Commensal bacteria at the interface of host metabolism and the immune system

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

MAIT cells, surveyors of a new class of antigen: development and functions

(2013) Lionel Le Bourhis et al.   CURRENT OPINION IN IMMUNOLOGY

The dynamic influence of commensal bacteria on the immune response to pathogens

(2013) Michael C Abt et al.   CURRENT OPINION IN MICROBIOLOGY

The Immune System as a Sensor of the Metabolic State

(2013) Justin I. Odegaard et al.   IMMUNITY

Metabolic Pathways in Immune Cell Activation and Quiescence

(2013) Erika L. Pearce et al.   IMMUNITY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Antibiotics as Part of the Management of Severe Acute Malnutrition

(2013) Indi Trehan et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Bile Acid Sensor FXR Is Required for Immune-Regulatory Activities of TLR-9 in Intestinal Inflammation

(2013) Barbara Renga et al.   PLoS One

Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor

(2013) M. I. Smith et al.   SCIENCE

Butyrate increases IL-23 production by stimulated dendritic cells

(2012) Bradford E. Berndt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells

(2012) Mary A. Zimmerman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Microbiome in Infectious Disease and Inflammation

(2012) Kenya Honda et al.   Annual Review of Immunology

Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content

(2012) Mohamed Bellahcene et al.   BRITISH JOURNAL OF NUTRITION

Microbiota Regulate Intestinal Absorption and Metabolism of Fatty Acids in the Zebrafish

(2012) Ivana Semova et al.   Cell Host & Microbe

The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism

(2012) Arvand Haschemi et al.   Cell Metabolism

Butyrate interferes with the differentiation and function of human monocyte-derived dendritic cells

(2012) Lu Liu et al.   CELLULAR IMMUNOLOGY

Dietary and commensal derived nutrients: shaping mucosal and systemic immunity

(2012) Sean P Spencer et al.   CURRENT OPINION IN IMMUNOLOGY

Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases

(2012) Henri Duboc et al.   GUT

Commensal Bacteria Calibrate the Activation Threshold of Innate Antiviral Immunity

(2012) Michael C. Abt et al.   IMMUNITY

Priming of Natural Killer Cells by Nonmucosal Mononuclear Phagocytes Requires Instructive Signals from Commensal Microbiota

(2012) Stephanie C. Ganal et al.   IMMUNITY

Amino acid catabolism: a pivotal regulator of innate and adaptive immunity

(2012) Tracy L. McGaha et al.   IMMUNOLOGICAL REVIEWS

Liver X receptor and peroxisome proliferator-activated receptor as integrators of lipid homeostasis and immunity

(2012) Yoko Kidani et al.   IMMUNOLOGICAL REVIEWS

Extracellular Ionic Locks Determine Variation in Constitutive Activity and Ligand Potency between Species Orthologs of the Free Fatty Acid Receptors FFA2 and FFA3

(2012) Brian D. Hudson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tryptophan hydroxylase-1 regulates immune tolerance and inflammation

(2012) Elizabeth C. Nowak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation

(2012) Dallas R. Donohoe et al.   MOLECULAR CELL

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation

(2012) Tatsuo Hashimoto et al.   NATURE

A metagenome-wide association study of gut microbiota in type 2 diabetes

(2012) Junjie Qin et al.   NATURE

Functional interactions between the gut microbiota and host metabolism

(2012) Valentina Tremaroli et al.   NATURE

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

Metabolic checkpoints in activated T cells

(2012) Ruoning Wang et al.   NATURE IMMUNOLOGY

A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

(2012) Keisuke Ito et al.   NATURE MEDICINE

The role of the gut microbiota in nutrition and health

(2012) Harry J. Flint et al.   Nature Reviews Gastroenterology & Hepatology

A Pivotal Role of Vitamin B9 in the Maintenance of Regulatory T Cells In Vitro and In Vivo

(2012) Jun Kunisawa et al.   PLoS One

Microbial Regulation of Glucose Metabolism and Cell-Cycle Progression in Mammalian Colonocytes

(2012) Dallas R. Donohoe et al.   PLoS One

Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function

(2012) T. Olszak et al.   SCIENCE

Interactions Between the Microbiota and the Immune System

(2012) L. V. Hooper et al.   SCIENCE

Host-Gut Microbiota Metabolic Interactions

(2012) J. K. Nicholson et al.   SCIENCE

Metabolic pathways in T cell fate and function

(2012) Valerie A. Gerriets et al.   TRENDS IN IMMUNOLOGY

Symptomatic atherosclerosis is associated with an altered gut metagenome

(2012) Fredrik H. Karlsson et al.   Nature Communications

Human MAIT and CD8   cells develop from a pool of type-17 precommitted CD8+ T cells

(2011) L. J. Walker et al.   BLOOD

Role of the Commensal Microbiota in Normal and Pathogenic Host Immune Responses

(2011) Dan R. Littman et al.   Cell Host & Microbe

TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading

(2011) Thijs W.H. Pols et al.   Cell Metabolism

The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon

(2011) Dallas R. Donohoe et al.   Cell Metabolism

Arginases and arginine deficiency syndromes

(2011) Sidney M. Morris   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Interactions Between the Host Innate Immune System and Microbes in Inflammatory Bowel Disease

(2011) Clara Abraham et al.   GASTROENTEROLOGY

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

(2011) R. M. Gadaleta et al.   GUT

The G-Protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) in mice

(2011) Yan-Dong Wang et al.   HEPATOLOGY

The effects of commensal microbiota on immune cell subsets and inflammatory responses

(2011) Takatoshi Chinen et al.   IMMUNOLOGICAL REVIEWS

Coordinate regulation of neutrophil homeostasis by liver X receptors in mice

(2011) Cynthia Hong et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

Gut Microbiota Modulate the Metabolism of Brown Adipose Tissue in Mice

(2011) Renaud Mestdagh et al.   JOURNAL OF PROTEOME RESEARCH

Human nutrition, the gut microbiome and the immune system

(2011) Andrew L. Kau et al.   NATURE

Microbial Dysbiosis in Colorectal Cancer (CRC) Patients

(2011) Iradj Sobhani et al.   PLoS One

SCFAs Induce Mouse Neutrophil Chemotaxis through the GPR43 Receptor

(2011) Marco A. R. Vinolo et al.   PLoS One

Farnesoid X Receptor (FXR) Activation and FXR Genetic Variation in Inflammatory Bowel Disease

(2011) Rian M. Nijmeijer et al.   PLoS One

The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis

(2011) Sabrina Cipriani et al.   PLoS One

Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)

(2011) I. Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila Microbiome Modulates Host Developmental and Metabolic Homeostasis via Insulin Signaling

(2011) S. C. Shin et al.   SCIENCE

Intestinal microbiota: Shaping local and systemic immune responses

(2011) Michael J. Molloy et al.   SEMINARS IN IMMUNOLOGY

Histone deacetylases as regulators of inflammation and immunity

(2011) Melanie R. Shakespear et al.   TRENDS IN IMMUNOLOGY

Understanding the role of gut microbiome–host metabolic signal disruption in health and disease

(2011) Elaine Holmes et al.   TRENDS IN MICROBIOLOGY

Colonization-Induced Host-Gut Microbial Metabolic Interaction

(2011) S. P. Claus et al.   mBio

Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet

(2010) Mikael Bjursell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Intestinal Bacteria and the Regulation of Immune Cell Homeostasis

(2010) David A. Hill et al.   Annual Review of Immunology

Interactions Between Gut Microbiota and Host Metabolism Predisposing to Obesity and Diabetes

(2010) Giovanni Musso et al.   Annual Review of Medicine

Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells

(2010) M. Dusseaux et al.   BLOOD

Butyrate in vitro immune-modulatory effects might be mediated through a proliferation-related induction of apoptosis

(2010) Elvira Bailón et al.   IMMUNOBIOLOGY

The Role of the Transcription Factor CREB in Immune Function

(2010) A. Y. Wen et al.   JOURNAL OF IMMUNOLOGY

Commensal Microbiota and CD8+ T Cells Shape the Formation of Invariant NKT Cells

(2010) B. Wei et al.   JOURNAL OF IMMUNOLOGY

Dietary Modulation of Gut Functional Ecology Studied by Fecal Metabonomics

(2010) Francois-Pierre J. Martin et al.   JOURNAL OF PROTEOME RESEARCH

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Antimicrobial activity of mucosal-associated invariant T cells

(2010) Lionel Le Bourhis et al.   NATURE IMMUNOLOGY

Human oral, gut, and plaque microbiota in patients with atherosclerosis

(2010) O. Koren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systemic gut microbial modulation of bile acid metabolism in host tissue compartments

(2010) J. R. Swann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of the Arginase Pathway in the Context of Microbial Pathogenesis: A Metabolic Enzyme Moonlighting as an Immune Modulator

(2010) Priyanka Das et al.   PLoS Pathogens

The Bile Acid Sensor Farnesoid X Receptor Is a Modulator of Liver Immunity in a Rodent Model of Acute Hepatitis

(2009) A. Mencarelli et al.   JOURNAL OF IMMUNOLOGY

The Bile Acid Receptor FXR Is a Modulator of Intestinal Innate Immunity

(2009) P. Vavassori et al.   JOURNAL OF IMMUNOLOGY

G Protein-Coupled Receptor 43 Is Essential for Neutrophil Recruitment during Intestinal Inflammation

(2009) C. Sina et al.   JOURNAL OF IMMUNOLOGY

Discovery of 6α-Ethyl-23(S)-methylcholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity

(2009) Roberto Pellicciari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Landscape Analysis of Interactions between Nutrition and Vaccine Responses in Children

(2009) Mathilde Savy et al.   JOURNAL OF NUTRITION

Effects of probiotics and commensals on intestinal epithelial physiology: implications for nutrient handling

(2009) Silvia C. Resta   JOURNAL OF PHYSIOLOGY-LONDON

Panorganismal Gut Microbiome−Host Metabolic Crosstalk

(2009) Francois-Pierre J. Martin et al.   JOURNAL OF PROTEOME RESEARCH

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

Autophagy genes in immunity

(2009) Herbert W Virgin et al.   NATURE IMMUNOLOGY

PPAR-δ senses and orchestrates clearance of apoptotic cells to promote tolerance

(2009) Lata Mukundan et al.   NATURE MEDICINE

Infectious tolerance via the consumption of essential amino acids and mTOR signaling

(2009) S. P. Cobbold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bile-acid-activated receptors: targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders

(2009) Stefano Fiorucci et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Short-chain fatty acids act as antiinflammatory mediatorsby regulating prostaglandin E2 and cytokines

(2009) Mary Ann Cox et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

(2008) Justin I. Odegaard et al.   Cell Metabolism

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon

(2008) Markus Waldecker et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Maternal and child undernutrition: global and regional exposures and health consequences

(2008) Robert E Black et al.   LANCET

Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes

(2008) Sandrine P Claus et al.   Molecular Systems Biology

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE

Targeting bile-acid signalling for metabolic diseases

(2008) Charles Thomas et al.   NATURE REVIEWS DRUG DISCOVERY

Enterococcus faecalis from newborn babies regulate endogenous PPAR  activity and IL-10 levels in colonic epithelial cells

(2008) A. Are et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome

(2008) B. V. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA