The inhibitor apoptosis protein antagonist Debio 1143 Is an attractive HIV-1 latency reversal candidate

Pevonedistat, a Nedd8-activating enzyme inhibitor, sensitizes neoplastic B-cells to death receptor-mediated apoptosis

(2017) Cody Paiva et al.   Oncotarget

In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and "kill" in strategy for virus eradication

(2017) Matthew D. Marsden et al.   PLoS Pathogens

Prevention of vaginal and rectal HIV transmission by antiretroviral combinations in humanized mice

(2017) Philippe A. Gallay et al.   PLoS One

Defective proviruses rapidly accumulate during acute HIV-1 infection

(2016) Katherine M Bruner et al.   NATURE MEDICINE

In vivo analysis of the effect of panobinostat on cell-associated HIV RNA and DNA levels and latent HIV infection

(2016) Perry Tsai et al.   Retrovirology

Broad activation of latent HIV-1 in vivo

(2016) Kirston Barton et al.   Nature Communications

C5A Protects Macaques from Vaginal Simian-Human Immunodeficiency Virus Challenge

(2015) Ronald S. Veazey et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Safety, pharmacokinetics, and pharmacodynamic properties of oral DEBIO1143 (AT-406) in patients with advanced cancer: results of a first-in-man study

(2015) Herbert I. Hurwitz et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

BIRC2/cIAP1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency

(2015) Lars Pache et al.   Cell Host & Microbe

Double Trouble: HIV Latency and CTL Escape

(2015) Matthew D. Marsden et al.   Cell Host & Microbe

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

(2015) Kai Deng et al.   NATURE

Phase I Dose-Escalation Study of LCL161, an Oral Inhibitor of Apoptosis Proteins Inhibitor, in Patients With Advanced Solid Tumors

(2014) Jeffrey R. Infante et al.   JOURNAL OF CLINICAL ONCOLOGY

Birinapant (TL32711), a Bivalent SMAC Mimetic, Targets TRAF2-Associated cIAPs, Abrogates TNF-Induced NF- B Activation, and Is Active in Patient-Derived Xenograft Models

(2014) C. A. Benetatos et al.   MOLECULAR CANCER THERAPEUTICS

New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo

(2014) C Korin Bullen et al.   NATURE MEDICINE

Small-molecule SMAC mimetics as new cancer therapeutics

(2014) Longchuan Bai et al.   PHARMACOLOGY & THERAPEUTICS

Quantification of HIV-1 latency reversal in resting CD4+ T cells from patients on suppressive antiretroviral therapy

(2014) A. R. Cillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone Deacetylase Inhibitor Romidepsin Induces HIV Expression in CD4 T Cells from Patients on Suppressive Antiretroviral Therapy at Concentrations Achieved by Clinical Dosing

(2014) Datsen George Wei et al.   PLoS Pathogens

Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial

(2014) Thomas A Rasmussen et al.   Lancet HIV

HIV/AIDS eradication

(2013) Matthew D. Marsden et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure

(2013) Ya-Chi Ho et al.   CELL

Molecular Pathways: Targeting Inhibitor of Apoptosis Proteins in Cancer--From Molecular Mechanism to Therapeutic Application

(2013) S. Fulda   CLINICAL CANCER RESEARCH

Highly potent, synthetically accessible prostratin analogs induce latent HIV expression in vitro and ex vivo

(2013) E. J. Beans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IAP proteins as targets for drug development in oncology

(2013) Laurence Dubrez et al.   OncoTargets and Therapy

IAPs on the move: role of inhibitors of apoptosis proteins in cell migration

(2013) T K Oberoi-Khanuja et al.   Cell Death & Disease

Rapid Quantification of the Latent Reservoir for HIV-1 Using a Viral Outgrowth Assay

(2013) Gregory M. Laird et al.   PLoS Pathogens

Targeting HIV latency: pharmacologic strategies toward eradication

(2012) Sifei Xing et al.   DRUG DISCOVERY TODAY

Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

(2012) John A. Flygare et al.   JOURNAL OF MEDICINAL CHEMISTRY

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

(2012) N. M. Archin et al.   NATURE

A Potent and Orally Active Antagonist (SM-406/AT-406) of Multiple Inhibitor of Apoptosis Proteins (IAPs) in Clinical Development for Cancer Treatment

(2011) Qian Cai et al.   JOURNAL OF MEDICINAL CHEMISTRY

HIV Latency in the Humanized BLT Mouse

(2011) M. D. Marsden et al.   JOURNAL OF VIROLOGY

Generation of HIV Latency in Humanized BLT Mice

(2011) P. W. Denton et al.   JOURNAL OF VIROLOGY

Activation of Latent HIV Using Drug-Loaded Nanoparticles

(2011) Michael Kovochich et al.   PLoS One

Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination

(2011) E. C. Dueber et al.   SCIENCE

Superior human leukocyte reconstitution and susceptibility to vaginal HIV transmission in humanized NOD-scid IL-2Rγ−/− (NSG) BLT mice

(2011) Cheryl A. Stoddart et al.   VIROLOGY

Activation of HIV Transcription by the Viral Tat Protein Requires a Demethylation Step Mediated by Lysine-specific Demethylase 1 (LSD1/KDM1)

(2011) Naoki Sakane et al.   PLoS Pathogens

Bryostatin-1 Synergizes with Histone Deacetylase Inhibitors to Reactivate HIV-1 from Latency

(2010) Moises Perez et al.   CURRENT HIV RESEARCH

NF-κB p52:RelB heterodimer recognizes two classes of κB sites with two distinct modes

(2008) Amanda J Fusco et al.   EMBO REPORTS

Epigenetic Silencing of Human Immunodeficiency Virus (HIV) Transcription by Formation of Restrictive Chromatin Structures at the Viral Long Terminal Repeat Drives the Progressive Entry of HIV into Latency

(2008) R. Pearson et al.   JOURNAL OF VIROLOGY

Hepatitis C virus NS5A anchor peptide disrupts human immunodeficiency virus

(2008) M. D. Bobardt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Practical Synthesis of Prostratin, DPP, and Their Analogs, Adjuvant Leads Against Latent HIV

(2008) P. A. Wender et al.   SCIENCE

In vitro selection of optimal RelB/p52 DNA-binding motifs

(2007) Liudmila V. Britanova et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS