Targeted HIV-1 Latency Reversal Using CRISPR/Cas9-Derived Transcriptional Activator Systems

Progress Toward HIV Eradication: Case Reports, Current Efforts, and the Challenges Associated with Cure

(2016) Alyssa R. Martin et al.   Annual Review of Medicine

Potent and Targeted Activation of Latent HIV-1 Using the CRISPR/dCas9 Activator Complex

(2016) Sheena M Saayman et al.   MOLECULAR THERAPY

CRISPR-mediated Activation of Latent HIV-1 Expression

(2016) Prajit Limsirichai et al.   MOLECULAR THERAPY

Specific Reactivation of Latent HIV-1 by dCas9-SunTag-VP64-mediated Guide RNA Targeting the HIV-1 Promoter

(2016) Haiyan Ji et al.   MOLECULAR THERAPY

Reactivation of Latent HIV-1 Expression by Engineered TALE Transcription Factors

(2016) Pedro Perdigão et al.   PLoS One

ddpcRquant: threshold determination for single channel droplet digital PCR experiments

(2015) Wim Trypsteen et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

A Hardwired HIV Latency Program

(2015) Brandon S. Razooky et al.   CELL

Ex vivo analysis identifies effective HIV-1 latency–reversing drug combinations

(2015) Gregory M. Laird et al.   JOURNAL OF CLINICAL INVESTIGATION

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

(2015) Kai Deng et al.   NATURE

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

(2015) Silvana Konermann et al.   NATURE

Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers

(2015) Isaac B Hilton et al.   NATURE BIOTECHNOLOGY

Highly efficient Cas9-mediated transcriptional programming

(2015) Alejandro Chavez et al.   NATURE METHODS

A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture

(2015) Henriette O'Geen et al.   NUCLEIC ACIDS RESEARCH

Towards an HIV-1 cure: measuring the latent reservoir

(2015) Katherine M. Bruner et al.   TRENDS IN MICROBIOLOGY

Patient-adapted, specific activation of HIV-1 by customized TAL effectors (TALEs), a proof of principle study

(2015) Rene Geissler et al.   VIROLOGY

CRISPR/gRNA-directed synergistic activation mediator (SAM) induces specific, persistent and robust reactivation of the HIV-1 latent reservoirs

(2015) Yonggang Zhang et al.   Scientific Reports

HIV Latency Is Established Directly and Early in Both Resting and Activated Primary CD4 T Cells

(2015) Leonard Chavez et al.   PLoS Pathogens

An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression

(2015) Gilles Darcis et al.   PLoS Pathogens

The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo

(2015) Ole S. Søgaard et al.   PLoS Pathogens

Epigenetic control of HIV-1 post integration latency: implications for therapy

(2015) Amit Kumar et al.   Clinical Epigenetics

A Protein-Tagging System for Signal Amplification in Gene Expression and Fluorescence Imaging

(2014) Marvin E. Tanenbaum et al.   CELL

Specific reactivation of latent HIV-1 with designer zinc-finger transcription factors targeting the HIV-1 5′-LTR promoter

(2014) P Wang et al.   GENE THERAPY

New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo

(2014) C Korin Bullen et al.   NATURE MEDICINE

AAV-Mediated Gene Therapy for Research and Therapeutic Purposes

(2014) R. Jude Samulski et al.   Annual Review of Virology

Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure

(2013) Ya-Chi Ho et al.   CELL

An Integrated Overview of HIV-1 Latency

(2013) Debbie S. Ruelas et al.   CELL

CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes

(2013) Luke A. Gilbert et al.   CELL

Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system

(2013) Albert W Cheng et al.   CELL RESEARCH

RNA-guided gene activation by CRISPR-Cas9–based transcription factors

(2013) Pablo Perez-Pinera et al.   NATURE METHODS

CRISPR RNA–guided activation of endogenous human genes

(2013) Morgan L Maeder et al.   NATURE METHODS

Cellular and molecular mechanisms involved in the establishment of HIV-1 latency

(2013) Daniel A Donahue et al.   Retrovirology

Dual-color HIV reporters trace a population of latently infected cells and enable their purification

(2013) Vincenzo Calvanese et al.   VIROLOGY

Therapeutics for HIV-1 reactivation from latency

(2013) Marco Sgarbanti et al.   Current Opinion in Virology

An In-Depth Comparison of Latent HIV-1 Reactivation in Multiple Cell Model Systems and Resting CD4+ T Cells from Aviremic Patients

(2013) Celsa A. Spina et al.   PLoS Pathogens

Highly Significant Antiviral Activity of HIV-1 LTR-Specific Tre-Recombinase in Humanized Mice

(2013) Ilona Hauber et al.   PLoS Pathogens

Targeting HIV latency: pharmacologic strategies toward eradication

(2012) Sifei Xing et al.   DRUG DISCOVERY TODAY

HDAC inhibitors in HIV

(2011) Fiona Wightman et al.   IMMUNOLOGY AND CELL BIOLOGY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

LTR real-time PCR for HIV-1 DNA quantitation in blood cells for early diagnosis in infants born to seropositive mothers treated in HAART area (ANRS CO 01)

(2008) Avettand-Fènoël Véronique et al.   JOURNAL OF MEDICAL VIROLOGY