17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization

Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice

(2016) Michael B. Stout et al.   Aging-US

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

(2015) Rachel J. Perry et al.   CELL

Promoting Health and Longevity through Diet: From Model Organisms to Humans

(2015) Luigi Fontana et al.   CELL

Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity

(2015) Allyson K. Palmer et al.   DIABETES

Short-term food restriction followed by controlled refeeding promotes gorging behavior, enhances fat deposition, and diminishes insulin sensitivity in mice

(2015) Kara L. Kliewer et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Aging and Multimorbidity: New Tasks, Priorities, and Frontiers for Integrated Gerontological and Clinical Research

(2015) Elisa Fabbri et al.   Journal of the American Medical Directors Association

Leptin resistance and diet-induced obesity: central and peripheral actions of leptin

(2015) Neira Sáinz et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

17α-Estradiol is generated locally in the male rat brain and can regulate GAD65 expression and anxiety

(2015) Takamitsu Ikeda et al.   NEUROPHARMACOLOGY

Estrogens and the control of energy homeostasis: a brain perspective

(2015) Miguel López et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Liver-Specific GH Receptor Gene-Disrupted (LiGHRKO) Mice Have Decreased Endocrine IGF-I, Increased Local IGF-I, and Altered Body Size, Body Composition, and Adipokine Profiles

(2014) Edward O. List et al.   ENDOCRINOLOGY

Aging and the Burden of Multimorbidity: Associations With Inflammatory and Anabolic Hormonal Biomarkers

(2014) Elisa Fabbri et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease

(2014) Gerald I. Shulman   NEW ENGLAND JOURNAL OF MEDICINE

Visualization of Extracellular Matrix Components within Sectioned Salmonella Biofilms on the Surface of Human Gallstones

(2014) Joanna M. Marshall et al.   PLoS One

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

(2014) Diana Jurk et al.   Nature Communications

Hypothalamic PGC-1α Protects Against High-Fat Diet Exposure by Regulating ERα

(2014) Eugenia Morselli et al.   Cell Reports

Glycolytic fast-twitch muscle fiber restoration counters adverse age-related changes in body composition and metabolism

(2013) Yuichi Akasaki et al.   AGING CELL

Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

(2013) David E. Harrison et al.   AGING CELL

Liver diseases and aging: friends or foes?

(2013) Fareeba Sheedfar et al.   AGING CELL

Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation

(2013) Olga Moiseeva et al.   AGING CELL

Transcriptional and phenotypic changes in aorta and aortic valve with aging and MnSOD deficiency in mice

(2013) Carolyn M. Roos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Estrogens and cardiovascular disease risk revisited

(2013) Barbara V. Howard et al.   CURRENT OPINION IN LIPIDOLOGY

Role of Reduced  -Cell Mass Versus Impaired  -Cell Function in the Pathogenesis of Type 2 Diabetes

(2013) J. J. Meier et al.   DIABETES CARE

The Role of Estrogens in Control of Energy Balance and Glucose Homeostasis

(2013) Franck Mauvais-Jarvis et al.   ENDOCRINE REVIEWS

Cellular Mechanism by Which Estradiol Protects Female Ovariectomized Mice From High-Fat Diet-Induced Hepatic and Muscle Insulin Resistance

(2013) João Paulo G. Camporez et al.   ENDOCRINOLOGY

Proinflammatory Cytokines, Aging, and Age-Related Diseases

(2013) Martin Michaud et al.   Journal of the American Medical Directors Association

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

The sexually dimorphic role of adipose and adipocyte estrogen receptors in modulating adipose tissue expansion, inflammation, and fibrosis

(2013) Kathryn E. Davis et al.   Molecular Metabolism

Skeletal Muscle Insulin Resistance Promotes Increased Hepatic De Novo Lipogenesis, Hyperlipidemia, and Hepatic Steatosis in the Elderly

(2012) C. Flannery et al.   DIABETES

Hepatocyte senescence predicts progression in non-alcohol-related fatty liver disease

(2012) Aloysious Aravinthan et al.   JOURNAL OF HEPATOLOGY

Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes

(2012) K. F. Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network

(2011) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Distinct Hypothalamic Neurons Mediate Estrogenic Effects on Energy Homeostasis and Reproduction

(2011) Yong Xu et al.   Cell Metabolism

Wnt10b activates the wnt, notch, and NFκB pathways in u2os osteosarcoma cells

(2011) Ulrike I. Mödder et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Aging Is Associated with an Increase in T Cells and Inflammatory Macrophages in Visceral Adipose Tissue

(2011) C. N. Lumeng et al.   JOURNAL OF IMMUNOLOGY

AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan

(2011) Antero Salminen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Hepatic steatosis by dietary-conjugated linoleic acid is accompanied by accumulation of diacylglycerol and increased membrane-associated protein kinase C ε in mice

(2011) Michael B. Stout et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Weight Loss, Exercise, or Both and Physical Function in Obese Older Adults

(2011) Dennis T. Villareal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fat tissue, aging, and cellular senescence

(2010) Tamara Tchkonia et al.   AGING CELL

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

The metabolic syndrome in older persons: a loosely defined constellation of symptoms or a distinct entity?

(2009) John E. Morley et al.   AGE AND AGEING

Age-related changes in total and regional fat distribution

(2009) Jennifer L. Kuk et al.   AGEING RESEARCH REVIEWS

Inflammation and impaired adipogenesis in hypertrophic obesity in man

(2009) Birgit Gustafson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Caloric restriction-induced life extension of rats and mice: A critique of proposed mechanisms

(2009) Edward J. Masoro   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Antiaging, longevity and calorie restriction

(2009) John E Morley et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Age-Associated Increase in Cytokine Production During Systemic Inflammation: Adipose Tissue as a Major Source of IL-6

(2009) M. E. Starr et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Ageing populations: the challenges ahead

(2009) Kaare Christensen et al.   LANCET

Age-related differences in inflammatory markers in men: contribution of visceral adiposity

(2009) Amélie Cartier et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Estrogen Reduces 11β-Hydroxysteroid Dehydrogenase Type 1 in Liver and Visceral, but Not Subcutaneous, Adipose Tissue in Rats

(2009) Therése Andersson et al.   Obesity

Visceral adipose tissue modulates mammalian longevity

(2008) Radhika Muzumdar et al.   AGING CELL

Ablation of estrogen receptor alpha (ERα) prevents upregulation of POMC by leptin and insulin

(2008) Michi Hirosawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Automated Separation of Visceral and Subcutaneous Adiposity in In Vivo Microcomputed Tomographies of Mice

(2008) Svetlana Lublinsky et al.   JOURNAL OF DIGITAL IMAGING

Central and Peripheral Regulation of Food Intake and Physical Activity: Pathways and Genes

(2008) Natalie R. Lenard et al.   Obesity