Epigenetic regulation of HIV-1 latency: focus on polycomb group (PcG) proteins

Dual functionality of cis -regulatory elements as developmental enhancers and Polycomb response elements

(2017) Jelena Erceg et al.   GENES & DEVELOPMENT

Engineering HIV-Resistant, Anti-HIV Chimeric Antigen Receptor T Cells

(2017) Malika Hale et al.   MOLECULAR THERAPY

Control of the gene activity by polycomb and trithorax group proteins in Drosophila

(2017) D. A. Chetverina et al.   RUSSIAN JOURNAL OF GENETICS

Causal role for inheritance of H3K27me3 in maintaining the OFF state of a Drosophila HOX gene

(2017) Rory T. Coleman et al.   SCIENCE

HIV Latency: Should We Shock or Lock?

(2017) Gilles Darcis et al.   TRENDS IN IMMUNOLOGY

Differential induction of anti-V3 crown antibodies with cradle- and ladle-binding modes in response to HIV-1 envelope vaccination

(2017) Preetha Balasubramanian et al.   VACCINE

In Vivo Suppression of HIV Rebound by Didehydro-Cortistatin A, a “Block-and-Lock” Strategy for HIV-1 Treatment

(2017) Cari F. Kessing et al.   Cell Reports

The effect of treatment simplification on HIV reservoirs

(2017) Gilles Darcis et al.   Lancet HIV

Identification of novel EZH2 inhibitors through pharmacophore-based virtual screening and biological assays

(2016) Yunlong Wu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The mTOR Complex Controls HIV Latency

(2016) Emilie Besnard et al.   Cell Host & Microbe

Challenges and strategies for the eradication of the HIV reservoir

(2016) Jason T Kimata et al.   CURRENT OPINION IN IMMUNOLOGY

Connecting HIV-1 integration and transcription: a step toward new treatments

(2016) Bojana Lucic et al.   FEBS LETTERS

Molecular basis of PRC1 targeting to Polycomb response elements by PhoRC

(2016) Felice Frey et al.   GENES & DEVELOPMENT

The roles of Polycomb group proteins in hematopoietic stem cells and hematological malignancies

(2016) Emi Takamatsu-Ichihara et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

RbAp48, a novel inhibitory factor that regulates the transcription of human immunodeficiency virus type 1

(2016) JUAN WANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors

(2016) Pei-Pei Kung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Long-Term Spontaneous Control of HIV-1 Is Related to Low Frequency of Infected Cells and Inefficient Viral Reactivation

(2016) Nicolas Noel et al.   JOURNAL OF VIROLOGY

Persistent HIV-1 replication maintains the tissue reservoir during therapy

(2016) Ramon Lorenzo-Redondo et al.   NATURE

Targeting the histone methyltransferase G9a activates imprinted genes and improves survival of a mouse model of Prader–Willi syndrome

(2016) Yuna Kim et al.   NATURE MEDICINE

Targeting EZH2 in cancer

(2016) Kimberly H Kim et al.   NATURE MEDICINE

The HIV therapy market

(2016) Steven I. Gubernick et al.   NATURE REVIEWS DRUG DISCOVERY

HIV-associated neurocognitive disorder — pathogenesis and prospects for treatment

(2016) Deanna Saylor et al.   Nature Reviews Neurology

Broadly Neutralizing Antibodies for HIV-1 Prevention or Immunotherapy

(2016) Marina Caskey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Combgap contributes to recruitment of Polycomb group proteins inDrosophila

(2016) Payal Ray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic balance of gene expression by Polycomb and COMPASS families

(2016) Andrea Piunti et al.   SCIENCE

Latency reversal and viral clearance to cure HIV-1

(2016) D. M. Margolis et al.   SCIENCE

Regulation of Genome Architecture and Function by Polycomb Proteins

(2016) Marianne Entrevan et al.   TRENDS IN CELL BIOLOGY

HIV-1 Reservoirs During Suppressive Therapy

(2016) Kirston Barton et al.   TRENDS IN MICROBIOLOGY

Reversal of Latency as Part of a Cure for HIV-1

(2016) Thomas Aagaard Rasmussen et al.   TRENDS IN MICROBIOLOGY

Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance

(2016) Alexei Brooun et al.   Nature Communications

HIV replication

(2016) Daniel Sauter et al.   Current Opinion in HIV and AIDS

Diversity of HIV-1 reservoirs in CD4+ T-cell subpopulations

(2016) Guinevere Q. Lee et al.   Current Opinion in HIV and AIDS

Residual inflammation and viral reservoirs

(2016) Marta Massanella et al.   Current Opinion in HIV and AIDS

Immunological strategies to target HIV persistence

(2016) Glòria Martrus et al.   Current Opinion in HIV and AIDS

Persistent HIV-1 replication during antiretroviral therapy

(2016) Javier Martinez-Picado et al.   Current Opinion in HIV and AIDS

Cell and gene therapy strategies to eradicate HIV reservoirs

(2016) Chelsea Spragg et al.   Current Opinion in HIV and AIDS

Trends in life expectancy of HIV-positive adults on antiretroviral therapy across the globe

(2016) Gilles Wandeler et al.   Current Opinion in HIV and AIDS

HIC1 controls cellular- and HIV-1- gene transcription via interactions with CTIP2 and HMGA1

(2016) Valentin Le Douce et al.   Scientific Reports

Tuning of AKT-pathway by Nef and its blockade by protease inhibitors results in limited recovery in latently HIV infected T-cell line

(2016) Amit Kumar et al.   Scientific Reports

Current status and prospects of HIV treatment

(2016) Tomas Cihlar et al.   Current Opinion in Virology

Epigenetic drugs: from chemistry via biology to medicine and back

(2016) Lucia Altucci et al.   Clinical Epigenetics

Development of 5‘ LTR DNA methylation of latent HIV-1 provirus in cell line models and in long-term-infected individuals

(2016) Kateřina Trejbalová et al.   Clinical Epigenetics

Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy

(2016) Ludovica Morera et al.   Clinical Epigenetics

Inhibition of HIV-1 reactivation by a telomerase-derived peptide in a HSP90-dependent manner

(2016) Hong Kim et al.   Scientific Reports

Limited HIV-1 Reactivation in Resting CD4+ T cells from Aviremic Patients under Protease Inhibitors

(2016) Amit Kumar et al.   Scientific Reports

Understanding HIV Latency: The Road to an HIV Cure

(2015) Matthew S. Dahabieh et al.   Annual Review of Medicine

Histone methylation modifiers in cellular signaling pathways

(2015) Hunain Alam et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The quest for mammalian Polycomb response elements: are we there yet?

(2015) Moritz Bauer et al.   CHROMOSOMA

RbAp48 is essential for viability of vertebrate cells and plays a role in chromosome stability

(2015) Pasjan Satrimafitrah et al.   CHROMOSOME RESEARCH

Sequential treatment with 5-aza-2'-deoxycytidine and deacetylase inhibitors reactivates HIV-1

(2015) S. Bouchat et al.   EMBO Molecular Medicine

EZH2 phosphorylation regulates Tat-induced HIV-1 transactivation via ROS/Akt signaling pathway

(2015) Hong-Sheng Zhang et al.   FEBS LETTERS

Histone lysine demethylases inDrosophila melanogaster

(2015) Andreana Holowatyj et al.   FLY

H3K27 Demethylation at the Proviral Promoter Sensitizes Latent HIV to the Effects of Vorinostat inEx VivoCultures of Resting CD4+T Cells

(2015) Manoj K. Tripathy et al.   JOURNAL OF VIROLOGY

Histone Deacetylase Inhibitors in Clinical Studies as Templates for New Anticancer Agents

(2015) Madhusoodanan Mottamal et al.   MOLECULES

Nuclear architecture dictates HIV-1 integration site selection

(2015) Bruna Marini et al.   NATURE

HIV reservoirs: what, where and how to target them

(2015) Melissa J. Churchill et al.   NATURE REVIEWS MICROBIOLOGY

DNA methylation pathways and their crosstalk with histone methylation

(2015) Jiamu Du et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Tat Inhibitor Didehydro-Cortistatin A Prevents HIV-1 Reactivation from Latency

(2015) Guillaume Mousseau et al.   mBio

An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression

(2015) Gilles Darcis et al.   PLoS Pathogens

Epigenetic control of HIV-1 post integration latency: implications for therapy

(2015) Amit Kumar et al.   Clinical Epigenetics

Epigenetic treatment of solid tumours: a review of clinical trials

(2015) Clara Nervi et al.   Clinical Epigenetics

Functional Role of G9a Histone Methyltransferase in Cancer

(2015) Francesco Casciello et al.   Frontiers in Immunology

Epigenetic Heterogeneity in HIV-1 Latency Establishment

(2015) Yuka Matsuda et al.   Scientific Reports

Chemical Probes of Histone Lysine Methyltransferases

(2014) H. Ümit Kaniskan et al.   ACS Chemical Biology

Antiretroviral-Free HIV-1 Remission and Viral Rebound After Allogeneic Stem Cell Transplantation

(2014) Timothy J. Henrich et al.   ANNALS OF INTERNAL MEDICINE

SnapShot: Histone Modifications

(2014) He Huang et al.   CELL

Disruption of Polycomb Repressor Complex-Mediated Gene Silencing Reactivates HIV-1 Provirus in Latently Infected Cells

(2014) Cheol-Hee Yoon et al.   INTERVIROLOGY

Insight into the Architecture of the NuRD Complex

(2014) Saad S. M. Alqarni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

No cure of HIV infection in a child despite early treatment and apparent viral clearance

(2014) Vania Giacomet et al.   LANCET

Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2-Mutant Non-Hodgkin Lymphoma

(2014) S. K. Knutson et al.   MOLECULAR CANCER THERAPEUTICS

Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues

(2014) Courtney V. Fletcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells

(2014) D. Barsyte-Lovejoy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 Latency in Monocytes/Macrophages

(2014) Amit Kumar et al.   Viruses-Basel

Transcriptional Silencing by Polycomb-Group Proteins

(2014) U. Grossniklaus et al.   Cold Spring Harbor Perspectives in Biology

EZH2 as a potential target in cancer therapy

(2014) Michael T McCabe et al.   Epigenomics

Combinatorial Interactions Are Required for the Efficient Recruitment of Pho Repressive Complex (PhoRC) to Polycomb Response Elements

(2014) Tatyana G. Kahn et al.   PLoS Genetics

An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1

(2013) Kyle D. Konze et al.   ACS Chemical Biology

Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure

(2013) Ya-Chi Ho et al.   CELL

An Integrated Overview of HIV-1 Latency

(2013) Debbie S. Ruelas et al.   CELL

PI3K-Akt pathway regulates polycomb group protein and stem cell maintenance

(2013) Yan Liu et al.   CELL CYCLE

The NuRD architecture

(2013) Hillary F. Allen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A new world of Polycombs: unexpected partnerships and emerging functions

(2013) Yuri B. Schwartz et al.   NATURE REVIEWS GENETICS

CTIP2 is a negative regulator of P-TEFb

(2013) T. Cherrier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 transcription and latency: an update

(2013) Carine Van Lint et al.   Retrovirology

SET for life: biochemical activities and biological functions of SET domain-containing proteins

(2013) Hans-Martin Herz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Polycomb Protein SCML2 Regulates the Cell Cycle by Binding and Modulating CDK/CYCLIN/p21 Complexes

(2013) Emilio Lecona et al.   PLOS BIOLOGY

Histone methyltransferase inhibitors induce HIV-1 recovery in resting CD4+ T cells from HIV-1-infected HAART-treated patients

(2012) Sophie Bouchat et al.   AIDS

An Analog of the Natural Steroidal Alkaloid Cortistatin A Potently Suppresses Tat-Dependent HIV Transcription

(2012) Guillaume Mousseau et al.   Cell Host & Microbe

Inner workings and regulatory inputs that control Polycomb repressive complex 2

(2012) M. Maggie O’Meara et al.   CHROMOSOMA

Viral latency and potential eradication of HIV-1

(2012) Kenneth A Matreyek et al.   Expert Review of Anti-Infective Therapy

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

(2012) Michael T. McCabe et al.   NATURE

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

(2012) Sarah K Knutson et al.   Nature Chemical Biology

Antiretroviral dynamics determines HIV evolution and predicts therapy outcome

(2012) Daniel I S Rosenbloom et al.   NATURE MEDICINE

A quantitative basis for antiretroviral therapy for HIV-1 infection

(2012) Benjamin L Jilek et al.   NATURE MEDICINE

Histone methylation: a dynamic mark in health, disease and inheritance

(2012) Eric L. Greer et al.   NATURE REVIEWS GENETICS

Molecular mechanisms and potential functions of histone demethylases

(2012) Susanne Marije Kooistra et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural plasticity of histones H3–H4 facilitates their allosteric exchange between RbAp48 and ASF1

(2012) Wei Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phase II trial of the histone deacetylase inhibitor romidepsin in patients with recurrent/metastatic head and neck cancer

(2012) Missak Haigentz et al.   ORAL ONCOLOGY

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

(2012) W. Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

One, two, three: how histone methylation is read

(2012) Wolfgang Fischle   Epigenomics

EZH2-Mediated Concordant Repression of Wnt Antagonists Promotes  -Catenin-Dependent Hepatocarcinogenesis

(2011) A. S. L. Cheng et al.   CANCER RESEARCH

Polycomb-Dependent Regulatory Contacts between Distant Hox Loci in Drosophila

(2011) Frédéric Bantignies et al.   CELL

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

The Suv39H1 methyltransferase inhibitor chaetocin causes induction of integrated HIV-1 without producing a T cell response

(2011) Wendy Bernhard et al.   FEBS LETTERS

Epigenetic Silencing of HIV-1 by the Histone H3 Lysine 27 Methyltransferase Enhancer of Zeste 2

(2011) J. Friedman et al.   JOURNAL OF VIROLOGY

Un virus tapi dans l’ombre : les bases moléculaires de la latence du VIH-1

(2011) Thomas Cherrier et al.   M S-MEDECINE SCIENCES

Trithorax group proteins: switching genes on and keeping them active

(2011) Bernd Schuettengruber et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transcriptional and epigenetic mechanisms of addiction

(2011) Alfred J. Robison et al.   NATURE REVIEWS NEUROSCIENCE

Bromodomain protein 7 interacts with PRMT5 and PRC2, and is involved in transcriptional repression of their target genes

(2011) Sookil Tae et al.   NUCLEIC ACIDS RESEARCH

LSD1 cooperates with CTIP2 to promote HIV-1 transcriptional silencing

(2011) V. Le Douce et al.   NUCLEIC ACIDS RESEARCH

Association between nasal shedding and fever that influenza A (H3N2) induces in dogs

(2011) Daesub Song et al.   Virology Journal

Epigenetic regulation of HIV-1 transcription

(2011) Manoj Kumar Tripathy et al.   Epigenomics

Mammalian Su(var) Genes in Chromatin Control

(2010) Barna D. Fodor et al.   Annual Review of Cell and Developmental Biology

Stable transmission of reversible modifications: maintenance of epigenetic information through the cell cycle

(2010) V. A. Blomen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Involvement of Histone H3 Lysine 9 (H3K9) Methyltransferase G9a in the Maintenance of HIV-1 Latency and Its Reactivation by BIX01294

(2010) Kenichi Imai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into Association of the NuRD Complex with FOG-1 from the Crystal Structure of an RbAp48·FOG-1 Complex

(2010) Sara Lejon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparative Analysis of Chromatin Binding by Sex Comb on Midleg (SCM) and Other Polycomb Group Repressors at a Drosophila Hox Gene

(2010) Liangjun Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB

(2010) Johanna C. Scheuermann et al.   NATURE

Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a

(2009) Feng Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation

(2009) T. B. Miranda et al.   MOLECULAR CANCER THERAPEUTICS

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

(2009) Nicolas Chomont et al.   NATURE MEDICINE

Linking DNA methylation and histone modification: patterns and paradigms

(2009) Howard Cedar et al.   NATURE REVIEWS GENETICS

Mechanisms of Polycomb gene silencing: knowns and unknowns

(2009) Jeffrey A. Simon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294

(2009) Yanqi Chang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies

(2009) Laurence Colin et al.   Retrovirology

Functional Anatomy of Polycomb and Trithorax Chromatin Landscapes in Drosophila Embryos

(2009) Bernd Schuettengruber et al.   PLOS BIOLOGY

Phase I Study of Epigenetic Modulation with 5-Azacytidine and Valproic Acid in Patients with Advanced Cancers

(2008) F. Braiteh et al.   CLINICAL CANCER RESEARCH

Dynamic Regulation by Polycomb Group Protein Complexes Controls Pattern Formation and the Cell Cycle in Drosophila

(2008) Katarzyna Oktaba et al.   DEVELOPMENTAL CELL

dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing

(2008) A. Lagarou et al.   GENES & DEVELOPMENT

Ezh1 and Ezh2 Maintain Repressive Chromatin through Different Mechanisms

(2008) Raphael Margueron et al.   MOLECULAR CELL

EZH1 Mediates Methylation on Histone H3 Lysine 27 and Complements EZH2 in Maintaining Stem Cell Identity and Executing Pluripotency

(2008) Xiaohua Shen et al.   MOLECULAR CELL

Stability and Dynamics of Polycomb Target Sites in Drosophila Development

(2008) Camilla Kwong et al.   PLoS Genetics