A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation
Published 2012 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation
Authors
Keywords
Genetic loci, Genome-wide association studies, Meta-analysis, Sex hormones, Hormone receptor signaling, Human genetics, Genomic signal processing, Testosterone
Journal
PLoS Genetics
Volume 8, Issue 7, Pages e1002805
Publisher
Public Library of Science (PLoS)
Online
2012-07-20
DOI
10.1371/journal.pgen.1002805
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Diverse Roles for Sex Hormone-Binding Globulin in Reproduction
- (2011) G. L. Hammond BIOLOGY OF REPRODUCTION
- Associations of common polymorphisms in GCKR with type 2 diabetes and related traits in a Han Chinese population: a case-control study
- (2011) Yan Ling et al. BMC Medical Genetics
- Genome-wide association studies (GWAS): impact on elucidating the aetiology of diabetes
- (2011) Hakon Hakonarson et al. DIABETES-METABOLISM RESEARCH AND REVIEWS
- Circulating Testosterone and SHBG Concentrations Are Heritable in Women: The Framingham Heart Study
- (2011) A. D. Coviello et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia
- (2011) Zhibin Hu et al. NATURE GENETICS
- Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
- (2011) John C Chambers et al. NATURE GENETICS
- Glucokinase Regulatory Protein Genetic Variant Interacts with Omega-3 PUFA to Influence Insulin Resistance and Inflammation in Metabolic Syndrome
- (2011) Pablo Perez-Martinez et al. PLoS One
- Genetic Determinants of Serum Testosterone Concentrations in Men
- (2011) Claes Ohlsson et al. PLoS Genetics
- Hepatic Hepatocyte Nuclear Factor 4α Is Essential for Maintaining Triglyceride and Cholesterol Homeostasis
- (2010) Liya Yin et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- TRIB1 and GCKR Polymorphisms, Lipid Levels, and Risk of Ischemic Heart Disease in the General Population
- (2010) Anette Varbo et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Nuclear Receptors in Leydig Cell Gene Expression and Function1
- (2010) Luc J. Martin et al. BIOLOGY OF REPRODUCTION
- GCKR gene functional variants in type 2 diabetes and metabolic syndrome: do the rare variants associate with increased carotid intima-media thickness?
- (2010) Márton Mohás et al. Cardiovascular Diabetology
- MicroRNA-27a Indirectly Regulates Estrogen Receptor α Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells
- (2010) Xiangrong Li et al. ENDOCRINOLOGY
- CBFA2T3-ZNF651, like CBFA2T3-ZNF652, functions as a transcriptional corepressor complex
- (2010) Raman Kumar et al. FEBS LETTERS
- Loci From a Genome-Wide Analysis of Bilirubin Levels Are Associated With Gallstone Risk and Composition
- (2010) Stephan Buch et al. GASTROENTEROLOGY
- Glucokinase-activating GCKR Polymorphisms Increase Plasma Levels of Triglycerides and Free Fatty Acids, but do not Elevate Cardiovascular Risk in the Ludwigshafen Risk and Cardiovascular Health Study
- (2010) D. H. Kozian et al. HORMONE AND METABOLIC RESEARCH
- The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population
- (2010) Hiroshi Onuma et al. JOURNAL OF HUMAN GENETICS
- Genetic variation in the GCKR gene is associated with non-alcoholic fatty liver disease in Chinese people
- (2010) Zhen Yang et al. MOLECULAR BIOLOGY REPORTS
- GT-094, a NO-NSAID, Inhibits Colon Cancer Cell Growth by Activation of a Reactive Oxygen Species-MicroRNA-27a: ZBTB10-Specificity Protein Pathway
- (2010) S. S. Pathi et al. MOLECULAR CANCER RESEARCH
- Suppression of ERα Activity by COUP-TFII Is Essential for Successful Implantation and Decidualization
- (2010) Dong-Kee Lee et al. MOLECULAR ENDOCRINOLOGY
- GCKR mutations in Japanese families with clustered type 2 diabetes
- (2010) Daisuke Tanaka et al. MOLECULAR GENETICS AND METABOLISM
- Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3
- (2010) Zi-Jiang Chen et al. NATURE GENETICS
- New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
- (2010) Josée Dupuis et al. NATURE GENETICS
- Protein arginine methyltransferase 6 regulates multiple aspects of gene expression
- (2010) Matthew J. Harrison et al. NUCLEIC ACIDS RESEARCH
- Co-expression of the androgen receptor and the transcription factor ZNF652 is related to prostate cancer outcome
- (2010) Callen ONCOLOGY REPORTS
- Effects of GCK, GCKR, G6PC2 and MTNR1B Variants on Glucose Metabolism and Insulin Secretion
- (2010) Cheng Hu et al. PLoS One
- Association of GCKR rs780094, alone or in combination with GCK rs1799884, with type 2 diabetes and related traits in a Han Chinese population
- (2009) Q. Qi et al. DIABETOLOGIA
- Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk
- (2009) E. Reiling et al. DIABETOLOGIA
- Common variants at the GCK, GCKR, G6PC2–ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations
- (2009) F. Takeuchi et al. DIABETOLOGIA
- Peroxisome-Proliferator Receptor γ Represses Hepatic Sex Hormone-Binding Globulin Expression
- (2009) David M. Selva et al. ENDOCRINOLOGY
- Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes
- (2009) John R.B. Perry et al. HUMAN MOLECULAR GENETICS
- Copy-number variations (CNVs) of the human sex steroid metabolizing genesUGT2B17andUGT2B28and their associations with aUGT2B15functional polymorphism
- (2009) Vincent Ménard et al. HUMAN MUTATION
- Thyroid hormones act indirectly to increase sex hormone-binding globulin production by liver via hepatocyte nuclear factor-4α
- (2009) David M Selva et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- Sex Hormone–Binding Globulin and Risk of Type 2 Diabetes in Women and Men
- (2009) Eric L. Ding et al. NEW ENGLAND JOURNAL OF MEDICINE
- Forty-Three Loci Associated with Plasma Lipoprotein Size, Concentration, and Cholesterol Content in Genome-Wide Analysis
- (2009) Daniel I. Chasman et al. PLoS Genetics
- Identification of Common Variants in the SHBG Gene Affecting Sex Hormone-Binding Globulin Levels and Breast Cancer Risk in Postmenopausal Women
- (2008) D. J. Thompson et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Interaction Effect of Genetic Polymorphisms in Glucokinase (GCK) and Glucokinase Regulatory Protein (GCKR) on Metabolic Traits in Healthy Chinese Adults and Adolescents
- (2008) C. H.T. Tam et al. DIABETES
- Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations
- (2008) M. Orho-Melander et al. DIABETES
- SLCO1B1Variants and Statin-Induced Myopathy — A Genomewide Study
- (2008) NEW ENGLAND JOURNAL OF MEDICINE
- A Genome-Wide Association Study Identifies Protein Quantitative Trait Loci (pQTLs)
- (2008) David Melzer et al. PLoS Genetics
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started