A New Quinoline BRD4 Inhibitor Targets a Distinct Latent HIV-1 Reservoir for Reactivation from Other “Shock” Drugs

CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses

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HIV Latency: Should We Shock or Lock?

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International AIDS Society global scientific strategy: towards an HIV cure 2016

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Position effects influence HIV latency reversal

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Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4

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Shocking HIV out of hiding

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Position effects influence HIV latency reversal

(2016) Heng-Chang Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Small Molecule Inhibitors of BAF; A Promising Family of Compounds in HIV-1 Latency Reversal

(2016) Mateusz Stoszko et al.   EBioMedicine

BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic β-Cell

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Starcode: sequence clustering based on all-pairs search

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A Hardwired HIV Latency Program

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A review on anticancer potential of bioactive heterocycle quinoline

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Ex vivo analysis identifies effective HIV-1 latency–reversing drug combinations

(2015) Gregory M. Laird et al.   JOURNAL OF CLINICAL INVESTIGATION

Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation

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HIV Tat controls RNA Polymerase II and the epigenetic landscape to transcriptionally reprogram target immune cells

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HDAC inhibitors and immunotherapy; a double edged sword?

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Quantitative Evaluation and Optimization of Co-drugging to Improve Anti-HIV Latency Therapy

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“Old Friends in New Guise”: Exploiting Privileged Structures for Scaffold Re-Evolution/Refining

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NF-κB Directs Dynamic Super Enhancer Formation in Inflammation and Atherogenesis

(2014) Jonathan D. Brown et al.   MOLECULAR CELL

Targeting bromodomains: epigenetic readers of lysine acetylation

(2014) Panagis Filippakopoulos et al.   NATURE REVIEWS DRUG DISCOVERY

Mapping of six somatic linker histone H1 variants in human breast cancer cells uncovers specific features of H1.2

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BET and HDAC inhibitors induce similar genes and biological effects and synergize to kill in Myc-induced murine lymphoma

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Screening for noise in gene expression identifies drug synergies

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10058-F4, a c-Myc inhibitor, markedly increases valproic acid-induced cell death in Jurkat and CCRF-CEM T-lymphoblastic leukemia cells

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BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism

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BET Protein Function Is Required for Inflammation: Brd2 Genetic Disruption and BET Inhibitor JQ1 Impair Mouse Macrophage Inflammatory Responses

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Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening

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Fragment-Based Discovery of 8-Hydroxyquinoline Inhibitors of the HIV-1 Integrase–Lens Epithelium-Derived Growth Factor/p75 (IN–LEDGF/p75) Interaction

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Administration of a Toll-Like Receptor 9 Agonist Decreases the Proviral Reservoir in Virologically Suppressed HIV-Infected Patients

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RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain

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Reactivation of latent HIV-1 in central memory CD4+ T cells through TLR-1/2 stimulation

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HIV-1 transcription and latency: an update

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Reactivation of latent HIV by histone deacetylase inhibitors

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Down-regulation of NF-κB Transcriptional Activity in HIV-associated Kidney Disease by BRD4 Inhibition

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BET bromodomain inhibition as a novel strategy for reactivation of HIV-1

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Combination of Biological Screening in a Cellular Model of Viral Latency and Virtual Screening Identifies Novel Compounds That Reactivate HIV-1

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The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation

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A Flexible Model of HIV-1 Latency Permitting Evaluation of Many Primary CD4 T-Cell Reservoirs

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Reactivation of Latent HIV-1 by Inhibition of BRD4

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BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

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Two-pronged Binding with Bromodomain-containing Protein 4 Liberates Positive Transcription Elongation Factor b from Inactive Ribonucleoprotein Complexes

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Fragment-Based Discovery of Bromodomain Inhibitors Part 1: Inhibitor Binding Modes and Implications for Lead Discovery

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

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Regional and mucosal memory T cells

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Suppression of inflammation by a synthetic histone mimic

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Selective inhibition of BET bromodomains

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Testing significance relative to a fold-change threshold is a TREAT

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TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts

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Brd4 Coactivates Transcriptional Activation of NF- B via Specific Binding to Acetylated RelA

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