In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and "kill" in strategy for virus eradication

Bryostatin-1 for latent virus reactivation in HIV-infected patients on antiretroviral therapy

(2016) Carolina Gutiérrez et al.   AIDS

Targeting type I interferon–mediated activation restores immune function in chronic HIV infection

(2016) Anjie Zhen et al.   JOURNAL OF CLINICAL INVESTIGATION

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

HIV-1 Eradication: Early Trials (and Tribulations)

(2016) Adam M. Spivak et al.   TRENDS IN MOLECULAR MEDICINE

Function through Synthesis-Informed Design

(2015) Paul A. Wender et al.   ACCOUNTS OF CHEMICAL RESEARCH

Double Trouble: HIV Latency and CTL Escape

(2015) Matthew D. Marsden et al.   Cell Host & Microbe

Ex vivo analysis identifies effective HIV-1 latency–reversing drug combinations

(2015) Gregory M. Laird et al.   JOURNAL OF CLINICAL INVESTIGATION

HIV-1 Vpr- and Reverse Transcription-Induced Apoptosis in Resting Peripheral Blood CD4 T Cells and Protection by Common Gamma-Chain Cytokines

(2015) Benjamin Trinité et al.   JOURNAL OF VIROLOGY

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

(2015) Kai Deng et al.   NATURE

Studies of retroviral infection in humanized mice

(2015) Matthew D. Marsden et al.   VIROLOGY

Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation

(2015) Guochun Jiang et al.   PLoS Pathogens

Bioengineered Vaults: Self-Assembling Protein Shell–Lipophilic Core Nanoparticles for Drug Delivery

(2014) Daniel C. Buehler et al.   ACS Nano

Neutralizing the HIV Reservoir

(2014) Matthew D. Marsden et al.   CELL

Broadly Neutralizing Antibodies and Viral Inducers Decrease Rebound from HIV-1 Latent Reservoirs in Humanized Mice

(2014) Ariel Halper-Stromberg et al.   CELL

New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo

(2014) C Korin Bullen et al.   NATURE MEDICINE

Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial

(2014) Thomas A Rasmussen et al.   Lancet HIV

HIV/AIDS eradication

(2013) Matthew D. Marsden et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure

(2013) Ya-Chi Ho et al.   CELL

Highly potent, synthetically accessible prostratin analogs induce latent HIV expression in vitro and ex vivo

(2013) E. J. Beans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

(2012) N. M. Archin et al.   NATURE

Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro

(2012) Brian A. DeChristopher et al.   Nature Chemistry

HIV Latency in the Humanized BLT Mouse

(2011) M. D. Marsden et al.   JOURNAL OF VIROLOGY

Generation of HIV Latency in Humanized BLT Mice

(2011) P. W. Denton et al.   JOURNAL OF VIROLOGY

Activation of Latent HIV Using Drug-Loaded Nanoparticles

(2011) Michael Kovochich et al.   PLoS One

Bryostatin-1 Synergizes with Histone Deacetylase Inhibitors to Reactivate HIV-1 from Latency

(2010) Moises Perez et al.   CURRENT HIV RESEARCH

Bryostatins: biological context and biotechnological prospects

(2010) Amaro E Trindade-Silva et al.   CURRENT OPINION IN BIOTECHNOLOGY

A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model

(2009) S. Shimizu et al.   BLOOD

Induction of Robust Cellular and Humoral Virus-Specific Adaptive Immune Responses in Human Immunodeficiency Virus-Infected Humanized BLT Mice

(2009) D. M. Brainard et al.   JOURNAL OF VIROLOGY

Practical Synthesis of Prostratin, DPP, and Their Analogs, Adjuvant Leads Against Latent HIV

(2008) P. A. Wender et al.   SCIENCE