrait of Tissue Phosphoprotein Stability in the Clinical Tissue Procurement Process

(2008) Virginia Espina et al.   MOLECULAR & CELLULAR PROTEOMICS