The UDP-Glycosyltransferase (UGT) Superfamily: New Members, New Functions, and Novel Paradigms
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Title
The UDP-Glycosyltransferase (UGT) Superfamily: New Members, New Functions, and Novel Paradigms
Authors
Keywords
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Journal
PHYSIOLOGICAL REVIEWS
Volume 99, Issue 2, Pages 1153-1222
Publisher
American Physiological Society
Online
2019-02-06
DOI
10.1152/physrev.00058.2017
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Note: Only part of the references are listed.- Cooperative Regulation of Intestinal UDP-Glucuronosyltransferases 1A8, -1A9, and 1A10 by CDX2 and HNF4αIs Mediated by a Novel Composite Regulatory Element
- (2018) Nurul Mubarokah et al. MOLECULAR PHARMACOLOGY
- Genetic variations in UGT2B28, UGT2B17, UGT2B15 genes and the risk of prostate cancer: A case-control study
- (2017) Mohsen Habibi et al. GENE
- Exemestane and Its Active Metabolite 17-Hydroexemestane Induce UDP-Glucuronosyltransferase (UGT) 2B17 Expression in Breast Cancer Cells
- (2017) Apichaya Chanawong et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Regulation of UDP-Glucuronosyltransferases UGT2B4 and UGT2B7 by MicroRNAs in Liver Cancer Cells
- (2017) Dhilushi D. Wijayakumara et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- UGT1A polymorphisms as genetic biomarkers for hepatocellular carcinoma risk in Caucasian population
- (2017) Elena De Mattia et al. LIVER INTERNATIONAL
- Common genetic variation drives molecular heterogeneity in human iPSCs
- (2017) Helena Kilpinen et al. NATURE
- Quantitative profiling of the UGT transcriptome in human drug-metabolizing tissues
- (2017) A Tourancheau et al. PHARMACOGENOMICS JOURNAL
- Role of the UGT2B17 deletion in exemestane pharmacogenetics
- (2017) S Luo et al. PHARMACOGENOMICS JOURNAL
- Uridine diphosphate-glucuronosyltransferase 2B15 D85Y gene polymorphism is associated with lower prostate cancer risk: a systematic review and meta-analysis
- (2017) Xiao Zhong et al. Oncotarget
- Interaction of gut microbiota with bile acid metabolism and its influence on disease states
- (2016) Christopher Staley et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARα in primary human hepatocytes
- (2016) Benjamin A. Kandel et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Androgen and Estrogen Receptors in Breast Cancer Coregulate Human UDP-Glucuronosyltransferases 2B15 and 2B17
- (2016) Dong G. Hu et al. CANCER RESEARCH
- UGT2B17 Expedites Progression of Castration-Resistant Prostate Cancers by Promoting Ligand-Independent AR Signaling
- (2016) Haolong Li et al. CANCER RESEARCH
- The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease
- (2016) William J. Astle et al. CELL
- Antiproliferative Effect of Androgen Receptor Inhibition in Mesenchymal Stem-Like Triple-Negative Breast Cancer
- (2016) Aiyu Zhu et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- An Intestinal Farnesoid X Receptor–Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice
- (2016) Cen Xie et al. DIABETES
- Genetic polymorphisms of human UDP-glucuronosyltransferase (UGT) genes and cancer risk
- (2016) Dong Gui Hu et al. DRUG METABOLISM REVIEWS
- Family Matters: Collaboration and Conflict Among the Steroid Receptors Raises a Need for Group Therapy
- (2016) Matthew J. Sikora ENDOCRINOLOGY
- The UGT2B28 Sex-steroid Inactivation Pathway Is a Regulator of Steroidogenesis and Modifies the Risk of Prostate Cancer Progression
- (2016) Anaïs Belledant et al. EUROPEAN UROLOGY
- Identification of novel bile acids as biomarkers for the early diagnosis of Niemann-Pick C disease
- (2016) Francesca Mazzacuva et al. FEBS LETTERS
- Epigenetic regulation of steroid inactivating UDP-glucuronosyltransferases by microRNAs in prostate cancer
- (2016) Guillaume Margaillan et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- 17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization
- (2016) Michael B. Stout et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- UGT genotyping in belinostat dosing
- (2016) Andrew K.L. Goey et al. PHARMACOLOGICAL RESEARCH
- Identification of a circulating microRNA signature to distinguish recurrence in breast cancer patients
- (2016) Dezheng Huo et al. Oncotarget
- Divergent Expression and Metabolic Functions of Human Glucuronosyltransferases through Alternative Splicing
- (2016) Michèle Rouleau et al. Cell Reports
- The cost-effectiveness of UGT1A1 genotyping before colorectal cancer treatment with irinotecan from the perspective of the German statutory health insurance
- (2015) Bettina Butzke et al. ACTA ONCOLOGICA
- Systematic review: bile acids and intestinal inflammation-luminal aggressors or regulators of mucosal defence?
- (2015) P. Pavlidis et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Homo- and hetero-dimerization of human UDP-glucuronosyltransferase 2B7 (UGT2B7) wild type and its allelic variants affect zidovudine glucuronidation activity
- (2015) Lingmin Yuan et al. BIOCHEMICAL PHARMACOLOGY
- Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline forUGT1A1and Atazanavir Prescribing
- (2015) RS Gammal et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- UDP-galactose (SLC35A2) and UDP-N-acetylglucosamine (SLC35A3) Transporters Form Glycosylation-related Complexes with Mannoside Acetylglucosaminyltransferases (Mgats)
- (2015) Dorota Maszczak-Seneczko et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2015) Shanly M. Chen et al. JOURNAL OF CLINICAL PHARMACOLOGY
- UGT1A1genotype-dependent dose adjustment of belinostat in patients with advanced cancers using population pharmacokinetic modeling and simulation
- (2015) Cody J. Peer et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Effects ofUGT1A1genotype on the pharmacokinetics, pharmacodynamics, and toxicities of belinostat administered by 48-hour continuous infusion in patients with cancer
- (2015) Andrew K. L. Goey et al. JOURNAL OF CLINICAL PHARMACOLOGY
- New paradigms in the treatment of hepatic cholestasis: From UDCA to FXR, PXR and beyond
- (2015) Ulrich Beuers et al. JOURNAL OF HEPATOLOGY
- Multiple roles for udp-glucuronosyltransferase (UGT)2B15 and UGT2B17 enzymes in androgen metabolism and prostate cancer evolution
- (2015) Louis Gauthier-Landry et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Unravelling the transcriptomic landscape of the major phase II UDP-glucuronosyltransferase drug metabolizing pathway using targeted RNA sequencing
- (2015) A Tourancheau et al. PHARMACOGENOMICS JOURNAL
- Structural basis for Notch1 engagement of Delta-like 4
- (2015) V. C. Luca et al. SCIENCE
- International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways
- (2015) Heather J. Cordell et al. Nature Communications
- Homeostatic Control of the Thyroid–Pituitary Axis: Perspectives for Diagnosis and Treatment
- (2015) Rudolf Hoermann et al. Frontiers in Endocrinology
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- (2015) Lai Peng et al. Acta Pharmaceutica Sinica B
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- (2015) Saran Vardhanabhuti et al. Open Forum Infectious Diseases
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- (2014) Nicole Schwab et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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- (2014) Katrin Wlcek et al. BIOCHEMICAL PHARMACOLOGY
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- (2014) Jian-Qing Ruan et al. CHEMICO-BIOLOGICAL INTERACTIONS
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- (2014) Jason M. Ridlon et al. CURRENT OPINION IN GASTROENTEROLOGY
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- (2014) Zhican Wang et al. ENDOCRINOLOGY
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- (2014) Arne Reimers et al. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
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- (2014) Andrea Y. Angstadt et al. GENES CHROMOSOMES & CANCER
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- (2014) Dominique Scherer et al. GENES CHROMOSOMES & CANCER
- Ceramide galactosyltransferase expression is regulated positively by Nkx2.2 and negatively by OLIG2
- (2014) Kyohei Okahara et al. GLYCOBIOLOGY
- ImpairedO-LinkedN-Acetylglucosaminylation in the Endoplasmic Reticulum by Mutated Epidermal Growth Factor (EGF) Domain-specificO-LinkedN-Acetylglucosamine Transferase Found in Adams-Oliver Syndrome
- (2014) Mitsutaka Ogawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Truncated UDP-glucuronosyltransferase (UGT) from a Crigler–Najjar syndrome type II patient colocalizes with intact UGT in the endoplasmic reticulum
- (2014) Masahiro Suzuki et al. JOURNAL OF HUMAN GENETICS
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- (2014) Tongmeng Yan et al. PHARMACEUTICAL RESEARCH
- Galactosylceramide Affects Tumorigenic and Metastatic Properties of Breast Cancer Cells as an Anti-Apoptotic Molecule
- (2014) Tomasz B. Owczarek et al. PLoS One
- UDP glucuronosyltransferase 1A expression levels determine the response of colorectal cancer cells to the heat shock protein 90 inhibitor ganetespib
- (2014) H Landmann et al. Cell Death & Disease
- Mosaicism of the UDP-Galactose Transporter SLC35A2 Causes a Congenital Disorder of Glycosylation
- (2013) Bobby G. Ng et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Mutations in EOGT Confirm the Genetic Heterogeneity of Autosomal-Recessive Adams-Oliver Syndrome
- (2013) Ranad Shaheen et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Enantiomer Selective Glucuronidation of the Non-Steroidal Pure Anti-Androgen Bicalutamide by Human Liver and Kidney: Role of the Human UDP-Glucuronosyltransferase (UGT)1A9 Enzyme
- (2013) Laurent Grosse et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- Epigenetic regulation of the tissue-specific expression of human UDP-glucuronosyltransferase (UGT) 1A10
- (2013) Shingo Oda et al. BIOCHEMICAL PHARMACOLOGY
- Novel associations of UDP-glucuronosyltransferase 2B gene variants with prostate cancer risk in a multiethnic study
- (2013) Adriana C Vidal et al. BMC CANCER
- Postmenopausal breast cancer, androgens, and aromatase inhibitors
- (2013) C. Campagnoli et al. BREAST CANCER RESEARCH AND TREATMENT
- The effect of copy number variation in the phase II detoxification genesUGT2B17andUGT2B28on colorectal cancer risk
- (2013) Andrea Y. Angstadt et al. CANCER
- Characterization of Raloxifene Glucuronidation: Potential Role of UGT1A8 Genotype on Raloxifene Metabolism In Vivo
- (2013) D. Sun et al. Cancer Prevention Research
- Androgen Glucuronidation: An Unexpected Target for Androgen Deprivation Therapy, with Prognosis and Diagnostic Implications
- (2013) L. Grosse et al. CANCER RESEARCH
- Common Genetic Polymorphisms Modify the Effect of Smoking on Absolute Risk of Bladder Cancer
- (2013) M. Garcia-Closas et al. CANCER RESEARCH
- Profiling Serum Bile Acid Glucuronides in Humans: Gender Divergences, Genetic Determinants, and Response to Fenofibrate
- (2013) J Trottier et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- UDP-glucuronosyltransferase 2B15 (UGT2B15) Is the Major Enzyme Responsible for Sipoglitazar Glucuronidation in Humans: Retrospective Identification of the UGT Isoform by In Vitro Analysis and the Effect of UGT2B15*2 Mutation
- (2013) Mitsuhiro Nishihara et al. Drug Metabolism and Pharmacokinetics
- Extensive Protein-Protein Interactions Involving UDP-glucuronosyltransferase (UGT) 2B7 in Human Liver Microsomes
- (2013) Ryoichi Fujiwara et al. Drug Metabolism and Pharmacokinetics
- Identification and Characterization of Human UDP-glucuronosyltransferases Responsible for the Glucuronidation of Fraxetin
- (2013) Yang-Liu Xia et al. Drug Metabolism and Pharmacokinetics
- Ceramide galactosyltransferase (UGT8) as a molecular marker of canine mammary tumor malignancy
- (2013) Marcin Nowak et al. FOLIA HISTOCHEMICA ET CYTOBIOLOGICA
- De Novo Mutations inSLC35A2Encoding a UDP-Galactose Transporter Cause Early-Onset Epileptic Encephalopathy
- (2013) Hirofumi Kodera et al. HUMAN MUTATION
- The UDP-glucuronosyltransferases: Their role in drug metabolism and detoxification
- (2013) Andrew Rowland et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- UDP-N-acetylglucosamine Transporter (SLC35A3) Regulates Biosynthesis of Highly BranchedN-Glycans and Keratan Sulfate
- (2013) Dorota Maszczak-Seneczko et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mutations in SLC35A3 cause autism spectrum disorder, epilepsy and arthrogryposis
- (2013) Simon Edvardson et al. JOURNAL OF MEDICAL GENETICS
- Regiospecificity of Human UDP-glucuronosyltransferase Isoforms in Chalcone and Flavanone Glucuronidation Determined by Metal Complexation and Tandem Mass Spectrometry
- (2013) Emily D. Niemeyer et al. JOURNAL OF NATURAL PRODUCTS
- Evidence for regulation of UDP-glucuronosyltransferase (UGT) 1A1 protein expression and activity via DNA methylation in healthy human livers
- (2013) Umit Yasar et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Roles of the nucleotide sugar transporters (SLC35 family) in health and disease
- (2013) Zhiwei Song MOLECULAR ASPECTS OF MEDICINE
- Commensal bacteria at the interface of host metabolism and the immune system
- (2013) Jonathan R Brestoff et al. NATURE IMMUNOLOGY
- MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b, miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells
- (2013) A Formosa et al. ONCOGENE
- Expression of UGT2B7 is driven by two mutually exclusive promoters and alternative splicing in human tissues
- (2013) Vincent Ménard et al. Pharmacogenetics and Genomics
- PharmGKB summary
- (2013) Julia M. Barbarino et al. Pharmacogenetics and Genomics
- Polymorphic Expression of UDP-Glucuronosyltransferase UGTlA Gene in Human Colorectal Cancer
- (2013) Min Wang et al. PLoS One
- Glucuronidation by UGT1A1 Is the Dominant Pathway of the Metabolic Disposition of Belinostat in Liver Cancer Patients
- (2013) Ling-Zhi Wang et al. PLoS One
- Genetic Variants in Hormone-Related Genes and Risk of Breast Cancer
- (2013) Tess Clendenen et al. PLoS One
- Variation in Trans-3′-Hydroxycotinine Glucuronidation Does Not Alter the Nicotine Metabolite Ratio or Nicotine Intake
- (2013) Andy Z. X. Zhu et al. PLoS One
- Role of Glucuronidation for Hepatic Detoxification and Urinary Elimination of Toxic Bile Acids during Biliary Obstruction
- (2013) Martin Perreault et al. PLoS One
- Sulfatides are required for renal adaptation to chronic metabolic acidosis
- (2013) P. Stettner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11)
- (2013) S. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- LC/ESI-MS/MS analysis of urinary 3β-sulfooxy-7β-N-acetylglucosaminyl-5-cholen-24-oic acid and its amides: New biomarkers for the detection of Niemann–Pick type C disease
- (2013) Masamitsu Maekawa et al. STEROIDS
- Fulvestrant up regulates UGT1A4 and MRPs through ERα and c-Myb pathways: a possible primary drug disposition mechanism
- (2013) Vineetha K Edavana et al. SpringerPlus
- Implication of Human UGT2B7, 2B15, and 2B17 in 19-Norandrosterone Metabolism
- (2013) Emmanuel Strahm et al. Frontiers in Endocrinology
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- (2012) Jae-Hong Kim et al. Annals of Dermatology
- Rs11892031[A] on chromosome 2q37 in an intronic region of the UGT1A locus is associated with urinary bladder cancer risk
- (2012) Silvia Selinski et al. ARCHIVES OF TOXICOLOGY
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- (2012) Toshifumi Shiraga et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Overexpression of uridine diphospho glucuronosyltransferase 2B17 in high-risk chronic lymphocytic leukemia
- (2012) M. Gruber et al. BLOOD
- Conservation and divergence of chemical defense system in the tunicate Oikopleura dioica revealed by genome wide response to two xenobiotics
- (2012) Fekadu Yadetie et al. BMC GENOMICS
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- (2012) Shuang-Xi Han et al. Cancer Epidemiology
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- (2012) Ido Goldstein et al. CARCINOGENESIS
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- (2012) Nobumitsu Hanioka et al. CHEMOSPHERE
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- (2012) C. J. Peer et al. CLINICAL CANCER RESEARCH
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- (2012) István Szanyi et al. EUROPEAN JOURNAL OF CANCER PREVENTION
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- (2012) Frances Stringer et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
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- (2012) Dorota Maszczak-Seneczko et al. FEBS LETTERS
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- (2012) Delores J. Grant et al. Genetic Testing and Molecular Biomarkers
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- (2012) Henri Duboc et al. GUT
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- (2012) Martin Lacko et al. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
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- (2012) Shujuan Chen et al. HEPATOLOGY
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- (2012) Wei Tang et al. HUMAN MOLECULAR GENETICS
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- (2012) Robyn Meech et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2012) Hansoo Park et al. JOURNAL OF MEDICAL GENETICS
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- (2011) Marion Meixner et al. BMC NEUROSCIENCE
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- (2011) Michael A Augello et al. EMBO JOURNAL
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- (2011) Jessica L L Robinson et al. EMBO JOURNAL
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- (2011) Arndt Vogel et al. GASTROENTEROLOGY
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- Role of Human UGT2B10 in N-Glucuronidation of Tricyclic Antidepressants, Amitriptyline, Imipramine, Clomipramine, and Trimipramine
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- Evidence for oxazepam as anin vivoprobe of UGT2B15: oxazepam clearance is reduced byUGT2B15D85Y polymorphism but unaffected byUGT2B17deletion
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- Cost effectiveness of pharmacogenetic testing for uridine diphosphate glucuronosyltransferase 1A1 before irinotecan administration for metastatic colorectal cancer
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- Sorafenib
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- Bilirubin and glutathione have complementary antioxidant and cytoprotective roles
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- Non-steroidal anti-inflammatory drugs interact with testosterone glucuronidation
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- (2008) M Asim et al. ONCOGENE
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- (2008) Nobumitsu Hanioka et al. PHARMACOLOGY
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- (2008) A. Rao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2008) Bo-Ying Bao et al. PROSTATE
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- (2008) Athena Starlard-Davenport et al. STEROIDS
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- (2008) Thomas J. Erichsen et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
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